MX2010010000A - Derivados de 2-trifluorometilnicotinamida como agentes para aumentar el colesterol de lipoproteinas de alta densidad. - Google Patents
Derivados de 2-trifluorometilnicotinamida como agentes para aumentar el colesterol de lipoproteinas de alta densidad.Info
- Publication number
- MX2010010000A MX2010010000A MX2010010000A MX2010010000A MX2010010000A MX 2010010000 A MX2010010000 A MX 2010010000A MX 2010010000 A MX2010010000 A MX 2010010000A MX 2010010000 A MX2010010000 A MX 2010010000A MX 2010010000 A MX2010010000 A MX 2010010000A
- Authority
- MX
- Mexico
- Prior art keywords
- hdl
- trifluoromethylnicotinamide
- derivatives
- raising agents
- cholesterol raising
- Prior art date
Links
- 239000004131 EU approved raising agent Substances 0.000 title abstract 2
- 108010023302 HDL Cholesterol Proteins 0.000 title abstract 2
- 235000010855 food raising agent Nutrition 0.000 title abstract 2
- PNXJWEQRIVLWBG-UHFFFAOYSA-N 2-(trifluoromethyl)pyridine-3-carboxamide Chemical class NC(=O)C1=CC=CN=C1C(F)(F)F PNXJWEQRIVLWBG-UHFFFAOYSA-N 0.000 title 1
- 208000032928 Dyslipidaemia Diseases 0.000 abstract 1
- 208000017170 Lipid metabolism disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
La presente invención, se refiere a compuestos de la fórmula (I) en donde R1 a R8 son tal y como se definen en la descripción y las reivindicaciones para la preparación de medicamentos para el tratamiento y/o profilaxis de enfermedades que pueden tratarse con agentes para aumentar el colesterol HDL, tal como preferiblemente dislipemia.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08153792 | 2008-03-31 | ||
| PCT/EP2009/053343 WO2009121740A1 (en) | 2008-03-31 | 2009-03-23 | 2-trifluoromethylnicotinamide derivatives as hdl-cholesterol raising agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010010000A true MX2010010000A (es) | 2010-09-30 |
Family
ID=40601113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010010000A MX2010010000A (es) | 2008-03-31 | 2009-03-23 | Derivados de 2-trifluorometilnicotinamida como agentes para aumentar el colesterol de lipoproteinas de alta densidad. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7897621B2 (es) |
| EP (1) | EP2262770B1 (es) |
| JP (1) | JP5442711B2 (es) |
| KR (1) | KR101249668B1 (es) |
| CN (1) | CN101981009B (es) |
| AR (1) | AR071096A1 (es) |
| AU (1) | AU2009231375A1 (es) |
| CA (1) | CA2717537A1 (es) |
| ES (1) | ES2391371T3 (es) |
| IL (1) | IL208021A0 (es) |
| MX (1) | MX2010010000A (es) |
| PE (1) | PE20091826A1 (es) |
| TW (1) | TW200944504A (es) |
| WO (1) | WO2009121740A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2774981A1 (en) * | 2009-09-21 | 2011-03-24 | Vanderbilt University | O-benzyl nicotinamide analogs as mglur5 positive allosteric modulators |
| WO2012031817A1 (en) | 2010-09-09 | 2012-03-15 | F. Hoffmann-La Roche Ag | Determination of abca1 protein levels in cells |
| US8410107B2 (en) | 2010-10-15 | 2013-04-02 | Hoffmann-La Roche Inc. | N-pyridin-3-yl or N-pyrazin-2-yl carboxamides |
| US8669254B2 (en) | 2010-12-15 | 2014-03-11 | Hoffman-La Roche Inc. | Pyridine, pyridazine, pyrimidine or pyrazine carboxamides as HDL-cholesterol raising agents |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0400208D0 (sv) | 2004-02-02 | 2004-02-02 | Astrazeneca Ab | Chemical compounds |
| ATE435207T1 (de) | 2005-04-06 | 2009-07-15 | Hoffmann La Roche | Pyridin-3-carbonsäureamidderivate als cb1-inverse agonisten |
| US7629346B2 (en) | 2006-06-19 | 2009-12-08 | Hoffmann-La Roche Inc. | Pyrazinecarboxamide derivatives as CB1 antagonists |
| US7781593B2 (en) | 2006-09-14 | 2010-08-24 | Hoffmann-La Roche Inc. | 5-phenyl-nicotinamide derivatives |
| AU2007304365A1 (en) | 2006-10-04 | 2008-04-10 | F. Hoffmann-La Roche Ag | 3-pyridinecarboxamide and 2-pyrazinecarboxamide derivatives as HDL-cholesterol raising agents |
| US7691863B2 (en) | 2006-10-04 | 2010-04-06 | Hoffman-La Roche Inc. | Pyrazine-2-carboxamide derivatives as CB2 receptor modulators |
-
2009
- 2009-03-16 US US12/404,364 patent/US7897621B2/en not_active Expired - Fee Related
- 2009-03-23 WO PCT/EP2009/053343 patent/WO2009121740A1/en not_active Ceased
- 2009-03-23 JP JP2011502334A patent/JP5442711B2/ja not_active Expired - Fee Related
- 2009-03-23 CN CN2009801105525A patent/CN101981009B/zh not_active Expired - Fee Related
- 2009-03-23 EP EP09727590A patent/EP2262770B1/en not_active Not-in-force
- 2009-03-23 MX MX2010010000A patent/MX2010010000A/es active IP Right Grant
- 2009-03-23 AU AU2009231375A patent/AU2009231375A1/en not_active Abandoned
- 2009-03-23 ES ES09727590T patent/ES2391371T3/es active Active
- 2009-03-23 KR KR1020107021707A patent/KR101249668B1/ko not_active Expired - Fee Related
- 2009-03-23 CA CA2717537A patent/CA2717537A1/en not_active Abandoned
- 2009-03-27 AR ARP090101099A patent/AR071096A1/es unknown
- 2009-03-30 PE PE2009000468A patent/PE20091826A1/es not_active Application Discontinuation
- 2009-03-30 TW TW098110488A patent/TW200944504A/zh unknown
-
2010
- 2010-09-06 IL IL208021A patent/IL208021A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US7897621B2 (en) | 2011-03-01 |
| US20090247588A1 (en) | 2009-10-01 |
| TW200944504A (en) | 2009-11-01 |
| PE20091826A1 (es) | 2009-11-25 |
| EP2262770A1 (en) | 2010-12-22 |
| CA2717537A1 (en) | 2009-10-08 |
| JP2011516444A (ja) | 2011-05-26 |
| KR20100117142A (ko) | 2010-11-02 |
| JP5442711B2 (ja) | 2014-03-12 |
| AR071096A1 (es) | 2010-05-26 |
| IL208021A0 (en) | 2010-12-30 |
| KR101249668B1 (ko) | 2013-04-01 |
| ES2391371T3 (es) | 2012-11-23 |
| WO2009121740A1 (en) | 2009-10-08 |
| CN101981009A (zh) | 2011-02-23 |
| AU2009231375A1 (en) | 2009-10-08 |
| EP2262770B1 (en) | 2012-08-01 |
| CN101981009B (zh) | 2013-09-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |