MX2010009743A - Uso de derivados de pirimidina para el tratamiento de las enfermedades dependientes de los receptores del factor de crecimiento epidermico (egfr) o de enfermedades que hayan adquirido resistencia a los agentes que se dirigen a los miembros de la fami - Google Patents
Uso de derivados de pirimidina para el tratamiento de las enfermedades dependientes de los receptores del factor de crecimiento epidermico (egfr) o de enfermedades que hayan adquirido resistencia a los agentes que se dirigen a los miembros de la famiInfo
- Publication number
- MX2010009743A MX2010009743A MX2010009743A MX2010009743A MX2010009743A MX 2010009743 A MX2010009743 A MX 2010009743A MX 2010009743 A MX2010009743 A MX 2010009743A MX 2010009743 A MX2010009743 A MX 2010009743A MX 2010009743 A MX2010009743 A MX 2010009743A
- Authority
- MX
- Mexico
- Prior art keywords
- diseases
- egfr
- treatment
- family members
- agents
- Prior art date
Links
- 108060006698 EGF receptor Proteins 0.000 title abstract 7
- 201000010099 disease Diseases 0.000 title abstract 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 7
- 230000001419 dependent effect Effects 0.000 title abstract 2
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
- 150000003230 pyrimidines Chemical class 0.000 title 1
- 102000001301 EGF receptor Human genes 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se refiere al uso de los compuestos de la fórmula (I): (ver fórmula (I)) en el tratamiento de las enfermedades dependientes de los miembros de la familia de los receptores del factor de crecimiento epidérmico (EGFR), o de las enfermedades que tengan una resistencia adquirida a los agentes que se dirigen a los miembros de la familia de los receptores del factor de crecimiento epidérmico (EGFR), al uso de estos compuestos para la fabricación de composiciones farmacéuticas para el tratamiento de estas enfermedades, a combinaciones de estos compuestos con moduladores de los receptores del factor de crecimiento epidérmico (EGFR) para dicho uso, a métodos para el tratamiento de estas enfermedades con tales compuestos, y a las preparaciones farmacéuticas para el tratamiento de estas enfermedades, las cuales comprenden estos compuestos, solos o en combinación, en especial con un modulador de los receptores del factor de crecimiento epidérmico (EGFR).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08152326 | 2008-03-05 | ||
| PCT/EP2009/052564 WO2009109605A1 (en) | 2008-03-05 | 2009-03-04 | Use of pyrimidine derivatives for the treatment of egfr dependent diseases or diseases that have acquired resistance to agents that target egfr family members |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010009743A true MX2010009743A (es) | 2010-09-28 |
Family
ID=39343633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010009743A MX2010009743A (es) | 2008-03-05 | 2009-03-04 | Uso de derivados de pirimidina para el tratamiento de las enfermedades dependientes de los receptores del factor de crecimiento epidermico (egfr) o de enfermedades que hayan adquirido resistencia a los agentes que se dirigen a los miembros de la fami |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20110033453A1 (es) |
| EP (3) | EP2259800B1 (es) |
| JP (2) | JP2011513364A (es) |
| KR (1) | KR20100131446A (es) |
| CN (2) | CN105343102A (es) |
| AU (1) | AU2009221164B2 (es) |
| BR (1) | BRPI0908049A2 (es) |
| CA (1) | CA2716518A1 (es) |
| ES (1) | ES2471452T3 (es) |
| MX (1) | MX2010009743A (es) |
| PL (1) | PL2259800T3 (es) |
| PT (1) | PT2259800E (es) |
| RU (2) | RU2496500C2 (es) |
| WO (1) | WO2009109605A1 (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20100039354A (ko) * | 2007-07-24 | 2010-04-15 | 노파르티스 아게 | Egfr 의존성 질환 또는 egfr 족 구성원을 표적으로 하는 작용제에 대한 내성을 획득한 질환의 치료를 위한 이미다조퀴놀린의 용도 |
| US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| EA029131B1 (ru) | 2008-05-21 | 2018-02-28 | Ариад Фармасьютикалз, Инк. | Фосфорсодержащие производные в качестве ингибиторов киназы |
| AU2011315831B2 (en) * | 2010-10-14 | 2015-01-22 | Takeda Pharmaceutical Company Limited | Methods for inhibiting cell proliferation in EGFR-driven cancers |
| EA201391626A1 (ru) | 2011-05-04 | 2014-03-31 | Ариад Фармасьютикалз, Инк. | Соединения для ингибирования клеточной пролиферации в egfr-стимулированных типах рака |
| WO2013046136A1 (en) | 2011-09-27 | 2013-04-04 | Novartis Ag | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh |
| CN102397544A (zh) * | 2011-11-25 | 2012-04-04 | 百泰生物药业有限公司 | 一种单克隆抗体用于治疗非小细胞肺癌的用途 |
| UY34632A (es) | 2012-02-24 | 2013-05-31 | Novartis Ag | Compuestos de oxazolidin- 2- ona y usos de los mismos |
| JP6469567B2 (ja) | 2012-05-05 | 2019-02-13 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Egfr発動性がんの細胞増殖阻害用化合物 |
| MX369518B (es) * | 2012-08-16 | 2019-11-11 | Novartis Ag | Combinacion de inhibidor de p13k e inhibidor de c-met. |
| US9296733B2 (en) | 2012-11-12 | 2016-03-29 | Novartis Ag | Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases |
| EA028033B1 (ru) | 2013-03-14 | 2017-09-29 | Новартис Аг | 3-пиримидин-4-ил-оксазолидин-2-оны в качестве ингибиторов мутантного idh |
| US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
| EP3229803B1 (en) | 2014-12-12 | 2020-01-29 | Massachusetts General Hospital | Treatment of breast cancer brain metastases |
| MX2021002805A (es) | 2018-09-10 | 2021-07-15 | Mirati Therapeutics Inc | Terapias de combinacion. |
| CN111529530B (zh) * | 2020-04-02 | 2021-06-04 | 中山大学 | 一种吡啶并咪唑类STAT3抑制剂在制备延缓或逆转TKIs获得性耐药药物中的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU661533B2 (en) * | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
| GB9508538D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| AU782994C (en) * | 1999-05-14 | 2006-08-24 | Imclone Llc | Treatment of refractory human tumors with epidermal growth factor receptor antagonists |
| MXPA05005477A (es) * | 2002-11-21 | 2005-07-25 | Chiron Corp | Pirimidinas 2,4,6-trisustituidas como inhibidores de fosfotidilinositol (pi) 3-cinasa y su uso en el tratamiento del cancer. |
| JO2660B1 (en) * | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
| KR20100039354A (ko) * | 2007-07-24 | 2010-04-15 | 노파르티스 아게 | Egfr 의존성 질환 또는 egfr 족 구성원을 표적으로 하는 작용제에 대한 내성을 획득한 질환의 치료를 위한 이미다조퀴놀린의 용도 |
-
2009
- 2009-03-04 CN CN201510646346.3A patent/CN105343102A/zh active Pending
- 2009-03-04 EP EP09716778.7A patent/EP2259800B1/en not_active Not-in-force
- 2009-03-04 BR BRPI0908049-0A patent/BRPI0908049A2/pt not_active IP Right Cessation
- 2009-03-04 EP EP13154400.9A patent/EP2591805A1/en not_active Withdrawn
- 2009-03-04 PL PL09716778T patent/PL2259800T3/pl unknown
- 2009-03-04 KR KR1020107019674A patent/KR20100131446A/ko not_active Abandoned
- 2009-03-04 US US12/867,058 patent/US20110033453A1/en not_active Abandoned
- 2009-03-04 JP JP2010549141A patent/JP2011513364A/ja active Pending
- 2009-03-04 PT PT97167787T patent/PT2259800E/pt unknown
- 2009-03-04 CA CA2716518A patent/CA2716518A1/en not_active Abandoned
- 2009-03-04 WO PCT/EP2009/052564 patent/WO2009109605A1/en not_active Ceased
- 2009-03-04 EP EP13155903.1A patent/EP2599499A1/en not_active Withdrawn
- 2009-03-04 MX MX2010009743A patent/MX2010009743A/es active IP Right Grant
- 2009-03-04 ES ES09716778.7T patent/ES2471452T3/es active Active
- 2009-03-04 RU RU2010140435/15A patent/RU2496500C2/ru not_active IP Right Cessation
- 2009-03-04 CN CN200980107270XA patent/CN101959533A/zh active Pending
- 2009-03-04 AU AU2009221164A patent/AU2009221164B2/en not_active Ceased
-
2013
- 2013-07-10 RU RU2013132018/15A patent/RU2013132018A/ru not_active Application Discontinuation
- 2013-10-01 JP JP2013206606A patent/JP5778735B2/ja not_active Expired - Fee Related
-
2014
- 2014-02-17 US US14/182,023 patent/US20140161722A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2599499A1 (en) | 2013-06-05 |
| EP2259800B1 (en) | 2014-05-07 |
| WO2009109605A1 (en) | 2009-09-11 |
| EP2591805A1 (en) | 2013-05-15 |
| RU2496500C2 (ru) | 2013-10-27 |
| CN105343102A (zh) | 2016-02-24 |
| PT2259800E (pt) | 2014-08-06 |
| US20140161722A1 (en) | 2014-06-12 |
| RU2013132018A (ru) | 2015-01-20 |
| ES2471452T3 (es) | 2014-06-26 |
| US20110033453A1 (en) | 2011-02-10 |
| AU2009221164A1 (en) | 2009-09-11 |
| JP5778735B2 (ja) | 2015-09-16 |
| BRPI0908049A2 (pt) | 2015-08-11 |
| JP2011513364A (ja) | 2011-04-28 |
| AU2009221164B2 (en) | 2012-07-26 |
| EP2259800A1 (en) | 2010-12-15 |
| CA2716518A1 (en) | 2009-09-11 |
| CN101959533A (zh) | 2011-01-26 |
| JP2014040446A (ja) | 2014-03-06 |
| KR20100131446A (ko) | 2010-12-15 |
| RU2010140435A (ru) | 2012-04-10 |
| PL2259800T3 (pl) | 2014-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |