[go: up one dir, main page]

MX2010007949A - Procedimiento para la fabricacion de un derivado de 6-fluoro-1,2-dihidro-2-oxo-3h-indol-3-ilideno. - Google Patents

Procedimiento para la fabricacion de un derivado de 6-fluoro-1,2-dihidro-2-oxo-3h-indol-3-ilideno.

Info

Publication number
MX2010007949A
MX2010007949A MX2010007949A MX2010007949A MX2010007949A MX 2010007949 A MX2010007949 A MX 2010007949A MX 2010007949 A MX2010007949 A MX 2010007949A MX 2010007949 A MX2010007949 A MX 2010007949A MX 2010007949 A MX2010007949 A MX 2010007949A
Authority
MX
Mexico
Prior art keywords
oxo
fluoro
manufacture
dol
dihydro
Prior art date
Application number
MX2010007949A
Other languages
English (en)
Inventor
Werner Rall
Juergen Schnaubelt
Waldemar Pfrengle
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MX2010007949A publication Critical patent/MX2010007949A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a un procedimiento para la elaboración del compuesto ácido 4-[(Z)-[[4-[(dimetilamino)metil]fe nil]amino](6-fluoro-1,2-dihidro-2-oxo-3H-indol-3-ilideno)metil]-b encenopropanoico y a un nuevo intermedio para la síntesis. (Ver fórmula I).
MX2010007949A 2008-01-25 2009-01-22 Procedimiento para la fabricacion de un derivado de 6-fluoro-1,2-dihidro-2-oxo-3h-indol-3-ilideno. MX2010007949A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08150661 2008-01-25
PCT/EP2009/000377 WO2009092580A1 (en) 2008-01-25 2009-01-22 Process for the manufacture of a 6-fluoro-1,2-dihydro-2-oxo-3h-indol-3-ylidene derivative

Publications (1)

Publication Number Publication Date
MX2010007949A true MX2010007949A (es) 2010-08-04

Family

ID=40419005

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010007949A MX2010007949A (es) 2008-01-25 2009-01-22 Procedimiento para la fabricacion de un derivado de 6-fluoro-1,2-dihidro-2-oxo-3h-indol-3-ilideno.

Country Status (14)

Country Link
US (1) US20110046395A1 (es)
EP (1) EP2238107A1 (es)
JP (1) JP2011510031A (es)
KR (1) KR20100114103A (es)
CN (1) CN101970407A (es)
AU (1) AU2009207861A1 (es)
BR (1) BRPI0906379A2 (es)
CA (1) CA2712385A1 (es)
IL (1) IL206886A0 (es)
MX (1) MX2010007949A (es)
NZ (1) NZ586760A (es)
RU (1) RU2010135196A (es)
WO (1) WO2009092580A1 (es)
ZA (1) ZA201004757B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104844499B (zh) * 2015-06-05 2017-03-08 北京康立生医药技术开发有限公司 一锅法制备尼达尼布的合成方法
CN115960030B (zh) * 2023-01-10 2024-09-27 湖北工业大学 一种3-亚基羟吲哚衍生物的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10233366A1 (de) * 2002-07-23 2004-02-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg In 6-Stellung substituierte Indolinonderivate, ihre Herstellung und ihre Verwendung als Arzneimittel
PE20040701A1 (es) * 2002-07-23 2004-11-30 Boehringer Ingelheim Pharma Derivados de indolinona sustituidos en posicion 6 y su preparacion como medicamentos
DE102004012070A1 (de) * 2004-03-12 2005-09-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue cycloalkyl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel
DE102004012068A1 (de) * 2004-03-12 2005-09-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue alkyl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel
WO2007122219A1 (en) * 2006-04-24 2007-11-01 Boehringer Ingelheim International Gmbh 3- (aminomethyliden) 2-indolinone derivatives and their use as cell proliferation inhibitors
MX2010007950A (es) * 2008-01-25 2010-08-04 Boehringer Ingelheim Int Formas salinas de un derivado de 6-fluoro-1,2-dihidro-2-oxo-3h-ind ol-3-ilideno, procedimiento para su preparacion y composiciones farmaceuticas que las contienen.

Also Published As

Publication number Publication date
JP2011510031A (ja) 2011-03-31
IL206886A0 (en) 2010-12-30
RU2010135196A (ru) 2012-02-27
CN101970407A (zh) 2011-02-09
US20110046395A1 (en) 2011-02-24
EP2238107A1 (en) 2010-10-13
NZ586760A (en) 2011-12-22
CA2712385A1 (en) 2009-07-30
ZA201004757B (en) 2011-03-30
KR20100114103A (ko) 2010-10-22
BRPI0906379A2 (pt) 2019-09-24
AU2009207861A1 (en) 2009-07-30
WO2009092580A1 (en) 2009-07-30

Similar Documents

Publication Publication Date Title
NO20084783L (no) Syntese av acylaminoalkenylenamider nyttige som substans P antagonister
CY1111793T1 (el) Μυκητοκτονες συνθεσεις
UA102817C2 (ru) Способ синтеза агомелатина
MY173448A (en) Phenyl and benzodioxinly substituted indazoles derivatives
WO2010062590A3 (en) Process for the preparation of protected l-alanine derivatives
GEP20125491B (en) New process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
TW200833657A (en) Novel process
GEP20125512B (en) Process for synthesis of agomelatin
TN2010000219A1 (en) 5-[(3,3,3-trifluoro-2-hydroxy-1-arylpropyl)amino]-1h-quinolin-2-ones, a process for their production and their use as anti-inflammatory agents
MX2010009860A (es) Sintesis total de salinosporamida a y sus analogos.
MY146084A (en) Benzyl amines, a process for their production and their use as anti-inflammatory agents
TN2009000401A1 (en) New methods
MY156630A (en) New process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
CL2010001639A1 (es) Proceso para preparacion del hemitartrato de [5-(4,6-dimetil-1h-benzoimidazol-2-il-metil-pirimidin-2-il]-[3-(metil-piperidin-4-il)propil]amina; proceso de recristalizacion del hemitartrato; y hemitaatrato cristalino de [5-(4,6-dimetil-1h-benzoimidazol-2-il)-4-metil- pirimidin-2-il]-[3-(1-metil-piperidin-4-il)-propil]-amina.
EA200801893A1 (ru) Производные тетрагидронафталина, способ их получения и их применение в качестве ингибиторов воспаления
WO2011009634A3 (en) Process for producing fingolimod salts
MX2012001411A (es) Proceso para la preparacion de derivados de acido 1-(2-halobifenil-4-il)-ciclopropanocarboxilico.
PL1758852T3 (pl) Podstawione związki cyklopentenu
MX2010009926A (es) Nuevo proceso para la preparacion de derivados de acido ciclohexancarboxilico.
MX2010009876A (es) Nuevo proceso para la preparacion de derivados de acido ciclohexanocarboxilico por medio del derivado de ciclohexanocarboxamida correspondiente.
UA106195C2 (ru) Способ синтеза агомелатина
MX2007007025A (es) Nuevos derivados de hidantoina como inhibidores de metaloproteinasa.
MX2010007949A (es) Procedimiento para la fabricacion de un derivado de 6-fluoro-1,2-dihidro-2-oxo-3h-indol-3-ilideno.
GEP20125460B (en) New process for the synthesis of ivabradine and its pharmaceutically acceptable acid addition salts
UA102816C2 (ru) Способ синтеза кристаллической формы v агомелатина

Legal Events

Date Code Title Description
FG Grant or registration