MX2010007034A - Configuraciones para eyector de gotas y metodos para realizar operaciones de gota. - Google Patents
Configuraciones para eyector de gotas y metodos para realizar operaciones de gota.Info
- Publication number
- MX2010007034A MX2010007034A MX2010007034A MX2010007034A MX2010007034A MX 2010007034 A MX2010007034 A MX 2010007034A MX 2010007034 A MX2010007034 A MX 2010007034A MX 2010007034 A MX2010007034 A MX 2010007034A MX 2010007034 A MX2010007034 A MX 2010007034A
- Authority
- MX
- Mexico
- Prior art keywords
- droplet
- methods
- electrode configuration
- operations surface
- actuator
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 230000015572 biosynthetic process Effects 0.000 abstract 4
- 238000009472 formulation Methods 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108010047303 von Willebrand Factor Proteins 0.000 abstract 1
- 102100036537 von Willebrand factor Human genes 0.000 abstract 1
- 229960001134 von willebrand factor Drugs 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
- B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/52—Containers specially adapted for storing or dispensing a reagent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/302—Micromixers the materials to be mixed flowing in the form of droplets
- B01F33/3021—Micromixers the materials to be mixed flowing in the form of droplets the components to be mixed being combined in a single independent droplet, e.g. these droplets being divided by a non-miscible fluid or consisting of independent droplets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/3031—Micromixers using electro-hydrodynamic [EHD] or electro-kinetic [EKI] phenomena to mix or move the fluids
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
- F04B19/006—Micropumps
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0605—Metering of fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/14—Process control and prevention of errors
- B01L2200/143—Quality control, feedback systems
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/16—Reagents, handling or storing thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0819—Microarrays; Biochips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/089—Virtual walls for guiding liquids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
- B01L2400/0427—Electrowetting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0241—Drop counters; Drop formers
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Clinical Laboratory Science (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- Medicinal Chemistry (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Coating Apparatus (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Application Of Or Painting With Fluid Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Electrostatic Spraying Apparatus (AREA)
- Medicinal Preparation (AREA)
- Particle Formation And Scattering Control In Inkjet Printers (AREA)
Abstract
Un aplicador de gotas con una configuración de electrodo de formación de gotas asociado con una superficie de operaciones de gotas, en donde las configuraciones de electrodo comprende uno o mas electrodos configurados para controlar el volumen de una gota durante la formación de una sub-gota en la superficie de operaciones de gotas. También se proporcionan métodos para hacer y usar el aplicador de gotas.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1648007P | 2007-12-23 | 2007-12-23 | |
| US1661807P | 2007-12-26 | 2007-12-26 | |
| PCT/US2008/088205 WO2009086403A2 (en) | 2007-12-23 | 2008-12-23 | Droplet actuator configurations and methods of conducting droplet operations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010007034A true MX2010007034A (es) | 2010-09-14 |
Family
ID=40825079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010007034A MX2010007034A (es) | 2007-12-23 | 2008-12-23 | Configuraciones para eyector de gotas y metodos para realizar operaciones de gota. |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20100270156A1 (es) |
| EP (1) | EP2237955A4 (es) |
| JP (1) | JP5462183B2 (es) |
| KR (1) | KR20100100974A (es) |
| CN (2) | CN101945767B (es) |
| AU (1) | AU2008345138B2 (es) |
| BR (1) | BRPI0821734A2 (es) |
| CA (1) | CA2709928A1 (es) |
| MX (1) | MX2010007034A (es) |
| WO (1) | WO2009086403A2 (es) |
Families Citing this family (108)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006081558A2 (en) | 2005-01-28 | 2006-08-03 | Duke University | Apparatuses and methods for manipulating droplets on a printed circuit board |
| US20140193807A1 (en) | 2006-04-18 | 2014-07-10 | Advanced Liquid Logic, Inc. | Bead manipulation techniques |
| US7439014B2 (en) | 2006-04-18 | 2008-10-21 | Advanced Liquid Logic, Inc. | Droplet-based surface modification and washing |
| US8658111B2 (en) | 2006-04-18 | 2014-02-25 | Advanced Liquid Logic, Inc. | Droplet actuators, modified fluids and methods |
| US8809068B2 (en) | 2006-04-18 | 2014-08-19 | Advanced Liquid Logic, Inc. | Manipulation of beads in droplets and methods for manipulating droplets |
| US10078078B2 (en) | 2006-04-18 | 2018-09-18 | Advanced Liquid Logic, Inc. | Bead incubation and washing on a droplet actuator |
| US8637324B2 (en) | 2006-04-18 | 2014-01-28 | Advanced Liquid Logic, Inc. | Bead incubation and washing on a droplet actuator |
| US9675972B2 (en) | 2006-05-09 | 2017-06-13 | Advanced Liquid Logic, Inc. | Method of concentrating beads in a droplet |
| US8685344B2 (en) | 2007-01-22 | 2014-04-01 | Advanced Liquid Logic, Inc. | Surface assisted fluid loading and droplet dispensing |
| KR101431778B1 (ko) | 2007-02-09 | 2014-08-20 | 어드밴스드 리퀴드 로직, 아이엔씨. | 자성 비즈를 이용하는 액적 작동기 장치 및 방법 |
| WO2008101194A2 (en) | 2007-02-15 | 2008-08-21 | Advanced Liquid Logic, Inc. | Capacitance detection in a droplet actuator |
| WO2011084703A2 (en) | 2009-12-21 | 2011-07-14 | Advanced Liquid Logic, Inc. | Enzyme assays on a droplet actuator |
| WO2009032863A2 (en) | 2007-09-04 | 2009-03-12 | Advanced Liquid Logic, Inc. | Droplet actuator with improved top substrate |
| CA2709928A1 (en) | 2007-12-23 | 2009-07-09 | Advanced Liquid Logic, Inc. | Droplet actuator configurations and methods of conducting droplet operations |
| WO2009137415A2 (en) | 2008-05-03 | 2009-11-12 | Advanced Liquid Logic, Inc. | Reagent and sample preparation, loading, and storage |
| EP2286228B1 (en) | 2008-05-16 | 2019-04-03 | Advanced Liquid Logic, Inc. | Droplet actuator devices and methods for manipulating beads |
| FR2933315B1 (fr) * | 2008-07-07 | 2012-02-10 | Commissariat Energie Atomique | Dispositif microfluidique de deplacement de liquide |
| US8364315B2 (en) * | 2008-08-13 | 2013-01-29 | Advanced Liquid Logic Inc. | Methods, systems, and products for conducting droplet operations |
| US20110297547A1 (en) * | 2009-01-14 | 2011-12-08 | National Chiao Tung University | Virtual channel platform |
| US8877512B2 (en) | 2009-01-23 | 2014-11-04 | Advanced Liquid Logic, Inc. | Bubble formation techniques using physical or chemical features to retain a gas bubble within a droplet actuator |
| US8926065B2 (en) | 2009-08-14 | 2015-01-06 | Advanced Liquid Logic, Inc. | Droplet actuator devices and methods |
| JP5610258B2 (ja) * | 2009-09-09 | 2014-10-22 | 国立大学法人 筑波大学 | 送液装置 |
| WO2011057197A2 (en) | 2009-11-06 | 2011-05-12 | Advanced Liquid Logic, Inc. | Integrated droplet actuator for gel electrophoresis and molecular analysis |
| US8834695B2 (en) * | 2010-03-09 | 2014-09-16 | Sparkle Power Inc. | Droplet manipulations on EWOD microelectrode array architecture |
| WO2011126892A2 (en) | 2010-03-30 | 2011-10-13 | Advanced Liquid Logic, Inc. | Droplet operations platform |
| CA2798123C (en) | 2010-05-05 | 2020-06-23 | The Governing Council Of The University Of Toronto | Method of processing dried samples using digital microfluidic device |
| EP2588322B1 (en) | 2010-06-30 | 2015-06-17 | Advanced Liquid Logic, Inc. | Droplet actuator assemblies and methods of making same |
| US20120006681A1 (en) * | 2010-07-06 | 2012-01-12 | Kaler Karan V I S | Controlled Dispensing of Ultrafine, Variable Volume, Emulsion Droplets |
| US20130168250A1 (en) * | 2010-09-16 | 2013-07-04 | Advanced Liquid Logic Inc | Droplet Actuator Systems, Devices and Methods |
| US20130068622A1 (en) * | 2010-11-24 | 2013-03-21 | Michael John Schertzer | Method and apparatus for real-time monitoring of droplet composition in microfluidic devices |
| AU2012250917B2 (en) * | 2011-05-02 | 2015-09-17 | Advanced Liquid Logic, Inc. | Molecular diagnostics platform |
| WO2012154745A2 (en) | 2011-05-09 | 2012-11-15 | Advanced Liquid Logic, Inc. | Microfluidic feedback using impedance detection |
| CN103597356A (zh) | 2011-05-10 | 2014-02-19 | 先进流体逻辑公司 | 酶浓缩与分析 |
| KR20140064771A (ko) | 2011-07-06 | 2014-05-28 | 어드밴스드 리퀴드 로직, 아이엔씨. | 비말 작동기 상의 시약 저장 |
| US8901043B2 (en) | 2011-07-06 | 2014-12-02 | Advanced Liquid Logic, Inc. | Systems for and methods of hybrid pyrosequencing |
| US20130018611A1 (en) * | 2011-07-11 | 2013-01-17 | Advanced Liquid Logic Inc | Systems and Methods of Measuring Gap Height |
| WO2013009927A2 (en) | 2011-07-11 | 2013-01-17 | Advanced Liquid Logic, Inc. | Droplet actuators and techniques for droplet-based assays |
| US9857332B2 (en) | 2011-07-22 | 2018-01-02 | Tecan Trading Ag | System for manipulating samples in liquid droplets |
| US9446404B2 (en) | 2011-07-25 | 2016-09-20 | Advanced Liquid Logic, Inc. | Droplet actuator apparatus and system |
| EP2776165A2 (en) | 2011-11-07 | 2014-09-17 | Illumina, Inc. | Integrated sequencing apparatuses and methods of use |
| WO2013078216A1 (en) | 2011-11-21 | 2013-05-30 | Advanced Liquid Logic Inc | Glucose-6-phosphate dehydrogenase assays |
| JP6329130B2 (ja) | 2012-04-10 | 2018-05-30 | アイノビア,インコーポレイティド | 噴霧エジェクタ機構、電荷分離及び制御可能な液滴電荷を提供する装置、並びに低投与量の点眼 |
| SG11201407431RA (en) | 2012-05-15 | 2014-12-30 | Eyenovia Inc | Ejector devices, methods, drivers, and circuits therefor |
| US9223317B2 (en) | 2012-06-14 | 2015-12-29 | Advanced Liquid Logic, Inc. | Droplet actuators that include molecular barrier coatings |
| BR112014032727B1 (pt) | 2012-06-27 | 2021-12-14 | Illumina France | Método e sistema para realizar operações de gotícula em uma gotícula em um atuador de gotículas para redução da formação de bolhas |
| US8830016B2 (en) * | 2012-09-10 | 2014-09-09 | Broadcom Corporation | Liquid MEMS magnetic component |
| US9863913B2 (en) | 2012-10-15 | 2018-01-09 | Advanced Liquid Logic, Inc. | Digital microfluidics cartridge and system for operating a flow cell |
| CA2889415C (en) * | 2012-10-24 | 2020-06-02 | Genmark Diagnostics, Inc. | Integrated multiplex target analysis |
| US20140322706A1 (en) | 2012-10-24 | 2014-10-30 | Jon Faiz Kayyem | Integrated multipelx target analysis |
| WO2014085802A1 (en) * | 2012-11-30 | 2014-06-05 | The Broad Institute, Inc. | High-throughput dynamic reagent delivery system |
| US9366647B2 (en) * | 2013-03-14 | 2016-06-14 | Taiwan Semiconductor Manufacturing Company, Ltd. | Optical detection for bio-entities |
| US9492824B2 (en) * | 2013-01-16 | 2016-11-15 | Sharp Kabushiki Kaisha | Efficient dilution method, including washing method for immunoassay |
| JP6351702B2 (ja) | 2013-03-15 | 2018-07-04 | ジェンマーク ダイアグノスティクス, インコーポレイテッド | 変形可能流体容器を操作するためのシステム、方法、および装置 |
| CN103406162A (zh) * | 2013-07-05 | 2013-11-27 | 复旦大学 | 基于介质电润湿数字微流芯片的精准液滴产生方法 |
| CN103406161A (zh) * | 2013-07-05 | 2013-11-27 | 复旦大学 | 一种能产生精确液滴的数字微流芯片 |
| CN111957453B (zh) * | 2013-08-13 | 2022-08-19 | 先进流体逻辑公司 | 使用作为流体输入的接通致动器储液器来提高液滴计量的准确度和精度的方法 |
| ITTO20130757A1 (it) | 2013-09-17 | 2015-03-18 | St Microelectronics Srl | Circuito microfluidico integrato con funzionamento basato sull'elettrobagnabilita' e relativo sistema microfluidico |
| USD881409S1 (en) | 2013-10-24 | 2020-04-14 | Genmark Diagnostics, Inc. | Biochip cartridge |
| US9498778B2 (en) | 2014-11-11 | 2016-11-22 | Genmark Diagnostics, Inc. | Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system |
| ES3000712T3 (en) * | 2014-04-16 | 2025-03-03 | Abbott Lab | Droplet actuator fabrication apparatus, systems, and related methods |
| US10005080B2 (en) | 2014-11-11 | 2018-06-26 | Genmark Diagnostics, Inc. | Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation |
| EP4578539A3 (en) | 2014-11-11 | 2025-10-01 | Roche Diagnostics GmbH | Instrument and cartridge for performing assays in a closed sample preparation and reaction system |
| US9598722B2 (en) | 2014-11-11 | 2017-03-21 | Genmark Diagnostics, Inc. | Cartridge for performing assays in a closed sample preparation and reaction system |
| CA2972577A1 (en) * | 2014-12-31 | 2016-07-07 | Abbott Laboratories | Digital microfluidic dilution apparatus, systems, and related methods |
| EP3096338B1 (en) * | 2015-05-21 | 2019-07-24 | Nokia Technologies Oy | An apparatus and method for providing a time varying voltage |
| CN108026494A (zh) | 2015-06-05 | 2018-05-11 | 米罗库鲁斯公司 | 限制蒸发和表面结垢的空气基质数字微流控装置和方法 |
| US10695762B2 (en) | 2015-06-05 | 2020-06-30 | Miroculus Inc. | Evaporation management in digital microfluidic devices |
| WO2017039654A1 (en) * | 2015-09-02 | 2017-03-09 | Tecan Trading Ag | Magnetic conduits in microfluidics |
| GB2542372A (en) * | 2015-09-16 | 2017-03-22 | Sharp Kk | Microfluidic device and a method of loading fluid therein |
| WO2017078059A1 (ja) * | 2015-11-06 | 2017-05-11 | シャープ マイクロフルイディック ソリューションズ リミテッド | エレクトロウェッティング装置およびその製造方法並びに液滴注入方法 |
| JP6736324B2 (ja) * | 2016-03-29 | 2020-08-05 | キヤノン株式会社 | 液体吐出ヘッド |
| CA3034064A1 (en) | 2016-08-22 | 2018-03-01 | Miroculus Inc. | Feedback system for parallel droplet control in a digital microfluidic device |
| US11300578B2 (en) | 2016-09-19 | 2022-04-12 | Roche Molecular Systems, Inc. | Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system |
| WO2018126082A1 (en) | 2016-12-28 | 2018-07-05 | Miroculis Inc. | Digital microfluidic devices and methods |
| US11698149B2 (en) * | 2017-02-15 | 2023-07-11 | Hewlett-Packard Development Company, L.P. | Microfluidic valve |
| US10330919B2 (en) * | 2017-03-31 | 2019-06-25 | Sharp Life Science (Eu) Limited | AM-EWOD device and control methods with intermittent actuation patterns |
| US11623219B2 (en) | 2017-04-04 | 2023-04-11 | Miroculus Inc. | Digital microfluidics apparatuses and methods for manipulating and processing encapsulated droplets |
| KR20240051316A (ko) | 2017-06-21 | 2024-04-19 | 라이트캐스트 디스커버리 엘티디 | 마이크로 유체 분석 장치 |
| US10730048B2 (en) * | 2017-06-21 | 2020-08-04 | Sharp Life Science (Eu) Limited | EWOD device with holdback feature for fluid loading |
| CN110831697B (zh) | 2017-06-21 | 2022-03-15 | 光投发现有限公司 | 微滴操控设备和使用该设备操控水性微滴的方法 |
| CN110892258A (zh) | 2017-07-24 | 2020-03-17 | 米罗库鲁斯公司 | 具有集成的血浆收集设备的数字微流控系统和方法 |
| CN115582155B (zh) | 2017-09-01 | 2025-08-26 | 因特格拉生物科学股份公司 | 数字微流控设备及其使用方法 |
| CN109668949B (zh) * | 2017-10-13 | 2023-08-08 | 马克西姆综合产品公司 | 具有分配化学品和微流体盖件的分析物传感器封装体 |
| US11740255B2 (en) | 2017-11-14 | 2023-08-29 | Illumina, Inc. | Droplet dispensing |
| CA3096855A1 (en) | 2018-05-23 | 2019-11-28 | Miroculus Inc. | Control of evaporation in digital microfluidics |
| US11207688B2 (en) * | 2018-06-25 | 2021-12-28 | Sharp Life Science (Eu) Limited | Adpative droplet operations in an AM-EWOD device based on test measurement of droplet properties |
| CN112449682B (zh) * | 2018-08-01 | 2024-03-08 | 澳门大学 | 用于芯片上微流体分配的设备和方法 |
| CN109603928A (zh) * | 2018-09-06 | 2019-04-12 | 澳门大学 | 基于液滴微流体控制的液滴分割装置及方法 |
| EP3623050A1 (en) * | 2018-09-12 | 2020-03-18 | Sharp Life Science (EU) Limited | Microfluidic device and a method of loading fluid therein |
| EP3623049A1 (en) * | 2018-09-12 | 2020-03-18 | Sharp Life Science (EU) Limited | Microfluidic device and a method of loading fluid therein |
| EP3639925B1 (en) * | 2018-10-18 | 2020-08-19 | Lightcast Discovery Ltd | Droplet generator and generation method |
| JP6899588B2 (ja) * | 2018-11-20 | 2021-07-07 | 国立研究開発法人産業技術総合研究所 | 液体操作装置 |
| CN109375365A (zh) * | 2018-11-30 | 2019-02-22 | 重庆秉为科技有限公司 | 一种电湿润液滴形状可调的显示装置 |
| CA3126435A1 (en) | 2019-01-31 | 2020-08-06 | Miroculus Inc. | Non fouling compositions and methods for manipulating and processing encapsulated droplets |
| EP3501658B1 (en) | 2019-03-19 | 2021-04-21 | Ace Medical Technology Co., Ltd. | Device for sorting bio-particles using a force generated from light-induced dielectrophoresis and operating method thereof |
| CN109870801B (zh) * | 2019-03-28 | 2021-08-06 | 上海天马微电子有限公司 | 电润湿面板和分析装置 |
| US11738345B2 (en) | 2019-04-08 | 2023-08-29 | Miroculus Inc. | Multi-cartridge digital microfluidics apparatuses and methods of use |
| WO2020220205A1 (zh) * | 2019-04-29 | 2020-11-05 | 京东方科技集团股份有限公司 | 细胞检测方法和细胞检测装置 |
| CN110064449B (zh) * | 2019-05-17 | 2021-09-03 | 北京京东方传感技术有限公司 | 一种生物液滴检测基板及其制备方法和检测装置 |
| US11524298B2 (en) | 2019-07-25 | 2022-12-13 | Miroculus Inc. | Digital microfluidics devices and methods of use thereof |
| US20220126287A1 (en) | 2020-05-13 | 2022-04-28 | Boe Technology Group Co., Ltd. | Micro-fluidic chip, liquid loading method thereof and micro-fluidic system |
| CN111822065B (zh) * | 2020-08-21 | 2022-08-23 | 上海天马微电子有限公司 | 一种微流控面板及液滴分离方法 |
| EP4151312A4 (en) * | 2020-12-25 | 2023-07-12 | BOE Technology Group Co., Ltd. | MICROFLUIDIC SUBSTRATE AND MICROFLUIDIC APPARATUS AND METHOD FOR CONTROLLING IT |
| KR102633840B1 (ko) * | 2021-10-12 | 2024-02-05 | 인제대학교 산학협력단 | 감지영역 가변 전극을 가지는 액적 생성칩 |
| US11857961B2 (en) | 2022-01-12 | 2024-01-02 | Miroculus Inc. | Sequencing by synthesis using mechanical compression |
| JP2023103043A (ja) * | 2022-01-13 | 2023-07-26 | キヤノンメディカルシステムズ株式会社 | 検査デバイス、検査キットおよび検査システム |
| CN114534811B (zh) * | 2022-02-28 | 2024-10-18 | 上海天马微电子有限公司 | 微流控装置及其制作方法 |
| CN115475669A (zh) * | 2022-09-15 | 2022-12-16 | 上海科技大学 | 一种液滴微流控芯片 |
Family Cites Families (205)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4127460A (en) | 1976-10-27 | 1978-11-28 | Desoto, Inc. | Radiation-curing aqueous coatings providing a nonadherent surface |
| US4244693A (en) | 1977-02-28 | 1981-01-13 | The United States Of America As Represented By The United States Department Of Energy | Method and composition for testing for the presence of an alkali metal |
| FR2543320B1 (fr) * | 1983-03-23 | 1986-01-31 | Thomson Csf | Dispositif indicateur a commande electrique de deplacement d'un fluide |
| US5038852A (en) | 1986-02-25 | 1991-08-13 | Cetus Corporation | Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps |
| US6013531A (en) | 1987-10-26 | 2000-01-11 | Dade International Inc. | Method to use fluorescent magnetic polymer particles as markers in an immunoassay |
| US5225332A (en) | 1988-04-22 | 1993-07-06 | Massachusetts Institute Of Technology | Process for manipulation of non-aqueous surrounded microdroplets |
| GB8917963D0 (en) | 1989-08-05 | 1989-09-20 | Scras | Apparatus for repeated automatic execution of a thermal cycle for treatment of biological samples |
| US5266498A (en) | 1989-10-27 | 1993-11-30 | Abbott Laboratories | Ligand binding assay for an analyte using surface-enhanced scattering (SERS) signal |
| US5181016A (en) * | 1991-01-15 | 1993-01-19 | The United States Of America As Represented By The United States Department Of Energy | Micro-valve pump light valve display |
| US5498392A (en) | 1992-05-01 | 1996-03-12 | Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification device and method |
| WO1994008759A1 (en) | 1992-10-16 | 1994-04-28 | Thomas Jefferson University | Method and apparatus for robotically performing sanger dideoxynucleotide dna sequencing reactions |
| US5472881A (en) | 1992-11-12 | 1995-12-05 | University Of Utah Research Foundation | Thiol labeling of DNA for attachment to gold surfaces |
| US6152181A (en) | 1992-11-16 | 2000-11-28 | The United States Of America As Represented By The Secretary Of The Air Force | Microdevices based on surface tension and wettability that function as sensors, actuators, and other devices |
| EP0636413B1 (en) | 1993-07-28 | 2001-11-14 | PE Corporation (NY) | Nucleic acid amplification reaction apparatus and method |
| US5486337A (en) * | 1994-02-18 | 1996-01-23 | General Atomics | Device for electrostatic manipulation of droplets |
| US6673533B1 (en) | 1995-03-10 | 2004-01-06 | Meso Scale Technologies, Llc. | Multi-array multi-specific electrochemiluminescence testing |
| US6319668B1 (en) | 1995-04-25 | 2001-11-20 | Discovery Partners International | Method for tagging and screening molecules |
| US5817526A (en) | 1995-05-09 | 1998-10-06 | Fujirebio Inc. | Method and apparatus for agglutination immunoassay |
| US6130098A (en) | 1995-09-15 | 2000-10-10 | The Regents Of The University Of Michigan | Moving microdroplets |
| US5945281A (en) | 1996-02-02 | 1999-08-31 | Becton, Dickinson And Company | Method and apparatus for determining an analyte from a sample fluid |
| DE19717085C2 (de) | 1997-04-23 | 1999-06-17 | Bruker Daltonik Gmbh | Verfahren und Geräte für extrem schnelle DNA-Vervielfachung durch Polymerase-Kettenreaktionen (PCR) |
| US5998224A (en) | 1997-05-16 | 1999-12-07 | Abbott Laboratories | Magnetically assisted binding assays utilizing a magnetically responsive reagent |
| US20020001544A1 (en) | 1997-08-28 | 2002-01-03 | Robert Hess | System and method for high throughput processing of droplets |
| US7214298B2 (en) * | 1997-09-23 | 2007-05-08 | California Institute Of Technology | Microfabricated cell sorter |
| DE19822123C2 (de) | 1997-11-21 | 2003-02-06 | Meinhard Knoll | Verfahren und Vorrichtung zum Nachweis von Analyten |
| US6063339A (en) | 1998-01-09 | 2000-05-16 | Cartesian Technologies, Inc. | Method and apparatus for high-speed dot array dispensing |
| US6565727B1 (en) * | 1999-01-25 | 2003-05-20 | Nanolytics, Inc. | Actuators for microfluidics without moving parts |
| US6294063B1 (en) | 1999-02-12 | 2001-09-25 | Board Of Regents, The University Of Texas System | Method and apparatus for programmable fluidic processing |
| AU3372800A (en) | 1999-02-23 | 2000-09-14 | Caliper Technologies Corporation | Manipulation of microparticles in microfluidic systems |
| EP1826572B1 (en) | 1999-03-25 | 2016-03-23 | Tosoh Corporation | Analyzer with scheduling verification |
| US6673620B1 (en) * | 1999-04-20 | 2004-01-06 | Cytologix Corporation | Fluid exchange in a chamber on a microscope slide |
| IT1309430B1 (it) | 1999-05-18 | 2002-01-23 | Guerrieri Roberto | Metodo ed apparato per la manipolazione di particelle per mezzo delladielettroforesi |
| FR2794039B1 (fr) | 1999-05-27 | 2002-05-03 | Osmooze Sa | Dispositif de formation, de deplacement et de diffusion de petites quantites calibrees de liquides |
| US6977145B2 (en) | 1999-07-28 | 2005-12-20 | Serono Genetics Institute S.A. | Method for carrying out a biochemical protocol in continuous flow in a microreactor |
| US20030027204A1 (en) | 1999-09-03 | 2003-02-06 | Yokogawa Electric Corporation, A Japan Corporation | Method and apparatus for producing biochips |
| US20040209376A1 (en) | 1999-10-01 | 2004-10-21 | Surromed, Inc. | Assemblies of differentiable segmented particles |
| EP1099484B1 (en) | 1999-11-11 | 2006-06-07 | The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | A dispensing method and assembly for liquid droplets |
| US6924792B1 (en) | 2000-03-10 | 2005-08-02 | Richard V. Jessop | Electrowetting and electrostatic screen display systems, colour displays and transmission means |
| JP3442338B2 (ja) | 2000-03-17 | 2003-09-02 | 株式会社日立製作所 | Dna分析装置、dna塩基配列決定装置、dna塩基配列決定方法、および反応モジュール |
| WO2002007503A1 (en) | 2000-07-25 | 2002-01-31 | The Regents Of The University Of California | Electrowetting-driven micropumping |
| CA2314398A1 (en) | 2000-08-10 | 2002-02-10 | Edward Shipwash | Microarrays and microsystems for amino acid analysis and protein sequencing |
| US6773566B2 (en) * | 2000-08-31 | 2004-08-10 | Nanolytics, Inc. | Electrostatic actuators for microfluidics and methods for using same |
| EP2299256A3 (en) * | 2000-09-15 | 2012-10-10 | California Institute Of Technology | Microfabricated crossflow devices and methods |
| US6453928B1 (en) | 2001-01-08 | 2002-09-24 | Nanolab Ltd. | Apparatus, and method for propelling fluids |
| US7010391B2 (en) | 2001-03-28 | 2006-03-07 | Handylab, Inc. | Methods and systems for control of microfluidic devices |
| US7179423B2 (en) | 2001-06-20 | 2007-02-20 | Cytonome, Inc. | Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system |
| US7211442B2 (en) | 2001-06-20 | 2007-05-01 | Cytonome, Inc. | Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system |
| US6734436B2 (en) | 2001-08-07 | 2004-05-11 | Sri International | Optical microfluidic devices and methods |
| US6995024B2 (en) | 2001-08-27 | 2006-02-07 | Sri International | Method and apparatus for electrostatic dispensing of microdroplets |
| JP2003094633A (ja) * | 2001-09-20 | 2003-04-03 | Ricoh Co Ltd | 静電インクジェットヘッドおよび記録装置 |
| US20040231987A1 (en) | 2001-11-26 | 2004-11-25 | Keck Graduate Institute | Method, apparatus and article for microfluidic control via electrowetting, for chemical, biochemical and biological assays and the like |
| CA2472029C (en) * | 2001-11-26 | 2014-04-15 | Keck Graduate Institute | Method, apparatus and article for microfluidic control via electrowetting, for chemical, biochemical and biological assays and the like |
| US7147763B2 (en) * | 2002-04-01 | 2006-12-12 | Palo Alto Research Center Incorporated | Apparatus and method for using electrostatic force to cause fluid movement |
| FR2841063B1 (fr) * | 2002-06-18 | 2004-09-17 | Commissariat Energie Atomique | Dispositif de deplacement de petits volumes de liquide le long d'un micro-catenaire par des forces electrostatiques |
| JP2006507921A (ja) | 2002-06-28 | 2006-03-09 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 流体分散のための方法および装置 |
| FR2842747B1 (fr) | 2002-07-23 | 2004-10-15 | Commissariat Energie Atomique | Procede et dispositif pour le criblage de molecules dans des cellules |
| FR2843048B1 (fr) * | 2002-08-01 | 2004-09-24 | Commissariat Energie Atomique | Dispositif d'injection et de melange de micro-gouttes liquides. |
| US7329545B2 (en) * | 2002-09-24 | 2008-02-12 | Duke University | Methods for sampling a liquid flow |
| US6989234B2 (en) * | 2002-09-24 | 2006-01-24 | Duke University | Method and apparatus for non-contact electrostatic actuation of droplets |
| US6911132B2 (en) * | 2002-09-24 | 2005-06-28 | Duke University | Apparatus for manipulating droplets by electrowetting-based techniques |
| US20040055871A1 (en) | 2002-09-25 | 2004-03-25 | The Regents Of The University Of California | Use of ion beams for protecting substrates from particulate defect contamination in ultra-low-defect coating processes |
| US7217542B2 (en) | 2002-10-31 | 2007-05-15 | Hewlett-Packard Development Company, L.P. | Microfluidic system for analyzing nucleic acids |
| US7547380B2 (en) * | 2003-01-13 | 2009-06-16 | North Carolina State University | Droplet transportation devices and methods having a fluid surface |
| GB0304033D0 (en) | 2003-02-21 | 2003-03-26 | Imp College Innovations Ltd | Apparatus |
| US7041481B2 (en) | 2003-03-14 | 2006-05-09 | The Regents Of The University Of California | Chemical amplification based on fluid partitioning |
| JP4404672B2 (ja) | 2003-05-28 | 2010-01-27 | セイコーエプソン株式会社 | 液滴吐出ヘッド、液滴吐出ヘッドの製造方法、マイクロアレイ製造装置、及びマイクロアレイの製造方法 |
| US6733566B1 (en) * | 2003-06-09 | 2004-05-11 | Alcoa Inc. | Petroleum coke melt cover for aluminum and magnesium alloys |
| TWI230760B (en) * | 2003-07-29 | 2005-04-11 | Univ Tsinghua | Electrowetting electrode design with electromagnetic field for actuation of the magnetic-beads biochemical detection system |
| US7767435B2 (en) | 2003-08-25 | 2010-08-03 | University Of Washington | Method and device for biochemical detection and analysis of subcellular compartments from a single cell |
| JP4563393B2 (ja) * | 2003-10-24 | 2010-10-13 | アドヒーシブズ・リサーチ・インコーポレイテッド | 診断デバイス用崩壊性フィルム |
| JP2005139011A (ja) | 2003-11-04 | 2005-06-02 | Nof Corp | 火薬原料及びその製造方法 |
| DE602004021624D1 (de) | 2003-11-17 | 2009-07-30 | Koninkl Philips Electronics Nv | System zur handhabung einer fluidmenge |
| CA2553025A1 (en) * | 2004-01-14 | 2005-07-28 | Luminex Corporation | Methods and systems for dynamic range expansion |
| KR20070037432A (ko) | 2004-01-15 | 2007-04-04 | 도꾸리쯔교세이호징 가가꾸 기쥬쯔 신꼬 기꼬 | 화학 분석장치 및 화학 분석방법 |
| FR2866493B1 (fr) * | 2004-02-16 | 2010-08-20 | Commissariat Energie Atomique | Dispositif de controle du deplacement d'une goutte entre deux ou plusieurs substrats solides |
| US7495031B2 (en) | 2004-02-24 | 2009-02-24 | Kao Corporation | Process for producing an emulsion |
| KR100552706B1 (ko) | 2004-03-12 | 2006-02-20 | 삼성전자주식회사 | 핵산 증폭 방법 및 장치 |
| US7048889B2 (en) | 2004-03-23 | 2006-05-23 | Lucent Technologies Inc. | Dynamically controllable biological/chemical detectors having nanostructured surfaces |
| US20050226991A1 (en) | 2004-04-07 | 2005-10-13 | Hossainy Syed F | Methods for modifying balloon of a catheter assembly |
| KR100583231B1 (ko) | 2004-04-13 | 2006-05-26 | 한국과학기술연구원 | 물방울형 세포 부유액을 이용한 세포 분리 장치 |
| JP2007536634A (ja) | 2004-05-04 | 2007-12-13 | フィッシャー−ローズマウント・システムズ・インコーポレーテッド | プロセス制御システムのためのサービス指向型アーキテクチャ |
| US8974652B2 (en) | 2004-05-28 | 2015-03-10 | Board Of Regents, The University Of Texas System | Programmable fluidic processors |
| FR2871076A1 (fr) | 2004-06-04 | 2005-12-09 | Univ Lille Sciences Tech | Dispositif pour desorption par rayonnement laser incorporant une manipulation de l'echantillon liquide sous forme de gouttes individuelles permettant leur traitement chimique et biochimique |
| US7121998B1 (en) | 2004-06-08 | 2006-10-17 | Eurica Califorrniaa | Vented microcradle for prenidial incubator |
| FR2872438B1 (fr) | 2004-07-01 | 2006-09-15 | Commissariat Energie Atomique | Dispositif de deplacement et de traitement de volumes de liquide |
| US7693666B2 (en) * | 2004-07-07 | 2010-04-06 | Rensselaer Polytechnic Institute | Method, system, and program product for controlling chemical reactions in a digital microfluidic system |
| FR2872715B1 (fr) * | 2004-07-08 | 2006-11-17 | Commissariat Energie Atomique | Microreacteur goutte |
| FR2872809B1 (fr) * | 2004-07-09 | 2006-09-15 | Commissariat Energie Atomique | Methode d'adressage d'electrodes |
| US7267752B2 (en) | 2004-07-28 | 2007-09-11 | University Of Rochester | Rapid flow fractionation of particles combining liquid and particulate dielectrophoresis |
| JP2006058031A (ja) * | 2004-08-17 | 2006-03-02 | Hitachi High-Technologies Corp | 化学分析装置 |
| DE602005024418D1 (de) | 2004-08-26 | 2010-12-09 | Life Technologies Corp | Elektrobenetzende abgabevorrichtungen und dazugehörige verfahren |
| JP4047314B2 (ja) | 2004-09-07 | 2008-02-13 | 株式会社東芝 | 微細流路構造体 |
| EP1802395B1 (en) | 2004-09-09 | 2020-01-22 | Institut Curie | Microfluidic device using a collinear electric field |
| CN2735342Y (zh) * | 2004-10-20 | 2005-10-19 | 清华大学 | 一种介质层上的电润湿微液滴驱动器 |
| JP4185904B2 (ja) * | 2004-10-27 | 2008-11-26 | 株式会社日立ハイテクノロジーズ | 液体搬送基板、分析システム、分析方法 |
| FR2879946B1 (fr) | 2004-12-23 | 2007-02-09 | Commissariat Energie Atomique | Dispositif de dispense de gouttes |
| CN100420575C (zh) * | 2004-12-27 | 2008-09-24 | 精工爱普生株式会社 | 静电驱动器、液滴喷头、液滴喷出装置以及静电设备 |
| US20060153745A1 (en) * | 2005-01-11 | 2006-07-13 | Applera Corporation | Fluid processing device for oligonucleotide synthesis and analysis |
| US7458661B2 (en) * | 2005-01-25 | 2008-12-02 | The Regents Of The University Of California | Method and apparatus for promoting the complete transfer of liquid drops from a nozzle |
| WO2006081558A2 (en) * | 2005-01-28 | 2006-08-03 | Duke University | Apparatuses and methods for manipulating droplets on a printed circuit board |
| US20060210443A1 (en) | 2005-03-14 | 2006-09-21 | Stearns Richard G | Avoidance of bouncing and splashing in droplet-based fluid transport |
| FR2884437B1 (fr) * | 2005-04-19 | 2007-07-20 | Commissariat Energie Atomique | Dispositif et procede microfluidique de transfert de matiere entre deux phases immiscibles. |
| AU2006247752B2 (en) | 2005-05-11 | 2012-04-12 | Advanced Liquid Logic, Inc. | Method and device for conducting biochemical or chemical reactions at multiple temperatures |
| JP2006317364A (ja) | 2005-05-16 | 2006-11-24 | Hitachi High-Technologies Corp | 分注装置 |
| EP1919618A2 (en) | 2005-05-21 | 2008-05-14 | Core-Microsolutions, Inc. | Mitigation of biomolecular adsorption with hydrophilic polymer additives |
| JP2006329904A (ja) | 2005-05-30 | 2006-12-07 | Hitachi High-Technologies Corp | 液体搬送デバイス及び分析システム |
| JP4500733B2 (ja) * | 2005-05-30 | 2010-07-14 | 株式会社日立ハイテクノロジーズ | 化学分析装置 |
| JP4969060B2 (ja) | 2005-06-08 | 2012-07-04 | 株式会社日立ハイテクノロジーズ | 自動分析装置 |
| CN101252993A (zh) * | 2005-06-16 | 2008-08-27 | 精华微技有限公司 | 利用液滴驱动、搅拌和蒸发的生物传感器检测 |
| FR2887305B1 (fr) | 2005-06-17 | 2011-05-27 | Commissariat Energie Atomique | Dispositif de pompage par electromouillage et application aux mesures d'activite electrique |
| JP4855467B2 (ja) | 2005-07-01 | 2012-01-18 | コミサリア ア レネルジー アトミック エ オ ゼネルジー アルテルナティブ | 濡れヒステリシスが低い疎水性表面被覆、その堆積方法、微細要素および使用 |
| US7964159B2 (en) * | 2005-07-08 | 2011-06-21 | The Trustees Of The University Of Pennsylvania | Nanotube-based sensors and probes |
| FR2888912B1 (fr) * | 2005-07-25 | 2007-08-24 | Commissariat Energie Atomique | Procede de commande d'une communication entre deux zones par electromouillage, dispositif comportant des zones isolables les unes des autres et procede de realisation d'un tel dispositif |
| US20070023292A1 (en) * | 2005-07-26 | 2007-02-01 | The Regents Of The University Of California | Small object moving on printed circuit board |
| US7556776B2 (en) | 2005-09-08 | 2009-07-07 | President And Fellows Of Harvard College | Microfluidic manipulation of fluids and reactions |
| CN101268355A (zh) * | 2005-09-21 | 2008-09-17 | 卢米尼克斯股份有限公司 | 图像数据处理的方法和系统 |
| FR2890875B1 (fr) * | 2005-09-22 | 2008-02-22 | Commissariat Energie Atomique | Fabrication d'un systeme diphasique liquide/liquide ou gaz en micro-fluidique |
| US20070075922A1 (en) | 2005-09-28 | 2007-04-05 | Jessop Richard V | Electronic display systems |
| US7344679B2 (en) * | 2005-10-14 | 2008-03-18 | International Business Machines Corporation | Method and apparatus for point of care osmolarity testing |
| US8304253B2 (en) * | 2005-10-22 | 2012-11-06 | Advanced Liquid Logic Inc | Droplet extraction from a liquid column for on-chip microfluidics |
| EP3431994B1 (en) | 2005-12-21 | 2024-03-06 | Meso Scale Technologies, LLC. | Assay modules having assay reagents and methods of making and using same |
| US20100137163A1 (en) | 2006-01-11 | 2010-06-03 | Link Darren R | Microfluidic Devices and Methods of Use in The Formation and Control of Nanoreactors |
| US20070207513A1 (en) | 2006-03-03 | 2007-09-06 | Luminex Corporation | Methods, Products, and Kits for Identifying an Analyte in a Sample |
| US8492168B2 (en) | 2006-04-18 | 2013-07-23 | Advanced Liquid Logic Inc. | Droplet-based affinity assays |
| US8637317B2 (en) | 2006-04-18 | 2014-01-28 | Advanced Liquid Logic, Inc. | Method of washing beads |
| US8613889B2 (en) | 2006-04-13 | 2013-12-24 | Advanced Liquid Logic, Inc. | Droplet-based washing |
| WO2010006166A2 (en) | 2008-07-09 | 2010-01-14 | Advanced Liquid Logic, Inc. | Bead manipulation techniques |
| JP5054096B2 (ja) | 2006-04-18 | 2012-10-24 | アドヴァンスト リキッド ロジック インコーポレイテッド | 液滴に基づく生化学 |
| WO2010027894A2 (en) | 2008-08-27 | 2010-03-11 | Advanced Liquid Logic, Inc. | Droplet actuators, modified fluids and methods |
| US8470606B2 (en) | 2006-04-18 | 2013-06-25 | Duke University | Manipulation of beads in droplets and methods for splitting droplets |
| US7815871B2 (en) | 2006-04-18 | 2010-10-19 | Advanced Liquid Logic, Inc. | Droplet microactuator system |
| WO2009052348A2 (en) | 2007-10-17 | 2009-04-23 | Advanced Liquid Logic, Inc. | Manipulation of beads in droplets |
| US8716015B2 (en) * | 2006-04-18 | 2014-05-06 | Advanced Liquid Logic, Inc. | Manipulation of cells on a droplet actuator |
| US7901947B2 (en) * | 2006-04-18 | 2011-03-08 | Advanced Liquid Logic, Inc. | Droplet-based particle sorting |
| US8658111B2 (en) | 2006-04-18 | 2014-02-25 | Advanced Liquid Logic, Inc. | Droplet actuators, modified fluids and methods |
| WO2010042637A2 (en) | 2008-10-07 | 2010-04-15 | Advanced Liquid Logic, Inc. | Bead incubation and washing on a droplet actuator |
| WO2007123908A2 (en) | 2006-04-18 | 2007-11-01 | Advanced Liquid Logic, Inc. | Droplet-based multiwell operations |
| US8980198B2 (en) | 2006-04-18 | 2015-03-17 | Advanced Liquid Logic, Inc. | Filler fluids for droplet operations |
| US7439014B2 (en) * | 2006-04-18 | 2008-10-21 | Advanced Liquid Logic, Inc. | Droplet-based surface modification and washing |
| US8809068B2 (en) | 2006-04-18 | 2014-08-19 | Advanced Liquid Logic, Inc. | Manipulation of beads in droplets and methods for manipulating droplets |
| US7851184B2 (en) | 2006-04-18 | 2010-12-14 | Advanced Liquid Logic, Inc. | Droplet-based nucleic acid amplification method and apparatus |
| US7816121B2 (en) * | 2006-04-18 | 2010-10-19 | Advanced Liquid Logic, Inc. | Droplet actuation system and method |
| US8685754B2 (en) | 2006-04-18 | 2014-04-01 | Advanced Liquid Logic, Inc. | Droplet actuator devices and methods for immunoassays and washing |
| US7763471B2 (en) * | 2006-04-18 | 2010-07-27 | Advanced Liquid Logic, Inc. | Method of electrowetting droplet operations for protein crystallization |
| US8637324B2 (en) | 2006-04-18 | 2014-01-28 | Advanced Liquid Logic, Inc. | Bead incubation and washing on a droplet actuator |
| WO2009026339A2 (en) | 2007-08-20 | 2009-02-26 | Advanced Liquid Logic, Inc. | Modular droplet actuator drive |
| US7939021B2 (en) * | 2007-05-09 | 2011-05-10 | Advanced Liquid Logic, Inc. | Droplet actuator analyzer with cartridge |
| CA2680062C (en) | 2006-05-09 | 2015-10-20 | Duke University | Droplet manipulation systems |
| US7822510B2 (en) * | 2006-05-09 | 2010-10-26 | Advanced Liquid Logic, Inc. | Systems, methods, and products for graphically illustrating and controlling a droplet actuator |
| US9675972B2 (en) | 2006-05-09 | 2017-06-13 | Advanced Liquid Logic, Inc. | Method of concentrating beads in a droplet |
| US8041463B2 (en) * | 2006-05-09 | 2011-10-18 | Advanced Liquid Logic, Inc. | Modular droplet actuator drive |
| ATE540750T1 (de) | 2006-05-11 | 2012-01-15 | Raindance Technologies Inc | Mikrofluidische vorrichtung und verfahren |
| WO2007146025A2 (en) | 2006-06-06 | 2007-12-21 | University Of Virginia Patent Foundation | Capillary force actuator device and related method of applications |
| US7629124B2 (en) | 2006-06-30 | 2009-12-08 | Canon U.S. Life Sciences, Inc. | Real-time PCR in micro-channels |
| US8128798B2 (en) | 2006-07-10 | 2012-03-06 | Hitachi High-Technologies Corporation | Liquid transfer device |
| EP1905513A1 (en) | 2006-09-13 | 2008-04-02 | Institut Curie | Methods and devices for sampling fluids |
| JP4901410B2 (ja) | 2006-10-10 | 2012-03-21 | シャープ株式会社 | バックライト装置及び映像表示装置 |
| US7788438B2 (en) * | 2006-10-13 | 2010-08-31 | Macronix International Co., Ltd. | Multi-input/output serial peripheral interface and method for data transmission |
| WO2008055256A2 (en) | 2006-11-02 | 2008-05-08 | The Regents Of The University Of California | Method and apparatus for real-time feedback control of electrical manipulation of droplets on chip |
| FR2909293B1 (fr) * | 2006-12-05 | 2011-04-22 | Commissariat Energie Atomique | Micro-dispositif de traitement d'echantillons liquides |
| CN102851369B (zh) | 2006-12-13 | 2015-01-21 | 卢米耐克斯公司 | 用于实时pcr多重分析的系统和方法 |
| US8338166B2 (en) | 2007-01-04 | 2012-12-25 | Lawrence Livermore National Security, Llc | Sorting, amplification, detection, and identification of nucleic acid subsequences in a complex mixture |
| US8685344B2 (en) * | 2007-01-22 | 2014-04-01 | Advanced Liquid Logic, Inc. | Surface assisted fluid loading and droplet dispensing |
| KR101431778B1 (ko) | 2007-02-09 | 2014-08-20 | 어드밴스드 리퀴드 로직, 아이엔씨. | 자성 비즈를 이용하는 액적 작동기 장치 및 방법 |
| WO2008101194A2 (en) | 2007-02-15 | 2008-08-21 | Advanced Liquid Logic, Inc. | Capacitance detection in a droplet actuator |
| EP2121329B1 (en) | 2007-03-01 | 2014-05-14 | Advanced Liquid Logic, Inc. | Droplet actuator structures |
| KR101523754B1 (ko) * | 2007-03-05 | 2015-05-28 | 어드밴스드 리퀴드 로직, 아이엔씨. | 과산화수소 액적에 기초한 분석평가법 |
| JP5519297B2 (ja) * | 2007-03-13 | 2014-06-11 | アドヴァンスト リキッド ロジック インコーポレイテッド | 吸光度検出を向上させるための液滴アクチュエータの装置、構成および方法 |
| US8440392B2 (en) * | 2007-03-22 | 2013-05-14 | Advanced Liquid Logic Inc. | Method of conducting a droplet based enzymatic assay |
| US8093062B2 (en) | 2007-03-22 | 2012-01-10 | Theodore Winger | Enzymatic assays using umbelliferone substrates with cyclodextrins in droplets in oil |
| US8202686B2 (en) * | 2007-03-22 | 2012-06-19 | Advanced Liquid Logic, Inc. | Enzyme assays for a droplet actuator |
| WO2008116221A1 (en) | 2007-03-22 | 2008-09-25 | Advanced Liquid Logic, Inc. | Bead sorting on a droplet actuator |
| EP2136920A2 (en) | 2007-03-23 | 2009-12-30 | Advanced Liquid Logic, Inc. | Droplet actuator loading and target concentration |
| JP2010524002A (ja) | 2007-04-10 | 2010-07-15 | アドヴァンスト リキッド ロジック インコーポレイテッド | 液滴分配装置および方法 |
| US20100130369A1 (en) * | 2007-04-23 | 2010-05-27 | Advanced Liquid Logic, Inc. | Bead-Based Multiplexed Analytical Methods and Instrumentation |
| US20100206094A1 (en) | 2007-04-23 | 2010-08-19 | Advanced Liquid Logic, Inc. | Device and Method for Sample Collection and Concentration |
| US20100087012A1 (en) * | 2007-04-23 | 2010-04-08 | Advanced Liquid Logic, Inc. | Sample Collector and Processor |
| US20080283414A1 (en) | 2007-05-17 | 2008-11-20 | Monroe Charles W | Electrowetting devices |
| US8951732B2 (en) | 2007-06-22 | 2015-02-10 | Advanced Liquid Logic, Inc. | Droplet-based nucleic acid amplification in a temperature gradient |
| WO2009003184A1 (en) | 2007-06-27 | 2008-12-31 | Digital Biosystems | Digital microfluidics based apparatus for heat-exchanging chemical processes |
| US20100120130A1 (en) * | 2007-08-08 | 2010-05-13 | Advanced Liquid Logic, Inc. | Droplet Actuator with Droplet Retention Structures |
| US20110303542A1 (en) | 2007-08-08 | 2011-12-15 | Advanced Liquid Logic, Inc. | Use of Additives for Enhancing Droplet Operations |
| US8268246B2 (en) * | 2007-08-09 | 2012-09-18 | Advanced Liquid Logic Inc | PCB droplet actuator fabrication |
| KR101451955B1 (ko) | 2007-08-24 | 2014-10-21 | 어드밴스드 리퀴드 로직, 아이엔씨. | 액적 작동기 상에서의 비드 조작법 |
| WO2009032863A2 (en) | 2007-09-04 | 2009-03-12 | Advanced Liquid Logic, Inc. | Droplet actuator with improved top substrate |
| US8454905B2 (en) | 2007-10-17 | 2013-06-04 | Advanced Liquid Logic Inc. | Droplet actuator structures |
| WO2009052095A1 (en) | 2007-10-17 | 2009-04-23 | Advanced Liquid Logic, Inc. | Reagent storage and reconstitution for a droplet actuator |
| US20100236928A1 (en) | 2007-10-17 | 2010-09-23 | Advanced Liquid Logic, Inc. | Multiplexed Detection Schemes for a Droplet Actuator |
| US7621059B2 (en) | 2007-10-18 | 2009-11-24 | Oceaneering International, Inc. | Underwater sediment evacuation system |
| US20100236929A1 (en) | 2007-10-18 | 2010-09-23 | Advanced Liquid Logic, Inc. | Droplet Actuators, Systems and Methods |
| WO2009076414A2 (en) | 2007-12-10 | 2009-06-18 | Advanced Liquid Logic, Inc. | Droplet actuator configurations and methods |
| CA2709928A1 (en) | 2007-12-23 | 2009-07-09 | Advanced Liquid Logic, Inc. | Droplet actuator configurations and methods of conducting droplet operations |
| WO2009135205A2 (en) | 2008-05-02 | 2009-11-05 | Advanced Liquid Logic, Inc. | Droplet actuator techniques using coagulatable samples |
| WO2009137415A2 (en) | 2008-05-03 | 2009-11-12 | Advanced Liquid Logic, Inc. | Reagent and sample preparation, loading, and storage |
| DK2279405T3 (da) * | 2008-05-13 | 2014-01-13 | Advanced Liquid Logic Inc | Dråbeaktuatorindretninger, -systemer og -fremgangsmåder |
| US20110097763A1 (en) | 2008-05-13 | 2011-04-28 | Advanced Liquid Logic, Inc. | Thermal Cycling Method |
| US8093064B2 (en) * | 2008-05-15 | 2012-01-10 | The Regents Of The University Of California | Method for using magnetic particles in droplet microfluidics |
| EP2286228B1 (en) | 2008-05-16 | 2019-04-03 | Advanced Liquid Logic, Inc. | Droplet actuator devices and methods for manipulating beads |
| FR2933713B1 (fr) | 2008-07-11 | 2011-03-25 | Commissariat Energie Atomique | Procede et dispositif de manipulation et d'observation de gouttes de liquide |
| US20120261264A1 (en) | 2008-07-18 | 2012-10-18 | Advanced Liquid Logic, Inc. | Droplet Operations Device |
| US8364315B2 (en) * | 2008-08-13 | 2013-01-29 | Advanced Liquid Logic Inc. | Methods, systems, and products for conducting droplet operations |
| US20110311980A1 (en) | 2008-12-15 | 2011-12-22 | Advanced Liquid Logic, Inc. | Nucleic Acid Amplification and Sequencing on a Droplet Actuator |
| US8877512B2 (en) * | 2009-01-23 | 2014-11-04 | Advanced Liquid Logic, Inc. | Bubble formation techniques using physical or chemical features to retain a gas bubble within a droplet actuator |
| US8846414B2 (en) * | 2009-09-29 | 2014-09-30 | Advanced Liquid Logic, Inc. | Detection of cardiac markers on a droplet actuator |
| WO2011057197A2 (en) | 2009-11-06 | 2011-05-12 | Advanced Liquid Logic, Inc. | Integrated droplet actuator for gel electrophoresis and molecular analysis |
-
2008
- 2008-12-23 CA CA2709928A patent/CA2709928A1/en not_active Abandoned
- 2008-12-23 KR KR1020107015759A patent/KR20100100974A/ko not_active Ceased
- 2008-12-23 US US12/682,830 patent/US20100270156A1/en not_active Abandoned
- 2008-12-23 JP JP2010539943A patent/JP5462183B2/ja not_active Expired - Fee Related
- 2008-12-23 AU AU2008345138A patent/AU2008345138B2/en not_active Ceased
- 2008-12-23 EP EP08868761.1A patent/EP2237955A4/en not_active Withdrawn
- 2008-12-23 WO PCT/US2008/088205 patent/WO2009086403A2/en not_active Ceased
- 2008-12-23 BR BRPI0821734A patent/BRPI0821734A2/pt not_active IP Right Cessation
- 2008-12-23 MX MX2010007034A patent/MX2010007034A/es active IP Right Grant
- 2008-12-23 CN CN2008801272542A patent/CN101945767B/zh not_active Expired - Fee Related
- 2008-12-23 CN CN201310415655.0A patent/CN103707643B/zh not_active Expired - Fee Related
-
2015
- 2015-01-06 US US14/590,470 patent/US9630180B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20150174578A1 (en) | 2015-06-25 |
| CN101945767A (zh) | 2011-01-12 |
| US9630180B2 (en) | 2017-04-25 |
| WO2009086403A2 (en) | 2009-07-09 |
| AU2008345138A1 (en) | 2009-07-09 |
| CN101945767B (zh) | 2013-10-30 |
| EP2237955A2 (en) | 2010-10-13 |
| US20100270156A1 (en) | 2010-10-28 |
| EP2237955A4 (en) | 2016-04-20 |
| CA2709928A1 (en) | 2009-07-09 |
| JP5462183B2 (ja) | 2014-04-02 |
| AU2008345138B2 (en) | 2014-05-29 |
| CN103707643A (zh) | 2014-04-09 |
| JP2011508224A (ja) | 2011-03-10 |
| KR20100100974A (ko) | 2010-09-15 |
| CN103707643B (zh) | 2016-06-01 |
| BRPI0821734A2 (pt) | 2022-10-25 |
| WO2009086403A3 (en) | 2009-10-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2010007034A (es) | Configuraciones para eyector de gotas y metodos para realizar operaciones de gota. | |
| MX2010007150A (es) | Formulaciones del factor de von-willebrand recombinante. | |
| WO2007002385A3 (en) | Mesoderm and definitive endoderm cell populations | |
| WO2008118507A3 (en) | Recombinant human factor ix and use thereof | |
| MX2009007145A (es) | Conjugados de polimero con factor viii y factor de von willebrand que tienen una ligadura liberable. | |
| WO2007124461A8 (en) | Glp-1 compounds | |
| BR112012011128A2 (pt) | composição farmacêutica compreendendo um agonista de glp-1, uma insulina e uma metionina | |
| CR20110221A (es) | Terapia de combinación con péptidos epoxicetonas peptídicas | |
| BRPI0910461A8 (pt) | hormônio de estimulação do folículo recombinante, sua composição farmacêutica, seu método de produção e seu uso. | |
| BR112012017345A2 (pt) | "composições e métodos de pgl para a produção aumentada de isopreno e outros produtos com 6-fosfogliconolactonase (pgl)" | |
| MX2009011165A (es) | Formulaciones farmaceuticas que contienen derivados del acido lipoico. | |
| NO20073065L (no) | Injiserbare nanopartikulaere olanzapinformuleringer | |
| WO2009149956A3 (en) | Fusion protein and use thereof | |
| MX2013013242A (es) | Combinacion farmaceutica para mejorar el control glucemico como terapia adicional a la insulina basal. | |
| CL2013000884A1 (es) | El compuesto (r)-(e)-2-(4-(2-(5-(1-(3,5-dicloropiridin-4-il)etoxi)-1h-indazol-3-il)vinil)-1h-pirazol-1-il)etanol cristalino, modulador del factor de crecimiento de fibroblastos (fgf); composicion farmaceutica, util en el tratamiento del cancer. | |
| NI201200086A (es) | Composición farmacéutica que comprende un agonista de glp - 1 y metionina | |
| MX343360B (es) | Conjugados peptidicos de agonistas del receptor de glp-1 y gastrina y su uso. | |
| CL2011001497A1 (es) | Compuestos derivados de heterociclos, modulador de gpr120; composicion farmaceutica; y su uso para el tratamiento de diabetes tipo i,ii y sindrome metabolico. | |
| EP2164560B8 (en) | Systems for cardiac rhythm management using an electrode arrangement | |
| EP4276180A3 (en) | Clostridium histolyticum enzyme | |
| MX2014005351A (es) | Conjugados de gastrina peptidicos de agonistas de receptor glp-1. | |
| SG162747A1 (en) | Erythropoietin receptor peptide formulations and uses | |
| WO2008136166A1 (ja) | 電気化学素子用電極とその製造方法およびそれを用いた電気化学素子 | |
| EA200900958A1 (ru) | Препарат невирапина пролонгированного высвобождения | |
| WO2007041386A3 (en) | Pulsatile delivery of gonadotropin-releasing hormone from a pre-loaded integrated electrotransport patch |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |