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MX2010006739A - Compuestos pirido[2,3-b]pirazina-8-sustituidos y su uso. - Google Patents

Compuestos pirido[2,3-b]pirazina-8-sustituidos y su uso.

Info

Publication number
MX2010006739A
MX2010006739A MX2010006739A MX2010006739A MX2010006739A MX 2010006739 A MX2010006739 A MX 2010006739A MX 2010006739 A MX2010006739 A MX 2010006739A MX 2010006739 A MX2010006739 A MX 2010006739A MX 2010006739 A MX2010006739 A MX 2010006739A
Authority
MX
Mexico
Prior art keywords
raf
compounds
inhibit
activity
cancer
Prior art date
Application number
MX2010006739A
Other languages
English (en)
Inventor
Caroline Joy Springer
Dan Niculescu-Duvaz
Ion Niculescu-Duvaz
Richard Marais
Bartholomeus Marinus Josephus Marie Suijkerbuijk
Alfonso Zambon
Delphine Menard
Arnaud Nourry
Original Assignee
Cancer Rec Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Rec Tech Ltd filed Critical Cancer Rec Tech Ltd
Publication of MX2010006739A publication Critical patent/MX2010006739A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Cardiology (AREA)
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  • Toxicology (AREA)
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Abstract

La presente invención concierne generalmente al campo de compuestos terapéuticos para el tratamiento de trastornos proliferativos, cáncer, etc., y más específicamente a ciertos compuestos pirido[2,3-b]pirazin-8-sustituidos, como se describen en la presente, los cuales, inter alia, inhiben la actividad PAF (por ejemplo, B RAF). La presente invención también concierne a composiciones farmacéuticas que comprenden tales compuestos, y el uso de tales compuestos y composiciones, tanto in vitro como in vivo, para inhibir la actividad PAF (por ejemplo, BRAF), para inhibir la actividad de tirosina cinasa del receptor (RTK), para inhibir la proliferación celular, y en el tratamiento de enfermedades y trastornos que se alivian por la inhibición de PAF, RTK, etc., trastornos proliferativos tales como cáncer (por ejemplo, cáncer colorectal, melanoma), etc.
MX2010006739A 2007-12-19 2008-12-19 Compuestos pirido[2,3-b]pirazina-8-sustituidos y su uso. MX2010006739A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1501907P 2007-12-19 2007-12-19
PCT/GB2008/004208 WO2009077766A1 (en) 2007-12-19 2008-12-19 Pyrido[2,3-b]pyrazine-8-substituted compounds and their use

Publications (1)

Publication Number Publication Date
MX2010006739A true MX2010006739A (es) 2010-10-08

Family

ID=40342728

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010006739A MX2010006739A (es) 2007-12-19 2008-12-19 Compuestos pirido[2,3-b]pirazina-8-sustituidos y su uso.

Country Status (18)

Country Link
US (5) US8198279B2 (es)
EP (1) EP2229391B1 (es)
JP (1) JP5511680B2 (es)
KR (1) KR101665143B1 (es)
CN (1) CN101945869B (es)
AU (1) AU2008337286B2 (es)
BR (1) BRPI0821227A2 (es)
CA (1) CA2709257C (es)
DK (1) DK2229391T3 (es)
EA (1) EA019974B1 (es)
ES (1) ES2520940T3 (es)
IL (1) IL206330A (es)
MX (1) MX2010006739A (es)
NZ (1) NZ586418A (es)
PL (1) PL2229391T3 (es)
UA (1) UA105763C2 (es)
WO (1) WO2009077766A1 (es)
ZA (1) ZA201004524B (es)

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