[go: up one dir, main page]

MX2010005188A - Inhibidores de peptido desformilasa. - Google Patents

Inhibidores de peptido desformilasa.

Info

Publication number
MX2010005188A
MX2010005188A MX2010005188A MX2010005188A MX2010005188A MX 2010005188 A MX2010005188 A MX 2010005188A MX 2010005188 A MX2010005188 A MX 2010005188A MX 2010005188 A MX2010005188 A MX 2010005188A MX 2010005188 A MX2010005188 A MX 2010005188A
Authority
MX
Mexico
Prior art keywords
peptide deformylase
compounds
deformylase inhibitors
bacterial
directed
Prior art date
Application number
MX2010005188A
Other languages
English (en)
Inventor
Siegfried Benjamin Christensen Iv
Kelly M Aubart
Xiangmin Liao
Donghui Qin
Beth Norton
Andrew Nicholson Knox
Yuhong Fang
Jason Christopher Dreabit
Andrew B Benowitz
Jinhwa Lee
Original Assignee
Glaxosmithkline Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40626160&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2010005188(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc
Publication of MX2010005188A publication Critical patent/MX2010005188A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se refiere a ciertos derivados de {2-(alquil)-3-[2-(5-fluoro-4-pirimidinil)hidrazino]-3-oxopropil}h idroxiformamida, a composiciones que los contienen y al uso de dichos compuestos en la inhibición de la actividad péptido desformilasa bacteriana (PDF) y en el tratamiento de infecciones bacterianas. Específicamente, la invención se refiere a compuestos de fórmula (I): (ver fórmula (I)) en la que R1, R2 y R3 se definen en la presente memoria y a sales farmacéuticamente aceptables de los mismos. Los compuestos de esta invención son inhibidores de péptido desformilasa bacteriana y pueden ser útiles en el tratamiento de infecciones bacterianas.
MX2010005188A 2007-11-09 2008-11-06 Inhibidores de peptido desformilasa. MX2010005188A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98663107P 2007-11-09 2007-11-09
PCT/US2008/082575 WO2009061879A1 (en) 2007-11-09 2008-11-06 Peptide deformylase inhibitors

Publications (1)

Publication Number Publication Date
MX2010005188A true MX2010005188A (es) 2010-05-27

Family

ID=40626160

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010005188A MX2010005188A (es) 2007-11-09 2008-11-06 Inhibidores de peptido desformilasa.

Country Status (22)

Country Link
US (2) US7893056B2 (es)
EP (1) EP2217226B1 (es)
JP (1) JP5728229B2 (es)
KR (2) KR20100110774A (es)
CN (1) CN101917981B (es)
AR (1) AR069230A1 (es)
AU (1) AU2008323998B2 (es)
CA (1) CA2705246A1 (es)
CL (1) CL2008003326A1 (es)
CO (1) CO6270305A2 (es)
CR (1) CR11483A (es)
EA (1) EA018953B1 (es)
ES (1) ES2549879T3 (es)
MA (1) MA31873B1 (es)
MX (1) MX2010005188A (es)
NZ (1) NZ585221A (es)
PE (1) PE20090984A1 (es)
PH (1) PH12013501288A1 (es)
TW (2) TW201441218A (es)
UA (1) UA108596C2 (es)
UY (1) UY31463A1 (es)
WO (1) WO2009061879A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY27813A1 (es) 2002-05-31 2003-12-31 Smithkline Beecham Corp Inhibidores de la peptido-desformilasa
JP5973994B2 (ja) 2010-09-13 2016-08-23 大塚製薬株式会社 複素環化合物
TW201249824A (en) * 2011-03-09 2012-12-16 Glaxosmithkline Llc Peptide deformylase inhibitors
JP2014512364A (ja) 2011-04-07 2014-05-22 コーネル ユニバーシティー 水溶液中で二量体化できる単量体、およびその使用法
TW201329087A (zh) * 2011-12-02 2013-07-16 Glaxosmithkline Llc 胜肽脫甲醯酶抑制劑
SI2788343T1 (sl) 2011-12-11 2019-09-30 Viamet Pharmaceuticals (NC), Inc. Spojine inhibitorja metaloencimov
CN102875482A (zh) * 2012-10-15 2013-01-16 盛世泰科生物医药技术(苏州)有限公司 一种十氢喹喔啉的合成方法
WO2014141181A1 (en) 2013-03-15 2014-09-18 Glaxosmithkline Intellectual Property No 2 Limited Process for preparing peptide deformylase inhibitors
EA031654B1 (ru) 2014-01-10 2019-02-28 Глэксосмитклайн Интеллекчуал Проперти (No.2) Лимитед Гидроксиформамидные производные и их применение
WO2015116242A1 (en) * 2014-02-03 2015-08-06 Brandeis University Supramolecular hydrogel of fmlf-based molecules and use thereof
WO2016020784A1 (en) 2014-08-05 2016-02-11 Pfizer Inc. N-acylpyrrolidine ether tropomyosin-related kinase inhibitors
CN104725323A (zh) * 2014-10-16 2015-06-24 江苏华益科技有限公司 一种2-甲氧基-4-肼基-5-氟嘧啶的合成工艺
CN107207509B (zh) 2014-11-19 2020-04-21 葛兰素史密斯克莱知识产权（第2 号）有限公司 作为沉默调节蛋白调节剂的取代的桥环脲类似物
WO2017006295A1 (en) 2015-07-08 2017-01-12 Glaxosmithkline Intellectual Property (No.2) Limited Hydroxy formamide derivatives and their use
EP3349753A4 (en) * 2015-09-18 2019-01-23 VPS-3, Inc. FUNGICIDE COMPOUNDS AND METHOD OF PREPARING THEREOF
CN109641893B (zh) 2016-06-20 2021-07-20 大邱庆北尖端医疗产业振兴财团 新的咪唑并吡啶衍生物及其制备方法和用途
CN113683596B (zh) * 2021-08-17 2023-02-10 上海应用技术大学 一种嘧啶类端锚聚合酶2抑制剂及其制备方法和应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9223904D0 (en) 1992-11-13 1993-01-06 British Bio Technology Inhibition of cytokine production
US6013792A (en) 1993-08-05 2000-01-11 Syntex (U.S.A.), Inc. Matrix metalloprotease inhibitors
US6037472A (en) 1993-11-04 2000-03-14 Syntex (U.S.A.) Inc. Matrix metalloprotease inhibitors
EP0763012B1 (en) 1994-05-28 1999-06-09 British Biotech Pharmaceuticals Limited Succinyl hydroxamic acid, n-formyl-n-hydroxy amino carboxylic acid and succinic acid amide derivatives as metalloprotease inhibitors
GB9612884D0 (en) 1996-06-20 1996-08-21 Smithkline Beecham Plc Novel compounds
GB9903119D0 (en) 1999-02-11 1999-04-07 Merck Sharp & Dohme Therapeutic agents
US6852752B2 (en) * 1999-12-17 2005-02-08 Vicuron Pharmaceuticals Inc. Urea compounds, compositions and methods of use and preparation
DE10040783A1 (de) 2000-08-21 2002-03-07 Merck Patent Gmbh AZA-Aminosäurederivate (Faktor X¶a¶-Inhibitoren 15)
AR032920A1 (es) 2001-03-01 2003-12-03 Smithkline Beecham Corp Compuestos inhibidores de las peptido-deformilasas y medios para tratar infecciones bacterianas utilizando dichos inhibidores
UY27813A1 (es) * 2002-05-31 2003-12-31 Smithkline Beecham Corp Inhibidores de la peptido-desformilasa
GB0228365D0 (en) 2002-12-05 2003-01-08 British Biotech Pharm Antibacterial agents
GB0229673D0 (en) 2002-12-19 2003-01-29 British Biotech Pharm Antibacterial agents
WO2005005456A2 (en) 2003-07-08 2005-01-20 Glaxo Group Limited Peptide deformylase inhibitors
WO2005026146A1 (en) 2003-09-12 2005-03-24 Warner-Lambert Company Llc Azetidinyl quinolones as antibacterial agents
WO2005049605A1 (en) 2003-11-18 2005-06-02 Warner-Lambert Company Llc Antibacterial aminoquinazolidinedione derivatives
US7102001B2 (en) 2003-12-12 2006-09-05 Bristol-Myers Squibb Company Process for preparing pyrrolotriazine
JP4227660B2 (ja) 2004-05-12 2009-02-18 ファイザー・プロダクツ・インク ジペプチジルペプチダーゼｉｖインヒビターとしてのプロリン誘導体およびそれらの使用
EP1827449A4 (en) 2004-11-17 2008-01-23 Smithkline Beecham Corp USE OF NOVEL ANTIBACTERIAL COMPOUNDS
GT200600196A (es) 2005-05-23 2007-01-15 Compuestos n-formil de hidroxilamina
US20070197512A1 (en) * 2006-01-27 2007-08-23 Japan Tobacco Inc. Carboxylic Acid Compounds and Use Thereof

Also Published As

Publication number Publication date
CR11483A (es) 2010-09-21
JP5728229B2 (ja) 2015-06-03
EP2217226B1 (en) 2015-07-22
HK1144070A1 (zh) 2011-01-28
UA108596C2 (xx) 2015-05-25
KR20160040321A (ko) 2016-04-12
PE20090984A1 (es) 2009-08-07
EP2217226A1 (en) 2010-08-18
AU2008323998B2 (en) 2013-01-10
UY31463A1 (es) 2009-05-29
AU2008323998A1 (en) 2009-05-14
AR069230A1 (es) 2010-01-06
CN101917981B (zh) 2012-11-14
EA018953B1 (ru) 2013-12-30
PH12013501288A1 (en) 2015-02-09
US20090306066A1 (en) 2009-12-10
US20130045962A1 (en) 2013-02-21
EP2217226A4 (en) 2012-03-21
WO2009061879A1 (en) 2009-05-14
CA2705246A1 (en) 2009-05-14
KR20100110774A (ko) 2010-10-13
US7893056B2 (en) 2011-02-22
MA31873B1 (fr) 2010-11-01
EA201070592A1 (ru) 2010-12-30
CL2008003326A1 (es) 2010-03-05
TW200934763A (en) 2009-08-16
ES2549879T3 (es) 2015-11-02
CN101917981A (zh) 2010-12-15
TW201441218A (zh) 2014-11-01
CO6270305A2 (es) 2011-04-20
NZ585221A (en) 2012-05-25
JP2011503092A (ja) 2011-01-27

Similar Documents

Publication Publication Date Title
PH12013501288A1 (en) Peptide deformylase inhibitors
GEP20146202B (en) Heteroaromatic aryl triazole derivatives as pde10a enzyme inhibitors
PH12013501941A1 (en) Pyrazolospiroketone derivatives for use as acetyl - coa carboxylase inhibitors
EA201200049A1 (ru) 1,3-дизамещенные производные имидазолидин-2-она в качестве ингибиторов cyp 17
MX2013004733A (es) Inhibidores de n1/n2-lactama acetil-coa carboxilasa.
TN2011000400A1 (en) Inhibitors of beta-secretase
PH12012500903A1 (en) N1 - pyrazolospiroketone acetyl-coa carboxylase inhibitors
ATE542813T1 (de) 6-substituierte 2- heterocyclylaminopyrazinverbindungen als chk-1- inhibitoren
TN2014000128A1 (en) 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh
JO3007B1 (ar) مركبات و تركيبات كمثبطات كيناز بروتين
GEP20146201B (en) Heteroaromatic aryl triazole derivatives as pde10a enzyme inhibitors
MX2010008460A (es) Derivado de tiazol y su uso como inhibidor de proteina-1 de adhesion vascular.
UA105788C2 (uk) Натрієва сіль 5-циклопропіл-2-{[2-(2,6-дифторфеніл)піримідин-5-іл]аміно}бензойної кислоти як інгібітори dhodh
MX341341B (es) Derivados de benzamida y su uso como inhibidores de proteina de choque termico 90 kda (hsp90).
MX2013008161A (es) Formas solidas del inhibidor de girasa (r)-1-etil-3-[6-fluoro-5-[2 -(1-hidroxi-1-metil-etil) pirimidin-5-il]-7-(tetrahidrofuran-2-il) -1h-benzimidazol-2-il]urea.
MX2019010096A (es) Derivados de 1, 4, 6-trisustituidos-2-alquil-1h-benzo[d]imidazol como inhibidores de dihidroorotato oxigenasa.
IL195016A0 (en) 1h-indol-5-yl-piperazin-1-yl-methanone derivatives
MX2013008163A (es) Formas solidas de inhibidor de girasa (r)-1-etil-3-[5-[2-(1-hidrox i-1-metil-etil)pirimidin-5-il]-7-(tetrahidrofuran-2-il)-1h-benzim idazol-2-il]urea.
MX2009004982A (es) Derivados heterociclicos como inhibidores cetp.
UA100018C2 (ru) Соединение-иммуномодулятор для лечения, профилактики, ингибирования или уменьшения проявлений аллергической болезни или ее эффектов
PH12013501830A1 (en) Peptide deformylase inhibitors
PH12014501215A1 (en) Peptide deformylase inhibitors
IN2012DN02069A (es)
DOP2010000132A (es) Inhibidores de peptido desformilasa
MX2008002754A (es) Derivados de amida como inhibidores de rock.

Legal Events

Date Code Title Description
FG Grant or registration