MX2010004614A - Composiciones para tratamiento del mal de parkinson. - Google Patents
Composiciones para tratamiento del mal de parkinson.Info
- Publication number
- MX2010004614A MX2010004614A MX2010004614A MX2010004614A MX2010004614A MX 2010004614 A MX2010004614 A MX 2010004614A MX 2010004614 A MX2010004614 A MX 2010004614A MX 2010004614 A MX2010004614 A MX 2010004614A MX 2010004614 A MX2010004614 A MX 2010004614A
- Authority
- MX
- Mexico
- Prior art keywords
- disease
- compositions
- treating parkinson
- administration
- treatment
- Prior art date
Links
- 208000018737 Parkinson disease Diseases 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- VMWNQDUVQKEIOC-CYBMUJFWSA-N apomorphine Chemical compound C([C@H]1N(C)CC2)C3=CC=C(O)C(O)=C3C3=C1C2=CC=C3 VMWNQDUVQKEIOC-CYBMUJFWSA-N 0.000 abstract 1
- 229960004046 apomorphine Drugs 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 230000002685 pulmonary effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención se refiere a tratamiento mejorado de enfermedades y trastornos del sistema nervioso central por la administración de apomorfina. En particular, la administración es por medio de inhalación pulmonar. La invención proporciona los medios para mejorar el tratamiento de un número de condiciones, incluyendo Mal de Parkinson.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0721394.5A GB0721394D0 (en) | 2007-10-31 | 2007-10-31 | Compositions for trating parkinson's disease |
| PCT/GB2008/003698 WO2009056851A1 (en) | 2007-10-31 | 2008-10-31 | Compositions for treating parkinson's disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010004614A true MX2010004614A (es) | 2010-05-20 |
Family
ID=38834618
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010004614A MX2010004614A (es) | 2007-10-31 | 2008-10-31 | Composiciones para tratamiento del mal de parkinson. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20100288276A1 (es) |
| EP (1) | EP2214649A1 (es) |
| JP (1) | JP2011500869A (es) |
| KR (1) | KR20100091970A (es) |
| CN (1) | CN101932307A (es) |
| AU (1) | AU2008320569B2 (es) |
| BR (1) | BRPI0818799A2 (es) |
| CA (1) | CA2703063A1 (es) |
| GB (1) | GB0721394D0 (es) |
| IL (1) | IL205153A (es) |
| MX (1) | MX2010004614A (es) |
| NZ (1) | NZ584622A (es) |
| RU (1) | RU2484823C2 (es) |
| SG (1) | SG185965A1 (es) |
| WO (1) | WO2009056851A1 (es) |
| ZA (1) | ZA201002751B (es) |
Families Citing this family (36)
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| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| WO2003080149A2 (en) | 2002-03-20 | 2003-10-02 | Mannkind Corporation | Inhalation apparatus |
| PL1786784T3 (pl) | 2004-08-20 | 2011-04-29 | Mannkind Corp | Kataliza syntezy diketopiperazyn |
| EP1791542B1 (en) | 2004-08-23 | 2015-05-20 | Mannkind Corporation | Diketopiperazine salts for drug delivery |
| KR101643478B1 (ko) | 2005-09-14 | 2016-07-27 | 맨카인드 코포레이션 | 활성제에 대한 결정질 미립자 표면의 친화력의 증가를 기반으로 하는 약물 제제화의 방법 |
| CA2643464C (en) | 2006-02-22 | 2018-09-04 | Mannkind Corporation | A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent |
| CN106039494B (zh) | 2008-06-13 | 2019-12-24 | 曼金德公司 | 干粉吸入器和用于药物输送的系统 |
| US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
| MX336361B (es) | 2008-06-20 | 2015-12-03 | Mannkind Corp | Un metodo y un aparato interactivo para perfilar en tiempo real esfuerzos de inhalacion. |
| TWI494123B (zh) | 2008-08-11 | 2015-08-01 | Mannkind Corp | 超快起作用胰島素之用途 |
| US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| DK2405963T3 (da) | 2009-03-11 | 2013-12-16 | Mannkind Corp | Apparat, system og fremgangsmåde til at måle modstand i en inhalator |
| US8551528B2 (en) | 2009-06-12 | 2013-10-08 | Mannkind Corporation | Diketopiperazine microparticles with defined specific surface areas |
| US9016147B2 (en) | 2009-11-03 | 2015-04-28 | Mannkind Corporation | Apparatus and method for simulating inhalation efforts |
| EP2582421A1 (en) | 2010-06-21 | 2013-04-24 | MannKind Corporation | Dry powder drug delivery system and methods |
| TW201304822A (zh) * | 2010-11-15 | 2013-02-01 | Vectura Ltd | 組成物及用途 |
| WO2012135765A2 (en) | 2011-04-01 | 2012-10-04 | Mannkind Corporation | Blister package for pharmaceutical cartridges |
| WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
| JP6018640B2 (ja) | 2011-10-24 | 2016-11-02 | マンカインド コーポレイション | 疼痛を緩和するのに有効な鎮痛組成物並びに当該組成物を含む乾燥粉末及び乾燥粉末薬剤輸送システム |
| US10022303B2 (en) * | 2012-02-28 | 2018-07-17 | Iceutica Pty Ltd. | Inhalable pharmaceutical compositions |
| ES2624294T3 (es) | 2012-07-12 | 2017-07-13 | Mannkind Corporation | Sistemas de suministro de fármacos en polvo seco |
| HK1212257A1 (en) * | 2012-10-22 | 2016-06-10 | Civitas Therapeutics, Inc. | Reducing inter-patient variability of levodopa plasma concentrations |
| WO2014066856A1 (en) | 2012-10-26 | 2014-05-01 | Mannkind Corporation | Inhalable influenza vaccine compositions and methods |
| WO2014144895A1 (en) | 2013-03-15 | 2014-09-18 | Mannkind Corporation | Microcrystalline diketopiperazine compositions and methods |
| GB201305825D0 (en) * | 2013-03-28 | 2013-05-15 | Vectura Ltd | New use |
| US20140377189A1 (en) * | 2013-06-19 | 2014-12-25 | Map Pharmaceuticals, Inc. | Pulmonary administration of rotigotine |
| WO2014205031A1 (en) * | 2013-06-19 | 2014-12-24 | Map Pharmaceuticals, Inc. | Sustained-release formulation of rotigotine |
| AU2014290438B2 (en) | 2013-07-18 | 2019-11-07 | Mannkind Corporation | Heat-stable dry powder pharmaceutical compositions and methods |
| WO2015021064A1 (en) | 2013-08-05 | 2015-02-12 | Mannkind Corporation | Insufflation apparatus and methods |
| WO2015148905A1 (en) | 2014-03-28 | 2015-10-01 | Mannkind Corporation | Use of ultrarapid acting insulin |
| US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
| EP3355887A1 (en) | 2015-09-28 | 2018-08-08 | EVER Neuro Pharma GmbH | Aqueous composition of apomorphine for subcutaneous administration |
| JP7282735B2 (ja) | 2018-02-26 | 2023-05-29 | 株式会社新日本科学 | 粉末製剤、カートリッジ、及びデバイス |
| WO2020013793A2 (en) * | 2018-07-12 | 2020-01-16 | Arven Ilac Sanayi Ve Ticaret Anonim Sirketi | Inhalation compositions comprising dopamine agonists |
| GB201912686D0 (en) * | 2019-09-04 | 2019-10-16 | Reown Pharma Inc | Pharmaceutical composition |
| JP2025520542A (ja) | 2022-06-15 | 2025-07-03 | エバー ニューロ ファーマ ゲーエムベーハー | アポモルヒネプロドラッグおよびその使用 |
Family Cites Families (35)
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| US4742054A (en) * | 1982-11-23 | 1988-05-03 | Naftchi Nosrat E | Treatment of mammals suffering from damage to the central nervous system |
| US5292520A (en) * | 1990-09-13 | 1994-03-08 | Akzo N.V. | Stabilized solid pharmaceutical composition containing acid addition salts of a basic drug and an alkaline stabilizer |
| DK0865789T3 (da) * | 1993-03-26 | 2005-07-18 | Franciscus Wilhelmus He Merkus | Farmaceutiske præparater til intranasal administration af dihydroergotamin |
| DK0978282T3 (da) * | 1994-04-22 | 2006-04-10 | Pentech Pharmaceuticals Inc | Sublingualt præparat indeholdende apomorphin til diagnosticering af funktionel impotens |
| US20020165122A1 (en) * | 1994-04-22 | 2002-11-07 | Heaton Jeremy P. W. | Method and compositions for the treatment or amelioration of female sexual dysfunction |
| US6566368B2 (en) * | 1994-04-22 | 2003-05-20 | Pentech Pharmaceuticals, Inc. | Apomorphine-containing dosage form for ameliorating male erectile dysfunction |
| US6395744B1 (en) * | 1994-04-22 | 2002-05-28 | Queen's University At Kingston | Method and compositions for the treatment or amelioration of female sexual dysfunction |
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| GB9501841D0 (en) * | 1995-01-31 | 1995-03-22 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
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| US6193954B1 (en) * | 1997-03-21 | 2001-02-27 | Abbott Laboratories | Formulations for pulmonary delivery of dopamine agonists |
| JP4754067B2 (ja) * | 1997-12-02 | 2011-08-24 | アルキメデス ディヴェロプメント リミテッド | 鼻孔投与用組成物 |
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| US6858199B1 (en) * | 2000-06-09 | 2005-02-22 | Advanced Inhalation Research, Inc. | High efficient delivery of a large therapeutic mass aerosol |
| BR0005797A (pt) * | 2000-03-20 | 2001-10-16 | Abbott Lab | Métodos para o tratamento de disfunção sexual com apomorfina em nìveis de concentração plasmática especificados |
| GB0007193D0 (en) * | 2000-03-25 | 2000-05-17 | Univ Manchester | Treatment of movrmrnt disorders |
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| US20040115133A1 (en) * | 2000-05-10 | 2004-06-17 | Wermeling Daniel P. | Intranasal opioid compositions |
| SE0002934D0 (sv) * | 2000-08-17 | 2000-08-17 | Axon Biochemicals Bv | New aporphine esters and in their use in therapy |
| SE0102036D0 (sv) * | 2001-06-08 | 2001-06-08 | Axon Biochemicals Bv | Pharmaceutical formulation for the efficient administration of apomorphine, 6aR- (-) -N- Propyl- norapomorphine and their derivatives and pro-drugs thereof |
| US6613308B2 (en) * | 2000-09-19 | 2003-09-02 | Advanced Inhalation Research, Inc. | Pulmonary delivery in treating disorders of the central nervous system |
| US6514482B1 (en) * | 2000-09-19 | 2003-02-04 | Advanced Inhalation Research, Inc. | Pulmonary delivery in treating disorders of the central nervous system |
| EP1341536A4 (en) * | 2000-11-15 | 2007-08-01 | Tap Pharmaceutical Prod Inc | TREATMENT OF SEXUAL DYSFUNCTION CAUSED BY ANTIDEPRESSIVE MEDICATION BY APOMORPHINE |
| US20020086876A1 (en) * | 2000-11-15 | 2002-07-04 | Ruff Dustin D. | Treatment of anti-depression drug-induced sexual dysfunction with apomorphine |
| MXPA03006265A (es) * | 2001-01-16 | 2004-06-25 | Purdue Research Foundation | Metodo de tratamiento de disfuncion relacionada con dopamina mediante administracion de un agonista de receptor de dopamina d1 completo, sin generacion de tolerancia. |
| CA2446904A1 (en) * | 2001-05-24 | 2003-04-03 | Alexza Molecular Delivery Corporation | Delivery of drug esters through an inhalation route |
| US20040028613A1 (en) * | 2001-06-25 | 2004-02-12 | Nastech Pharmaceutical Company Inc | Dopamine agonist formulations for enhanced central nervous system delivery |
| ITMI20012174A1 (it) * | 2001-10-18 | 2003-04-18 | Univ Parma | Polvere per somministrazione nasale di farmaci |
| WO2004093848A2 (en) * | 2003-04-14 | 2004-11-04 | Vectura Ltd | Dry power inhaler devices and dry power formulations for enhancing dosing efficiency |
| AU2004228757A1 (en) * | 2003-04-14 | 2004-10-21 | Vectura Ltd | Pharmaceutical compositions comprising apomorphine for pulmonary inhalation |
| US20040204439A1 (en) * | 2003-04-14 | 2004-10-14 | Staniforth John Nicholas | Composition, device, and method for treating sexual dysfunction via inhalation |
| US20050090518A1 (en) * | 2003-10-24 | 2005-04-28 | Nastech Pharmaceutical Company Inc. | Method for treating parkinson's disease using apomorphine and apomorphine prodrugs |
| GB0426301D0 (en) * | 2004-11-30 | 2004-12-29 | Vectura Ltd | Pharmaceutical formulations |
-
2007
- 2007-10-31 GB GBGB0721394.5A patent/GB0721394D0/en not_active Ceased
-
2008
- 2008-10-31 SG SG2012082087A patent/SG185965A1/en unknown
- 2008-10-31 WO PCT/GB2008/003698 patent/WO2009056851A1/en not_active Ceased
- 2008-10-31 US US12/740,323 patent/US20100288276A1/en not_active Abandoned
- 2008-10-31 CN CN2008801230145A patent/CN101932307A/zh active Pending
- 2008-10-31 RU RU2010121827/15A patent/RU2484823C2/ru not_active IP Right Cessation
- 2008-10-31 NZ NZ584622A patent/NZ584622A/en not_active IP Right Cessation
- 2008-10-31 JP JP2010531580A patent/JP2011500869A/ja active Pending
- 2008-10-31 BR BRPI0818799 patent/BRPI0818799A2/pt not_active IP Right Cessation
- 2008-10-31 CA CA2703063A patent/CA2703063A1/en not_active Abandoned
- 2008-10-31 AU AU2008320569A patent/AU2008320569B2/en not_active Ceased
- 2008-10-31 KR KR1020107010375A patent/KR20100091970A/ko not_active Ceased
- 2008-10-31 MX MX2010004614A patent/MX2010004614A/es not_active Application Discontinuation
- 2008-10-31 EP EP08846120A patent/EP2214649A1/en not_active Withdrawn
-
2010
- 2010-04-15 IL IL205153A patent/IL205153A/en not_active IP Right Cessation
- 2010-04-20 ZA ZA2010/02751A patent/ZA201002751B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2008320569A1 (en) | 2009-05-07 |
| EP2214649A1 (en) | 2010-08-11 |
| WO2009056851A1 (en) | 2009-05-07 |
| NZ584622A (en) | 2012-06-29 |
| BRPI0818799A2 (pt) | 2015-04-22 |
| US20100288276A1 (en) | 2010-11-18 |
| CN101932307A (zh) | 2010-12-29 |
| ZA201002751B (en) | 2011-06-29 |
| IL205153A (en) | 2014-11-30 |
| RU2010121827A (ru) | 2011-12-10 |
| GB0721394D0 (en) | 2007-12-12 |
| JP2011500869A (ja) | 2011-01-06 |
| IL205153A0 (en) | 2010-11-30 |
| AU2008320569B2 (en) | 2014-01-30 |
| KR20100091970A (ko) | 2010-08-19 |
| SG185965A1 (en) | 2012-12-28 |
| RU2484823C2 (ru) | 2013-06-20 |
| CA2703063A1 (en) | 2009-05-07 |
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