MX2010003878A - Metodos computacionales para diseño genico sintetico. - Google Patents
Metodos computacionales para diseño genico sintetico.Info
- Publication number
- MX2010003878A MX2010003878A MX2010003878A MX2010003878A MX2010003878A MX 2010003878 A MX2010003878 A MX 2010003878A MX 2010003878 A MX2010003878 A MX 2010003878A MX 2010003878 A MX2010003878 A MX 2010003878A MX 2010003878 A MX2010003878 A MX 2010003878A
- Authority
- MX
- Mexico
- Prior art keywords
- sequences
- methods
- sequence
- synthetic
- interest
- Prior art date
Links
- 108700005078 Synthetic Genes Proteins 0.000 title 1
- 238000000205 computational method Methods 0.000 title 1
- 239000002773 nucleotide Substances 0.000 abstract 2
- 125000003729 nucleotide group Chemical group 0.000 abstract 2
- 108020004414 DNA Proteins 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 108700026244 Open Reading Frames Proteins 0.000 abstract 1
- 230000002363 herbicidal effect Effects 0.000 abstract 1
- 239000004009 herbicide Substances 0.000 abstract 1
- 230000000361 pesticidal effect Effects 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
Landscapes
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- General Health & Medical Sciences (AREA)
- Evolutionary Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Theoretical Computer Science (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Evolutionary Computation (AREA)
- Epidemiology (AREA)
- Databases & Information Systems (AREA)
- Data Mining & Analysis (AREA)
- Bioethics (AREA)
- Artificial Intelligence (AREA)
- Software Systems (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Saccharide Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente invención se dirige a métodos para diseñar secuencias de nucleótidos sintéticos que codifican para polipéptidos de interés; los métodos implican organizar una base de datos de secuencias como se establece en las secuencias de oligómeros de longitud N y compilar una lista de registros de probabilidad para cada secuencia de longitud N; los registros de probabilidad se utilizan para sustituir una o más secuencias de registro superior en la secuencia de nucleótidos de origen para generar una secuencia optimizada; la secuencia de nucleótidos de interés puede además optimizarse al remover cualquiera o ambos marcos de lectura abierta no planeados o elementos de ADN cortos no deseados, y/o al sustituir la secuencia de oligómeros para lograr un contenido G:C especifico; estos métodos pueden utilizarse para optimizar la expresión de genes heterólogos en cualquier organismo, particularmente en plantas; el método genera secuencias sintéticas con una composición similar a la de una base de datos objetivo; estas secuencias sintéticas pueden utilizarse, por ejemplo para regular la actividad pesticida o resistencia herbicida en organismos, particularmente plantas o células de plantas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97872907P | 2007-10-09 | 2007-10-09 | |
| PCT/US2008/079343 WO2009049045A1 (en) | 2007-10-09 | 2008-10-09 | Computational methods for synthetic gene design |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010003878A true MX2010003878A (es) | 2010-10-15 |
Family
ID=40193507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010003878A MX2010003878A (es) | 2007-10-09 | 2008-10-09 | Metodos computacionales para diseño genico sintetico. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8175813B2 (es) |
| EP (1) | EP2208157B1 (es) |
| CN (1) | CN101821744B (es) |
| AT (1) | ATE504045T1 (es) |
| AU (1) | AU2008310806A1 (es) |
| BR (1) | BRPI0818507B8 (es) |
| CA (1) | CA2702084C (es) |
| DE (1) | DE602008005920D1 (es) |
| MX (1) | MX2010003878A (es) |
| WO (1) | WO2009049045A1 (es) |
| ZA (1) | ZA201002472B (es) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130060481A1 (en) * | 2010-01-15 | 2013-03-07 | Board of Regents of the Nevada System of Higher Ed ucation,on behalf of The Desert Reserach Institut | Systems and Methods for Identifying Structurally or Functionally Significant Nucleotide Sequences |
| US9321814B2 (en) | 2011-03-30 | 2016-04-26 | Athenix Corp. | AXMI238 toxin gene and methods for its use |
| WO2012135501A2 (en) | 2011-03-30 | 2012-10-04 | Athenix Corp. | Axmi232, axmi233, and axmi249 toxin genes and methods for their use |
| ES2743322T3 (es) | 2011-04-05 | 2020-02-18 | BASF Agricultural Solutions Seed US LLC | Gen insecticida variante AXMI115 y procedimientos de uso |
| MX363910B (es) | 2011-07-28 | 2019-04-08 | Athenix Corp | Gen de la toxina axmi270 y sus metodos de uso. |
| BR112014002027A8 (pt) | 2011-07-29 | 2022-07-05 | Athenix Corp | Gene pesticida axmi279 e métodos para a sua utilização |
| WO2013134523A1 (en) | 2012-03-08 | 2013-09-12 | Athenix Corp. | Bacillus thuringiensis toxin gene axmi335 and methods for its use |
| CA2866241C (en) | 2012-03-08 | 2021-03-16 | Athenix Corp. | Axmi345 delta-endotoxin gene and methods for its use |
| UA117731C2 (uk) | 2012-06-29 | 2018-09-25 | Атенікс Корп. | Токсин axmi277 проти нематод та його застосування |
| WO2014036238A1 (en) | 2012-08-30 | 2014-03-06 | Athenix Corp. | Axmi-234 and axmi-235 toxin genes and methods for their use |
| ES2682351T3 (es) | 2013-02-13 | 2018-09-20 | Athenix Corp. | Uso de AXMI184 para el control de los insectos del gusano de la raíz |
| CN110172466A (zh) | 2013-03-07 | 2019-08-27 | 巴斯夫农业解决方案种子美国有限责任公司 | 毒素基因及其使用方法 |
| WO2015038262A2 (en) | 2013-08-09 | 2015-03-19 | Athenix Corp. | Axmi281 toxin gene and methods for its use |
| UY35696A (es) | 2013-08-09 | 2015-03-27 | Athenix Corp | ?molécula de adn recombinante que comprende al gen de toxina axmi440, vector, célula huésped, plantas, composiciones y métodos relacionados?. |
| WO2015077525A1 (en) | 2013-11-25 | 2015-05-28 | Bayer Cropscience Lp | Use of axmi-011 for the control of hemipteran insects |
| ES2982696T3 (es) | 2013-12-09 | 2024-10-17 | BASF Agricultural Solutions Seed US LLC | Gen de la toxina AXMI486 y procedimientos para su uso |
| US11041158B2 (en) | 2014-12-22 | 2021-06-22 | AgBiome, Inc. | Optimization methods for making a synthetic gene |
| US10468119B2 (en) | 2015-07-28 | 2019-11-05 | Yeda Research And Development Co. Ltd. | Stable proteins and methods for designing same |
| WO2017017673A2 (en) * | 2015-07-28 | 2017-02-02 | Yeda Research And Development Co. Ltd. | Stable proteins and methods for designing same |
| US11151497B2 (en) * | 2016-04-27 | 2021-10-19 | Zymergen Inc. | Microbial strain design system and methods for improved large-scale production of engineered nucleotide sequences |
| CN118256514A (zh) | 2016-11-23 | 2024-06-28 | 巴斯夫农业种子解决方案美国有限责任公司 | Axmi669和axmi991毒素基因及其使用方法 |
| KR20190095411A (ko) | 2016-12-22 | 2019-08-14 | 바스프 아그리컬쳐럴 솔루션즈 시드 유에스 엘엘씨 | 선충 해충의 방제를 위한 ｃｒｙ１４의 용도 |
| WO2018136604A1 (en) | 2017-01-18 | 2018-07-26 | Bayer Cropscience Lp | Bp005 toxin gene and methods for its use |
| WO2018136611A1 (en) | 2017-01-18 | 2018-07-26 | Bayer Cropscience Lp | Use of bp005 for the control of plant pathogens |
| AU2020367523A1 (en) | 2019-10-14 | 2022-04-28 | BASF Agricultural Solutions Seed US LLC | Novel insect resistant genes and methods of use |
| CA3157808A1 (en) | 2019-10-14 | 2021-04-22 | BASF Agricultural Solutions Seed US LLC | Novel insect resistant genes and methods of use |
| US11049590B1 (en) | 2020-02-12 | 2021-06-29 | Peptilogics, Inc. | Artificial intelligence engine architecture for generating candidate drugs |
| CN113793639B (zh) * | 2021-08-03 | 2024-01-05 | 杭州瑞丰生物科技有限公司 | 一种管理玉米螟对Bt毒素抗性的方法 |
| WO2024137438A2 (en) | 2022-12-19 | 2024-06-27 | BASF Agricultural Solutions Seed US LLC | Insect toxin genes and methods for their use |
| WO2025111030A2 (en) | 2023-07-07 | 2025-05-30 | Basf Agricultural Solutions Us Llc | Use of novel genes for the control of nematode pests |
| WO2025090606A1 (en) | 2023-10-27 | 2025-05-01 | Basf Agricultural Solutions Us Llc | Use of novel genes for the control of nematode pests |
| WO2026010930A1 (en) | 2024-07-05 | 2026-01-08 | BASF Agricultural Solutions Seed US LLC | Use of axmi277 for the control of rotylenchulus reniformis nematode pests |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5567600A (en) * | 1983-09-26 | 1996-10-22 | Mycogen Plant Sciences, Inc. | Synthetic insecticidal crystal protein gene |
| US5380831A (en) * | 1986-04-04 | 1995-01-10 | Mycogen Plant Science, Inc. | Synthetic insecticidal crystal protein gene |
| US6114138A (en) * | 1984-06-04 | 2000-09-05 | Mycogen Plant Science, Inc. | Insecticidal protein fragments |
| TR27832A (tr) * | 1987-04-29 | 1995-08-31 | Monsanto Co | Zararli ucucu hasarata mukavim bitkiler. |
| NZ230375A (en) | 1988-09-09 | 1991-07-26 | Lubrizol Genetics Inc | Synthetic gene encoding b. thuringiensis insecticidal protein |
| US6015891A (en) * | 1988-09-09 | 2000-01-18 | Mycogen Plant Science, Inc. | Synthetic insecticidal crystal protein gene having a modified frequency of codon usage |
| DK0413019T3 (da) * | 1989-02-24 | 2001-11-12 | Monsanto Technology Llc | Syntetiske plantegener og fremgangsmåde til fremstilling af disse |
| US20010003849A1 (en) * | 1989-08-07 | 2001-06-14 | Kenneth A. Barton | Expression of genes in plants |
| US6403865B1 (en) * | 1990-08-24 | 2002-06-11 | Syngenta Investment Corp. | Method of producing transgenic maize using direct transformation of commercially important genotypes |
| UA48104C2 (uk) * | 1991-10-04 | 2002-08-15 | Новартіс Аг | Фрагмент днк, який містить послідовність,що кодує інсектицидний протеїн, оптимізовану для кукурудзи,фрагмент днк, який забезпечує направлену бажану для серцевини стебла експресію зв'язаного з нею структурного гена в рослині, фрагмент днк, який забезпечує специфічну для пилку експресію зв`язаного з нею структурного гена в рослині, рекомбінантна молекула днк, спосіб одержання оптимізованої для кукурудзи кодуючої послідовності інсектицидного протеїну, спосіб захисту рослин кукурудзи щонайменше від однієї комахи-шкідника |
| AT405624B (de) * | 1996-09-25 | 1999-10-25 | Stempfer Ferdinand Ing | Schweissgerät und schweissverfahren, insbesondere widerstandsschweissverfahren |
| US8434105B2 (en) * | 2007-11-13 | 2013-04-30 | Tp Lab, Inc. | Television scripting language |
-
2008
- 2008-10-09 MX MX2010003878A patent/MX2010003878A/es active IP Right Grant
- 2008-10-09 CA CA2702084A patent/CA2702084C/en active Active
- 2008-10-09 BR BRPI0818507A patent/BRPI0818507B8/pt active IP Right Grant
- 2008-10-09 AT AT08837046T patent/ATE504045T1/de not_active IP Right Cessation
- 2008-10-09 CN CN2008801107865A patent/CN101821744B/zh active Active
- 2008-10-09 DE DE602008005920T patent/DE602008005920D1/de active Active
- 2008-10-09 EP EP08837046A patent/EP2208157B1/en active Active
- 2008-10-09 US US12/248,750 patent/US8175813B2/en active Active
- 2008-10-09 WO PCT/US2008/079343 patent/WO2009049045A1/en not_active Ceased
- 2008-10-09 AU AU2008310806A patent/AU2008310806A1/en not_active Abandoned
-
2010
- 2010-04-08 ZA ZA2010/02472A patent/ZA201002472B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101821744A (zh) | 2010-09-01 |
| BRPI0818507A2 (pt) | 2015-06-16 |
| AU2008310806A1 (en) | 2009-04-16 |
| EP2208157B1 (en) | 2011-03-30 |
| US8175813B2 (en) | 2012-05-08 |
| DE602008005920D1 (en) | 2011-05-12 |
| ZA201002472B (en) | 2011-06-29 |
| BRPI0818507B1 (pt) | 2019-09-17 |
| EP2208157A1 (en) | 2010-07-21 |
| BRPI0818507B8 (pt) | 2022-07-05 |
| CN101821744B (zh) | 2013-05-22 |
| CA2702084A1 (en) | 2009-04-16 |
| US20090137409A1 (en) | 2009-05-28 |
| CA2702084C (en) | 2017-07-25 |
| ATE504045T1 (de) | 2011-04-15 |
| WO2009049045A1 (en) | 2009-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |