MX2010002675A - Profarmacos para analogos de hormonas tiroideas. - Google Patents
Profarmacos para analogos de hormonas tiroideas.Info
- Publication number
- MX2010002675A MX2010002675A MX2010002675A MX2010002675A MX2010002675A MX 2010002675 A MX2010002675 A MX 2010002675A MX 2010002675 A MX2010002675 A MX 2010002675A MX 2010002675 A MX2010002675 A MX 2010002675A MX 2010002675 A MX2010002675 A MX 2010002675A
- Authority
- MX
- Mexico
- Prior art keywords
- diseases
- prodrugs
- thyroid hormone
- hormone analogs
- compounds
- Prior art date
Links
- AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical class IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 6
- 201000010099 disease Diseases 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000024770 Thyroid neoplasm Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 208000003532 hypothyroidism Diseases 0.000 abstract 1
- 230000002989 hypothyroidism Effects 0.000 abstract 1
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000002510 thyroid cancer Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Se proporcionan en este documento los compuestos de la fórmula (I): así como también sales y ésteres farmacéuticamente aceptables de los mismos, en donde los sustituyentes son aquellos dados a conocer en la especificación. Estos compuestos, y las composiciones farmacéuticas que los contienen, son útiles para el tratamiento de enfermedades tales como la obesidad, hiperlipidemia, hipercolesterolemia y diabetes y otros trastornos y enfermedades relacionados y pueden ser útiles para otras enfermedades tales como NASH, aterosclerosis, enfermedades cardiovasculares, hipotiroidismo, cáncer de tiroides y otros trastornos y enfermedades relacionados con los mismos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97384607P | 2007-09-20 | 2007-09-20 | |
| PCT/EP2008/062017 WO2009037172A1 (en) | 2007-09-20 | 2008-09-11 | Prodrugs to thyroid hormone analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010002675A true MX2010002675A (es) | 2010-03-26 |
Family
ID=39930638
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010002675A MX2010002675A (es) | 2007-09-20 | 2008-09-11 | Profarmacos para analogos de hormonas tiroideas. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8076334B2 (es) |
| EP (1) | EP2203443B1 (es) |
| JP (1) | JP5456676B2 (es) |
| KR (1) | KR101189040B1 (es) |
| CN (1) | CN101801960B (es) |
| AU (1) | AU2008300649B2 (es) |
| BR (1) | BRPI0817060B1 (es) |
| CA (1) | CA2699338C (es) |
| ES (1) | ES2461341T3 (es) |
| IL (1) | IL204231A (es) |
| MX (1) | MX2010002675A (es) |
| WO (1) | WO2009037172A1 (es) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20171415T4 (hr) * | 2009-06-25 | 2023-03-03 | Alkermes Pharma Ireland Limited | Heterociklični spojevi za liječenje neuroloških i psiholoških poremećaja |
| US8686009B2 (en) * | 2009-06-25 | 2014-04-01 | Alkermes Pharma Ireland Limited | Prodrugs of NH-acidic compounds |
| NZ722096A (en) | 2011-12-15 | 2016-11-25 | Alkermes Pharma Ireland Ltd | Prodrugs of secondary amine compounds |
| EP4023641B1 (en) | 2012-09-17 | 2024-05-01 | Madrigal Pharmaceuticals, Inc. | Method of synthesizing thyroid hormone analogs and polymorphs thereof |
| EP3142228A1 (de) | 2015-09-10 | 2017-03-15 | Siemens Aktiengesellschaft | Stator für eine elektrische maschine, elektrische maschine sowie herstellungsverfahren |
| IL266054B2 (en) * | 2016-10-18 | 2023-10-01 | Madrigal Pharmaceuticals Inc | Methods for treating liver disorders or lipid disorders using a THR-BETA agonist |
| CN109574995B (zh) * | 2018-01-23 | 2020-07-24 | 深圳市塔吉瑞生物医药有限公司 | 取代的哒嗪酮化合物 |
| CN108383798B (zh) * | 2018-01-29 | 2020-09-01 | 上海博邦医药科技有限公司 | 酞嗪酮衍生物前药或其药学上可接受的盐及其药物组合物和应用 |
| AU2019230014B2 (en) | 2018-03-05 | 2024-11-28 | Alkermes Pharma Ireland Limited | Aripiprazole dosing strategy |
| JP7181386B2 (ja) * | 2018-06-12 | 2022-11-30 | スーチョワン ハイスコ ファーマスーティカル カンパニー リミテッド | 甲状腺ホルモン受容体アゴニスト及びその用途 |
| KR20210076932A (ko) | 2018-10-12 | 2021-06-24 | 인벤티스바이오 컴퍼니 리미티드 | 갑상선 호르몬 수용체 작용제 |
| CN121081472A (zh) | 2018-12-13 | 2025-12-09 | 拓臻股份有限公司 | 一种THRβ受体激动剂化合物及其制备方法和用途 |
| WO2020169069A1 (en) | 2019-02-21 | 2020-08-27 | Nanjing Ruijie Pharma Co., Ltd. | Novel compounds and their uses as thyroid hormone receptor agonists |
| PH12021552782A1 (en) * | 2019-05-08 | 2023-01-16 | Aligos Therapeutics Inc | Modulators of thr-ã and methods of use thereof |
| WO2020228577A1 (zh) * | 2019-05-10 | 2020-11-19 | 深圳微芯生物科技股份有限公司 | 一种哒嗪酮衍生物及其应用 |
| WO2020239076A1 (zh) * | 2019-05-29 | 2020-12-03 | 南京明德新药研发有限公司 | 作为甲状腺素受体-β激动剂的哒嗪酮类衍生物及其应用 |
| TW202115029A (zh) * | 2019-07-31 | 2021-04-16 | 大陸商深圳微芯生物科技股份有限公司 | 雜環化合物及其用途 |
| AU2020336272A1 (en) * | 2019-08-23 | 2022-04-14 | Terns Pharmaceuticals, Inc. | Thyroid hormone receptor beta agonist compounds |
| WO2021043185A1 (en) * | 2019-09-04 | 2021-03-11 | Sunshine Lake Pharma Co., Ltd. | A compound as a thyroid hormone beta receptor agonist and use thereof |
| EP4028008A4 (en) | 2019-09-12 | 2023-09-13 | Terns Pharmaceuticals, Inc. | Thyroid hormone receptor beta agonist compounds |
| US20220411400A1 (en) * | 2019-09-24 | 2022-12-29 | Sunshine Lake Pharma Co., Ltd. | Chemical compound as thyroid hormone beta receptor agonist and use thereof |
| CN112707892A (zh) * | 2019-10-24 | 2021-04-27 | 苏州泽璟生物制药股份有限公司 | 哒嗪酮或哒嗪类化合物及其衍生物和药物组合物 |
| CA3158379A1 (en) * | 2019-11-26 | 2021-06-03 | Hejun Lv | 1,2,4-triazine-3,5-dione compound, preparation method therefor, and application thereof |
| CN115244037B (zh) | 2020-01-13 | 2024-10-25 | 诚益生物(美国)公司 | 作为甲状腺激素受体激动剂的被取代的三嗪酮类 |
| CN113278013B (zh) * | 2020-02-20 | 2022-09-23 | 昆药集团股份有限公司 | 2,6-二取代的1,2,4-三嗪-3,5-二酮化合物及其制备方法和应用 |
| CN113698388B (zh) * | 2020-05-20 | 2022-11-22 | 江苏恒瑞医药股份有限公司 | 6-氧代-1,6-二氢吡啶类衍生物、其制备方法及其在医药上的应用 |
| US20230312527A1 (en) | 2020-08-19 | 2023-10-05 | Chengdu Fanxi Biopharma Co., Ltd. | Cyanotriazine derivative, preparation method therefor, and application thereof |
| US20230339911A1 (en) * | 2020-08-27 | 2023-10-26 | InventisBio Co., Ltd. | Pyridazinone compounds |
| CN112645936B (zh) | 2020-12-17 | 2022-03-01 | 山东第一医科大学(山东省医学科学院) | 取代的哒嗪酮类化合物及其用途 |
| CN114685450A (zh) | 2020-12-30 | 2022-07-01 | 昆药集团股份有限公司 | 2-吡啶酮类衍生物及其制备方法和在医药上的应用 |
| CN116354934A (zh) * | 2021-12-28 | 2023-06-30 | 中国科学院上海药物研究所 | 一类喹啉类化合物及其制备方法、药物组合物和用途 |
| WO2024141076A1 (en) * | 2022-12-29 | 2024-07-04 | Gannex Pharma Co., Ltd. | Prodrugs to thyroid hormone analogs and method of making and use thereof |
| EP4568664A1 (en) | 2023-04-07 | 2025-06-18 | Terns Pharmaceuticals, Inc. | Combination comprising a thr-beta agonist and a glp-1r agonist for use in treating a liver disorder or a cardiometabolic disease |
| US12377104B1 (en) | 2024-02-06 | 2025-08-05 | Madrigal Pharmaceuticals, Inc. | Methods for treating a fatty liver disease |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2388799A1 (fr) | 1977-04-28 | 1978-11-24 | Rolland Sa A | Derives de pyridazinone, leur procede de preparation et leur application comme medicaments |
| GB8501372D0 (en) | 1985-01-18 | 1985-02-20 | Smith Kline French Lab | Chemical compounds |
| US5284971A (en) | 1992-07-16 | 1994-02-08 | Syntex (U.S.A.) Inc. | 4-(3-cyclohexyl-4-hydroxy or-methoxy phenylsulfonyl) 3,5 dibromo phenyl acetic thyromimetic cholesterol-lowering agents |
| AU4440596A (en) | 1995-02-10 | 1996-08-22 | Smithkline Beecham Corporation | Use of hcp SH2 specific compounds to enhance erythropoiesis |
| AU6480796A (en) | 1995-06-30 | 1997-02-05 | Smithkline Beecham Corporation | Use of stat 6 sh2 domain specific compounds to treat allergic reactions |
| US5883294A (en) | 1997-06-18 | 1999-03-16 | The Regeants Of The University Of California | Selective thyroid hormone analogs |
| GB9713739D0 (en) | 1997-06-27 | 1997-09-03 | Karobio Ab | Thyroid receptor ligands |
| JP2007512359A (ja) | 2003-11-19 | 2007-05-17 | メタバシス・セラピューティクス・インコーポレイテッド | 新規なリン含有甲状腺ホルモン様物質 |
| NZ565190A (en) | 2005-07-21 | 2010-02-26 | Hoffmann La Roche | Pyridazinone derivatives as thyroid hormone receptor agonists |
-
2008
- 2008-09-02 US US12/202,552 patent/US8076334B2/en active Active
- 2008-09-11 JP JP2010525305A patent/JP5456676B2/ja active Active
- 2008-09-11 WO PCT/EP2008/062017 patent/WO2009037172A1/en not_active Ceased
- 2008-09-11 CA CA2699338A patent/CA2699338C/en active Active
- 2008-09-11 BR BRPI0817060-6A patent/BRPI0817060B1/pt active IP Right Grant
- 2008-09-11 AU AU2008300649A patent/AU2008300649B2/en active Active
- 2008-09-11 EP EP08803984.7A patent/EP2203443B1/en active Active
- 2008-09-11 CN CN200880107432.5A patent/CN101801960B/zh active Active
- 2008-09-11 MX MX2010002675A patent/MX2010002675A/es active IP Right Grant
- 2008-09-11 KR KR1020107005937A patent/KR101189040B1/ko active Active
- 2008-09-11 ES ES08803984.7T patent/ES2461341T3/es active Active
-
2010
- 2010-03-01 IL IL204231A patent/IL204231A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CA2699338A1 (en) | 2009-03-26 |
| AU2008300649B2 (en) | 2013-05-02 |
| EP2203443A1 (en) | 2010-07-07 |
| JP5456676B2 (ja) | 2014-04-02 |
| EP2203443B1 (en) | 2014-03-05 |
| KR101189040B1 (ko) | 2012-10-08 |
| CN101801960B (zh) | 2014-04-16 |
| JP2010539209A (ja) | 2010-12-16 |
| CA2699338C (en) | 2017-02-07 |
| CN101801960A (zh) | 2010-08-11 |
| WO2009037172A1 (en) | 2009-03-26 |
| US20090082310A1 (en) | 2009-03-26 |
| AU2008300649A1 (en) | 2009-03-26 |
| IL204231A (en) | 2014-04-30 |
| BRPI0817060A2 (pt) | 2019-02-26 |
| ES2461341T3 (es) | 2014-05-19 |
| BRPI0817060B1 (pt) | 2021-07-20 |
| US8076334B2 (en) | 2011-12-13 |
| KR20100043285A (ko) | 2010-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |