MX2010001636A - Derivados de pirazolo[3,4-d]-pirimidina como agentes antiproliferativos. - Google Patents
Derivados de pirazolo[3,4-d]-pirimidina como agentes antiproliferativos.Info
- Publication number
- MX2010001636A MX2010001636A MX2010001636A MX2010001636A MX2010001636A MX 2010001636 A MX2010001636 A MX 2010001636A MX 2010001636 A MX2010001636 A MX 2010001636A MX 2010001636 A MX2010001636 A MX 2010001636A MX 2010001636 A MX2010001636 A MX 2010001636A
- Authority
- MX
- Mexico
- Prior art keywords
- diazo bicyclic
- smac mimetics
- mimetics
- bicyclic smac
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención está dirigida a derivados de pirazolo[3,4-d]pirimidina novedosos de fórmula (I), y sales y ésteres farmacéuticamente aceptables de los mismos, donde R, el Anillo A, L y el anillo B son como se describe aquí. Esos compuestos y sus sales y ésteres farmacéuticamente aceptables inhiben la Raf cinasa y tienen actividad antiproliferativa. Por lo tanto, son útiles en el tratamiento o control de trastornos proliferativos como el cáncer, en particular tumores sólidos, de manera más particular tumor de mama, tumor de colón, tumor de pulmón, tumor de próstata y melanoma. También se describe una composición y una formulación de dosis unitaria que comprende ese compuesto, o una sal o éster farmacéuticamente aceptable del mismo para producir esos compuestos, y métodos para usar esos compuestos, o sus sales o ésteres farmacéuticamente aceptables, en el tratamiento de trastornos proliferativos. (Ver fórmula I).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95565307P | 2007-08-14 | 2007-08-14 | |
| PCT/US2008/060215 WO2008128171A2 (en) | 2007-04-13 | 2008-04-14 | Diazo bicyclic smac mimetics and the uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010001636A true MX2010001636A (es) | 2010-03-15 |
Family
ID=39760502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010001636A MX2010001636A (es) | 2007-08-14 | 2008-04-14 | Derivados de pirazolo[3,4-d]-pirimidina como agentes antiproliferativos. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7968554B2 (es) |
| EP (1) | EP2188290B1 (es) |
| JP (1) | JP5296790B2 (es) |
| KR (1) | KR20100038431A (es) |
| CN (1) | CN101965349B (es) |
| AT (1) | ATE512152T1 (es) |
| AU (1) | AU2008288538A1 (es) |
| BR (1) | BRPI0815334A2 (es) |
| CA (1) | CA2694666C (es) |
| ES (1) | ES2366268T3 (es) |
| MX (1) | MX2010001636A (es) |
| WO (1) | WO2009021869A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9408885B2 (en) | 2011-12-01 | 2016-08-09 | Vib Vzw | Combinations of therapeutic agents for treating melanoma |
| EP3579872A1 (en) | 2017-02-10 | 2019-12-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of cancers associated with activation of the mapk pathway |
| WO2019133810A1 (en) | 2017-12-28 | 2019-07-04 | Tract Pharmaceuticals, Inc. | Stem cell culture systems for columnar epithelial stem cells, and uses related thereto |
| SG11202110547YA (en) * | 2019-04-10 | 2021-10-28 | Cellestia Biotech Ag | Compounds for the treatment of oncovirus induced cancer and methods of use thereof |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2732970B1 (fr) | 1995-04-14 | 1997-05-16 | Hoechst Schering Agrevo Sa | Nouveaux derives de l'acide beta-methoxy acrylique, leur procede de preparation et leur application comme pesticides |
| US6232320B1 (en) * | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| UA60365C2 (uk) | 1998-06-04 | 2003-10-15 | Пфайзер Продактс Інк. | Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця |
| DK1140938T3 (da) | 1999-01-11 | 2003-12-22 | Univ Princeton | Højaffinitetsinhibitorer for målvalidering og anvendelser heraf |
| HN2000000051A (es) | 1999-05-19 | 2001-02-02 | Pfizer Prod Inc | Derivados heterociclicos utiles como agentes anticancerosos |
| JP2004514714A (ja) | 2000-11-28 | 2004-05-20 | ファイザー・プロダクツ・インク | イソチアゾール−４−カルボキサミドの塩及びそれらの抗増殖過剰剤としての使用 |
| EA007987B1 (ru) | 2002-03-29 | 2007-02-27 | Чирон Корпорейшн | Замещённые бензазолы и их применение в качестве ингибиторов киназы raf |
| EP1556053A4 (en) * | 2002-10-31 | 2006-04-19 | Amgen Inc | ANTI-INFLAMMATORY AGENTS |
| JP2006528685A (ja) | 2003-05-06 | 2006-12-21 | スミスクライン ビーチャム コーポレーション | 新規化合物 |
| US20050020619A1 (en) * | 2003-07-24 | 2005-01-27 | Patrick Betschmann | Thienopyridine kinase inhibitors |
| US20050026944A1 (en) * | 2003-07-24 | 2005-02-03 | Patrick Betschmann | Thienopyridine and furopyridine kinase inhibitors |
| US7202363B2 (en) * | 2003-07-24 | 2007-04-10 | Abbott Laboratories | Thienopyridine and furopyridine kinase inhibitors |
| KR20070029643A (ko) | 2003-12-05 | 2007-03-14 | 베링거 인겔하임 파마슈티칼즈, 인코포레이티드 | ＩＫＫ 억제제로서의 치환된3-아미노-티에노[2,3-ｂ]피리딘-2-카복실산 아미드 화합물 |
| US20060025383A1 (en) * | 2004-02-03 | 2006-02-02 | Neil Wishart | Aminobenzoxazoles as therapeutic agents |
| US20050256154A1 (en) * | 2004-05-04 | 2005-11-17 | Kin-Chun Luk | 4-Amino-thieno[3,2-c]pyridine-7-carboxylic acid amides |
| US7405220B2 (en) | 2004-06-09 | 2008-07-29 | Hoffmann-La Roche Inc. | Pyrazolopyrimidines |
| EP1831225A2 (en) | 2004-11-19 | 2007-09-12 | The Regents of the University of California | Anti-inflammatory pyrazolopyrimidines |
| WO2006125101A2 (en) | 2005-05-20 | 2006-11-23 | Array Biopharma Inc. | Raf inhibitor compounds and methods of use thereof |
| NZ565255A (en) * | 2005-06-22 | 2010-04-30 | Plexxikon Inc | Pyrrolo[2,3-b] pyridine derivatives as protein kinase inhibitors |
| AR057455A1 (es) * | 2005-07-22 | 2007-12-05 | Merck & Co Inc | Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica |
| EP1926737B1 (en) * | 2005-09-15 | 2017-03-15 | F. Hoffmann-La Roche AG | 4-amino-thieno[3,2-c]pyridine-7-carboxylic acid derivatives |
| CN101336244B (zh) * | 2005-12-08 | 2011-11-30 | 雅培制药有限公司 | 用作蛋白激酶抑制剂的9元杂二环化合物 |
| WO2007075554A2 (en) | 2005-12-19 | 2007-07-05 | Osi Pharmaceuticals, Inc. | Combination of igfr inhibitor and anti-cancer agent |
-
2008
- 2008-04-14 MX MX2010001636A patent/MX2010001636A/es not_active Application Discontinuation
- 2008-07-18 US US12/175,562 patent/US7968554B2/en not_active Expired - Fee Related
- 2008-08-04 CN CN200880102683.4A patent/CN101965349B/zh not_active Expired - Fee Related
- 2008-08-04 EP EP08786828A patent/EP2188290B1/en not_active Not-in-force
- 2008-08-04 ES ES08786828T patent/ES2366268T3/es active Active
- 2008-08-04 KR KR1020107002618A patent/KR20100038431A/ko not_active Ceased
- 2008-08-04 AU AU2008288538A patent/AU2008288538A1/en not_active Abandoned
- 2008-08-04 WO PCT/EP2008/060215 patent/WO2009021869A1/en not_active Ceased
- 2008-08-04 BR BRPI0815334A patent/BRPI0815334A2/pt not_active IP Right Cessation
- 2008-08-04 AT AT08786828T patent/ATE512152T1/de not_active IP Right Cessation
- 2008-08-04 JP JP2010520530A patent/JP5296790B2/ja not_active Expired - Fee Related
- 2008-08-04 CA CA2694666A patent/CA2694666C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010535835A (ja) | 2010-11-25 |
| CN101965349B (zh) | 2016-05-04 |
| CA2694666C (en) | 2015-07-14 |
| BRPI0815334A2 (pt) | 2019-09-24 |
| US7968554B2 (en) | 2011-06-28 |
| ATE512152T1 (de) | 2011-06-15 |
| EP2188290B1 (en) | 2011-06-08 |
| AU2008288538A1 (en) | 2009-02-19 |
| CN101965349A (zh) | 2011-02-02 |
| JP5296790B2 (ja) | 2013-09-25 |
| CA2694666A1 (en) | 2009-02-19 |
| WO2009021869A1 (en) | 2009-02-19 |
| KR20100038431A (ko) | 2010-04-14 |
| EP2188290A1 (en) | 2010-05-26 |
| ES2366268T3 (es) | 2011-10-18 |
| US20090048274A1 (en) | 2009-02-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |