MX2010001238A - Derivados de n-heteroaril-carboxamidas triciclicos su preparacion y su aplicacion terapeutico. - Google Patents
Derivados de n-heteroaril-carboxamidas triciclicos su preparacion y su aplicacion terapeutico.Info
- Publication number
- MX2010001238A MX2010001238A MX2010001238A MX2010001238A MX2010001238A MX 2010001238 A MX2010001238 A MX 2010001238A MX 2010001238 A MX2010001238 A MX 2010001238A MX 2010001238 A MX2010001238 A MX 2010001238A MX 2010001238 A MX2010001238 A MX 2010001238A
- Authority
- MX
- Mexico
- Prior art keywords
- sub
- heteroaryl
- pyrrolo
- pyridinyl
- nitrogen atom
- Prior art date
Links
- 229940053202 antiepileptics carboxamide derivative Drugs 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 5
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 4
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- -1 pyrrolo[2,3-c]pyridinyl Chemical group 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- AEOCXXJPGCBFJA-UHFFFAOYSA-N ethionamide Chemical compound CCC1=CC(C(N)=S)=CC=N1 AEOCXXJPGCBFJA-UHFFFAOYSA-N 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 125000002911 monocyclic heterocycle group Chemical group 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Obesity (AREA)
- Biotechnology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La invención se refiere a derivados de N-heteroaril-carboxamidas triciclicas de formula (l) donde A representa: junto con a Z2 Z3 un enlace biciclico a la que esta obligado, un grupo cicloalquilo de 4 a 7 átomos de carbono, un heteroarilo monociclicos o un heterociclo monociclicos con 4 a 7 miembros que comprende entre uno y tres heteroátomos elegidos entre O, S o N. incluyendo átomos Z2 y Z3 Z1, Z5. Z6 Z7 y Z8 representan, independientemente uno del otro, un átomo de nitrógeno, un átomo de carbono o un grupo C-R2 Z2. Z3 Z4 y Z9 representan, independientemente uno del otro, un átomo de nitrógeno o un átomo de carbono y Z1, Z9, Z3 Z4, Z5 Z6, Z7 Z8 y Z9 juntos forman un enlace heteroarilo biciclico al átomo de nitrógeno de la amida o tioamida de fórmula (l) por las posiciones Z5, Z6, Z7 o Z8 cuando tales posiciones corresponden a un átomo de carbono, por lo menos uno de los Z4, Z5, Z6, Z7. Z8 y Z9 correspondiente a un átomo de nitrógeno; W representa un átomo de oxigeno o de azufre, y P representa un indolil, pirrolo[2,3-c]piridinil, pirrolo(2.3-6)piridinil, pirrolo[3.2-/])piridinil o pirrolo[3,2-c] Tal grupo piridinil de acuerdo al grupo sustituyente. La invención también se refiere a un método para la preparación mismo y con 'el uso terapéutico de la misma.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0705677A FR2919610B1 (fr) | 2007-08-02 | 2007-08-02 | Derives de n-heteroaryl-carboxamides tricycliques,leur preparation et leur application en therapeutique |
| PCT/FR2008/001141 WO2009050348A1 (fr) | 2007-08-02 | 2008-07-31 | Dérivés de λ/-hétéroaryl-carboxamides tricycliques, leur préparation et leur application en thérapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010001238A true MX2010001238A (es) | 2010-03-04 |
Family
ID=39185736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010001238A MX2010001238A (es) | 2007-08-02 | 2008-07-31 | Derivados de n-heteroaril-carboxamidas triciclicos su preparacion y su aplicacion terapeutico. |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US8153796B2 (es) |
| EP (1) | EP2185558B1 (es) |
| JP (1) | JP5259713B2 (es) |
| KR (1) | KR20100041804A (es) |
| CN (1) | CN101772499B (es) |
| AR (1) | AR067754A1 (es) |
| AU (1) | AU2008313601B2 (es) |
| BR (1) | BRPI0814756A2 (es) |
| CA (1) | CA2694994C (es) |
| CL (1) | CL2008002289A1 (es) |
| CO (1) | CO6251362A2 (es) |
| EA (1) | EA017808B1 (es) |
| FR (1) | FR2919610B1 (es) |
| MA (1) | MA31687B1 (es) |
| MX (1) | MX2010001238A (es) |
| MY (1) | MY150428A (es) |
| NZ (1) | NZ582970A (es) |
| PA (1) | PA8790901A1 (es) |
| PE (1) | PE20090565A1 (es) |
| SG (1) | SG183080A1 (es) |
| TW (1) | TWI366566B (es) |
| UY (1) | UY31264A1 (es) |
| WO (1) | WO2009050348A1 (es) |
| ZA (1) | ZA201000745B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10189840B2 (en) * | 2015-03-18 | 2019-01-29 | Bristol-Myers Squibb Company | Substituted tricyclic heterocyclic compounds |
| EP3320241A4 (en) | 2015-07-09 | 2018-07-18 | Vistadeltek, LLC | Control plate in a valve |
| AU2016315648B2 (en) * | 2015-08-28 | 2021-04-01 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| WO2022111473A1 (en) * | 2020-11-26 | 2022-06-02 | Bioardis Llc | Compounds as mrgprx2 antagonists |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0156327B1 (ko) * | 1995-07-12 | 1998-11-16 | 김종인 | 벤즈 또는 피리도이미다졸 유도체 |
| US6313242B1 (en) * | 1996-05-20 | 2001-11-06 | Fina Technology, Inc. | Stereorigid bis-fluorenyl metallocenes |
| US5708187A (en) * | 1996-06-27 | 1998-01-13 | Eli Lilly And Company | 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists |
| ES2337254T3 (es) * | 2003-02-14 | 2010-04-22 | Glaxo Group Limited | Derivados de carboxamida. |
| US20050004133A1 (en) * | 2003-06-05 | 2005-01-06 | Makings Lewis R. | Modulators of VR1 receptor |
| GB0319151D0 (en) * | 2003-08-14 | 2003-09-17 | Glaxo Group Ltd | Novel compounds |
| FR2888847B1 (fr) * | 2005-07-22 | 2007-08-31 | Sanofi Aventis Sa | Derives de n-(heteriaryl)-1-heteorarylalkyl-1h-indole-2- carboxamides, leur preparation et application en therapeutique |
| FR2888848B1 (fr) * | 2005-07-22 | 2007-09-28 | Sanofi Aventis Sa | Derives de n-(arylalkyl)-1h-pyrrrolopyridine-2-carboxamides, leur preparation et leur application en therapeutique |
| FR2897061B1 (fr) * | 2006-02-03 | 2010-09-03 | Sanofi Aventis | Derives de n-heteroaryl-carboxamides tricycliques contenant un motif benzimidazole, leur preparation et leur application en therapeutique. |
-
2007
- 2007-08-02 FR FR0705677A patent/FR2919610B1/fr active Active
-
2008
- 2008-07-29 PA PA20088790901A patent/PA8790901A1/es unknown
- 2008-07-30 TW TW097128801A patent/TWI366566B/zh not_active IP Right Cessation
- 2008-07-31 MY MYPI20100448 patent/MY150428A/en unknown
- 2008-07-31 MX MX2010001238A patent/MX2010001238A/es active IP Right Grant
- 2008-07-31 AR ARP080103318A patent/AR067754A1/es not_active Application Discontinuation
- 2008-07-31 PE PE2008001286A patent/PE20090565A1/es not_active Application Discontinuation
- 2008-07-31 CN CN2008801014470A patent/CN101772499B/zh not_active Expired - Fee Related
- 2008-07-31 SG SG2012055265A patent/SG183080A1/en unknown
- 2008-07-31 KR KR1020107002302A patent/KR20100041804A/ko not_active Ceased
- 2008-07-31 CA CA2694994A patent/CA2694994C/fr not_active Expired - Fee Related
- 2008-07-31 BR BRPI0814756A patent/BRPI0814756A2/pt not_active IP Right Cessation
- 2008-07-31 WO PCT/FR2008/001141 patent/WO2009050348A1/fr not_active Ceased
- 2008-07-31 NZ NZ582970A patent/NZ582970A/en not_active IP Right Cessation
- 2008-07-31 AU AU2008313601A patent/AU2008313601B2/en not_active Ceased
- 2008-07-31 JP JP2010518710A patent/JP5259713B2/ja not_active Expired - Fee Related
- 2008-07-31 EP EP08839139.6A patent/EP2185558B1/fr active Active
- 2008-07-31 EA EA201070217A patent/EA017808B1/ru not_active IP Right Cessation
- 2008-08-01 UY UY31264A patent/UY31264A1/es not_active Application Discontinuation
- 2008-08-01 CL CL2008002289A patent/CL2008002289A1/es unknown
-
2010
- 2010-01-29 US US12/696,149 patent/US8153796B2/en not_active Expired - Fee Related
- 2010-02-01 CO CO10010102A patent/CO6251362A2/es active IP Right Grant
- 2010-02-01 ZA ZA2010/00745A patent/ZA201000745B/en unknown
- 2010-03-01 MA MA32663A patent/MA31687B1/fr unknown
-
2012
- 2012-03-06 US US13/412,855 patent/US8420817B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |