MX2010001195A - Derivados de benzoil-peperidina como moduladores dobles de los receptores 5-ht2a y d3. - Google Patents
Derivados de benzoil-peperidina como moduladores dobles de los receptores 5-ht2a y d3.Info
- Publication number
- MX2010001195A MX2010001195A MX2010001195A MX2010001195A MX2010001195A MX 2010001195 A MX2010001195 A MX 2010001195A MX 2010001195 A MX2010001195 A MX 2010001195A MX 2010001195 A MX2010001195 A MX 2010001195A MX 2010001195 A MX2010001195 A MX 2010001195A
- Authority
- MX
- Mexico
- Prior art keywords
- sub
- receptors
- ht2a
- benzoyl
- piperidine derivatives
- Prior art date
Links
- 230000009977 dual effect Effects 0.000 title abstract 2
- YXTROGRGRSPWKL-UHFFFAOYSA-N 1-benzoylpiperidine Chemical class C=1C=CC=CC=1C(=O)N1CCCCC1 YXTROGRGRSPWKL-UHFFFAOYSA-N 0.000 title 1
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 9
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229960003638 dopamine Drugs 0.000 abstract 2
- 229940076279 serotonin Drugs 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 206010013663 drug dependence Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 206010027175 memory impairment Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000011117 substance-related disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se refiere a compuestos de la fórmula general (l), (ver formula 1) en la que R1 y A tienen los significados definidos en la descripción, como moduladores duales de los receptores de la serotonina 5-HT2a y de la dopamina ID3, su obtención, las composiciones farmacéuticas que los contienen y su utilización como medicamentos. Los compuestos de general fórmula (I) tienen una gran afinidad con los receptores de la dopamina ID3 y de la serotonina (5-hidroxitriptamina; 5-HT) 5-I-IT2A y Son eficaces para el tratamiento de trastornos psicóticos, así como otros trastornos, tales como la depresión y la ansiedad, la dependencia de fármacos, las demencias y los desequi20 librios de memoria.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07114119 | 2007-08-09 | ||
| PCT/EP2008/059971 WO2009019174A1 (en) | 2007-08-09 | 2008-07-30 | Benzoyl-piperidine derivatives as dual modulators of the 5-ht2a and d3 receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010001195A true MX2010001195A (es) | 2010-03-01 |
Family
ID=39865594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010001195A MX2010001195A (es) | 2007-08-09 | 2008-07-30 | Derivados de benzoil-peperidina como moduladores dobles de los receptores 5-ht2a y d3. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8097637B2 (es) |
| EP (1) | EP2185513B1 (es) |
| JP (1) | JP5296073B2 (es) |
| KR (1) | KR101171467B1 (es) |
| CN (1) | CN101778820B (es) |
| AR (1) | AR067873A1 (es) |
| AT (1) | ATE512137T1 (es) |
| AU (1) | AU2008285729B2 (es) |
| BR (1) | BRPI0814999A2 (es) |
| CA (1) | CA2694057A1 (es) |
| CL (1) | CL2008002310A1 (es) |
| ES (1) | ES2366766T3 (es) |
| MX (1) | MX2010001195A (es) |
| PE (1) | PE20090513A1 (es) |
| TW (1) | TW200914422A (es) |
| WO (1) | WO2009019174A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2396265C2 (ru) | 2006-02-17 | 2010-08-10 | Ф. Хоффманн-Ля Рош Аг | Производные бензоилпиперидина в качестве модуляторов рецепторов 5ht2 и d3 |
| KR101169518B1 (ko) * | 2007-07-26 | 2012-07-27 | 에프. 호프만-라 로슈 아게 | 5-ｈｔ2ａ 및 ｄ3 수용체의 이중 조절제 |
| US8586579B2 (en) | 2010-06-21 | 2013-11-19 | Hoffmann-La Roche Inc. | Anellated pyridine compounds |
| US8470828B2 (en) | 2010-07-06 | 2013-06-25 | Hoffmann-La Roche Inc. | Anellated pyridine compounds |
| US8921397B2 (en) * | 2011-05-04 | 2014-12-30 | Hoffmann-La Roche Inc. | Benzofurane-piperidine compounds |
| WO2013086266A2 (en) * | 2011-12-08 | 2013-06-13 | The Board Of Regents Of The University Of Texas System | Allosteric modulators of 5-hydroxytryptamine 2c receptor (5-ht2cr) |
| PE20171119A1 (es) | 2014-12-12 | 2017-08-08 | Japan Tobacco Inc | Compuestos de dihidropirimidin-2-ona y sus usos medicos |
| CN117550989B (zh) * | 2023-11-14 | 2024-09-27 | 泰州精英化成医药科技有限公司 | 一种反式-2-(4-氨基环己基)乙酸乙酯盐酸盐的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2717479B1 (fr) * | 1994-03-18 | 1996-06-07 | Pf Medicament | Nouvelles 3-(omega-benzoylpipéridino) alcoyl)-4H-Benzopyran-4-ones, leur préparation et leur application en thérapeutique. |
| HUP0103986A2 (hu) * | 2001-09-28 | 2003-06-28 | Richter Gedeon Vegyészeti Gyár Rt. | Új karbonsavamid szerkezetet tartalmazó piperidinil vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények |
| HU227543B1 (en) * | 2001-09-28 | 2011-08-29 | Richter Gedeon Nyrt | N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them |
| AU2002366766A1 (en) * | 2001-12-13 | 2003-07-09 | Sumitomo Pharmaceuticals Co., Ltd. | Serotonine reuptake inhibitor |
| RU2396265C2 (ru) * | 2006-02-17 | 2010-08-10 | Ф. Хоффманн-Ля Рош Аг | Производные бензоилпиперидина в качестве модуляторов рецепторов 5ht2 и d3 |
-
2008
- 2008-07-30 KR KR1020107002763A patent/KR101171467B1/ko not_active Expired - Fee Related
- 2008-07-30 JP JP2010519432A patent/JP5296073B2/ja not_active Expired - Fee Related
- 2008-07-30 AU AU2008285729A patent/AU2008285729B2/en not_active Ceased
- 2008-07-30 ES ES08786606T patent/ES2366766T3/es active Active
- 2008-07-30 CA CA2694057A patent/CA2694057A1/en not_active Abandoned
- 2008-07-30 MX MX2010001195A patent/MX2010001195A/es active IP Right Grant
- 2008-07-30 BR BRPI0814999-2A2A patent/BRPI0814999A2/pt not_active Application Discontinuation
- 2008-07-30 WO PCT/EP2008/059971 patent/WO2009019174A1/en not_active Ceased
- 2008-07-30 AT AT08786606T patent/ATE512137T1/de active
- 2008-07-30 CN CN2008801026707A patent/CN101778820B/zh not_active Expired - Fee Related
- 2008-07-30 EP EP08786606A patent/EP2185513B1/en not_active Not-in-force
- 2008-08-01 US US12/184,272 patent/US8097637B2/en not_active Expired - Fee Related
- 2008-08-06 CL CL2008002310A patent/CL2008002310A1/es unknown
- 2008-08-07 AR ARP080103450A patent/AR067873A1/es unknown
- 2008-08-07 PE PE2008001318A patent/PE20090513A1/es not_active Application Discontinuation
- 2008-08-08 TW TW097130407A patent/TW200914422A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2366766T3 (es) | 2011-10-25 |
| CN101778820B (zh) | 2012-12-05 |
| EP2185513B1 (en) | 2011-06-08 |
| CL2008002310A1 (es) | 2009-05-29 |
| CA2694057A1 (en) | 2009-02-12 |
| US20090042943A1 (en) | 2009-02-12 |
| US8097637B2 (en) | 2012-01-17 |
| AU2008285729A1 (en) | 2009-02-12 |
| AR067873A1 (es) | 2009-10-28 |
| KR20100029850A (ko) | 2010-03-17 |
| JP2010535735A (ja) | 2010-11-25 |
| AU2008285729B2 (en) | 2012-11-01 |
| CN101778820A (zh) | 2010-07-14 |
| BRPI0814999A2 (pt) | 2015-02-03 |
| WO2009019174A1 (en) | 2009-02-12 |
| ATE512137T1 (de) | 2011-06-15 |
| TW200914422A (en) | 2009-04-01 |
| PE20090513A1 (es) | 2009-04-29 |
| JP5296073B2 (ja) | 2013-09-25 |
| KR101171467B1 (ko) | 2012-08-07 |
| EP2185513A1 (en) | 2010-05-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HH | Correction or change in general | ||
| FG | Grant or registration |