MX2010001190A - Compuesto biciclico fusionado. - Google Patents
Compuesto biciclico fusionado.Info
- Publication number
- MX2010001190A MX2010001190A MX2010001190A MX2010001190A MX2010001190A MX 2010001190 A MX2010001190 A MX 2010001190A MX 2010001190 A MX2010001190 A MX 2010001190A MX 2010001190 A MX2010001190 A MX 2010001190A MX 2010001190 A MX2010001190 A MX 2010001190A
- Authority
- MX
- Mexico
- Prior art keywords
- cycloalkyl
- substituent
- substituted
- alkyl
- hydrogen
- Prior art date
Links
- -1 bicyclic compound Chemical class 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 229940030600 antihypertensive agent Drugs 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 239000002395 mineralocorticoid Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/16—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with only hydrogen or carbon atoms directly attached in positions 2 and 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
La presente invención proporciona un compuesto biciclico fusionado novedoso que tiene una afinidad por un receptor del corticoide mineral (MR), mostrado por la fórmula [1]: (ver formula 1) n donde el anillo A es un anillo de benceno que tiene un sustituyente R1, fusionado a un anillo heterocíclico de 6 miembros adyacente, que tiene opcionalmente además, un sustituyente diferente de R1, R1 es un grupo alquilsulfonilamino, etc., R2 y R3 son (a) los mismos o diferentes y un átomo de hidrógeno, un grupo alquilo o un grupo arilo sustituido o no sustituido, (b) se combinan uno con el otro para formar un grupo oxo o (c) se combinan uno con el otro en su terminal, junto con el átomo de carbono adyacente para formar un grupo cicloalquilo, X es un grupo de =N-, =C(R4)- o -CH(R4)-, R4 es (a) un átomo de hidrógeno, (b) un grupo ciano, (c) un átomo de halógeno, (d) un grupo alquilo, (e) un grupo alquenilo, (f) un grupo cicloalquilo (g) un grupo alcanoilo, (h) un grupo carbamoilo o (i) un grupo cicloalquenilo, Ar es un grupo cíclico aromático sustituido opcionalmente, y una línea punteada significa la presencia o ausencia de un enlace doble, o una sal farmacéuticamente aceptable del mismo, que es útil como un agente antihipertensivo, etc.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007200264 | 2007-08-01 | ||
| PCT/JP2008/063751 WO2009017190A1 (ja) | 2007-08-01 | 2008-07-31 | 縮合二環式化合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010001190A true MX2010001190A (es) | 2010-03-01 |
Family
ID=40304418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010001190A MX2010001190A (es) | 2007-08-01 | 2008-07-31 | Compuesto biciclico fusionado. |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8258131B2 (es) |
| EP (1) | EP2179994B1 (es) |
| JP (1) | JP5357027B2 (es) |
| KR (1) | KR101338813B1 (es) |
| CN (1) | CN101809005B (es) |
| AU (1) | AU2008283265B2 (es) |
| BR (1) | BRPI0815037A2 (es) |
| CA (1) | CA2693180C (es) |
| ES (1) | ES2419254T3 (es) |
| MX (1) | MX2010001190A (es) |
| PH (1) | PH12013500442A1 (es) |
| RU (1) | RU2468017C2 (es) |
| TW (1) | TWI396540B (es) |
| WO (1) | WO2009017190A1 (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2013000623A (es) | 2010-07-16 | 2013-06-13 | Abbvie Inc | Proceso para la preparación de compuestos antivirales. |
| WO2012009698A1 (en) | 2010-07-16 | 2012-01-19 | Abbott Laboratories | Phosphine ligands for catalytic reactions |
| US9255074B2 (en) | 2010-07-16 | 2016-02-09 | Abbvie Inc. | Process for preparing antiviral compounds |
| US8975443B2 (en) | 2010-07-16 | 2015-03-10 | Abbvie Inc. | Phosphine ligands for catalytic reactions |
| CN103483237B (zh) * | 2013-10-15 | 2015-04-08 | 安徽工业大学 | 一种双磺酸根离子液体催化制备吡咯衍生物的方法 |
| EP3126360A1 (en) | 2014-03-29 | 2017-02-08 | Lupin Limited | Sulfonamide compounds as voltage gated sodium channel modulators |
| MX367404B (es) | 2014-06-30 | 2019-08-20 | Astrazeneca Ab | Amidas de benzoxazinona como moduladores del receptor de mineralocorticoides. |
| WO2017064121A1 (en) | 2015-10-13 | 2017-04-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of choroidal neovascularisation |
| EP3490606B8 (en) | 2016-07-26 | 2024-04-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antagonist of mineralocorticoid receptor for the treatment of osteoarthritis |
| BR112019005456A2 (pt) * | 2016-09-27 | 2019-06-04 | Mitsubishi Tanabe Pharma Corp | composição farmacêutica e método para tratamento de esteatose hepática não alcoólica |
| CN112442022B (zh) * | 2019-09-02 | 2022-05-20 | 承德医学院 | 苯并嗪-4-酮类化合物、其制备方法及医药用途 |
| WO2021180818A1 (en) | 2020-03-11 | 2021-09-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of determining whether a subject has or is at risk of having a central serous chorioretinopathy |
| CN117355520A (zh) | 2021-05-18 | 2024-01-05 | 巴斯夫欧洲公司 | 用作杀真菌剂的新型取代喹啉类 |
| EP4341256A1 (en) | 2021-05-18 | 2024-03-27 | Basf Se | New substituted pyridines as fungicides |
| WO2023031277A1 (en) | 2021-08-31 | 2023-03-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of ocular rosacea |
| CN115260197B (zh) * | 2022-07-14 | 2024-03-12 | 深圳市国华光电研究院 | 一种稠环化合物及其制备方法和应用 |
| EP4618761A1 (en) | 2022-11-14 | 2025-09-24 | Basf Se | Fungicidal mixture comprising substituted pyridines |
| WO2026021911A1 (en) | 2024-07-23 | 2026-01-29 | Basf Se | New substituted benzothiazine pyridine compounds for combatting phytopathogenic fungi |
| WO2026021909A1 (en) | 2024-07-23 | 2026-01-29 | Basf Se | New substituted benzothiazine pyridine compounds for combatting phytopathogenic fungi |
| WO2026021912A1 (en) | 2024-07-23 | 2026-01-29 | Basf Se | New substituted benzothiazine pyridine compounds for combatting phytopathogenic fungi |
| WO2026021910A1 (en) | 2024-07-23 | 2026-01-29 | Basf Se | New substituted benzothiazine pyridine compounds for combatting phytopathogenic fungi |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0597824A (ja) * | 1990-09-25 | 1993-04-20 | Takeda Chem Ind Ltd | １，３−ベンゾオキサジン誘導体 |
| CN1060467A (zh) | 1990-09-25 | 1992-04-22 | 武田药品工业株式会社 | 1，3-苯并嗪衍生物、其生产方法和用途 |
| JPH06107647A (ja) * | 1992-08-12 | 1994-04-19 | Takeda Chem Ind Ltd | １，３−ベンゾオキサジン誘導体の製造法 |
| WO1997023209A1 (en) | 1995-12-25 | 1997-07-03 | Nissan Chemical Industries, Ltd. | Therapeutic agent for cardiac failure |
| US20030073850A1 (en) | 1998-08-07 | 2003-04-17 | Altenbach Robert J. | 4-Imidazole derivatives of benzyl and restricted benzyl sulfonamides, sulfamides, ureas, carbamates, and amides and their use |
| RU2195457C1 (ru) * | 2001-07-31 | 2002-12-27 | Кубанский государственный технологический университет | Замещенные 4,4-дифенил-1,2-дигидро-4н-3,1-бензоксазины, проявляющие росторегулирующую и антистрессовую активность |
| WO2003096982A2 (en) | 2002-05-16 | 2003-11-27 | Cytovia, Inc. | Substituted 4h-chromenes, 2h-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| WO2005037830A1 (en) | 2003-10-10 | 2005-04-28 | Wyeth | Piperidinylchromen-6-ylsulfonamide compounds as 5-hydroxytryptamine-6 ligands |
| WO2006077821A1 (ja) | 2005-01-19 | 2006-07-27 | Dainippon Sumitomo Pharma Co., Ltd. | アルドステロン受容体調節剤としての芳香族スルホン化合物 |
| US7598261B2 (en) | 2005-03-31 | 2009-10-06 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| JP5099814B2 (ja) | 2006-02-02 | 2012-12-19 | 田辺三菱製薬株式会社 | 含窒素複素二環式化合物 |
| TWI385161B (zh) | 2006-02-02 | 2013-02-11 | Mitsubishi Tanabe Pharma Corp | 含氮雜雙環化合物 |
-
2008
- 2008-07-21 US US12/671,479 patent/US8258131B2/en not_active Expired - Fee Related
- 2008-07-29 TW TW097128581A patent/TWI396540B/zh not_active IP Right Cessation
- 2008-07-31 MX MX2010001190A patent/MX2010001190A/es active IP Right Grant
- 2008-07-31 AU AU2008283265A patent/AU2008283265B2/en not_active Ceased
- 2008-07-31 BR BRPI0815037 patent/BRPI0815037A2/pt not_active IP Right Cessation
- 2008-07-31 KR KR1020107004381A patent/KR101338813B1/ko not_active Expired - Fee Related
- 2008-07-31 RU RU2010107277/04A patent/RU2468017C2/ru not_active IP Right Cessation
- 2008-07-31 CN CN200880110498XA patent/CN101809005B/zh not_active Expired - Fee Related
- 2008-07-31 WO PCT/JP2008/063751 patent/WO2009017190A1/ja not_active Ceased
- 2008-07-31 EP EP08791966.8A patent/EP2179994B1/en not_active Not-in-force
- 2008-07-31 CA CA2693180A patent/CA2693180C/en active Active
- 2008-07-31 JP JP2009525446A patent/JP5357027B2/ja not_active Expired - Fee Related
- 2008-07-31 ES ES08791966T patent/ES2419254T3/es active Active
-
2012
- 2012-07-30 US US13/561,662 patent/US8410166B2/en not_active Expired - Fee Related
-
2013
- 2013-03-07 PH PH12013500442A patent/PH12013500442A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2179994A1 (en) | 2010-04-28 |
| CN101809005A (zh) | 2010-08-18 |
| BRPI0815037A2 (pt) | 2015-03-17 |
| PH12013500442B1 (en) | 2015-09-07 |
| KR20100046230A (ko) | 2010-05-06 |
| EP2179994A4 (en) | 2010-08-25 |
| JPWO2009017190A1 (ja) | 2010-10-21 |
| US8410166B2 (en) | 2013-04-02 |
| CN101809005B (zh) | 2013-05-01 |
| AU2008283265A1 (en) | 2009-02-05 |
| US20130029979A1 (en) | 2013-01-31 |
| TW200914026A (en) | 2009-04-01 |
| RU2010107277A (ru) | 2011-09-10 |
| AU2008283265B2 (en) | 2012-05-24 |
| WO2009017190A1 (ja) | 2009-02-05 |
| EP2179994B1 (en) | 2013-06-26 |
| CA2693180C (en) | 2012-11-20 |
| ES2419254T3 (es) | 2013-08-20 |
| CA2693180A1 (en) | 2009-02-05 |
| JP5357027B2 (ja) | 2013-12-04 |
| PH12013500442A1 (en) | 2015-09-07 |
| US8258131B2 (en) | 2012-09-04 |
| US20100204218A1 (en) | 2010-08-12 |
| TWI396540B (zh) | 2013-05-21 |
| RU2468017C2 (ru) | 2012-11-27 |
| KR101338813B1 (ko) | 2013-12-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |