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MX2010000370A - METHODS OF INHIBITING THE FORMATION OF AMYLOID-beta DIFFUSABLE LIGANDS USING A ACYLHYDRAZIDE COMPOUDS. - Google Patents

METHODS OF INHIBITING THE FORMATION OF AMYLOID-beta DIFFUSABLE LIGANDS USING A ACYLHYDRAZIDE COMPOUDS.

Info

Publication number
MX2010000370A
MX2010000370A MX2010000370A MX2010000370A MX2010000370A MX 2010000370 A MX2010000370 A MX 2010000370A MX 2010000370 A MX2010000370 A MX 2010000370A MX 2010000370 A MX2010000370 A MX 2010000370A MX 2010000370 A MX2010000370 A MX 2010000370A
Authority
MX
Mexico
Prior art keywords
amyloid
formation
methods
inhibiting
acylhydrazide
Prior art date
Application number
MX2010000370A
Other languages
Spanish (es)
Inventor
Grant A Krafft
Todd Pray
William F Goure
Gary Charles Look
Lauri Schultz
Alexandre Mikhaylovich Polozov
Nikhil Bhagat
Jian Wang
David E Zembower
Original Assignee
Acumen Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/777,264 external-priority patent/US9006283B2/en
Priority claimed from US11/777,266 external-priority patent/US8962677B2/en
Application filed by Acumen Pharmaceuticals Inc filed Critical Acumen Pharmaceuticals Inc
Publication of MX2010000370A publication Critical patent/MX2010000370A/en

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    • A61K31/13—Amines
    • A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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Abstract

Disclosed are methods of inhibiting, regulating, and/or modulating the formation of soluble, globular, non-fibrillar, neurotoxic amyloid ß1-42 oligomers from amyloid ß1-42 monomers using acylhydrazidecompounds. Also disclosed are methods of treating a patient suffering from diseases associated with the formation of soluble, globular, non-fibrillar, neurotoxic amyloid ß1-42 oligomers using acylhydrazidecompounds.
MX2010000370A 2007-07-12 2008-07-11 METHODS OF INHIBITING THE FORMATION OF AMYLOID-beta DIFFUSABLE LIGANDS USING A ACYLHYDRAZIDE COMPOUDS. MX2010000370A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11/777,264 US9006283B2 (en) 2007-07-12 2007-07-12 Methods of modifying amyloid β oligomers using non-peptidic compounds
US11/777,266 US8962677B2 (en) 2007-07-12 2007-07-12 Methods of restoring cognitive ability using non-peptidic compounds
US95081007P 2007-07-19 2007-07-19
US95072407P 2007-07-19 2007-07-19
PCT/US2008/069878 WO2009009768A2 (en) 2007-07-12 2008-07-11 METHODS OF INHIBITING THE FORMATION OF AMYLOID-β DIFFUSABLE LIGANDS USING A ACYLHYDRAZIDE COMPOUDS

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US12352719B2 (en) 2019-09-20 2025-07-08 KYCERA AVX Components Corporation Somatic cell-based electrical biosensor

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10303974A1 (en) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid β (1-42) oligomers, process for their preparation and their use
EP1976877B2 (en) 2005-11-30 2016-10-05 AbbVie Inc. Monoclonal antibodies against amyloid beta protein and uses thereof
CA2628703C (en) 2005-11-30 2019-10-29 Abbott Laboratories Anti-a.beta. globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
EP2124952A2 (en) 2007-02-27 2009-12-02 Abbott GmbH & Co. KG Method for the treatment of amyloidoses
CA2707309A1 (en) 2007-12-18 2009-06-25 Acumen Pharmaceuticals, Inc. Novel addl receptor polypeptides, polynucleotides and host cells for recombinant production
US8987419B2 (en) 2010-04-15 2015-03-24 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
MX358739B (en) 2010-08-14 2018-09-03 Abbvie Inc Star Amyloid-beta binding proteins.
WO2015188130A1 (en) * 2014-06-05 2015-12-10 The University Of Kansas Marmelin analogs and methods of use in cancer treatment

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WO2002032896A1 (en) * 2000-10-16 2002-04-25 Novo Nordisk A/S Furazanyl-triazole derivates for the treatment of diseases
DE10348044A1 (en) * 2003-10-15 2005-05-19 Imtm Gmbh Dual alanyl aminopeptidase and dipeptidyl peptidase IV inhibitors for the functional influence of different cells and for the treatment of immunological, inflammatory, neuronal and other diseases
DE10348023A1 (en) * 2003-10-15 2005-05-19 Imtm Gmbh New alanyl aminopeptidase inhibitors for the functional manipulation of different cells and for the treatment of immunological, inflammatory, neuronal and other diseases
EP1751553B1 (en) * 2004-05-24 2008-10-08 Ludwig-Maximilians-Universität München Identification of anti-prion drugs by high-throughput screening based on sift

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US12352719B2 (en) 2019-09-20 2025-07-08 KYCERA AVX Components Corporation Somatic cell-based electrical biosensor

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