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MX2009013779A - Uso de agonistas de tlr y/o interferonas tipo 1 para aliviar la toxicidad de los regimenes terapeuticos de agonistas de tnf-r. - Google Patents

Uso de agonistas de tlr y/o interferonas tipo 1 para aliviar la toxicidad de los regimenes terapeuticos de agonistas de tnf-r.

Info

Publication number
MX2009013779A
MX2009013779A MX2009013779A MX2009013779A MX2009013779A MX 2009013779 A MX2009013779 A MX 2009013779A MX 2009013779 A MX2009013779 A MX 2009013779A MX 2009013779 A MX2009013779 A MX 2009013779A MX 2009013779 A MX2009013779 A MX 2009013779A
Authority
MX
Mexico
Prior art keywords
tnf
type
interferons
therapeutic regimens
tlr agonists
Prior art date
Application number
MX2009013779A
Other languages
English (en)
Inventor
Ross Kedl
Cory Ahonen
Randolph Noelle
Original Assignee
Immurx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immurx Inc filed Critical Immurx Inc
Publication of MX2009013779A publication Critical patent/MX2009013779A/es

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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K36/06—Fungi, e.g. yeasts
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]

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Abstract

Se proporcionan métodos de terapia mejorados (más seguros y más efectivos) usando agonistas de TNF-R, por ejemplo, agonistas de CD40. Estos métodos proporcionan la adición de una cantidad de una interferona tipo 1 y/o un agonista de TLR que es efectiva para prevenir o reducir la toxicidad (toxicidad del hígado) que de otra manera puede resultar en algunos pacientes del agonista de TNF-R que se utiliza como una monoterapia (sin la interferona tipo 1 y/o agonista de TLR).
MX2009013779A 2007-06-15 2008-06-16 Uso de agonistas de tlr y/o interferonas tipo 1 para aliviar la toxicidad de los regimenes terapeuticos de agonistas de tnf-r. MX2009013779A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94428807P 2007-06-15 2007-06-15
PCT/US2008/067088 WO2008157473A1 (en) 2007-06-15 2008-06-16 Use of tlr agonists and/or type 1 interferons to alleviate toxicity of tnf-r agonist therapeutic regimens

Publications (1)

Publication Number Publication Date
MX2009013779A true MX2009013779A (es) 2010-05-20

Family

ID=40156653

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009013779A MX2009013779A (es) 2007-06-15 2008-06-16 Uso de agonistas de tlr y/o interferonas tipo 1 para aliviar la toxicidad de los regimenes terapeuticos de agonistas de tnf-r.

Country Status (9)

Country Link
US (2) US20110182847A1 (es)
EP (1) EP2170931A4 (es)
JP (1) JP2010530005A (es)
KR (1) KR20100034010A (es)
CN (1) CN101778861A (es)
AU (1) AU2008265911B2 (es)
CA (1) CA2691089A1 (es)
MX (1) MX2009013779A (es)
WO (1) WO2008157473A1 (es)

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US9376473B2 (en) 2011-01-10 2016-06-28 Cleveland Biolabs, Inc. Use of Toll-Like Receptor agonist for treating cancer
US20150238582A1 (en) * 2012-09-10 2015-08-27 Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science Individualized immunomodulation therapy for neurodegenerative disorders, cns injury and age-related dementia
CA2994218A1 (en) 2014-07-30 2016-02-04 Cleveland Biolabs, Inc. Flagellin compositons and uses
CA2964367C (en) * 2014-10-14 2024-01-30 Novartis Ag Antibody molecules to pd-l1 and uses thereof
WO2016109002A2 (en) 2014-10-16 2016-07-07 Cleveland Biolabs, Inc. Methods and compositions for the treatment of radiation-related disorders
WO2017185180A1 (en) * 2016-04-26 2017-11-02 Qu Biologics Inc. Therapeutically triggering an innate immune response in a target tissue
KR102590454B1 (ko) 2016-07-07 2023-10-17 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 항체-애쥬번트 접합체
US20200087625A1 (en) * 2017-03-30 2020-03-19 Dennis A. Carson Methods for isolating, expanding and administering cancer specific cd8+ t cells
AR111651A1 (es) * 2017-04-28 2019-08-07 Novartis Ag Conjugados de anticuerpos que comprenden agonistas del receptor de tipo toll y terapias de combinación
JP2022525594A (ja) 2019-03-15 2022-05-18 ボルト バイオセラピューティクス、インコーポレーテッド Ｈｅｒ２を標的とする免疫結合体
CN119264273A (zh) 2019-12-03 2025-01-07 埃沃特克国际有限责任公司 干扰素相关抗原结合蛋白及其用途
IL303265A (en) * 2020-12-04 2023-07-01 Univ Antwerpen Combination immunotherapy of il-15 and cd40 agonist in cancer treatment
CN115590952B (zh) * 2021-07-08 2025-08-12 中山大学 利用无毒弓形体刺激DCs获得的NRTUA-DC的肿瘤免疫治疗用途及制备方法
CN113827586B (zh) * 2021-09-06 2022-07-26 武汉市金银潭医院(武汉市传染病医院) 盐酸去甲替林在制备抗肠道病毒药物中的应用

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JP5427027B2 (ja) * 2006-05-03 2014-02-26 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・コロラド，ア・ボディー・コーポレイト Ｃｄ４０アゴニスト抗体／ｉ型インターフェロン相乗性アジュバントの結合体、それを含む複合体、および細胞性免疫を強化する治療としてのその使用

Also Published As

Publication number Publication date
US20110182847A1 (en) 2011-07-28
CA2691089A1 (en) 2008-12-24
EP2170931A1 (en) 2010-04-07
EP2170931A4 (en) 2010-06-30
US20130302278A1 (en) 2013-11-14
AU2008265911A1 (en) 2008-12-24
KR20100034010A (ko) 2010-03-31
JP2010530005A (ja) 2010-09-02
AU2008265911B2 (en) 2013-05-16
CN101778861A (zh) 2010-07-14
WO2008157473A1 (en) 2008-12-24

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