[go: up one dir, main page]

MX2009013778A - Apparatus and methods for automatic insertion, debubbling, cleaning and calibration of a spectral probe during dissolution testing. - Google Patents

Apparatus and methods for automatic insertion, debubbling, cleaning and calibration of a spectral probe during dissolution testing.

Info

Publication number
MX2009013778A
MX2009013778A MX2009013778A MX2009013778A MX2009013778A MX 2009013778 A MX2009013778 A MX 2009013778A MX 2009013778 A MX2009013778 A MX 2009013778A MX 2009013778 A MX2009013778 A MX 2009013778A MX 2009013778 A MX2009013778 A MX 2009013778A
Authority
MX
Mexico
Prior art keywords
probe
test apparatus
dissolution test
vessel
calibration
Prior art date
Application number
MX2009013778A
Other languages
Spanish (es)
Inventor
Laurence Dwayne Chin
Archibald Williams
Martin Schwalm
Brett Andrew Feeney
Original Assignee
Varian Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Varian Inc filed Critical Varian Inc
Publication of MX2009013778A publication Critical patent/MX2009013778A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/15—Preventing contamination of the components of the optical system or obstruction of the light path
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/85—Investigating moving fluids or granular solids
    • G01N21/8507—Probe photometers, i.e. with optical measuring part dipped into fluid sample
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
    • G01N2013/006—Dissolution of tablets or the like
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/15—Preventing contamination of the components of the optical system or obstruction of the light path
    • G01N2021/154—Ultrasonic cleaning
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/85—Investigating moving fluids or granular solids
    • G01N21/8507—Probe photometers, i.e. with optical measuring part dipped into fluid sample
    • G01N2021/8528—Immerged light conductor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G01N21/274—Calibration, base line adjustment, drift correction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Optical Measuring Cells (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

A dissolution test apparatus includes an optical probe, an automated actuator. The probe takes an optics-based measurement in dissolution media contained in a test vessel and transmits the measurement to an analytical instrument situated remotely from the vessel. The optical probe is movable by the actuator into and out from the vessel. The dissolution test apparatus may include a bubble removal apparatus that communicates with the optical probe and is configured for transmitting a variable vibrating force to the probe, wherein bubbles are removed from a light path gap of the probe. In another dissolution test apparatus, the bubble removal apparatus rotates the probe to remove bubbles. Another dissolution test apparatus includes a movable cleaning mechanism, a movable calibration mechanism, or both mechanisms.
MX2009013778A 2007-06-20 2008-06-18 Apparatus and methods for automatic insertion, debubbling, cleaning and calibration of a spectral probe during dissolution testing. MX2009013778A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93625707P 2007-06-20 2007-06-20
PCT/US2008/067302 WO2008157584A2 (en) 2007-06-20 2008-06-18 Apparatus and methods for automatic insertion, debubbling, cleaning and calibration of a spectral probe during dissolution testing

Publications (1)

Publication Number Publication Date
MX2009013778A true MX2009013778A (en) 2010-02-17

Family

ID=40156950

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009013778A MX2009013778A (en) 2007-06-20 2008-06-18 Apparatus and methods for automatic insertion, debubbling, cleaning and calibration of a spectral probe during dissolution testing.

Country Status (8)

Country Link
EP (1) EP2162725A4 (en)
JP (1) JP2010530542A (en)
KR (1) KR20100023963A (en)
CN (1) CN101688825A (en)
BR (1) BRPI0813135A2 (en)
DE (1) DE08771330T1 (en)
MX (1) MX2009013778A (en)
WO (1) WO2008157584A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010094341A1 (en) * 2009-02-20 2010-08-26 Erweka Gmbh Decay time measurement device
JP5861010B2 (en) * 2013-12-11 2016-02-16 オリンパス株式会社 Calibrator and calibration device
CN104492364A (en) * 2014-12-29 2015-04-08 常州市龙道电子商务有限公司 Reaction kettle with rotary defoaming device
CN104492365A (en) * 2014-12-29 2015-04-08 常州市龙道电子商务有限公司 Reaction kettle
ES2879953T3 (en) * 2015-12-04 2021-11-23 Atten2 Advanced Monitoring Tech S L U Near infrared spectroscopy-based fluid monitoring system
US9945830B2 (en) * 2016-01-21 2018-04-17 Rosemount Inc. Standard solution with cleaning reagent for wet chemistry analyzer
CN113388488B (en) * 2020-03-12 2023-09-29 迪必尔智能科技(深圳)有限公司 Probe type biomass on-line detection device capable of achieving high-temperature sterilization
JP7446614B2 (en) * 2020-10-23 2024-03-11 富山産業株式会社 Collapse test basket and collapse detection device
WO2024091881A1 (en) * 2022-10-24 2024-05-02 Thermo Scientific Portable Analytical Instruments Inc. Self centering vial holder for immersion probes

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH636200A5 (en) * 1979-03-20 1983-05-13 Zellweger Uster Ag Method and device for removing gas bubbles and other deposits from cuvettes (cells)
US6174497B1 (en) * 1997-06-04 2001-01-16 Euro-Celtique, S.A. Detection systems and methods for predicting the dissolution curve of a drug from a pharmaceutical dosage form
US6762841B1 (en) * 2000-02-22 2004-07-13 Spectraalliance, Inc. Method of performing spectral analysis in a pharmaceutical dissolution process
AU2001240121B2 (en) * 2000-03-10 2005-06-23 Textron Systems Corporation Optical probes and methods for spectral analysis
US6580506B2 (en) * 2001-02-10 2003-06-17 Leap Technologies, Inc. Fiber optic probes apparatus for spectrophotometry
US6962674B2 (en) * 2001-02-28 2005-11-08 Varian, Inc. Dissolution test apparatus
US6764651B2 (en) * 2001-11-07 2004-07-20 Varian, Inc. Fiber-optic dissolution systems, devices, and methods
WO2003098199A1 (en) * 2002-05-17 2003-11-27 Delphian Technology, Inc. In situ methods for measuring the release of a substance from a dosage form

Also Published As

Publication number Publication date
EP2162725A4 (en) 2010-06-09
DE08771330T1 (en) 2010-09-30
CN101688825A (en) 2010-03-31
KR20100023963A (en) 2010-03-04
WO2008157584A3 (en) 2009-03-05
BRPI0813135A2 (en) 2014-12-23
EP2162725A2 (en) 2010-03-17
JP2010530542A (en) 2010-09-09
WO2008157584A2 (en) 2008-12-24

Similar Documents

Publication Publication Date Title
MX2009013778A (en) Apparatus and methods for automatic insertion, debubbling, cleaning and calibration of a spectral probe during dissolution testing.
WO2009115344A3 (en) Cuvette, insert, adapter and method for optically examining small amounts of liquid
MX386629B (en) METHOD AND APPARATUS FOR CODING DIAGNOSTIC METERS.
WO2007120465A3 (en) Apparatus and method for aspirating and dispensing liquid
WO2007090147A3 (en) Method and apparatus for measurement of optical properties in tissue
WO2010091410A3 (en) Improvements in and relating to microfluidic devices for processing a sample
EP2634574A3 (en) A cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method
SI2490810T1 (en) Test set for a photometric measuring device and photometric measuring method for a sample liquid
TW200731444A (en) Image sensor testing method and apparatus
EP2129805A4 (en) BIOLOGICAL TEST SYSTEM WITH OPTICAL DETECTION APPARATUS, AND METHOD OF DETECTING BIOMOLECULE
EP1934620A4 (en) APPARATUS AND METHOD FOR TESTING SEPARATE FLAKES
NO20084215L (en) Method and apparatus for coding diagnostic painters
EP2430981A4 (en) BLOOD VESSEL INTERIOR WALL ANALYSIS DEVICE AND BLOOD VESSEL INTERIOR WALL ANALYSIS PROCEDURE
ATE554541T1 (en) DETERMINING OPTICAL IN-BAND SIGNAL-NOISE DISTANCES IN OPTICAL SIGNALS WITH TIME-VARYING POLARIZATION STATES USING POLARIZATION EXTINCTION
WO2008058281A3 (en) Method and apparatus for obtaining the distance from an optical measurement instrument to and object under test
NO20100021L (en) Method and apparatus for quantifying the quality of fluid samples
EP2499804A4 (en) METHOD AND APPARATUS FOR INPUT TYPE CHANGE IN AN INPUT SYSTEM UTILIZING A UNIVERSAL PLUG AND PLAY DEVICE
DK2035813T3 (en) OPTICAL SENSOR AND PROCEDURE FOR INDICATING THE AGE OR QUALITY OF A NATURAL PRODUCT
WO2009010960A3 (en) Medical device and method for use in tissue characterization and treatment
FR2894843B1 (en) METHOD AND APPARATUS FOR INTEGRITY TESTING OF FILTRATION MEMBRANES
GB0625393D0 (en) Apparatus and method for measuring the coagulation characteristics of a test liqid
WO2010048277A3 (en) Optical auto-calibration method
WO2006111977A3 (en) Automatic recording volume measurement apparatus
WO2010144553A3 (en) Methods for diagnosing blood vessel reocclusion
WO2013180245A1 (en) Viscometer

Legal Events

Date Code Title Description
FA Abandonment or withdrawal