MX2009013431A - Derivados de pirrol como antagonistas de p2y12. - Google Patents
Derivados de pirrol como antagonistas de p2y12.Info
- Publication number
- MX2009013431A MX2009013431A MX2009013431A MX2009013431A MX2009013431A MX 2009013431 A MX2009013431 A MX 2009013431A MX 2009013431 A MX2009013431 A MX 2009013431A MX 2009013431 A MX2009013431 A MX 2009013431A MX 2009013431 A MX2009013431 A MX 2009013431A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- formula
- adp receptor
- platelet adp
- antagonists
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- 150000003233 pyrroles Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 102100037600 P2Y purinoceptor 1 Human genes 0.000 abstract 3
- 108010085249 Purinergic P2 Receptors Proteins 0.000 abstract 3
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000001435 Thromboembolism Diseases 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000002744 anti-aggregatory effect Effects 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 230000002441 reversible effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a compuestos de la fórmula I, (ver fórmula I) en la que R1; R2; R3; R4; R5; R6; R7; R8; R9; R10; R11; R12; R13; A; B, D y E tienen los significados indicados en las reivindicaciones. Los compuestos de la fórmula 1 son valiosos compuestos farmacológicamente activos. Exhiben un fuerte efecto anti-agregante sobre las plaquetas y, así, un efecto anti-trombótico y son adecuados, p. ej., para la terapia y profilaxis de trastornos cardiovasculares tales como enfermedades tromboembólicas o restenosis. Son antagonistas reversibles del receptor de ADP de plaquetas P2Y12 y, en general, pueden emplearse en condIciones en las que está presente una activación no deseada del receptor de ADP de plaquetas P2Y12 o para la curación o prevención de las que se pretende una inhibición del receptor de ADP de plaquetas P2Y12. La invención se refiere además a procesos para la preparación de compuestos de la fórmula I, a su uso, en particular como ingredientes activos en productos farmacéuticos, y a preparaciones farmacéuticas que los comprenden.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07290755 | 2007-06-18 | ||
| PCT/EP2008/004459 WO2008155022A1 (en) | 2007-06-18 | 2008-06-04 | Pyrrole derivatives as p2y12 antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009013431A true MX2009013431A (es) | 2010-01-15 |
Family
ID=39092503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009013431A MX2009013431A (es) | 2007-06-18 | 2008-06-04 | Derivados de pirrol como antagonistas de p2y12. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7910576B2 (es) |
| EP (1) | EP2167487B1 (es) |
| JP (1) | JP5371969B2 (es) |
| KR (1) | KR20100020478A (es) |
| CN (1) | CN101679358B (es) |
| AU (1) | AU2008266515B2 (es) |
| BR (1) | BRPI0812912A2 (es) |
| CA (1) | CA2690243A1 (es) |
| IL (1) | IL202758A (es) |
| MX (1) | MX2009013431A (es) |
| MY (1) | MY148901A (es) |
| WO (1) | WO2008155022A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2102195A1 (en) | 2006-10-20 | 2009-09-23 | Novartis AG | Crystal modifications -3- (1h-ind0l-3-yl) -4- [2- (4-methyl-piperazin-1-yl) -quinazolin-4-yl]-pyrrole-2, 5-d ione |
| EP2750676B1 (en) | 2011-08-30 | 2018-01-10 | University of Utah Research Foundation | Methods and compositions for treating nephrogenic diabetes insipidus |
| DE102014108210A1 (de) | 2014-06-11 | 2015-12-17 | Dietrich Gulba | Rodentizid |
| UA129029C2 (uk) | 2019-04-03 | 2024-12-25 | Алігос Терапьютікс, Інк. | Сполуки піролу |
| EP4070658A1 (de) | 2021-04-06 | 2022-10-12 | BIORoxx GmbH | Verwendung von blutgerinnungshemmenden verbindungen als rodentizide |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3458515A (en) * | 1966-07-21 | 1969-07-29 | American Home Prod | Piperazine substituted pyrroles |
| US20020061892A1 (en) * | 2000-02-22 | 2002-05-23 | Tao Wang | Antiviral azaindole derivatives |
| US6861424B2 (en) | 2001-06-06 | 2005-03-01 | Schering Aktiengesellschaft | Platelet adenosine diphosphate receptor antagonists |
| US6956040B2 (en) * | 2001-07-16 | 2005-10-18 | Ranbaxy Laboratories Limited | Oxazolidinone piperazinyl derivatives as potential antimicrobials |
| ES2348942T3 (es) | 2002-12-11 | 2010-12-17 | Bayer Schering Pharma Aktiengesellschaft | Compuestos de 2-aminocarbonil-quinolina como antagonistas del receptor plaquetario de adenosin difosfato. |
| KR20060041254A (ko) | 2003-07-24 | 2006-05-11 | 아스텔라스세이야쿠 가부시키가이샤 | 퀴놀론 유도체 또는 그의 염 |
| US7273881B2 (en) * | 2004-01-16 | 2007-09-25 | Bristol-Myers Squibb Company | Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
| CN1778801A (zh) * | 2004-11-22 | 2006-05-31 | 中国农业科学院兰州畜牧与兽药研究所 | 喹诺酮7－((4－((z)－2－(2－氨基－4－噻唑基)－2－甲氧亚胺乙酰基)－1－哌嗪基)化合物及其制备方法 |
| RU2007129779A (ru) * | 2005-01-06 | 2009-02-20 | Астразенека Аб (Se) | Новые соединения пиридина |
| JP2008094720A (ja) | 2005-01-20 | 2008-04-24 | Astellas Pharma Inc | キノロン誘導体のプロドラッグ又はその塩 |
| WO2006103544A2 (en) * | 2005-03-28 | 2006-10-05 | Pharmacia & Upjohn Company Llc | 4-piperazinylthieno [2, 3-d] pyrimidine compounds as platelet aggregation inhibitors |
| ZA200804241B (en) * | 2005-11-03 | 2009-09-30 | Portola Pharm Inc | [4-(6-halo-7-substituted-2,4-dioxo-1,4-dihydro-2H-quina-zolin-3-yl)-phenyl]-5-chlorothiophen-2-yl-sulfonylureas and forms and methods related thereto |
| WO2007103456A2 (en) * | 2006-03-06 | 2007-09-13 | Trimeris, Inc. | Piperazine and piperidine biaryl derivatives |
-
2008
- 2008-06-04 JP JP2010512555A patent/JP5371969B2/ja not_active Expired - Fee Related
- 2008-06-04 KR KR1020097026371A patent/KR20100020478A/ko not_active Ceased
- 2008-06-04 MY MYPI20094985A patent/MY148901A/en unknown
- 2008-06-04 CA CA2690243A patent/CA2690243A1/en not_active Abandoned
- 2008-06-04 MX MX2009013431A patent/MX2009013431A/es active IP Right Grant
- 2008-06-04 BR BRPI0812912-6A2A patent/BRPI0812912A2/pt not_active IP Right Cessation
- 2008-06-04 WO PCT/EP2008/004459 patent/WO2008155022A1/en not_active Ceased
- 2008-06-04 CN CN2008800208356A patent/CN101679358B/zh not_active Expired - Fee Related
- 2008-06-04 AU AU2008266515A patent/AU2008266515B2/en not_active Ceased
- 2008-06-04 EP EP08759015.4A patent/EP2167487B1/en not_active Withdrawn - After Issue
-
2009
- 2009-12-15 IL IL202758A patent/IL202758A/en not_active IP Right Cessation
- 2009-12-16 US US12/639,500 patent/US7910576B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2167487A1 (en) | 2010-03-31 |
| EP2167487B1 (en) | 2015-02-18 |
| CN101679358B (zh) | 2013-10-30 |
| IL202758A0 (en) | 2010-06-30 |
| HK1142593A1 (en) | 2010-12-10 |
| KR20100020478A (ko) | 2010-02-22 |
| US20100226918A1 (en) | 2010-09-09 |
| JP2010530380A (ja) | 2010-09-09 |
| AU2008266515B2 (en) | 2014-05-01 |
| US7910576B2 (en) | 2011-03-22 |
| CA2690243A1 (en) | 2008-12-24 |
| IL202758A (en) | 2013-09-30 |
| JP5371969B2 (ja) | 2013-12-18 |
| CN101679358A (zh) | 2010-03-24 |
| MY148901A (en) | 2013-06-14 |
| WO2008155022A1 (en) | 2008-12-24 |
| AU2008266515A1 (en) | 2008-12-24 |
| BRPI0812912A2 (pt) | 2014-12-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |