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MX2009012345A - Derivados de 3,3-espiroindolinona. - Google Patents

Derivados de 3,3-espiroindolinona.

Info

Publication number
MX2009012345A
MX2009012345A MX2009012345A MX2009012345A MX2009012345A MX 2009012345 A MX2009012345 A MX 2009012345A MX 2009012345 A MX2009012345 A MX 2009012345A MX 2009012345 A MX2009012345 A MX 2009012345A MX 2009012345 A MX2009012345 A MX 2009012345A
Authority
MX
Mexico
Prior art keywords
spiroindolinone derivatives
spiroindolinone
derivatives
compounds
general formulas
Prior art date
Application number
MX2009012345A
Other languages
English (en)
Inventor
Jin-Jun Liu
Zhuming Zhang
Jefferson Wright Tilley
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2009012345A publication Critical patent/MX2009012345A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Se proporcionan compuestos de las fórmulas generales (ver fórmulas (Ia) e (Ib)) en las que X, Y, R1, R2, R3, R4 y R5 tienen los significados definidos anteriormente. Estos compuestos presentan actividad anticancerosa.
MX2009012345A 2007-05-17 2008-05-06 Derivados de 3,3-espiroindolinona. MX2009012345A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93849407P 2007-05-17 2007-05-17
PCT/EP2008/055516 WO2008141917A1 (en) 2007-05-17 2008-05-06 3,3-spiroindolinone derivatives

Publications (1)

Publication Number Publication Date
MX2009012345A true MX2009012345A (es) 2009-12-01

Family

ID=39645551

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009012345A MX2009012345A (es) 2007-05-17 2008-05-06 Derivados de 3,3-espiroindolinona.

Country Status (16)

Country Link
US (1) US7553833B2 (es)
EP (1) EP2158205B1 (es)
JP (1) JP2010527340A (es)
KR (1) KR101162518B1 (es)
CN (1) CN101679446B (es)
AR (1) AR066583A1 (es)
AT (1) ATE536355T1 (es)
AU (1) AU2008253154A1 (es)
BR (1) BRPI0811718A2 (es)
CA (1) CA2686675A1 (es)
ES (1) ES2377245T3 (es)
IL (1) IL201973A0 (es)
MX (1) MX2009012345A (es)
PE (1) PE20090279A1 (es)
TW (1) TW200906832A (es)
WO (1) WO2008141917A1 (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7638548B2 (en) * 2006-11-09 2009-12-29 Hoffmann-La Roche Inc. Spiroindolinone derivatives
US7723372B2 (en) 2008-03-19 2010-05-25 Hoffman-La Roche Inc. Spiroindolinone derivatives
US20100190814A1 (en) * 2009-01-26 2010-07-29 Li Chen Spiroindolinone derivative prodrugs
US7928233B2 (en) * 2009-02-10 2011-04-19 Hoffmann-La Roche Inc. Spiroindolinone pyridine derivatives
US8217051B2 (en) * 2009-02-17 2012-07-10 Hoffmann-La Roche Inc. Spiroindolinone derivatives
US8076482B2 (en) 2009-04-23 2011-12-13 Hoffmann-La Roche Inc. 3,3′-spiroindolinone derivatives
AU2010319595B2 (en) * 2009-11-12 2015-09-17 The Regents Of The University Of Michigan Spiro-oxindole MDM2 antagonists
US8088815B2 (en) * 2009-12-02 2012-01-03 Hoffman-La Roche Inc. Spiroindolinone pyrrolidines
US8288431B2 (en) * 2010-02-17 2012-10-16 Hoffmann-La Roche Inc. Substituted spiroindolinones
US8217044B2 (en) 2010-04-28 2012-07-10 Hoffmann-La Roche Inc. Spiroindolinone pyrrolidines
JP2014500870A (ja) 2010-11-12 2014-01-16 ザ、リージェンツ、オブ、ザ、ユニバーシティ、オブ、ミシガン スピロ−オキシインドールｍｄｍ２アンタゴニスト
CA2829188C (en) 2011-03-10 2016-10-18 Daiichi Sankyo Company, Limited Dispiropyrrolidine derivatives
ES2624808T3 (es) 2011-05-11 2017-07-17 The Regents Of The University Of Michigan Antagonistas de MDM2 espirooxindólicos
TWI586668B (zh) 2012-09-06 2017-06-11 第一三共股份有限公司 二螺吡咯啶衍生物之結晶
TW201429969A (zh) 2012-12-20 2014-08-01 Merck Sharp & Dohme 作爲ｈｄｍ２抑制劑之經取代咪唑吡啶
CN103992334A (zh) * 2014-05-29 2014-08-20 中国人民解放军第二军医大学 吲哚酮螺四氢硫代吡喃类抗肿瘤衍生物及其制备方法
JP6503386B2 (ja) 2014-07-03 2019-04-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ＭＤＭ２−ｐ５３阻害剤としての新しいスピロ［３Ｈ−インドール−３，２’−ピロリジン］−２（１Ｈ）−オン化合物および誘導体
KR20170042779A (ko) 2014-08-21 2017-04-19 베링거 인겔하임 인터내셔날 게엠베하 Mdm2-p53 억제제로서의 신규 스피로[3h-인돌-3,2'-피롤리딘]-2(1h)-온 화합물 및 유도체
CA2976752C (en) 2015-02-20 2019-12-17 Daiichi Sankyo Company, Limited Method for treating cancer by combined use
CN105541716B (zh) 2015-03-26 2024-02-23 Ａｇｃ株式会社 吡唑衍生物的制造方法
TWI697329B (zh) 2015-04-13 2020-07-01 日商第一三共股份有限公司 血液癌症治療用之醫藥及其用途
PL3359542T3 (pl) 2015-10-09 2021-09-20 Boehringer Ingelheim International Gmbh Związki i pochodne spiro[3h-indolo-3,2’-pirolidyno]-2(1h)-onowe jako inhibitory mdm2-p53
CN109415336B (zh) 2016-04-06 2023-08-29 密执安大学评议会 Mdm2蛋白质降解剂
US10759808B2 (en) 2016-04-06 2020-09-01 The Regents Of The University Of Michigan Monofunctional intermediates for ligand-dependent target protein degradation
JP2019522633A (ja) 2016-05-20 2019-08-15 ジェネンテック， インコーポレイテッド Ｐｒｏｔａｃ抗体コンジュゲート及び使用方法
KR20190068544A (ko) 2016-10-17 2019-06-18 다이이찌 산쿄 가부시키가이샤 Mdm2 저해제와 dna 메틸트랜스페라아제 저해제의 병용 치료법
CN107337638A (zh) * 2017-08-14 2017-11-10 侯茜茜 一种吡啶甲酸类食品添加剂的高效合成方法
MX2021003999A (es) 2018-10-08 2021-06-23 Univ Michigan Regents Moleculas de bajo peso molecular degradadoras de la proteina mdm2.
US12528785B2 (en) 2020-03-19 2026-01-20 Kymera Therapeutics, Inc. MDM2 degraders and uses thereof
WO2023056069A1 (en) 2021-09-30 2023-04-06 Angiex, Inc. Degrader-antibody conjugates and methods of using same
CN116496281B (zh) * 2022-12-30 2025-05-13 重庆文理学院 一种苯并氮卓螺二氢吲哚化合物及其合成方法与应用
WO2024240858A1 (en) 2023-05-23 2024-11-28 Valerio Therapeutics Protac molecules directed against dna damage repair system and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2098212B (en) * 1981-05-12 1984-11-14 Ici Plc Process for preparing 1'-substituted-spiro(imidazolidine)-4,3'-indoline-2,2',5-triones
EP0947511A1 (en) 1998-03-30 1999-10-06 F. Hoffmann-La Roche Ag Derivatives of phenoxy acetic acid and of phenoxymethyl tetrazole having antitumor activity
MY144968A (en) * 2005-04-11 2011-11-30 Xenon Pharmaceuticals Inc Spiro-oxindole compounds and their uses as therapeutic agents
US20070213341A1 (en) * 2006-03-13 2007-09-13 Li Chen Spiroindolinone derivatives

Also Published As

Publication number Publication date
KR20090130312A (ko) 2009-12-22
AR066583A1 (es) 2009-09-02
AU2008253154A1 (en) 2008-11-27
BRPI0811718A2 (pt) 2014-11-18
WO2008141917A1 (en) 2008-11-27
CN101679446B (zh) 2012-06-27
JP2010527340A (ja) 2010-08-12
CN101679446A (zh) 2010-03-24
CA2686675A1 (en) 2008-11-27
ES2377245T3 (es) 2012-03-23
ATE536355T1 (de) 2011-12-15
TW200906832A (en) 2009-02-16
EP2158205B1 (en) 2011-12-07
EP2158205A1 (en) 2010-03-03
KR101162518B1 (ko) 2012-07-09
IL201973A0 (en) 2010-06-16
PE20090279A1 (es) 2009-04-02
US20080287421A1 (en) 2008-11-20
US7553833B2 (en) 2009-06-30

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