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MX2009011532A - Derivados de piridina sustituidos por un anillo heterociclico y grupo fosfonoamino, y agente anti-fungal que contiene los mismos. - Google Patents

Derivados de piridina sustituidos por un anillo heterociclico y grupo fosfonoamino, y agente anti-fungal que contiene los mismos.

Info

Publication number
MX2009011532A
MX2009011532A MX2009011532A MX2009011532A MX2009011532A MX 2009011532 A MX2009011532 A MX 2009011532A MX 2009011532 A MX2009011532 A MX 2009011532A MX 2009011532 A MX2009011532 A MX 2009011532A MX 2009011532 A MX2009011532 A MX 2009011532A
Authority
MX
Mexico
Prior art keywords
alkyl
atom
phosphonoamino
hydrogen atom
alkoxylated
Prior art date
Application number
MX2009011532A
Other languages
English (en)
Inventor
Keigo Tanaka
Naoaki Watanabe
Eiichi Yamamoto
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of MX2009011532A publication Critical patent/MX2009011532A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/664—Amides of phosphorus acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención proporciona un agente anti-fungal que tiene una excelente acción antifungal y excelentes propiedades fisicoquímicas tales como seguridad y solubilidad en agua. La presente invención divulga un compuesto representado por la siguiente fórmula (I) o una sal del mismo: (ver fórmula (I)) [en donde R1 representa un átomo de hidrógeno, un átomo de halógeno, un grupo amino, R11-NH- (en donde R11 representa un grupo alquilo de C1-6, un grupo hidroxi-alquilo de C1-6, un grupo alcoxi de C1-6-alquilo de C1-6 o un grupo alcoxicarbonil de C1-6-alquilo de C1-6), R12- (CO)-NH- (en donde R12 representa un grupo alquilo de C1-6 o un grupo alcoxi de C1-6-alquilo de C1-6), un grupo alquilo de C1-6, un grupo hidroxi-alquilo de C1-6, un grupo ciano-alquilo de C1-6, un grupo alcoxi de C1-6 o un grupo alcoxi de C1-6-alquilo de C1-6 o un grupo fosfonoamino; R2 representa un átomo de hidrógeno, un grupo alquilo de C1-6, un grupo amino o un grupo di-alquilamino de C1-6 o un grupo fosfonoamino; uno de X y Y es un átomo de nitrógeno mientras que el otro es un átomo de nitrógeno o un átomo de oxígeno; el anillo A representa un anillo heteroarilo de 5 o 6 miembros o un anillo de benceno el cual puede tener un átomo de halógeno o 1 o 2 grupos alquilo de C1-6; Z representa un enlace sencillo, un grupo metileno, un grupo etileno, un átomo de oxigeno, un átomo de azufre, -CH2O-, -OCH2-, -NH-, -CH2NH-, -NHCH2-, -CH2S-o -SCH2-; R3 representa un átomo de hidrógeno o un átomo de halógeno o un grupo alquilo de C1-6, un grupo cicloalquilo de C3-8, un grupo arilo de C6-10, un grupo heteroarilo de 5 o 6 miembros o un grupo heterocíclico no aromático de 5 o 6 miembros el cual puede tener 1 o 2 sustituyentes; y R4 representa un átomo de hidrógeno o átomo de halógeno; con la condición de que cualquiera de R1 o R2 representa un grupo fosfonoamino].
MX2009011532A 2007-04-27 2008-04-23 Derivados de piridina sustituidos por un anillo heterociclico y grupo fosfonoamino, y agente anti-fungal que contiene los mismos. MX2009011532A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91461507P 2007-04-27 2007-04-27
JP2007118356 2007-04-27
PCT/JP2008/057851 WO2008136324A1 (ja) 2007-04-27 2008-04-23 ヘテロ環およびホスホノアミノ基が置換したピリジン誘導体ならびにそれらを含有する抗真菌剤

Publications (1)

Publication Number Publication Date
MX2009011532A true MX2009011532A (es) 2009-11-10

Family

ID=39943436

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009011532A MX2009011532A (es) 2007-04-27 2008-04-23 Derivados de piridina sustituidos por un anillo heterociclico y grupo fosfonoamino, y agente anti-fungal que contiene los mismos.

Country Status (16)

Country Link
US (1) US8507530B2 (es)
EP (1) EP2141171A4 (es)
JP (1) JPWO2008136324A1 (es)
KR (1) KR20100015909A (es)
CN (1) CN101668767A (es)
AU (1) AU2008246754B2 (es)
BR (1) BRPI0808833A2 (es)
CA (1) CA2684503A1 (es)
IL (1) IL201421A0 (es)
MX (1) MX2009011532A (es)
NZ (1) NZ578930A (es)
RU (1) RU2009143926A (es)
SA (1) SA08290258B1 (es)
TW (1) TW200841879A (es)
WO (1) WO2008136324A1 (es)
ZA (1) ZA200905435B (es)

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AU2008246754B2 (en) 2012-07-12
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TW200841879A (en) 2008-11-01
US8507530B2 (en) 2013-08-13
US20090082403A1 (en) 2009-03-26
WO2008136324A1 (ja) 2008-11-13
ZA200905435B (en) 2010-09-29
IL201421A0 (en) 2010-05-31
JPWO2008136324A1 (ja) 2010-07-29
BRPI0808833A2 (pt) 2014-08-26
EP2141171A1 (en) 2010-01-06
AU2008246754A1 (en) 2008-11-13
KR20100015909A (ko) 2010-02-12
SA08290258B1 (ar) 2011-10-08
EP2141171A4 (en) 2012-05-02
RU2009143926A (ru) 2011-06-10
CA2684503A1 (en) 2008-11-13

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