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MX2009011574A - Metodos para la preparacion de derivados de n-isobutil-n-(2-hidrox i-3-amino-4-fenilbutil)-p-nitrobencensulfonilamida. - Google Patents

Metodos para la preparacion de derivados de n-isobutil-n-(2-hidrox i-3-amino-4-fenilbutil)-p-nitrobencensulfonilamida.

Info

Publication number
MX2009011574A
MX2009011574A MX2009011574A MX2009011574A MX2009011574A MX 2009011574 A MX2009011574 A MX 2009011574A MX 2009011574 A MX2009011574 A MX 2009011574A MX 2009011574 A MX2009011574 A MX 2009011574A MX 2009011574 A MX2009011574 A MX 2009011574A
Authority
MX
Mexico
Prior art keywords
hydroxy
phenylbutyl
isobutyl
amino
preparation
Prior art date
Application number
MX2009011574A
Other languages
English (en)
Inventor
Hartmut Burghard Zinser
Peter Hermann Hoelzle
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of MX2009011574A publication Critical patent/MX2009011574A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un procedimiento para la preparación de derivados de N-isobutil-N-(2-hidroxi-3-amino-4-fenilbutil)-p-nitrobencensulfon ilamida (I) en el cual un derivado de 1-bencil-2-hidroxi-3-isobuti lamina (II) se hace reaccionar con un haluro de p-nitrofenilsulfonilo (III) en un solvente que comprende un alcohol secundario o terciario.
MX2009011574A 2007-04-27 2008-04-25 Metodos para la preparacion de derivados de n-isobutil-n-(2-hidrox i-3-amino-4-fenilbutil)-p-nitrobencensulfonilamida. MX2009011574A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07107177 2007-04-27
PCT/EP2008/055042 WO2008132154A1 (en) 2007-04-27 2008-04-25 Methods for the preparation of n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives

Publications (1)

Publication Number Publication Date
MX2009011574A true MX2009011574A (es) 2009-11-09

Family

ID=38924830

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009011574A MX2009011574A (es) 2007-04-27 2008-04-25 Metodos para la preparacion de derivados de n-isobutil-n-(2-hidrox i-3-amino-4-fenilbutil)-p-nitrobencensulfonilamida.

Country Status (20)

Country Link
US (1) US8076513B2 (es)
EP (1) EP2152667B1 (es)
JP (1) JP2010525029A (es)
CN (1) CN101668734A (es)
AT (1) ATE498606T1 (es)
AU (1) AU2008244306A1 (es)
BR (1) BRPI0810609A2 (es)
CA (1) CA2682616A1 (es)
CY (1) CY1111457T1 (es)
DE (1) DE602008005012D1 (es)
DK (1) DK2152667T3 (es)
ES (1) ES2360654T3 (es)
HR (1) HRP20110290T1 (es)
IL (1) IL200811A0 (es)
MX (1) MX2009011574A (es)
PL (1) PL2152667T3 (es)
PT (1) PT2152667E (es)
RU (1) RU2009143867A (es)
SI (1) SI2152667T1 (es)
WO (1) WO2008132154A1 (es)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
ES2516916T3 (es) 2010-01-28 2014-10-31 Mapi Pharma Limited Procedimiento para la preparación de darunavir e intermedios de darunavir
WO2011158259A1 (en) * 2010-06-18 2011-12-22 Matrix Laboratories Ltd Novel process for the preparation of (3s)-tetrahydrofuran-3-yl (is, 2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-(phosphonooxy) propylcarbamate and its pharmaceutically acceptable salts thereof
ES2607279T3 (es) 2010-11-23 2017-03-29 Mylan Laboratories, Limited Procedimiento para la preparación de (3R,3aS,6aR)-hexahidrofuro[2,3-b]furan-3-ol
CN105315178B (zh) * 2014-07-09 2018-07-06 浙江九洲药业股份有限公司 达芦那韦相关物质及其制备方法
CN114685322B (zh) * 2020-12-30 2023-08-25 上海飞腾医药科技有限公司 一种抗hiv类药物中间体晶体的生长方法和所得晶体及其应用

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DE3000377A1 (de) * 1980-01-07 1981-07-09 Boehringer Mannheim Gmbh, 6800 Mannheim Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
JPH07110846B2 (ja) * 1987-12-23 1995-11-29 アグロカネショウ株式会社 置換ベンジルスルホアミド誘導体、その製法及び選択性除草剤
ES2177868T3 (es) * 1992-08-25 2002-12-16 Searle & Co Hidroxietilaminosulfonamidas de alfa- y beta-aminoacidos utiles como inhibidores de proteasas retroviricas.
IS2334B (is) 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
EP0715618B1 (en) 1993-08-24 1998-12-16 G.D. Searle & Co. Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
ES2167541T3 (es) 1995-02-03 2002-05-16 Kaneka Corp Procedimientos de produccion de alfa-halocetonas, de alfa-halohidrinas y de epoxidos.
AU7722296A (en) 1995-11-15 1997-06-05 G.D. Searle & Co. Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
ES2235492T3 (es) 1998-06-19 2005-07-01 Vertex Pharmaceuticals Incorporated Inhibidores de aspartil proteasa de tipo sulfonamida.
AU4828199A (en) 1998-06-23 2000-01-10 Board Of Trustees Of The University Of Illinois, The Multi-drug resistant retroviral protease inhibitors and associated methods
CA2336160C (en) 1998-06-23 2015-02-17 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Use of compounds for treating hiv
KR20010031394A (ko) 1998-08-25 2001-04-16 후루타 타케시 (2ｒ,3ｓ)-3-아미노-1,2-옥시란의 제조법
US6344572B1 (en) 1999-01-29 2002-02-05 Kaneka Corporation Processes for the preparation of threo-1,2-epoxy-3-amino-4-phenylbutane derivatives
EP1159278B1 (en) 1999-02-12 2005-11-30 Vertex Pharmaceuticals Incorporated Inhibitors of aspartyl protease
AR031520A1 (es) 1999-06-11 2003-09-24 Vertex Pharma Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion
KR100708221B1 (ko) 1999-08-31 2007-04-17 아지노모토 가부시키가이샤 에폭사이드 결정의 제조방법
DE60039533D1 (de) * 1999-12-23 2008-08-28 Ampac Fine Chemicals Llc Verbessertes verfahren zur herstellung von 2s,3s-n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamid hydrochlorid und anderen derivaten von 2-hydroxy-1,3-diamin
US6764545B2 (en) 2000-12-12 2004-07-20 Ajinomoto Co., Inc. Production method of epoxide crystal
JP2002332270A (ja) * 2001-03-07 2002-11-22 Ajinomoto Co Inc スルホンアミド誘導体の製造方法
PT1448567E (pt) 2001-09-10 2010-03-12 Tibotec Pharm Ltd Método de preparação de hexa-hidro-furo[2,3-b]furan-3-ol
US6919465B2 (en) 2002-10-09 2005-07-19 The Board Of Trustees Of The University Of Illinois Method of preparing (3R, 3aS, 6aR)-3-hydroxyhexahydrofuro[2,3,-b] furan and related compounds
WO2004060895A1 (ja) * 2002-12-27 2004-07-22 Sumitomo Chemical Company, Limited ヘキサヒドロフロフラノール誘導体の製造方法、その中間体及びその製造方法
UA79404C2 (en) * 2003-10-02 2007-06-11 Basf Ag 2-cyanobenzenesulfonamide for controlling pests
DK1725566T3 (da) * 2003-12-23 2009-10-05 Tibotec Pharm Ltd Fremgangsmåde til fremstilling af (3R,3AS, 6AR)-hexahydrofuro [2,3.B] furan-3-yl (1S,2R)-3-3[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamat
TWI383975B (zh) 2004-03-31 2013-02-01 悌柏泰克醫藥有限公司 製備（３Ｒ，３ａＳ，６ａＲ）六氫-呋喃并〔２，３-ｂ〕呋喃-３-醇之方法

Also Published As

Publication number Publication date
AU2008244306A1 (en) 2008-11-06
WO2008132154A1 (en) 2008-11-06
DK2152667T3 (da) 2011-05-16
HRP20110290T1 (hr) 2011-05-31
ES2360654T3 (es) 2011-06-08
CA2682616A1 (en) 2008-11-06
EP2152667A1 (en) 2010-02-17
SI2152667T1 (sl) 2011-06-30
US8076513B2 (en) 2011-12-13
ATE498606T1 (de) 2011-03-15
BRPI0810609A2 (pt) 2014-10-21
PT2152667E (pt) 2011-04-06
IL200811A0 (en) 2010-05-17
CY1111457T1 (el) 2015-08-05
PL2152667T3 (pl) 2011-06-30
EP2152667B1 (en) 2011-02-16
RU2009143867A (ru) 2011-06-10
JP2010525029A (ja) 2010-07-22
CN101668734A (zh) 2010-03-10
DE602008005012D1 (de) 2011-03-31
US20100121094A1 (en) 2010-05-13

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