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MX2009011358A - Derivados de pirimidinona y metodos para su uso. - Google Patents

Derivados de pirimidinona y metodos para su uso.

Info

Publication number
MX2009011358A
MX2009011358A MX2009011358A MX2009011358A MX2009011358A MX 2009011358 A MX2009011358 A MX 2009011358A MX 2009011358 A MX2009011358 A MX 2009011358A MX 2009011358 A MX2009011358 A MX 2009011358A MX 2009011358 A MX2009011358 A MX 2009011358A
Authority
MX
Mexico
Prior art keywords
methods
pyrimidinone derivatives
pyrimidinone
derivatives
gpr119
Prior art date
Application number
MX2009011358A
Other languages
English (en)
Inventor
Samuel Chackalamannil
Jinsong Hao
Hong Liu
Craig D Boyle
Unmesh G Shah
Bernard R Neustadt
Andrew W Stamford
Santhosh Francis Neelamkavil
Joel Harris
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of MX2009011358A publication Critical patent/MX2009011358A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a Derivados de Pirimidinona, composiciones caracterizado además porque comprenden un Derivado de Pirimidinona, y métodos de uso de los Derivados de Pirimidinona para tratar o prevenir la obesidad, diabetes, un trastorno metabólico, una enfermedad cardiovascular o un trastorno relacionado con la actividad del receptor 119 acoplado a la proteína G ("GPR119") en un paciente.
MX2009011358A 2007-04-20 2008-04-17 Derivados de pirimidinona y metodos para su uso. MX2009011358A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92545007P 2007-04-20 2007-04-20
US95334207P 2007-08-01 2007-08-01
PCT/US2008/004933 WO2008130581A1 (en) 2007-04-20 2008-04-17 Pyrimidinone derivatives and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2009011358A true MX2009011358A (es) 2009-11-05

Family

ID=39655056

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009011358A MX2009011358A (es) 2007-04-20 2008-04-17 Derivados de pirimidinona y metodos para su uso.

Country Status (11)

Country Link
US (1) US20100190687A1 (es)
EP (1) EP2148869A1 (es)
JP (1) JP2010524940A (es)
CN (1) CN102015677A (es)
AR (1) AR066121A1 (es)
CA (1) CA2684633A1 (es)
CL (1) CL2008001126A1 (es)
MX (1) MX2009011358A (es)
PE (1) PE20090151A1 (es)
TW (1) TW200900403A (es)
WO (1) WO2008130581A1 (es)

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EP2078719A4 (en) * 2006-09-28 2009-11-11 Dainippon Sumitomo Pharma Co COMPOUND WITH BICYCLIC PYRIMIDINE STRUCTURE AND THE COMPOUND CONTAINING PHARMACEUTICAL COMPOSITION
JP2012518597A (ja) * 2009-02-23 2012-08-16 Ｍｓｄ株式会社 ピリミジン−４（３ｈ）−オン誘導体
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
JP2013522279A (ja) 2010-03-18 2013-06-13 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 糖尿病及び関連状態の治療で用いるｇｐｒ１１９作動薬とｄｄｐ−ｉｖ阻害薬リナグリプチンの組合せ
CN102234287B (zh) 2010-04-26 2015-08-05 上海阳帆医药科技有限公司 硝基咪唑类化合物、其制备方法和用途
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
CN102464661B (zh) * 2010-11-16 2015-04-01 天津药明康德新药开发有限公司 一种5,6,7,8-四氢-咪唑并[1,5-a]吡嗪-1-羧酸乙酯的制备方法
ES2602813T3 (es) 2011-06-09 2017-02-22 Rhizen Pharmaceuticals S.A. Nuevos compuestos como moduladores de GPR-119
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
CA2878625A1 (en) 2012-07-11 2014-01-16 Elcelyx Therapeutics, Inc. Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk
JP6211530B2 (ja) 2012-11-19 2017-10-11 武田薬品工業株式会社 含窒素複素環化合物
JP2016222621A (ja) * 2015-06-02 2016-12-28 学校法人九州文化学園 メラニン合成促進組成物
TN2017000544A1 (en) 2015-07-31 2019-04-12 Pfizer 1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives and 1,1,1-trifluoro-4-hydroxybutan-2-yl carbamate derivatives as magl inhibitors
RU2720203C1 (ru) 2017-01-20 2020-04-27 Пфайзер Инк. 1,1,1-трифтор-3-гидроксипропан-2-илкарбаматные производные как ингибиторы magl
MX2019008690A (es) 2017-01-23 2019-09-18 Pfizer Compuestos espiro heterociclicos como inhibidores de magl.
CN110452157B (zh) * 2018-12-28 2020-11-03 广州市朗启医药科技有限责任公司 常山酮及其中间体的合成方法
US20230091047A1 (en) 2019-03-14 2023-03-23 Janssen Sciences Ireland Unlimited Company Fused ring pyrimidone derivatives for use in the treatment of hbv infection or of hbv-induced diseases
GB202103704D0 (en) * 2021-03-17 2021-04-28 Pathios Therapeutics Ltd Compounds
KR20230022433A (ko) * 2020-06-05 2023-02-15 파티오스 테라퓨틱스 리미티드 Gpr65의 조절제로서 n-(페닐아미노카보닐) 테트라하이드로-이소퀴놀린 및 관련 화합물
AU2021289729A1 (en) * 2020-06-09 2023-02-02 Dana-Farber Cancer Institute, Inc. Allosteric EGFR inhibitors and methods of use thereof
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IL291418B2 (en) 2022-03-16 2024-05-01 Anima Biotech Inc Substances that function as modulators of cMYC-mRNA translation and their uses for cancer treatment
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Also Published As

Publication number Publication date
TW200900403A (en) 2009-01-01
EP2148869A1 (en) 2010-02-03
AR066121A1 (es) 2009-07-22
WO2008130581A1 (en) 2008-10-30
US20100190687A1 (en) 2010-07-29
CL2008001126A1 (es) 2008-10-24
PE20090151A1 (es) 2009-02-26
JP2010524940A (ja) 2010-07-22
CN102015677A (zh) 2011-04-13
CA2684633A1 (en) 2008-10-30

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