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MX2009007426A - Compuesto de piridina condensado. - Google Patents

Compuesto de piridina condensado.

Info

Publication number
MX2009007426A
MX2009007426A MX2009007426A MX2009007426A MX2009007426A MX 2009007426 A MX2009007426 A MX 2009007426A MX 2009007426 A MX2009007426 A MX 2009007426A MX 2009007426 A MX2009007426 A MX 2009007426A MX 2009007426 A MX2009007426 A MX 2009007426A
Authority
MX
Mexico
Prior art keywords
compound
jak3
diseases
therapeutic
confirmed
Prior art date
Application number
MX2009007426A
Other languages
English (en)
Inventor
Shohei Shirakami
Takayuki Inoue
Keiko Hatanaka
Yutaka Nakajima
Koichiro Mukoyoshi
Hisao Hamaguchi
Yasuyuki Higashi
Hiroyuki Usuda
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of MX2009007426A publication Critical patent/MX2009007426A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se proporciona un compuesto que tiene una actividad de inhibición JAK3 excelente y útil como un ingrediente activo para un agente terapéutico o profiláctico para diversas enfermedades inmunes que incluyen enfermedades autoinmune, enfermedades inflamatorias y enfermedades alérgicas. Se realizó un estudio en un derivado heterocíclico condensado novedoso, y se confirmó que el compuesto de piridina condensado de la presente invención tiene una excelente actividad que inhibe JAK3. Se confirmó que el compuesto es útil como un ingrediente activo para un agente terapéutico o profiláctico para una enfermedad inducida por señalización de citocina indeseable tal como rechazo al momento de transplante de donantes vivos, una enfermedad autoinmune, asma, dermatitis atópica, reumatismo, psoriasis, y ateroesclerosis, o una enfermedad inducida por una señalización de citocina anormal tal como cáncer y leucemia debido a su actividad inhibidora del JAK3.
MX2009007426A 2007-01-12 2008-01-11 Compuesto de piridina condensado. MX2009007426A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007005236 2007-01-12
PCT/JP2008/050300 WO2008084861A1 (ja) 2007-01-12 2008-01-11 縮合ピリジン化合物

Publications (1)

Publication Number Publication Date
MX2009007426A true MX2009007426A (es) 2009-07-17

Family

ID=39608748

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009007426A MX2009007426A (es) 2007-01-12 2008-01-11 Compuesto de piridina condensado.

Country Status (10)

Country Link
US (1) US20100105661A1 (es)
EP (1) EP2123651A4 (es)
JP (1) JP5287253B2 (es)
KR (1) KR20090106604A (es)
CN (1) CN101578285A (es)
AR (1) AR064879A1 (es)
CA (1) CA2675288A1 (es)
MX (1) MX2009007426A (es)
TW (1) TW200900061A (es)
WO (1) WO2008084861A1 (es)

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Also Published As

Publication number Publication date
US20100105661A1 (en) 2010-04-29
JP5287253B2 (ja) 2013-09-11
CN101578285A (zh) 2009-11-11
WO2008084861A1 (ja) 2008-07-17
AR064879A1 (es) 2009-04-29
EP2123651A4 (en) 2011-05-04
JPWO2008084861A1 (ja) 2010-05-06
KR20090106604A (ko) 2009-10-09
TW200900061A (en) 2009-01-01
CA2675288A1 (en) 2008-07-17
EP2123651A1 (en) 2009-11-25

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