MX2009006650A - Pirimidinas substituidas que contienen una porcion heteroarilamida o heteroarilfenilo. - Google Patents
Pirimidinas substituidas que contienen una porcion heteroarilamida o heteroarilfenilo.Info
- Publication number
- MX2009006650A MX2009006650A MX2009006650A MX2009006650A MX2009006650A MX 2009006650 A MX2009006650 A MX 2009006650A MX 2009006650 A MX2009006650 A MX 2009006650A MX 2009006650 A MX2009006650 A MX 2009006650A MX 2009006650 A MX2009006650 A MX 2009006650A
- Authority
- MX
- Mexico
- Prior art keywords
- heteroarylphenyl
- heteroarylamide
- moiety
- substituted piperidines
- group
- Prior art date
Links
- 150000003053 piperidines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002950 monocyclic group Chemical group 0.000 abstract 2
- 238000001321 HNCO Methods 0.000 abstract 1
- OWIKHYCFFJSOEH-UHFFFAOYSA-N Isocyanic acid Chemical compound N=C=O OWIKHYCFFJSOEH-UHFFFAOYSA-N 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La invención proporciona compuestos de la fórmula (I) que tienen compuestos inhibidores de PKA o PKB cinasa de la fórmula (I): GP 1 J T 2 J N 4 R N H (I) o sales, solvatos, tautómeros o N-óxidos de los mismos, en donde (1) GP es un grupo GP1; HET 2a a Q G (HNCO)f 7 (R )x N * (GP1) (2) GP es un grupo GP2: 10 (R)r O 2a a QG (CH2)w N y H N * (GP2), en donde HET es un grupo heterocíclico monocíclico o bicíclico que contiene hasta 4 miembros de anti de átomo heterogéneo; el anillo y es un grupo heteroarilo monocíclico o bicíclico de 5 a 10 miembros de anillo; y JI, J2, R4, R7, RI0, Q2a, Ga, x, w y f son como se define en las reivindicaciones.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87135506P | 2006-12-21 | 2006-12-21 | |
| GB0625682A GB0625682D0 (en) | 2006-12-21 | 2006-12-21 | Pharmaceutical compounds |
| US98263607P | 2007-10-25 | 2007-10-25 | |
| US98615007P | 2007-11-07 | 2007-11-07 | |
| PCT/GB2007/050777 WO2008075110A1 (en) | 2006-12-21 | 2007-12-20 | Substituted piperidines containing a heteroarylamide or heteroarylphenyl moiety |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009006650A true MX2009006650A (es) | 2009-08-20 |
Family
ID=39301245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009006650A MX2009006650A (es) | 2006-12-21 | 2007-12-20 | Pirimidinas substituidas que contienen una porcion heteroarilamida o heteroarilfenilo. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20100120798A1 (es) |
| EP (1) | EP2125820A1 (es) |
| JP (1) | JP2010513453A (es) |
| KR (1) | KR20090104030A (es) |
| AR (1) | AR064415A1 (es) |
| AU (1) | AU2007335969A1 (es) |
| BR (1) | BRPI0721124A2 (es) |
| CA (1) | CA2672841A1 (es) |
| EC (1) | ECSP099446A (es) |
| MX (1) | MX2009006650A (es) |
| NO (1) | NO20092341L (es) |
| PE (1) | PE20081680A1 (es) |
| TW (1) | TW200833694A (es) |
| UY (1) | UY30823A1 (es) |
| WO (1) | WO2008075110A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
| EP3421471B1 (en) | 2006-04-25 | 2021-05-26 | Astex Therapeutics Limited | Purine and deazapurine derivatives as pharmaceutical compounds |
| ES2522365T3 (es) | 2007-10-11 | 2014-11-14 | Astrazeneca Ab | Derivados de pirrolo [2,3-D] pirimidina como inhibidores de proteína quinasas B |
| EP2297153B1 (en) * | 2008-04-21 | 2015-05-27 | Lexicon Pharmaceuticals, Inc. | Limk2 inhibitors, compositions comprising them, and methods of their use |
| ES2617339T3 (es) | 2010-12-16 | 2017-06-16 | Calchan Limited | Derivados de pirrolopirimidina inhibidores de ASK1 |
| US9402847B2 (en) | 2011-04-01 | 2016-08-02 | Astrazeneca Ab | Combinations comprising (S)-4-amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide |
| JP5914667B2 (ja) | 2011-09-22 | 2016-05-11 | ファイザー・インク | ピロロピリミジンおよびプリン誘導体 |
| DK2785349T4 (da) | 2011-11-30 | 2023-01-09 | Astrazeneca Ab | Kombinationsbehandling af cancer |
| AU2013204533B2 (en) | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
| CN104119342A (zh) * | 2013-04-25 | 2014-10-29 | 苏州科捷生物医药有限公司 | 一种制备高纯度4-氯-5-甲基-7H-吡咯[2,3-d]嘧啶的方法 |
| RS64972B1 (sr) | 2019-06-10 | 2024-01-31 | Lupin Ltd | Inhibitori prmt5 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2563699C (en) * | 2004-04-23 | 2014-03-25 | Exelixis, Inc. | Kinase modulators and method of use |
| MY179032A (en) * | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
| JP5274842B2 (ja) * | 2004-12-28 | 2013-08-28 | エグゼリクシス， インコーポレイテッド | 免疫疾患、炎症疾患および増殖疾患の処置のためのセリン−スレオニンキナーゼモジュレーター（ｐ７０Ｓ６Ｋ、Ａｋｔ−１およびＡｋｔ−２）としての［１Ｈ−ピペラゾ［３，４−ｄ］ピリミジン−４−イル］−ピペラジンまたは［１Ｈ−ピペラゾ［３，４−ｄ］ピリミジン−４−イル］−ピペラジン化合物 |
| EP2029592A1 (en) * | 2006-04-25 | 2009-03-04 | Astex Therapeutics Limited | Pharmaceutical compounds |
| WO2007125310A2 (en) * | 2006-04-25 | 2007-11-08 | Astex Therapeutics Limited | Pharmaceutical combinations of pk inhibitors and other active agents |
| EP2013206A1 (en) * | 2006-04-25 | 2009-01-14 | Astex Therapeutics Limited | Pharmaceutical compounds |
-
2007
- 2007-12-18 AR ARP070105690A patent/AR064415A1/es unknown
- 2007-12-19 TW TW096148757A patent/TW200833694A/zh unknown
- 2007-12-20 JP JP2009542237A patent/JP2010513453A/ja active Pending
- 2007-12-20 US US12/519,993 patent/US20100120798A1/en not_active Abandoned
- 2007-12-20 AU AU2007335969A patent/AU2007335969A1/en not_active Abandoned
- 2007-12-20 BR BRPI0721124-4A patent/BRPI0721124A2/pt not_active Application Discontinuation
- 2007-12-20 UY UY30823A patent/UY30823A1/es not_active Application Discontinuation
- 2007-12-20 EP EP07848737A patent/EP2125820A1/en not_active Withdrawn
- 2007-12-20 CA CA002672841A patent/CA2672841A1/en not_active Abandoned
- 2007-12-20 KR KR1020097014899A patent/KR20090104030A/ko not_active Withdrawn
- 2007-12-20 MX MX2009006650A patent/MX2009006650A/es not_active Application Discontinuation
- 2007-12-20 WO PCT/GB2007/050777 patent/WO2008075110A1/en not_active Ceased
-
2008
- 2008-01-02 PE PE2008000081A patent/PE20081680A1/es not_active Application Discontinuation
-
2009
- 2009-06-18 NO NO20092341A patent/NO20092341L/no not_active Application Discontinuation
- 2009-06-19 EC EC2009009446A patent/ECSP099446A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2125820A1 (en) | 2009-12-02 |
| ECSP099446A (es) | 2009-09-29 |
| AR064415A1 (es) | 2009-04-01 |
| CA2672841A1 (en) | 2008-06-26 |
| BRPI0721124A2 (pt) | 2014-03-04 |
| TW200833694A (en) | 2008-08-16 |
| US20100120798A1 (en) | 2010-05-13 |
| WO2008075110A1 (en) | 2008-06-26 |
| JP2010513453A (ja) | 2010-04-30 |
| AU2007335969A1 (en) | 2008-06-26 |
| KR20090104030A (ko) | 2009-10-05 |
| UY30823A1 (es) | 2008-07-31 |
| NO20092341L (no) | 2009-07-21 |
| PE20081680A1 (es) | 2008-12-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |