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MX2009005463A - Proceso para sintetizar analogos cuaternarios de 4,5-epoxi-morfinano y aislar sus n-estereoisomeros. - Google Patents

Proceso para sintetizar analogos cuaternarios de 4,5-epoxi-morfinano y aislar sus n-estereoisomeros.

Info

Publication number
MX2009005463A
MX2009005463A MX2009005463A MX2009005463A MX2009005463A MX 2009005463 A MX2009005463 A MX 2009005463A MX 2009005463 A MX2009005463 A MX 2009005463A MX 2009005463 A MX2009005463 A MX 2009005463A MX 2009005463 A MX2009005463 A MX 2009005463A
Authority
MX
Mexico
Prior art keywords
epoxy
stereoisomers
isolating
processes
synthesizing quaternary
Prior art date
Application number
MX2009005463A
Other languages
English (en)
Inventor
Amy Qi Han
Julio Perez
Alfred A Avey
Original Assignee
Progenics Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39430057&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2009005463(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Progenics Pharm Inc filed Critical Progenics Pharm Inc
Publication of MX2009005463A publication Critical patent/MX2009005463A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se describen métodos para la síntesis de 4,5-epoxi-morfinanos usando dimetil formamida y resolución de los productos diaestereoméricos por medio de HPLC.
MX2009005463A 2006-11-22 2007-11-19 Proceso para sintetizar analogos cuaternarios de 4,5-epoxi-morfinano y aislar sus n-estereoisomeros. MX2009005463A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86710306P 2006-11-22 2006-11-22
PCT/US2007/085085 WO2008064150A1 (en) 2006-11-22 2007-11-19 Processes for synthesizing quaternary 4,5-epoxy-morphinan analogs and isolating their n-stereoisomers

Publications (1)

Publication Number Publication Date
MX2009005463A true MX2009005463A (es) 2009-08-28

Family

ID=39430057

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009005463A MX2009005463A (es) 2006-11-22 2007-11-19 Proceso para sintetizar analogos cuaternarios de 4,5-epoxi-morfinano y aislar sus n-estereoisomeros.

Country Status (9)

Country Link
US (1) US20080161570A1 (es)
EP (1) EP2097418A1 (es)
JP (1) JP2010510318A (es)
CN (1) CN101636400A (es)
AU (1) AU2007323718A1 (es)
BR (1) BRPI0719593A2 (es)
CA (1) CA2670386A1 (es)
MX (1) MX2009005463A (es)
WO (1) WO2008064150A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2368553B1 (en) 2003-04-08 2014-12-31 Progenics Pharmaceuticals, Inc. Pharmaceutical formulations containing methylnaltrexone
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
TWI489984B (zh) 2006-08-04 2015-07-01 Wyeth Corp 用於非經腸道傳輸化合物之配方及其用途
TW200815451A (en) 2006-08-04 2008-04-01 Wyeth Corp 6-carboxy-normorphinan derivatives, synthesis and uses thereof
US8546418B2 (en) 2007-03-29 2013-10-01 Progenics Pharmaceuticals, Inc. Peripheral opioid receptor antagonists and uses thereof
EP3263571B2 (en) 2007-03-29 2023-08-23 Progenics Pharmaceuticals, Inc. Crystal form of (r)-n-methylnaltrexone bromide and uses thereof
JP5469593B2 (ja) 2007-03-29 2014-04-16 ワイス・エルエルシー 末梢性オピオイド受容体アンタゴニストおよびその使用
CN101959892B (zh) 2008-02-06 2014-01-08 普罗热尼奇制药公司 (r),(r)-2,2’-二-甲基纳曲酮的制备和用途
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof
JP2012518652A (ja) * 2009-02-23 2012-08-16 マリンクロッド インコーポレイテッド （＋）−６−ヒドロキシ−モルフィナンまたは（＋）−６−アミノ−モルフィナン誘導体
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
US8436174B2 (en) * 2009-02-23 2013-05-07 Mallinckrodt Llc (+)-morphinanium quaternary salts and processes for their production
EP2398806A1 (en) * 2009-02-23 2011-12-28 Mallinckrodt LLC (+)-morphinanium n-oxides and processes for their production
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
BR112014005421A2 (pt) 2011-09-08 2017-04-04 Mallinckrodt Llc produção de alcaloides sem o isolamento de intermediários
CN105777766B (zh) * 2014-12-15 2017-11-24 北大方正集团有限公司 Delta‑7溴甲纳曲酮的制备方法
CN105777767A (zh) * 2014-12-15 2016-07-20 北大方正集团有限公司 一种乙酰化Delta-7溴甲纳曲酮及其制备方法
CN105753875A (zh) * 2014-12-15 2016-07-13 北大方正集团有限公司 一种乙酰化Delta-7甲基纳曲酮甲酸盐及其制备方法
CN105753874A (zh) * 2014-12-15 2016-07-13 北大方正集团有限公司 一种Delta-7甲基纳曲酮甲酸盐及其制备方法
CN105753876A (zh) * 2014-12-15 2016-07-13 北大方正集团有限公司 一种Delta-7溴甲纳曲酮的制备方法
CN107033155B (zh) * 2016-02-04 2019-04-26 国药集团国瑞药业有限公司 一种吗啡酮类化合物的立体选择性还原方法
CN111323529B (zh) * 2020-04-23 2023-08-25 广东华南药业集团有限公司 一种液相色谱法分离测定右美沙芬与左美沙芬的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4176186A (en) * 1978-07-28 1979-11-27 Boehringer Ingelheim Gmbh Quaternary derivatives of noroxymorphone which relieve intestinal immobility
DE10229842A1 (de) * 2002-07-03 2004-02-05 Helmut Prof. Dr. Schmidhammer Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung
MXPA05004759A (es) * 2002-11-08 2005-08-02 Mallinckrodt Inc Proceso para la preparacion de sales alcaloides n-alquil morfinan cuaternarias.

Also Published As

Publication number Publication date
WO2008064150A1 (en) 2008-05-29
CA2670386A1 (en) 2008-05-29
JP2010510318A (ja) 2010-04-02
EP2097418A1 (en) 2009-09-09
US20080161570A1 (en) 2008-07-03
CN101636400A (zh) 2010-01-27
AU2007323718A1 (en) 2008-05-29
BRPI0719593A2 (pt) 2013-12-17

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