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MX2009005009A - Compuestos heterociclicos biciclicos 4-cianofenilamino sustituidos como inhibidores del virus de inmunodeficiencia humana. - Google Patents

Compuestos heterociclicos biciclicos 4-cianofenilamino sustituidos como inhibidores del virus de inmunodeficiencia humana.

Info

Publication number
MX2009005009A
MX2009005009A MX2009005009A MX2009005009A MX2009005009A MX 2009005009 A MX2009005009 A MX 2009005009A MX 2009005009 A MX2009005009 A MX 2009005009A MX 2009005009 A MX2009005009 A MX 2009005009A MX 2009005009 A MX2009005009 A MX 2009005009A
Authority
MX
Mexico
Prior art keywords
cyanophenylamino
substituted bicyclic
heterocyclic compounds
bicyclic heterocyclic
hiv inhibitors
Prior art date
Application number
MX2009005009A
Other languages
English (en)
Inventor
Zhi Hong
Yung-Hyo Koh
Stephanie Shaw
Jean-Luc Girardet
Original Assignee
Ardea Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ardea Biosciences Inc filed Critical Ardea Biosciences Inc
Publication of MX2009005009A publication Critical patent/MX2009005009A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Esta solicitud involucra ciertos heterociclos bicíclicos 4-cianofenilamino sustituidos de fórmula (I) (ver fórmula (I)) en donde la línea punteada representa un enlace doble que puede ubicarse ya sea entre A y C(V) o entre C(V) y D, en donde A es S o C(Z); D es S o C(W); siempre que uno y solo uno de A y D sea S; en donde T es NH, O o S; y en donde otros sustituyentes se definen aquí; estos compuestos son inhibidores de transcriptasa inversa no nucleósida y tienen potencial como tratamiento anti VIH.
MX2009005009A 2006-11-09 2007-11-09 Compuestos heterociclicos biciclicos 4-cianofenilamino sustituidos como inhibidores del virus de inmunodeficiencia humana. MX2009005009A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85808206P 2006-11-09 2006-11-09
PCT/US2007/084342 WO2008058285A2 (en) 2006-11-09 2007-11-09 4-cyanophenylamino-substituted bicyclic heterocyclic compounds as hiv inhibitors

Publications (1)

Publication Number Publication Date
MX2009005009A true MX2009005009A (es) 2009-09-22

Family

ID=39365405

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009005009A MX2009005009A (es) 2006-11-09 2007-11-09 Compuestos heterociclicos biciclicos 4-cianofenilamino sustituidos como inhibidores del virus de inmunodeficiencia humana.

Country Status (6)

Country Link
US (3) US7595324B2 (es)
EP (1) EP2132211A4 (es)
BR (1) BRPI0718592A2 (es)
CA (1) CA2668997C (es)
MX (1) MX2009005009A (es)
WO (1) WO2008058285A2 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2496565C (en) * 2002-08-23 2013-04-02 Ribapharm Inc. Non-nucleoside reverse transcriptase inhibitors
US20060229305A1 (en) * 2005-03-22 2006-10-12 Markus Berger Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
BRPI0718592A2 (pt) * 2006-11-09 2017-06-06 Ardea Biosciences Inc compostos heterocíclicos bicíclicos substituidos por 4-cianofenilamino como inibidores de hiv
WO2009055730A1 (en) * 2007-10-25 2009-04-30 Genentech, Inc. Process for making thienopyrimidine compounds
GB0908394D0 (en) * 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
KR101094446B1 (ko) * 2009-11-19 2011-12-15 한국과학기술연구원 단백질 키나아제 저해활성을 가지는 2,4,7-치환된 티에노［3,2-ｄ］피리미딘 화합물
CN103517990A (zh) 2010-10-07 2014-01-15 通用医疗公司 癌症生物标志物
CA2817165A1 (en) 2010-11-15 2012-05-24 Patrick Chaltin Novel antiviral compounds
WO2012097013A1 (en) 2011-01-10 2012-07-19 Nimbus Iris, Inc. Irak inhibitors and uses thereof
TW201728592A (zh) 2012-01-10 2017-08-16 林伯士艾瑞斯公司 Ｉｒａｋ抑制劑及其用途
WO2014011906A2 (en) 2012-07-11 2014-01-16 Nimbus Iris, Inc. Irak inhibitors and uses thereof
US9085586B2 (en) 2012-07-11 2015-07-21 Nimbus Iris, Inc. IRAK inhibitors and uses thereof
EP2943202A4 (en) * 2013-01-10 2016-08-24 Nimbus Iris Inc IRAQ INHIBITORS AND USES THEREOF
US8778365B1 (en) 2013-01-31 2014-07-15 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
CN103242341B (zh) * 2013-04-19 2015-12-09 中国科学院广州生物医药与健康研究院 噻吩并2，4取代嘧啶类化合物及其药物组合物与应用
CA2925211A1 (en) 2013-09-27 2015-04-02 Nimbus Iris, Inc. Irak inhibitors and uses thereof
US10301624B2 (en) 2014-06-25 2019-05-28 The General Hospital Corporation Targeting human satellite II (HSATII)
CN104926829A (zh) * 2015-06-08 2015-09-23 山东大学 一种噻吩并嘧啶类衍生物及其制备方法和应用
CN106831814B (zh) * 2017-02-15 2018-11-23 山东大学 一种噻吩并[3,2-d]嘧啶类HIV-1逆转录酶抑制剂及其制备方法和应用
CN106866699B (zh) * 2017-03-29 2019-03-08 山东大学 一种二芳基噻吩并嘧啶类hiv-1逆转录酶抑制剂及其制备方法和应用
CN109206435B (zh) * 2017-06-29 2020-09-08 中国医药研究开发中心有限公司 噻吩并[3,2-d]嘧啶类化合物及其制备方法和医药用途
AU2019217875A1 (en) 2018-02-06 2020-08-20 Icahn School Of Medicine At Mount Sinai Repeat RNA as biomarkers of tumor immune response
CN108440559B (zh) * 2018-04-12 2020-06-16 山东大学 二芳基噻吩并嘧啶类hiv-1逆转录酶抑制剂及其制备方法和应用
CN114853781B (zh) * 2022-06-06 2023-09-08 山东大学苏州研究院 一种hiv-1逆转录酶靶向共价抑制剂及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5280026A (en) * 1989-05-30 1994-01-18 Smithkline Beecham Intercredit B.V. Thienopyrimidines
DE69943247D1 (de) * 1998-03-27 2011-04-14 Janssen Pharmaceutica Nv HIV hemmende Pyrimidin Derivate
PT1129096E (pt) 1998-11-12 2003-09-30 Neurocrine Biosciences Inc Antagonistas de receptor de crf e metodos de tratamento relacionados com os mesmos
JO3429B1 (ar) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
EP1465900B1 (en) * 2002-01-10 2008-05-14 Bayer HealthCare AG Rho-kinase inhibitors
ES2598404T3 (es) 2003-02-07 2017-01-27 Janssen Pharmaceutica Nv Derivados de pirimidina para la prevención de infección por el VIH
EA009734B1 (ru) * 2003-09-25 2008-02-28 Янссен Фармацевтика Н.В. Производные пурина, ингибирующие репликацию вич
BRPI0718592A2 (pt) 2006-11-09 2017-06-06 Ardea Biosciences Inc compostos heterocíclicos bicíclicos substituidos por 4-cianofenilamino como inibidores de hiv

Also Published As

Publication number Publication date
US8211898B2 (en) 2012-07-03
CA2668997C (en) 2012-10-09
CA2668997A1 (en) 2008-05-15
US20120225894A1 (en) 2012-09-06
US20080176871A1 (en) 2008-07-24
EP2132211A2 (en) 2009-12-16
US7595324B2 (en) 2009-09-29
US8324223B2 (en) 2012-12-04
WO2008058285A2 (en) 2008-05-15
WO2008058285A3 (en) 2009-04-09
EP2132211A4 (en) 2011-12-07
US20090281124A1 (en) 2009-11-12
BRPI0718592A2 (pt) 2017-06-06

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