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MX2009005047A - 4-imidazoles sustituidos. - Google Patents

4-imidazoles sustituidos.

Info

Publication number
MX2009005047A
MX2009005047A MX2009005047A MX2009005047A MX2009005047A MX 2009005047 A MX2009005047 A MX 2009005047A MX 2009005047 A MX2009005047 A MX 2009005047A MX 2009005047 A MX2009005047 A MX 2009005047A MX 2009005047 A MX2009005047 A MX 2009005047A
Authority
MX
Mexico
Prior art keywords
disorders
lower alkyl
hydrogen
compounds
halogen
Prior art date
Application number
MX2009005047A
Other languages
English (en)
Inventor
Guido Galley
Henri Stalder
Katrin Groebke Zbinden
Roger Norcross
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39304662&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2009005047(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2009005047A publication Critical patent/MX2009005047A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a compuestos de la fórmula (I) en la que R1 es hidrógeno o alquilo inferior; R2 es hidrógeno o alquilo inferior; R3 es hidrógeno, alquilo inferior, alcoxi inferior, feniloxi, benciloxi, halógeno o alquilo inferior sustituido por halógeno; R4 es hidrógeno o alquilo inferior; X es -CH2-, -CH- o -O-; Y es -CH2-, -CH2CH2-, -CH- o un enlace; cuando X es-O-, entonces Y es -CH2-; Z es -CH2- o -CH-; m es 1 ó 2; cuando m es 2, R2 puede ser idéntico o no; n es 1 ó 2; cuando n es 2, R3 puede ser idéntico o no; y a sus sales de adición de ácido farmacéuticamente aceptables. Se ha encontrado que los compuestos de fórmula I tienen una buena afinidad a los receptores asociados a trazas de amina (TARRs), especialmente para TARR1. Los compuestos se pueden usar para el tratamiento de depresión, trastornos de ansiedad, trastorno bipolar, trastorno de hiperactividad con déficit de atención (ADHD), trastornos relacionados con el estrés, trastornos psicóticos tal como esquizofrenia, enfermedades neurológicas tal como enfermedad de Parkinson, trastornos neurodegenerativos tal como enfermedad de Alzheimer, epilepsia, migraña, hipertensión, abuso de sustancias y trastornos metabólicos tales como trastornos del comer, diabetes, complicaciones diabéticas, obesidad, dislipidemia, trastornos del consumo y asimilación de energía, trastornos y malfuncionamiento de la hemeostasis de temperatura corporal, trastornos del sueño y del ritmo circadiano, y trastornos cardiovasculares.
MX2009005047A 2006-11-16 2007-11-06 4-imidazoles sustituidos. MX2009005047A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06124182 2006-11-16
PCT/EP2007/061921 WO2008058867A2 (en) 2006-11-16 2007-11-06 Substituted 4-imidazoles

Publications (1)

Publication Number Publication Date
MX2009005047A true MX2009005047A (es) 2009-05-25

Family

ID=39304662

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009005047A MX2009005047A (es) 2006-11-16 2007-11-06 4-imidazoles sustituidos.

Country Status (18)

Country Link
US (1) US7858652B2 (es)
EP (1) EP2084152A2 (es)
JP (1) JP2010510184A (es)
KR (1) KR101134226B1 (es)
CN (1) CN101535298A (es)
AR (1) AR063811A1 (es)
AU (1) AU2007321376A1 (es)
BR (1) BRPI0718400A2 (es)
CA (1) CA2669112A1 (es)
CL (1) CL2007003275A1 (es)
IL (1) IL198469A0 (es)
MX (1) MX2009005047A (es)
NO (1) NO20091721L (es)
PE (1) PE20081117A1 (es)
RU (1) RU2456281C2 (es)
TW (1) TWI377203B (es)
WO (1) WO2008058867A2 (es)
ZA (1) ZA200903382B (es)

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WO2016030306A1 (en) * 2014-08-27 2016-03-03 F. Hoffmann-La Roche Ag Substituted pyrazino[2,1-a]isoquinoline derivatives for the treatment of cns disorders

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Also Published As

Publication number Publication date
US20080139533A1 (en) 2008-06-12
CN101535298A (zh) 2009-09-16
RU2456281C2 (ru) 2012-07-20
WO2008058867A2 (en) 2008-05-22
ZA200903382B (en) 2010-04-28
CL2007003275A1 (es) 2008-06-20
JP2010510184A (ja) 2010-04-02
EP2084152A2 (en) 2009-08-05
KR20090064481A (ko) 2009-06-18
AU2007321376A1 (en) 2008-05-22
AR063811A1 (es) 2009-02-18
RU2009117643A (ru) 2010-12-27
PE20081117A1 (es) 2008-08-15
WO2008058867A3 (en) 2008-07-10
NO20091721L (no) 2009-07-28
KR101134226B1 (ko) 2012-04-10
TW200831492A (en) 2008-08-01
BRPI0718400A2 (pt) 2014-03-11
IL198469A0 (en) 2010-02-17
US7858652B2 (en) 2010-12-28
CA2669112A1 (en) 2008-05-22
TWI377203B (en) 2012-11-21

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