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MX2009004714A - Derivados de pirazol fusionado 3-aminocarbonilo sustituidos como moduladores de proteina cinasa. - Google Patents

Derivados de pirazol fusionado 3-aminocarbonilo sustituidos como moduladores de proteina cinasa.

Info

Publication number
MX2009004714A
MX2009004714A MX2009004714A MX2009004714A MX2009004714A MX 2009004714 A MX2009004714 A MX 2009004714A MX 2009004714 A MX2009004714 A MX 2009004714A MX 2009004714 A MX2009004714 A MX 2009004714A MX 2009004714 A MX2009004714 A MX 2009004714A
Authority
MX
Mexico
Prior art keywords
protein kinase
aminocarbonyi
derivatives
substituted fused
kinase modulators
Prior art date
Application number
MX2009004714A
Other languages
English (en)
Inventor
Patricia Imbach
Pascal Furet
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2009004714A publication Critical patent/MX2009004714A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Los compuestos de fórmula (I), en donde los residuos tienen varios significados, su utilización farmacéutica, las composiciones farmacéuticas que comprenden dichos compuestos y métodos para la preparación y utilización para el tratamiento de desordenes que responden a modulación de proteína cinasa.
MX2009004714A 2006-10-30 2007-10-29 Derivados de pirazol fusionado 3-aminocarbonilo sustituidos como moduladores de proteina cinasa. MX2009004714A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06123186A EP1918291A1 (en) 2006-10-30 2006-10-30 3-Aminocarbonyl-substituted fused pyrazolo-derivatives as protein kinase modulators
PCT/EP2007/061618 WO2008052964A1 (en) 2006-10-30 2007-10-29 3-aminocarbonyi-substituted fused pyrazolo-derivatives as protein kinase modulators

Publications (1)

Publication Number Publication Date
MX2009004714A true MX2009004714A (es) 2009-05-20

Family

ID=37745980

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009004714A MX2009004714A (es) 2006-10-30 2007-10-29 Derivados de pirazol fusionado 3-aminocarbonilo sustituidos como moduladores de proteina cinasa.

Country Status (10)

Country Link
US (1) US20100069395A1 (es)
EP (2) EP1918291A1 (es)
JP (1) JP2010508324A (es)
KR (1) KR20090084837A (es)
CN (1) CN101535313A (es)
AU (1) AU2007316180A1 (es)
BR (1) BRPI0718269A2 (es)
CA (1) CA2667963A1 (es)
MX (1) MX2009004714A (es)
WO (1) WO2008052964A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8394802B2 (en) * 2008-09-19 2013-03-12 Nerviano Medical Sciences S.R.L. 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-one derivatives for the modulation of the activity of protein kinases
AU2011217961B2 (en) * 2010-02-18 2016-05-05 Incyte Holdings Corporation Cyclobutane and methylcyclobutane derivatives as Janus kinase inhibitors
ES2628418T3 (es) 2010-05-20 2017-08-02 Array Biopharma, Inc. Compuestos macrocíclicos como inhibidores de la TRK cinasa
US20130324521A1 (en) * 2010-11-26 2013-12-05 Reza Ghotbi Implant for treating or preventing an aneurysm
GB201322333D0 (en) 2013-12-17 2014-01-29 Agency Science Tech & Res WNT pathway modulators
CN103819478B (zh) * 2014-03-21 2016-05-04 成都诺维尔生物医药有限公司 阿拉格列汀中间体2-甲基-吡唑并[1,5-a]嘧啶-6-羧酸的制备方法
WO2015152319A1 (ja) * 2014-04-02 2015-10-08 株式会社 三和化学研究所 ５，７－無置換－ピラゾロ［１，５－ａ］ピリミジン－６－カルボン酸の製造方法
WO2017011776A1 (en) 2015-07-16 2017-01-19 Array Biopharma, Inc. Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors
ES2953467T3 (es) * 2016-04-15 2023-11-13 Elanco Animal Health Gmbh Derivados de pirazolopirimidina
TWI704148B (zh) 2016-10-10 2020-09-11 美商亞雷生物製藥股份有限公司 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物
JOP20190077A1 (ar) 2016-10-10 2019-04-09 Array Biopharma Inc مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret
WO2018136663A1 (en) 2017-01-18 2018-07-26 Array Biopharma, Inc. Ret inhibitors
EP3571203B1 (en) 2017-01-18 2023-06-07 Array BioPharma Inc. Substituted pyrazolo[1,5-a]pyrazine compounds as ret kinase inhibitors
JOP20190213A1 (ar) 2017-03-16 2019-09-16 Array Biopharma Inc مركبات حلقية ضخمة كمثبطات لكيناز ros1
CN106866680B (zh) * 2017-03-31 2019-02-01 陕西理工大学 一种3-芳基-6-甲酰胺吡唑并[1,5-a]嘧啶类化合物及其应用
ES2998110T3 (en) 2017-04-27 2025-02-19 Elanco Animal Health Gmbh New bicyclic pyrazole derivatives
TWI876442B (zh) 2017-10-10 2025-03-11 美商絡速藥業公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物
TWI791053B (zh) 2017-10-10 2023-02-01 美商亞雷生物製藥股份有限公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物
WO2019143994A1 (en) 2018-01-18 2019-07-25 Array Biopharma Inc. Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors
WO2019143977A1 (en) 2018-01-18 2019-07-25 Array Biopharma Inc. Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
EP3740490A1 (en) 2018-01-18 2020-11-25 Array Biopharma, Inc. Substituted pyrazolo[3,4-d]pyrimidine compounds as ret kinase inhibitors
EP3849986B1 (en) 2018-09-10 2022-06-08 Array Biopharma, Inc. Fused heterocyclic compounds as ret kinase inhibitors
CN112876482B (zh) * 2020-12-31 2023-07-28 中国药科大学 一类多取代杂环衍生物、其制备方法及其在医药上的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004076458A1 (en) * 2003-02-28 2004-09-10 Teijin Pharma Limited Pyrazolo[1,5-a]pyrimidine derivatives
AR049769A1 (es) * 2004-01-22 2006-09-06 Novartis Ag Derivados de pirazolo(1,5-a)pirimidin 7-il-amina para utilizarse en el tratamiento de enfermedades dependientes de la quinasa de proteina

Also Published As

Publication number Publication date
BRPI0718269A2 (pt) 2013-11-12
CA2667963A1 (en) 2008-05-08
CN101535313A (zh) 2009-09-16
EP2079745A1 (en) 2009-07-22
AU2007316180A1 (en) 2008-05-08
KR20090084837A (ko) 2009-08-05
WO2008052964A1 (en) 2008-05-08
JP2010508324A (ja) 2010-03-18
US20100069395A1 (en) 2010-03-18
EP1918291A1 (en) 2008-05-07

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Legal Events

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