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MX2009004283A - Derivados de piridazina. - Google Patents

Derivados de piridazina.

Info

Publication number
MX2009004283A
MX2009004283A MX2009004283A MX2009004283A MX2009004283A MX 2009004283 A MX2009004283 A MX 2009004283A MX 2009004283 A MX2009004283 A MX 2009004283A MX 2009004283 A MX2009004283 A MX 2009004283A MX 2009004283 A MX2009004283 A MX 2009004283A
Authority
MX
Mexico
Prior art keywords
optionally substituted
c6alkyl
hydrogen
pyridazine derivatives
activity
Prior art date
Application number
MX2009004283A
Other languages
English (en)
Inventor
Stephan Trah
Clemens Lamberth
Sebastian Wendeborn
Original Assignee
Syngenta Participations Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syngenta Participations Ag filed Critical Syngenta Participations Ag
Publication of MX2009004283A publication Critical patent/MX2009004283A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/18—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/58—1,2-Diazines; Hydrogenated 1,2-diazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/12—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/60—Two oxygen atoms, e.g. succinic anhydride
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Agronomy & Crop Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se refiere a nuevos derivados de piridazina de la fórmula (I) como ingredientes activos que tienen actividad microbiocida, en particular actividad fungicida: en donde R1 es hidrógeno, alquilo de C1-C6, haloalquilo de C1-C6 o cicloalquilo de C3-C6; R2 es cicloalquilo, cicloalquilalquilo, halocicloalquilo, cicloalcoxi, halocicloalcoxi, cicloalquilalcoxi, halocicloalquilalcoxi, alcoxialquilo, cicloalcoxialcoxialquilo, haloalcoxialquilo, trialquilsililo, alquiltioalquilo, haloalquiltioalquilo, cicloalquiltio, halocicloalquiltio, cicloalquilalquiltio, halocicloalquilalquiltio , alquilsulfinilalquilo, alquilsulfonilalquilo, alquilsulfinilo, haloalquilsulfinilo, alquilsulfonilo, haloalquilsulfonilo, alquenilo de C2-C6, alquinilo de C2-C6, arilsulfonilo opcionalmente substituido, ariloxi opcionalmente substituido, heteroariloxi opcionalmente substituido, ariltio opcionalmente substituido, heteroariltio opcionalmente substituido; o R2 junto con un átomo de carbono adyacente forma un anillo fusionado opcionalmente substituido; R3 es un arilo opcionalmente substituido; R4 es hidrógeno, halógeno, alquilo de C1-C6, haloalquilo de C1-C6, alcoxi de C1-C6, haloalcoxi de C1-C6, hidroxi o ciano; y n en un número entero desde 1 hasta 4; o una forma de la sal del mismo que se puede utilizar agroquímicamente. (ver fórmula (I)).
MX2009004283A 2006-10-25 2007-10-23 Derivados de piridazina. MX2009004283A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06022285A EP1916240A1 (en) 2006-10-25 2006-10-25 Pyridazine derivatives
PCT/EP2007/009189 WO2008049585A1 (en) 2006-10-25 2007-10-23 Pyridazine derivatives

Publications (1)

Publication Number Publication Date
MX2009004283A true MX2009004283A (es) 2009-05-05

Family

ID=37685818

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009004283A MX2009004283A (es) 2006-10-25 2007-10-23 Derivados de piridazina.

Country Status (18)

Country Link
US (1) US20100144674A1 (es)
EP (2) EP1916240A1 (es)
JP (1) JP2010507609A (es)
KR (1) KR20090074259A (es)
CN (1) CN101535275A (es)
AR (1) AR063515A1 (es)
AU (1) AU2007308411A1 (es)
BR (1) BRPI0718180A2 (es)
CA (1) CA2667235A1 (es)
CL (1) CL2007003060A1 (es)
CO (1) CO6170356A2 (es)
CR (1) CR10742A (es)
GT (1) GT200700095A (es)
IL (1) IL198244A0 (es)
MX (1) MX2009004283A (es)
RU (1) RU2009119357A (es)
TW (1) TW200835441A (es)
WO (1) WO2008049585A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1958948T3 (da) * 2005-12-07 2011-10-31 Sumitomo Chemical Co Pyridazinforbindelse og anvendelse deraf
WO2008135413A1 (de) * 2007-05-02 2008-11-13 Basf Se Fungizide pyridazine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
CL2008001356A1 (es) * 2007-05-10 2008-11-14 Smithkline Beecham Corp Compuestos derivados de quinoxalina, inhibidores de la pi3 quinasa _(p13ka, pi3ko, pi3b y/o pi3ky); composicion farmaceutica; uso para tratar un trastorno autoinmune, enfermedad inflamatoria, cardiovascular, neurodegerativa, alergia, asma, enfermedad renal, cancer, rechazo de transplante, lesiones pulmonares.
AU2010279686A1 (en) 2009-08-07 2012-02-09 E. I. Du Pont De Nemours And Company Fungicidal diphenyl-substituted pyridazines
GB201117019D0 (en) * 2011-10-04 2011-11-16 Syngenta Ltd Herbicidal compounds
WO2011095459A1 (en) 2010-02-04 2011-08-11 Syngenta Participations Ag Pyridazine derivatives, process for their preparation and their use as fungicides
WO2011095461A1 (en) 2010-02-04 2011-08-11 Syngenta Participations Ag Pyridazine derivatives, processes for their preparation and their use as fungicides
JP5857513B2 (ja) * 2010-08-10 2016-02-10 住友化学株式会社 植物病害防除組成物およびその用途
JP5857512B2 (ja) * 2010-08-10 2016-02-10 住友化学株式会社 植物病害防除組成物およびその用途
JP2012036142A (ja) 2010-08-10 2012-02-23 Sumitomo Chemical Co Ltd 植物病害防除組成物およびその用途
JP5857511B2 (ja) * 2010-08-10 2016-02-10 住友化学株式会社 植物病害防除組成物およびその用途
AU2012288895A1 (en) * 2011-07-27 2014-02-20 Bayer Intellectual Property Gmbh Substituted picolinic acids and pyrimidine-4-carboxylic acids, method for the production thereof, and use thereof as herbicides and plant growth regulators
TN2015000547A1 (fr) 2013-06-27 2017-04-06 Pfizer Composes heteroaromatiques et leur utilisation comme ligands de dopamine d1
EP3277673B1 (en) 2015-04-01 2022-05-04 Rigel Pharmaceuticals, Inc. Tgf-beta inhibitors
BR112018074644B1 (pt) * 2016-05-30 2022-09-13 Syngenta Participations Ag Compostos derivados de tiazol microbicidas, composição agroquímica, método de controle ou prevenção da infestação de plantas úteis por microrganismos fitopatogênicos e uso do referido composto
AR117183A1 (es) * 2018-11-30 2021-07-14 Syngenta Crop Protection Ag Derivados de tiazol microbiocidas
AR117200A1 (es) * 2018-11-30 2021-07-21 Syngenta Participations Ag Derivados de tiazol microbiocidas
EP3898620A1 (en) * 2018-12-20 2021-10-27 Bayer Aktiengesellschaft Heterocyclyl pyridazine as fungicidal compounds
CN117222640A (zh) * 2021-04-03 2023-12-12 先声再明医药有限公司 作为fgfr抑制剂的杂环化合物及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0975604B1 (en) * 1997-03-14 2004-07-21 Merck Frosst Canada & Co. Pyridazinones as inhibitors of cyclooxygenase-2
HK1041876B (en) * 1998-10-27 2006-06-23 Abbott Laboratories Prostaglandin endoperoxide h synthase biosynthesis inhibitors
WO2001090097A2 (en) * 2000-05-22 2001-11-29 Dr. Reddy's Research Foundation Novel compounds having antiinflammatory activity: process for their preparation and pharmaceutical compositions containing them
AU2005252061B2 (en) * 2004-06-09 2010-02-11 Sumitomo Chemical Company, Limited Pyridazine compound and use thereof
EP1775290B1 (en) * 2004-06-28 2010-11-17 Sumitomo Chemical Company, Limited Pyridazine compound and use thereof
BRPI0710845A2 (pt) * 2006-04-06 2011-08-23 Syngenta Participations Ag composições fungicidas
GB0615213D0 (en) * 2006-07-31 2006-09-06 Syngenta Participations Ag Fungicidal compounds and compositions
AR063514A1 (es) * 2006-10-25 2009-01-28 Syngenta Participations Ag Derivados de piridazinas, composiciones agroquimicas que los contienen, proceso de preparacion y usos como agentes fungicidas en el control o proteccion de microorganismos fitopatogenicos
AR064962A1 (es) * 2007-01-22 2009-05-06 Syngenta Participations Ag Derivados de piridazina utiles como fungicidas

Also Published As

Publication number Publication date
WO2008049585A1 (en) 2008-05-02
AU2007308411A1 (en) 2008-05-02
GT200700095A (es) 2008-06-02
AR063515A1 (es) 2009-01-28
CN101535275A (zh) 2009-09-16
BRPI0718180A2 (pt) 2013-12-17
EP2077997A1 (en) 2009-07-15
TW200835441A (en) 2008-09-01
RU2009119357A (ru) 2011-04-27
IL198244A0 (en) 2009-12-24
EP1916240A1 (en) 2008-04-30
US20100144674A1 (en) 2010-06-10
CO6170356A2 (es) 2010-06-18
CL2007003060A1 (es) 2008-01-25
KR20090074259A (ko) 2009-07-06
JP2010507609A (ja) 2010-03-11
CR10742A (es) 2009-07-23
CA2667235A1 (en) 2008-05-02

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