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MX2009001110A - Anticuerpos monoclonales anti-il-6 y usos de los mismos. - Google Patents

Anticuerpos monoclonales anti-il-6 y usos de los mismos.

Info

Publication number
MX2009001110A
MX2009001110A MX2009001110A MX2009001110A MX2009001110A MX 2009001110 A MX2009001110 A MX 2009001110A MX 2009001110 A MX2009001110 A MX 2009001110A MX 2009001110 A MX2009001110 A MX 2009001110A MX 2009001110 A MX2009001110 A MX 2009001110A
Authority
MX
Mexico
Prior art keywords
monoclonal antibodies
amino acid
well
region selected
acid variants
Prior art date
Application number
MX2009001110A
Other languages
English (en)
Inventor
Ernest S Smith
Wei Wang
Original Assignee
Vaccinex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vaccinex Inc filed Critical Vaccinex Inc
Publication of MX2009001110A publication Critical patent/MX2009001110A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención proporciona novedosos anticuerpos monoclonales que se enlazan específicamente con IL-6. Los anticuerpos de la invención comprenden una región de cadena pesada variable (VH) a partir de cualquiera de las regiones VH dadas a conocer en la presente, así como las variantes de aminoácidos de las mismas, y/o una región de cadena ligera variable (VL) seleccionada a partir de cualquiera de las regiones VL dadas a conocer en la presente, así como las variantes de aminoácidos de las mismas. La invención también proporciona métodos para el tratamiento de enfermedades y trastornos asociados con la expresión y/o actividad de IL-6.
MX2009001110A 2006-08-03 2007-08-03 Anticuerpos monoclonales anti-il-6 y usos de los mismos. MX2009001110A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83510706P 2006-08-03 2006-08-03
PCT/US2007/017337 WO2008019061A2 (en) 2006-08-03 2007-08-03 Anti-il-6 monoclonal antibodies and uses thereof

Publications (1)

Publication Number Publication Date
MX2009001110A true MX2009001110A (es) 2009-05-11

Family

ID=39033490

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009001110A MX2009001110A (es) 2006-08-03 2007-08-03 Anticuerpos monoclonales anti-il-6 y usos de los mismos.

Country Status (17)

Country Link
US (1) US7919095B2 (es)
EP (1) EP2064241B1 (es)
JP (1) JP2009545319A (es)
KR (1) KR101479537B1 (es)
CN (1) CN101563365B (es)
AU (1) AU2007282023B2 (es)
BR (1) BRPI0715115A2 (es)
CA (1) CA2657763C (es)
CO (1) CO6150192A2 (es)
CR (1) CR10563A (es)
EA (1) EA200900037A1 (es)
IL (1) IL196550A0 (es)
MA (1) MA30653B1 (es)
MX (1) MX2009001110A (es)
NO (1) NO20090224L (es)
WO (1) WO2008019061A2 (es)
ZA (1) ZA200900514B (es)

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Also Published As

Publication number Publication date
ZA200900514B (en) 2010-04-28
KR20090039801A (ko) 2009-04-22
CO6150192A2 (es) 2010-04-20
JP2009545319A (ja) 2009-12-24
AU2007282023A1 (en) 2008-02-14
US7919095B2 (en) 2011-04-05
EA200900037A1 (ru) 2009-10-30
CA2657763A1 (en) 2008-02-14
NO20090224L (no) 2009-03-31
WO2008019061A3 (en) 2008-10-09
KR101479537B1 (ko) 2015-01-07
CN101563365B (zh) 2012-10-31
IL196550A0 (en) 2011-08-01
CN101563365A (zh) 2009-10-21
MA30653B1 (fr) 2009-08-03
AU2007282023B2 (en) 2012-09-13
EP2064241A2 (en) 2009-06-03
US20080075726A1 (en) 2008-03-27
EP2064241B1 (en) 2015-10-07
CA2657763C (en) 2016-05-31
CR10563A (es) 2009-04-14
BRPI0715115A2 (pt) 2013-06-04
WO2008019061A2 (en) 2008-02-14

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