MX2008015324A - Derivados de pirrolidina utiles como inhibidores de bace. - Google Patents
Derivados de pirrolidina utiles como inhibidores de bace.Info
- Publication number
- MX2008015324A MX2008015324A MX2008015324A MX2008015324A MX2008015324A MX 2008015324 A MX2008015324 A MX 2008015324A MX 2008015324 A MX2008015324 A MX 2008015324A MX 2008015324 A MX2008015324 A MX 2008015324A MX 2008015324 A MX2008015324 A MX 2008015324A
- Authority
- MX
- Mexico
- Prior art keywords
- beta
- treatment
- compound
- substituted pyrrolidine
- secretase
- Prior art date
Links
- 150000003235 pyrrolidines Chemical class 0.000 title abstract 3
- 101150058765 BACE1 gene Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Natural products C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 4
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 abstract 3
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 abstract 3
- 102000013455 Amyloid beta-Peptides Human genes 0.000 abstract 3
- 108010090849 Amyloid beta-Peptides Proteins 0.000 abstract 3
- 238000004220 aggregation Methods 0.000 abstract 3
- 230000002776 aggregation Effects 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- -1 pyrrolidine compound Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuestos novedosos de pirrolidina 3-mono-, 3,4,-di- y 3-4,4,-tri-sustituida, estos compuestos para utilizarse en el diagnóstico y el tratamiento terapéutico de un animal de sangre caliente, en especial para el tratamiento de una enfermedad (= trastorno) que dependa de la actividad de la beta-secretasa y/o de la generación de beta-amiloide y de la acumulación subsiguiente en oligómeros y fibrilos; el uso de un compuesto de esta clase para la preparación de un formulación farmacéutica para el tratamiento de una enfermedad que dependa de la actividad de la beta-secretasa y/o de la generación de beta-amiloide y de la acumulación subsiguiente en oligómeros y fibrilos; el uso de un compuesto de esta clase en el tratamiento de una enfermedad que dependa de la actividad de la beta-secretasa y/o de la generación de beta-amiloide y de la acumulación subsiguiente en oligómeros y fibrilos; formulaciones farmacéuticas que comprenden a este compuesto de pirrolidina sustituida, y/o un método de tratamiento, el cual comprende administrar este compuesto de pirrolidina sustituida. Los compuestos de pirrolidina sustituida son en especial de la fórmula I: (ver fórmula (I)) en donde los sustituyentes son como se definen en la memoria descriptiva.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0611064.7A GB0611064D0 (en) | 2006-06-05 | 2006-06-05 | Organic compounds |
| PCT/EP2007/004959 WO2007140980A1 (en) | 2006-06-05 | 2007-06-04 | Pyrrolidine derivatives useful as bace inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2008015324A true MX2008015324A (es) | 2008-12-12 |
Family
ID=36694963
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2008015324A MX2008015324A (es) | 2006-06-05 | 2007-06-04 | Derivados de pirrolidina utiles como inhibidores de bace. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20090247577A1 (es) |
| EP (1) | EP2029544A1 (es) |
| JP (1) | JP2009539789A (es) |
| KR (1) | KR20090018707A (es) |
| CN (1) | CN101460464A (es) |
| AU (1) | AU2007256405A1 (es) |
| BR (1) | BRPI0712347A2 (es) |
| CA (1) | CA2653238A1 (es) |
| GB (1) | GB0611064D0 (es) |
| MX (1) | MX2008015324A (es) |
| RU (1) | RU2008151049A (es) |
| WO (1) | WO2007140980A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100398936C (zh) * | 2003-08-28 | 2008-07-02 | 上海交通大学 | 太阳能-空气热泵热水器 |
| US10202355B2 (en) | 2013-02-12 | 2019-02-12 | Buck Institute For Research On Aging | Hydantoins that modulate bace-mediated app processing |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6846813B2 (en) * | 2000-06-30 | 2005-01-25 | Pharmacia & Upjohn Company | Compounds to treat alzheimer's disease |
| CN1863797A (zh) * | 2003-08-08 | 2006-11-15 | 先灵公司 | 具有苯甲酰胺取代基的环胺bace－1抑制剂 |
-
2006
- 2006-06-05 GB GBGB0611064.7A patent/GB0611064D0/en not_active Ceased
-
2007
- 2007-06-04 JP JP2009513589A patent/JP2009539789A/ja active Pending
- 2007-06-04 RU RU2008151049/04A patent/RU2008151049A/ru not_active Application Discontinuation
- 2007-06-04 CA CA002653238A patent/CA2653238A1/en not_active Abandoned
- 2007-06-04 CN CNA2007800209458A patent/CN101460464A/zh active Pending
- 2007-06-04 MX MX2008015324A patent/MX2008015324A/es not_active Application Discontinuation
- 2007-06-04 KR KR1020097000026A patent/KR20090018707A/ko not_active Withdrawn
- 2007-06-04 WO PCT/EP2007/004959 patent/WO2007140980A1/en not_active Ceased
- 2007-06-04 EP EP07725827A patent/EP2029544A1/en not_active Withdrawn
- 2007-06-04 BR BRPI0712347-7A patent/BRPI0712347A2/pt not_active Application Discontinuation
- 2007-06-04 US US12/303,495 patent/US20090247577A1/en not_active Abandoned
- 2007-06-04 AU AU2007256405A patent/AU2007256405A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20090018707A (ko) | 2009-02-20 |
| CN101460464A (zh) | 2009-06-17 |
| GB0611064D0 (en) | 2006-07-12 |
| WO2007140980A1 (en) | 2007-12-13 |
| JP2009539789A (ja) | 2009-11-19 |
| AU2007256405A1 (en) | 2007-12-13 |
| US20090247577A1 (en) | 2009-10-01 |
| BRPI0712347A2 (pt) | 2012-06-05 |
| RU2008151049A (ru) | 2010-07-20 |
| CA2653238A1 (en) | 2007-12-13 |
| EP2029544A1 (en) | 2009-03-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |