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MX2008001709A - Produccion de celulas reprogramadas con potencial restablecido. - Google Patents

Produccion de celulas reprogramadas con potencial restablecido.

Info

Publication number
MX2008001709A
MX2008001709A MX2008001709A MX2008001709A MX2008001709A MX 2008001709 A MX2008001709 A MX 2008001709A MX 2008001709 A MX2008001709 A MX 2008001709A MX 2008001709 A MX2008001709 A MX 2008001709A MX 2008001709 A MX2008001709 A MX 2008001709A
Authority
MX
Mexico
Prior art keywords
production
potential
reprogrammed cells
restored
cells
Prior art date
Application number
MX2008001709A
Other languages
English (en)
Inventor
Kenneth J Eilertsen
Original Assignee
Nupotential Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nupotential Inc filed Critical Nupotential Inc
Publication of MX2008001709A publication Critical patent/MX2008001709A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Se describe un método para tratar células y/o unidades de transferencia nuclear y/o células germinales en cultivo con tales compuestos, de manera individual o en combinación; el método resulta en un genoma hipometilado globalmente y en un restablecimiento del potencial de diferenciación y/o desarrollo de la célula, o potencialidad; además, se describe un método para la producción in vitro de células reprogramdas que han tenido un potencial de diferenciación (totipotencial, pluropotencial o multipotencial) restablecido mediante la de metilación del genoma.
MX2008001709A 2005-08-01 2006-08-01 Produccion de celulas reprogramadas con potencial restablecido. MX2008001709A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70446505P 2005-08-01 2005-08-01
PCT/US2006/029944 WO2007016566A2 (en) 2005-08-01 2006-08-01 Production of reprogrammed cells with restored potential

Publications (1)

Publication Number Publication Date
MX2008001709A true MX2008001709A (es) 2008-11-26

Family

ID=37334108

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008001709A MX2008001709A (es) 2005-08-01 2006-08-01 Produccion de celulas reprogramadas con potencial restablecido.

Country Status (11)

Country Link
US (2) US7601699B2 (es)
EP (1) EP1917356A2 (es)
JP (1) JP4395193B2 (es)
KR (1) KR101004634B1 (es)
CN (1) CN101313065A (es)
AU (1) AU2006275479B2 (es)
BR (1) BRPI0614470A2 (es)
CA (1) CA2617611A1 (es)
IL (1) IL189113A (es)
MX (1) MX2008001709A (es)
WO (1) WO2007016566A2 (es)

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US7682828B2 (en) 2003-11-26 2010-03-23 Whitehead Institute For Biomedical Research Methods for reprogramming somatic cells
US20090253203A1 (en) * 2005-08-01 2009-10-08 Nupotential, Inc. Reprogramming a Cell by Inducing a Pluripotent Gene Through Use of a Small Molecule Modulator
US7601699B2 (en) * 2005-08-01 2009-10-13 Nupotential, Inc. Production of reprogrammed cells with restored potential
US8357666B2 (en) * 2005-08-01 2013-01-22 Nupotential, Inc. Reprogramming a cell by inducing a pluripotent gene through RNA interference
EP4223769A3 (en) * 2005-12-13 2023-11-01 Kyoto University Nuclear reprogramming factor
US20090252711A1 (en) * 2006-05-11 2009-10-08 Andrew Craig Boquest Stem Cells And Methods Of Making And Using Stem Cells
EP3878949B1 (en) 2007-04-07 2025-06-04 Whitehead Institute for Biomedical Research Reprogramming of somatic cells
WO2009102983A2 (en) * 2008-02-15 2009-08-20 President And Fellows Of Harvard College Efficient induction of pluripotent stem cells using small molecule compounds
SG10201808863UA (en) 2008-03-17 2018-11-29 Scripps Research Inst Combined chemical and genetic approaches for generation of induced pluripotent stem cells
CA2727681C (en) 2008-06-13 2017-07-25 Whitehead Institute For Biomedical Research Programming and reprogramming of cells
EP2373784B1 (en) 2008-12-17 2017-10-25 The Scripps Research Institute Generation and maintenance of stem cells
US20120115225A1 (en) * 2009-04-23 2012-05-10 Xu C W Reprogramming of somatic cells with purified proteins
DK2432881T3 (en) 2009-05-18 2018-02-26 Curna Inc TREATMENT OF REPROGRAMMING FACTOR-RELATED DISEASES BY INHIBITING NATURAL ANTISENSE TRANSCRIPTS TO A REPROGRAMMING FACTOR
US20110016548A1 (en) * 2009-07-16 2011-01-20 University Of Southern California Control of endogenous dnmt1 gene expression by exogenous binary regulatory systems
GB0915523D0 (en) 2009-09-07 2009-10-07 Genome Res Ltd Cells and methods for obtaining them
CN102741394B (zh) 2009-10-16 2016-05-04 斯克里普斯研究所 多能细胞的诱导
CN105176930B (zh) 2010-03-31 2021-05-04 斯克里普斯研究所 重编程细胞
ES2986590T3 (es) 2010-06-14 2024-11-12 Scripps Research Inst Reprogramación de células hacia un nuevo destino
KR101975688B1 (ko) 2010-12-22 2019-05-07 페이트 세러퓨틱스, 인코포레이티드 단세포 분류 및 iPSC의 증강된 재프로그래밍을 위한 세포 배양 플랫폼
US9433583B2 (en) 2011-04-22 2016-09-06 Frank J. Farrell Colon vitamin
EP2857501A1 (en) 2013-10-03 2015-04-08 ETH Zurich Reprogramming of pluripotent stem cells for improved control of their differentiation pathways
CN103757022B (zh) * 2014-01-17 2015-05-20 中国人民解放军总医院第一附属医院 一种干扰rna分子及其应用
CN103757021B (zh) * 2014-01-17 2015-05-20 中国人民解放军总医院第一附属医院 沉默DNMT基因的双链siRNA分子及其应用
ES2966757T3 (es) 2014-03-04 2024-04-24 Fate Therapeutics Inc Métodos de reprogramación mejorados y plataformas de cultivo celular
AU2016206649A1 (en) * 2015-01-14 2017-08-03 Memorial Sloan-Kettering Cancer Center Age-modified cells and methods for making age-modified cells
US10576105B2 (en) * 2015-09-03 2020-03-03 Escape Therapeutics, Inc. Mesenchymal stem cells with enhanced immunosuppressive capability
SG11201802957PA (en) 2015-10-16 2018-05-30 Fate Therapeutics Inc Platform for the induction & maintenance of ground state pluripotency
US11376270B2 (en) 2015-12-03 2022-07-05 Epidestiny, Inc. Compositions containing decitabine, 5Azacytidine and tetrahydrouridine and uses thereof
GB2594084A (en) * 2020-04-17 2021-10-20 Bertrand Marie Rene Joseph Medical methods and medical uses
CN112063599B (zh) * 2020-06-01 2023-01-17 南通大学附属医院 一种与中枢神经衰老相关的乙酰化修饰sirt2蛋白标记分子及其应用

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US5061620A (en) 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
US5635387A (en) 1990-04-23 1997-06-03 Cellpro, Inc. Methods and device for culturing human hematopoietic cells and their precursors
US5827670A (en) 1990-08-02 1998-10-27 Fred Hutchinson Cancer Research Center Methods of isolating and detecting bone marrow stromal cells with VCAM-1-specific antibodies
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5811094A (en) 1990-11-16 1998-09-22 Osiris Therapeutics, Inc. Connective tissue regeneration using human mesenchymal stem cell preparations
US5837539A (en) 1990-11-16 1998-11-17 Osiris Therapeutics, Inc. Monoclonal antibodies for human mesenchymal stem cells
US5460964A (en) 1992-04-03 1995-10-24 Regents Of The University Of Minnesota Method for culturing hematopoietic cells
AU4543193A (en) 1992-06-22 1994-01-24 Henry E. Young Scar inhibitory factor and use thereof
US5409813A (en) 1993-09-30 1995-04-25 Systemix, Inc. Method for mammalian cell separation from a mixture of cell populations
US5677136A (en) 1994-11-14 1997-10-14 Systemix, Inc. Methods of obtaining compositions enriched for hematopoietic stem cells, compositions derived therefrom and methods of use thereof
US5736396A (en) 1995-01-24 1998-04-07 Case Western Reserve University Lineage-directed induction of human mesenchymal stem cell differentiation
US5827740A (en) 1996-07-30 1998-10-27 Osiris Therapeutics, Inc. Adipogenic differentiation of human mesenchymal stem cells
US6066625A (en) * 1998-02-03 2000-05-23 Methylgene, Inc. Optimized antisense oligonucleotides complementary to DNA methyltransferase sequences
GB0107267D0 (en) 2001-03-23 2001-05-16 Babraham Inst Diagnostic method for determining the methylation state of cloned embryos
WO2006088867A2 (en) 2005-02-15 2006-08-24 Medistem Laboratories, Incorporated Method for expansion of stem cells
US7601699B2 (en) * 2005-08-01 2009-10-13 Nupotential, Inc. Production of reprogrammed cells with restored potential
EP3878949B1 (en) 2007-04-07 2025-06-04 Whitehead Institute for Biomedical Research Reprogramming of somatic cells

Also Published As

Publication number Publication date
KR101004634B1 (ko) 2011-01-04
AU2006275479A1 (en) 2007-02-08
EP1917356A2 (en) 2008-05-07
US20070032447A1 (en) 2007-02-08
IL189113A (en) 2011-07-31
JP4395193B2 (ja) 2010-01-06
CA2617611A1 (en) 2007-02-08
KR20080043805A (ko) 2008-05-19
US7601699B2 (en) 2009-10-13
WO2007016566A2 (en) 2007-02-08
CN101313065A (zh) 2008-11-26
IL189113A0 (en) 2008-08-07
WO2007016566A9 (en) 2008-03-13
US20100159459A1 (en) 2010-06-24
JP2009502201A (ja) 2009-01-29
WO2007016566A3 (en) 2007-07-12
US8987220B2 (en) 2015-03-24
BRPI0614470A2 (pt) 2011-03-29
AU2006275479B2 (en) 2012-11-29

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