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MX2007016185A - Inhibidores de aspartil proteasa heterociclicos macrociclicos. - Google Patents

Inhibidores de aspartil proteasa heterociclicos macrociclicos.

Info

Publication number
MX2007016185A
MX2007016185A MX2007016185A MX2007016185A MX2007016185A MX 2007016185 A MX2007016185 A MX 2007016185A MX 2007016185 A MX2007016185 A MX 2007016185A MX 2007016185 A MX2007016185 A MX 2007016185A MX 2007016185 A MX2007016185 A MX 2007016185A
Authority
MX
Mexico
Prior art keywords
formula
aspartyl protease
compounds
disclosed
protease inhibitors
Prior art date
Application number
MX2007016185A
Other languages
English (en)
Inventor
Andrew Stamford
Zhaoning Zhu
Ulrich Iserloh
Johannes H Voigt
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of MX2007016185A publication Critical patent/MX2007016185A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se describen compuestos de la formula I (ver formula I) o su estereoisomero, tautomero o sal, solvato o ester farmaceuticamente aceptable del mismo, donde U, W, X, L, Y, M, Z, c, d, e, f, g, h, s, t, R1, R2, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17 y R18 son como estan definidos en la memoria; y composiciones farmaceuticas que comprenden los compuestos de formula I; tambien es revelado el metodo de inhibicion de aspartil proteasa, y en particular, los metodos de tratamiento de enfermedades cardiovasculares, enfermedades cognitivas y neurodegenerativas; tambien son revelados metodos de tratamiento de enfermedades cognitivas o neurodegenerativas que utilizan los compuestos de formula I en combinacion con un inhibidor de colinesterasa o un agonista m1 o antagonista m2 muscarinico.
MX2007016185A 2005-06-14 2006-06-12 Inhibidores de aspartil proteasa heterociclicos macrociclicos. MX2007016185A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69054205P 2005-06-14 2005-06-14
PCT/US2006/022701 WO2006138195A1 (en) 2005-06-14 2006-06-12 Macrocyclic heterocyclic aspartyl protease inhibitors

Publications (1)

Publication Number Publication Date
MX2007016185A true MX2007016185A (es) 2008-03-07

Family

ID=37309231

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007016185A MX2007016185A (es) 2005-06-14 2006-06-12 Inhibidores de aspartil proteasa heterociclicos macrociclicos.

Country Status (10)

Country Link
US (2) US7812013B2 (es)
EP (1) EP1902057B1 (es)
JP (1) JP2008543841A (es)
CN (1) CN101193892A (es)
AR (1) AR053902A1 (es)
CA (1) CA2609562A1 (es)
MX (1) MX2007016185A (es)
PE (1) PE20070078A1 (es)
TW (1) TW200716645A (es)
WO (1) WO2006138195A1 (es)

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JP2009515951A (ja) * 2005-11-15 2009-04-16 アストラゼネカ・アクチエボラーグ 新規な２−アミノピリミジノンまたは２−アミノピリジノン誘導体およびそれらの使用
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CN101360720A (zh) * 2005-11-15 2009-02-04 阿斯利康(瑞典)有限公司 新颖的2-氨基嘧啶酮衍生物及其用途
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TW200734311A (en) * 2005-11-21 2007-09-16 Astrazeneca Ab New compounds
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JP2009532464A (ja) * 2006-04-05 2009-09-10 アストラゼネカ・アクチエボラーグ ２−アミノピリミジン−４−オン及びＡβ−関連の病理を治療又は予防するためのその使用
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EP2064191B1 (en) 2006-12-12 2014-06-25 Merck Sharp & Dohme Corp. Aspartyl protease inhibitors
TW200831484A (en) * 2006-12-20 2008-08-01 Astrazeneca Ab New compounds
TW200902499A (en) * 2007-05-15 2009-01-16 Astrazeneca Ab New compounds
TW200902503A (en) * 2007-05-15 2009-01-16 Astrazeneca Ab New compounds
US8518975B2 (en) 2007-09-06 2013-08-27 Merck Sharp + Dohme Corp. Gamma secretase modulators
JP2011503002A (ja) 2007-11-05 2011-01-27 シェーリング コーポレイション γセクレターゼ調節剤
JP2011506461A (ja) 2007-12-11 2011-03-03 シェーリング コーポレイション γ−セクレターゼモジュレーター
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AR074702A1 (es) 2008-12-22 2011-02-02 Schering Corp Moduladores de gamma secretasa y composiciones farmaceuticas que los contienen
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JP6326232B2 (ja) 2011-02-08 2018-05-16 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 関節症の処置のためのアミノスタチン誘導体
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KR20140054295A (ko) 2011-08-22 2014-05-08 머크 샤프 앤드 돔 코포레이션 Bace 억제제로서의 2-스피로-치환된 이미노티아진 및 그의 모노- 및 디옥시드, 조성물 및 그의 용도
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Also Published As

Publication number Publication date
US8557798B2 (en) 2013-10-15
AR053902A1 (es) 2007-05-23
EP1902057A1 (en) 2008-03-26
US20060281729A1 (en) 2006-12-14
CN101193892A (zh) 2008-06-04
WO2006138195A1 (en) 2006-12-28
US20100063121A1 (en) 2010-03-11
PE20070078A1 (es) 2007-03-08
JP2008543841A (ja) 2008-12-04
TW200716645A (en) 2007-05-01
CA2609562A1 (en) 2006-12-28
EP1902057B1 (en) 2013-10-23
US7812013B2 (en) 2010-10-12

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