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MX2007014803A - Composiciones que penetran el nucleo celular. - Google Patents

Composiciones que penetran el nucleo celular.

Info

Publication number
MX2007014803A
MX2007014803A MX2007014803A MX2007014803A MX2007014803A MX 2007014803 A MX2007014803 A MX 2007014803A MX 2007014803 A MX2007014803 A MX 2007014803A MX 2007014803 A MX2007014803 A MX 2007014803A MX 2007014803 A MX2007014803 A MX 2007014803A
Authority
MX
Mexico
Prior art keywords
cell nucleus
entering
amino acid
acid sequence
compositions
Prior art date
Application number
MX2007014803A
Other languages
English (en)
Inventor
Allan L Goldstein
Ewald Hannappel
Thomas Huff
David Crockford
Original Assignee
Regenerx Biopharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regenerx Biopharmaceuticals filed Critical Regenerx Biopharmaceuticals
Publication of MX2007014803A publication Critical patent/MX2007014803A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2292—Thymosin; Related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invencion se refiere a una composicion farmaceuticamente aceptable y un metodo para entrar a un nucleo de celula utiliza un polipeptido que entra a un nucleo celular que incluye cuando menos una de las secuencias de aminoacidos LKKTET, la secuencia de aminoacidos LKKTNT o la secuencia de aminoacidos KSKLKK, o una variante conservativa de esta, unida a un agente fisiologicamente activo que tiene cuando menos una aplicacion de diagnostico o terapeutica en el nucleo de la celula.
MX2007014803A 2005-05-27 2005-10-03 Composiciones que penetran el nucleo celular. MX2007014803A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68499305P 2005-05-27 2005-05-27
PCT/US2005/035716 WO2006130171A1 (en) 2005-05-27 2005-10-03 Cell nucleus-entering compositions

Publications (1)

Publication Number Publication Date
MX2007014803A true MX2007014803A (es) 2008-04-21

Family

ID=37481967

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007014803A MX2007014803A (es) 2005-05-27 2005-10-03 Composiciones que penetran el nucleo celular.

Country Status (9)

Country Link
EP (1) EP1904076A4 (es)
JP (1) JP2008542265A (es)
KR (1) KR20080016675A (es)
CN (1) CN101184498A (es)
AU (1) AU2005332297A1 (es)
CA (1) CA2607701A1 (es)
IL (1) IL187217A0 (es)
MX (1) MX2007014803A (es)
WO (1) WO2006130171A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2811030A3 (en) * 2008-03-17 2015-01-21 Regenerx Biopharmaceuticals, Inc. Improved beta Thymosin fragments
CN110790821B (zh) * 2019-11-19 2022-09-02 南阳师范学院 一种细胞核穿透肽及其用途
CN115266995B (zh) * 2022-08-02 2023-10-13 兆科（广州）眼科药物有限公司 一种生发肽制剂中有关物质的分析方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6919208B2 (en) * 2000-05-22 2005-07-19 The Children's Hospital Of Philadelphia Methods and compositions for enhancing the delivery of a nucleic acid to a cell
JP2007525445A (ja) * 2003-03-31 2007-09-06 リジェナークス・バイオファーマスーティカルズ・インコーポレイテッド サイモシンβ４、類似体、アイソフォーム及び他の誘導体を送達するための組成物及び方法
WO2004099768A1 (en) * 2003-05-05 2004-11-18 Regenerx Biopharmaceuticals, Inc. Method for detecting development of a physiological disorder in a subject
CN1822850A (zh) * 2003-07-18 2006-08-23 雷根内克斯生物制药有限公司 由放射线照射引起的损伤的治疗或预防

Also Published As

Publication number Publication date
CA2607701A1 (en) 2006-12-07
KR20080016675A (ko) 2008-02-21
CN101184498A (zh) 2008-05-21
EP1904076A1 (en) 2008-04-02
WO2006130171A1 (en) 2006-12-07
AU2005332297A1 (en) 2006-12-07
JP2008542265A (ja) 2008-11-27
IL187217A0 (en) 2008-02-09
EP1904076A4 (en) 2009-12-09

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal