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ME02000B - Peptidni inhibitori jnk signalnog transdukcijskog puta koji su permeabilni za ćeliju - Google Patents

Peptidni inhibitori jnk signalnog transdukcijskog puta koji su permeabilni za ćeliju

Info

Publication number
ME02000B
ME02000B MEP-2014-123A MEP12314A ME02000B ME 02000 B ME02000 B ME 02000B ME P12314 A MEP12314 A ME P12314A ME 02000 B ME02000 B ME 02000B
Authority
ME
Montenegro
Prior art keywords
jnk
sequence
peptide
inhibitome
seq
Prior art date
Application number
MEP-2014-123A
Other languages
English (en)
Inventor
Christophe Bonny
Original Assignee
Xigen Inflammation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xigen Inflammation Ltd filed Critical Xigen Inflammation Ltd
Publication of ME02000B publication Critical patent/ME02000B/me

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Claims (16)

1.    JNK inhibitoma sekvenca, naznačena time, da se sastoji od neke D retro inverzo amino kiselinske sekvence u skladu sa SEQ ID NO: 2.
2.    JNK inhibitoma sekvenca iz zahteva 1, naznačena time, da pomenuta JNK inhibitoma sekvenca veže c-jun amino terminalnu kinazu (JNK).
3.    JNK inhibitoma sekvenca iz bilo kojeg od zahteva od 1 do 2, naznačena time, da pomenuta JNK inhibitoma sekvenca inhibira aktivisanje najmanje jednog JNK ciljanog transkripcijskog faktora kada je pomenuta JNK inhibitoma sekvenca prisutna u ćeliji koja eksprimira JNK.
4.    JNK inhibitoma sekvenca iz bilo kojeg od zahteva od 1 do 3, naznačena time, da pomenuti JNK ciljani transkripcijski faktor je izabran iz grupe koja se sastoji od c-Jun, ATF2 i Elkl.
5.    . JNK inhibitoma sekvenca iz bilo kojeg od zahteva od 1 do 4, naznačena time, da pomenuta JNK inhibitoma sekvenca menja JNK efekat kada je pomenuti peptid prisutan u ćeliji koja eksprimira JNK.
6. Himemi peptid, naznačen time, da se sastoji od prvog domena i od drugog domena koji su povezani sa kovalentnom vezom, pri čemu prvi domen obuhvata neku prometnu sekvencu, a drugi sadrži neku JNK inhibitomu sekvencu u skladu sa bilo kojim od zahteva od 1-5, gde je prvi domen vezan na C-terminus drugog domena.
7.    Peptid iz zahteva 6, naznačen time, da pomenuta prometna sekvenca obuhvata amino kiselinsku sekvencu iz TAT polipeptiđa iz humanog virusa imunodificijencije.
8.    Peptid iz bilo kojeg od zahteva od 6 dc 7, naznačen time, da pomenuta prometna sekvenca obuhvata L amino kiselinsku sekvencu iz SEQ ID NO: 5 ili 7 ili D retro-inverzo sekvencu u skladu sa SEQ ID NO: 6 ili 8.
9.    Peptid iz bilo kojeg od zahteva od 6 do 8, naznačen time, da pomenuta prometna sekvenca povećava ćelijsko ulaženje pomenutog peptida.
10.    Peptid iz bilo kojeg od zahteva od 6 do 9, naznačen time, gde pomenuta prometna sekvenca usmerava jedrino lokalizovanje pomenutog peptida.
11.    Peptid iz bilo kojeg od zahteva od 6 do 10, naznačen time, gde pomenuta JNK inhibitoma sekvenca obuhvata D retro-inverzo amino kiselinsku sekvencu u skladu sa SEQ ID NO: 11.
12.    Peptid iz bilo kojeg od zahteva od 6 do 11, naznačen time, gde pomenuti peptid obuhvata ili se sastoji od D retro-inverzo amino kiselinske sekvence u skladu sa SEQ ID NO: 11.
13.    Farmaceutska kompozicija, naznačena time, da obuhvata neku JNK inhibitomu sekvencu koja se sastoji od sekvence u skladu sa bilo kojem od zahteva od 1 do 5 ili neki himernog peptid u skladu sa bilo kojem od zahteva od 6 do 12 i nekog farmaceutski prihvatljivog nosioca.
14.    Upotreba neke JNK inhibitome sekvence u skladu sa bilo kojem od zahteva od 1 do 5 ili nekog himernog peptida u skladu sa bilo kojem od zahteva od 6 do 12, naznačena time, da se pomenuti primenjuju u pripremi neke farmaceutske kompozicije za tretman patofiziologije koja je izabrana iz malignih bolesti pluća, dojki, limfoidnog, gastrointestinalnog i genito-urinamog trakta kao i iz adenokarcinoma, uključujući maligna stanja poput raka debelog creva, karcinoma renalnih ćelija, raka prostate, karcinoma velikih ćelija u plućima, raka tankog creva i raka ezofagusa, kao i leukemija, rakova sa Bcr-Abl onkogenim transformacijama, psorijaza, pemphigus vulgaris, Behcet-ovog sindroma, akutnog respiratornog stresnog sindroma (ARDS), ishemične bolesti srca, sindroma nakon dijalize, reumatoidnog artritisa, sindroma stečene imuno dificijencije, vaskulitisa, septičkog šoka, restenoze, gubitka sluha, trauma uva, ishemije, kapi; reperfuzijskih ozleda, hipoksije, sekundarnih efekata zbog tretmana sa proinflamatomim citokinima, dijabetičkog srca i kardijačne hipertrofije i arteriosklerotičnih lezija, patoloških stanja usled jonizacijske radijacije tokom radioterapije i zračenja sa ultravioletnim svetlom (UV svetla), patološka stanja indukovana uz pomoć agenasa koji oštećuju DNK, uključujući hemoterapeutske lekove, hipo- i hipertermija, bolesti zapaljenja, auto-zapaljenja, imunih i auto-imunih bolesti, degenerativnih bolesti, miopatija, kardiomiopatija i odbacivanje transplantata.
15.    Upotreba u skladu sa zahtevom 19, naznačena time, gde pomenuta farmaceutska kompozicija treba da se administrira preko neke rute za administraciju koja je izabrana iz grupe koja se sastoji od intraperitoneainih, nazalnih, intravenoznih, oralnih ruta i ruta za dostavu preko nalepnica.
16.    Komplet hemikalija (kit), naznačen time, da obuhvata neku JNK inhibitomu sekvencu koja se sastoji od neke sekvence u skladu sa bilo kojem od zahteva od 1 do 5 i/ili nekog himernog peptida u skladu sa bilo kojem od zahteva od 8 do 16,
MEP-2014-123A 2005-09-12 2006-09-12 Peptidni inhibitori jnk signalnog transdukcijskog puta koji su permeabilni za ćeliju ME02000B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/EP2005/009782 WO2007031098A1 (en) 2005-09-12 2005-09-12 Cell-permeable peptide inhibitors of the jnk signal transduction pathway
EP06792004A EP1928903B1 (en) 2005-09-12 2006-09-12 Cell-permeable peptide inhibitors of the jnk signal transduction pathway
PCT/EP2006/008882 WO2007031280A2 (en) 2005-09-12 2006-09-12 Cell-permeable peptide inhibitors of the jnk signal transduction pathway

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ME02000B true ME02000B (me) 2015-05-20

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MEP-2016-62A ME02426B (me) 2005-09-12 2006-09-12 Peptidni inhibitori jnk signalnog transdukcijskog puta koji su permeabilni za ćeliju

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US (5) US8748395B2 (me)
EP (3) EP1928903B1 (me)
JP (3) JP5386169B2 (me)
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