ME02754B - Ligandi opioidnih receptora i postupci njihove upotrebe i pripreme - Google Patents
Ligandi opioidnih receptora i postupci njihove upotrebe i pripremeInfo
- Publication number
- ME02754B ME02754B MEP-2017-129A MEP2017129A ME02754B ME 02754 B ME02754 B ME 02754B ME P2017129 A MEP2017129 A ME P2017129A ME 02754 B ME02754 B ME 02754B
- Authority
- ME
- Montenegro
- Prior art keywords
- alkyl
- pharmaceutically acceptable
- acceptable salt
- compound
- compound according
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 3
- 102000003840 Opioid Receptors Human genes 0.000 title 1
- 108090000137 Opioid Receptors Proteins 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 25
- 150000003839 salts Chemical class 0.000 claims 20
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 14
- 125000001475 halogen functional group Chemical group 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 9
- 125000004093 cyano group Chemical group *C#N 0.000 claims 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 8
- 238000006467 substitution reaction Methods 0.000 claims 8
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 7
- 125000003545 alkoxy group Chemical group 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000002950 monocyclic group Chemical group 0.000 claims 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 1
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (20)
1. Jedinjenje formule IV-1, ili neka njegova farmaceutski prihvatljiva so,: u kojoj: R21 i R22 su nezavisno H ili CH3; A4 je neki opciono supstituisan cikl formule C(CH2)n, u kojoj n = 2-5, pri čemu je opciona supstitucija halo, cijano, C1-C6 alkil, C1-C6 razgranat alkil, halogenovan C1-C6 alkil, hidroksil, C1-C6 alkiloksi, amino, ili C1-C6 alkilamino; B3 je H ili neki opciono supstituisan C1-C6 alkil, pri čemu je opciona supstitucija halo, hidroksi ili C1-C6 alkoksi; B4 je C1-C6 alkilen; D1 je neki opciono supstituisan monociklični ili biciklični aril ili heteroaril, u kom je svaki prsten neki 5, 6 ili 7-člani prsten, a opciona supstitucija je halo, cijano, C1-C6 alkil, C1-C6 razgranat alkil, halogenovan C1-C6 alkil, hidroksil, C1-C6 alkiloksi, amino, ili C1-C6 alkilamino; i B5 je neki opciono supstituisan monociklični ili biciklični aril ili heteroaril, u kom je svaki prsten neki 5, 6, ili 7-člani prsten, a opciona supstitucija je halo, cijano, C1-C6 alkil, C1-C6 razgranat alkil, halogenovan C1-C6 alkil, hidroksil, C1-C6 alkiloksi, amino, ili C1-C6 alkilamino.
2.Jedinjenje prema zahtevu 1, ili neka njegova farmaceutski prihvatljiva so, koje ima strukturu formule VIII: u kojoj su R26 i R27 nezavisno H ili neki njegov izotop.
3.Jedinjenje prema zahtevu 2, ili neka njegova farmaceutski prihvatljiva so, pri čemu jedinjenje ima formulu IX
4.Jedinjenje prema zahtevima 2 ili 3, ili neka njegova farmaceutski prihvatljiva so, pri čemu jedinjenje ima formulu VII-l
5.Jedinjenje prema nekom od zahteva 2-4, ili neka njegova farmaceutski prihvatljiva so, pri čemu jedinjenje ima formulu X
6. Jedinjenje prema nekom od zahteva 1-5, ili neka njegova farmaceutski prihvatljiva so, kod kog je D1 neki opciono supstituisan fenil, pri čemu je opciona supstitucija halo, cijano, C1-C6 alkil, C1-C6 razgranat alkil, halogenovan C1-C6 alkil, hidroksil, C1-C6 alkiloksi, amino, ili C1-C6 alkilamino ili neki opciono supstituisan piridil, pri čemu je opciona supstitucija halo, cijano, C1-C6 alkil, C1-C6 razgranat alkil, halogenovan C1-C6 alkil, hidroksil, C1-C6 alkiloksi, amino, ili C1-C6 alkilamino.
7.Jedinjenje prema nekom od zahteva 1-5, ili neka njegova farmaceutski prihvatljiva so, kod kog je B5 neki opciono supstituisan monociklični ili biciklični heteroaril, u kom je svaki prsten neki 5, 6, ili 7- člani prsten, a opciona supstitucija je halo, cijano, C1-C6 alkil, C1-C6 razgranat alkil, halogenovan C1-C6alkil, hidroksil, C1-C6 alkiloksi, amino, ili C1-C6 alkilamino.
8.Jedinjenje prema nekom od zahteva 1-5, ili neka njegova farmaceutski prihvatljiva so, kod kog je B5 neki opciono supstituisan aril ili heteroaril odabran iz grupe koju čine pri čemu je opciona supstitucija halo, cijano, C1-C6 alkil, C1-C6 razgranat alkil, halogenovan C1-C6 alkil, hidroksil, C1-C6 alkiloksi, amino, ili C1-C6 alkilamino.
9.Jedinjenje prema zahtevima 1-5, ili neka njegova farmaceutski prihvatljiva so, kod kog je B5 odabran iz grupe koju čine u kojima R23, R24, i R30 su svaki nezavisno nula, H, OH, halo, razgranat ili nerazgranat C1-C6 alkil, cijano, C1-C6alkoksi, amino, C1-C6 haloalkil, ili, R23 i R24 zajedno obrazuju neki aril, heteroaril ili ciki koji je vezan za jedan ili više atoma B5; a R25 je H ili neki opciono supstituisan razgranat ili nerazgranat alkil, pri čemu je opciona supstitucija halo, hidroksi ili C1-C3 alkoksi.
10.Jedinjenje prema zahtevu 9, ili neka njegova farmaceutski prihvatljiva so, kod kog su R23, R24, i R30 svaki nezavisno H, NH2, OH, CI, Br, F, I, OMe, CN, ili CH3.
11.Jedinjenje prema zahtevu 9, ili neka njegova farmaceutski prihvatljiva so, kod kog B5 predstavlja
12.Jedinjenje prema zahtevu 9 ili 11, ili neka njegova farmaceutski prihvatljiva so, kod kog R23 predstavlja C1-C6 alkoksi.
13.Jedinjenje prema nekom od zahteva 1-12, ili neka njegova farmaceutski prihvatljiva so, kod kog B3 predstavlja H ili C1-C6 alkil.
14.Jedinjenje prema zahtevu 1, ili neka njegova farmaceutski prihvatljiva so, koje ima formulu:
15.Jedinjenje prema zahtevu 1, ili neka njegova farmaceutski prihvatljiva so, koje ima formulu:
16.Jedinjenje prema zahtevu 1, ili neka njegova farmaceutski prihvatljiva so, koje ima formulu:
17.Jedinjenje prema zahtevu 1, ili neka njegova farmaceutski prihvatljiva so, koje ima formulu:
18.Farmaceutska kompozicija koja obuhvata jedinjenje, ili neku njegovu farmaceutski prihvatljivu so, prema bilo kom od zahteva 1-17 i neki farmaceutski prihvatljiv nosač.
19.Jedinjenje ili neka njegova farmaceutski prihvatljiva so, ili kompozicija prema bilo kom od zahteva 1-18 za upotrebu u tretiranju bola.
20. Postupak pripreme jedinjenja, ili neke njegove farmaceutski prihvatljive soli, prema zahtevu 2, gde R26 i R27 predstavljaju H, pri čemu taj postupak obuhvata: dovođenje u kontakt pod pogodnim uslovima za obrazovanje jedinjenja koje ima strukturu pod pogodnim uslovima za obrazovanje jedinjenja koje ima strukturu
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161466809P | 2011-03-23 | 2011-03-23 | |
| US201261596808P | 2012-02-09 | 2012-02-09 | |
| PCT/US2012/030327 WO2012129495A1 (en) | 2011-03-23 | 2012-03-23 | Opioid receptor ligands and methods of using and making same |
| EP12760456.9A EP2688403B1 (en) | 2011-03-23 | 2012-03-23 | Opioid receptor ligands and methods of using and making same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME02754B true ME02754B (me) | 2018-01-20 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2017-129A ME02754B (me) | 2011-03-23 | 2012-03-23 | Ligandi opioidnih receptora i postupci njihove upotrebe i pripreme |
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| Country | Link |
|---|---|
| US (8) | US8835488B2 (me) |
| EP (3) | EP3872076A1 (me) |
| JP (6) | JP5912169B2 (me) |
| KR (3) | KR102129247B1 (me) |
| CN (1) | CN103702561B (me) |
| AU (2) | AU2012230761B2 (me) |
| CA (1) | CA2830742C (me) |
| CY (1) | CY1119057T1 (me) |
| DK (2) | DK3290415T3 (me) |
| EA (1) | EA025456B1 (me) |
| ES (2) | ES2857549T3 (me) |
| HR (1) | HRP20171021T1 (me) |
| HU (2) | HUE032948T2 (me) |
| IL (4) | IL228506A (me) |
| LT (1) | LT2688403T (me) |
| ME (1) | ME02754B (me) |
| PL (2) | PL2688403T3 (me) |
| PT (2) | PT3290415T (me) |
| RS (1) | RS56111B1 (me) |
| SI (1) | SI2688403T1 (me) |
| SM (1) | SMT201700325T1 (me) |
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Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3290415T (pt) * | 2011-03-23 | 2021-03-29 | Trevena Inc | Ligandos de recetores opioides e métodos de utilização e fabrico dos mesmos |
| ES2553449T3 (es) | 2011-07-06 | 2015-12-09 | Gilead Sciences, Inc. | Compuestos para el tratamiento de VIH |
| TWI694071B (zh) | 2013-03-01 | 2020-05-21 | 美商基利科學股份有限公司 | 治療反轉錄病毒科(Retroviridae)病毒感染之治療性化合物 |
| US10202353B2 (en) | 2014-02-28 | 2019-02-12 | Gilead Sciences, Inc. | Therapeutic compounds |
| EP3350166A4 (en) | 2015-09-16 | 2019-05-01 | Metacrine, Inc. | FARNESOID-X RECEPTOR AGONISTS AND USES THEREOF |
| JP6905530B2 (ja) | 2015-09-16 | 2021-07-21 | メタクリン，インク． | ファルネソイドｘ受容体アゴニストとその使用 |
| EP3350158A4 (en) | 2015-09-16 | 2019-05-08 | Metacrine, Inc. | Farnesoid x receptor agonists and uses thereof |
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