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ME01699B - Methods of stimulating liver regeneration - Google Patents

Methods of stimulating liver regeneration

Info

Publication number
ME01699B
ME01699B MEP-2012-120A MEP12012A ME01699B ME 01699 B ME01699 B ME 01699B ME P12012 A MEP12012 A ME P12012A ME 01699 B ME01699 B ME 01699B
Authority
ME
Montenegro
Prior art keywords
liver
methods
liver regeneration
stimulating liver
regeneration
Prior art date
Application number
MEP-2012-120A
Other languages
Unknown language (me)
Inventor
Stephen Tomlinson
Songqing He
Carl Atkinson
Original Assignee
Musc Found For Res Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Musc Found For Res Dev filed Critical Musc Found For Res Dev
Publication of ME01699B publication Critical patent/ME01699B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Ovde su obezbeđene metode i kompozicije uključujući farmaceutske kompozicije, za stimulaciju regeneracije jetre nako delimične hepatoktomije (uklanjanje dela jetre), masivne resekcije jetre i toksičnog oštećenja, ili nakon transplantacije jetre, uključujući ,,small-for-size“ transplantaciju jetre putem inhibicije aktivacije komplementa.Methods and compositions, including pharmaceutical compositions, are provided herein to stimulate liver regeneration of a partially partial hepatectomy (removal of a portion of the liver), massive liver resection and toxic damage, or after liver transplantation, including small-for-size liver transplantation by inhibiting complement activation .

MEP-2012-120A 2009-07-02 2010-07-02 Methods of stimulating liver regeneration ME01699B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22286709P 2009-07-02 2009-07-02
EP10794833.3A EP2453906A4 (en) 2009-07-02 2010-07-02 METHODS FOR STIMULATING LIVER REGENERATION
PCT/US2010/040973 WO2011003098A1 (en) 2009-07-02 2010-07-02 Methods of stimulating liver regeneration

Publications (1)

Publication Number Publication Date
ME01699B true ME01699B (en) 2014-09-20

Family

ID=43411491

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2012-120A ME01699B (en) 2009-07-02 2010-07-02 Methods of stimulating liver regeneration

Country Status (8)

Country Link
US (1) US9066925B2 (en)
EP (1) EP2453906A4 (en)
JP (1) JP5871798B2 (en)
AU (1) AU2010266127B2 (en)
CA (1) CA2767105A1 (en)
ME (1) ME01699B (en)
RS (1) RS20120461A1 (en)
WO (1) WO2011003098A1 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1569685E (en) 2002-11-15 2012-11-02 Univ Colorado Regents Complement receptor 2 targeted complement modulators
PT1713503E (en) 2004-02-10 2013-11-14 Nat Jewish Health Inhibition of factor b, the alternative complement pathway and methods related thereto
CA2610340C (en) * 2005-05-26 2016-02-16 Vernon Michael Holers Inhibition of the alternative complement pathway for treatment of traumatic brain injury, spinal cord injury and related conditions
EP2044111B1 (en) * 2006-06-21 2014-08-13 MUSC Foundation For Research Development Targeting complement factor h for treatment of diseases
CA2680344A1 (en) 2007-03-14 2008-11-20 Woodruff Emlen Humaneered anti-factor b antibody
WO2011003098A1 (en) 2009-07-02 2011-01-06 Musc Foundation For Research Development Methods of stimulating liver regeneration
US10239937B2 (en) 2009-11-05 2019-03-26 Alexion Pharmaceuticals, Inc. Treatment of paroxysmal nocturnal hemoglobinuria, hemolytic anemias and disease states involving intravascular and extravascular hemolysis
CN103038252A (en) 2010-05-14 2013-04-10 科罗拉多大学董事会,法人团体 Modified Complement Receptor 2 (CR2) Targeting Group
WO2011163412A1 (en) 2010-06-22 2011-12-29 The Regents Of The University Of Colorado, A Body Corporate Antibodies to the c3d fragment of complement component 3
WO2012095519A1 (en) * 2011-01-13 2012-07-19 Leibniz-Institut Für Naturstoff-Forschung Und Infektionsbiologie Potent inhibitors of complement activation
US9803005B2 (en) 2012-05-24 2017-10-31 Alexion Pharmaceuticals, Inc. Humaneered anti-factor B antibody
US10413620B2 (en) * 2012-08-17 2019-09-17 The Regents Of The University Of Colorado, A Body Corporate Light-emitting versions of the monoclonal antibody to C3D (MAB 3D29) for imaging
JP2015535212A (en) 2012-08-17 2015-12-10 ザ・リージエンツ・オブ・ザ・ユニバーシテイ・オブ・コロラド、ア・ボデイー・コーポレイト Compositions and methods for detecting complement activation
SMT201900141T1 (en) 2013-03-15 2019-05-10 Shire Viropharma Inc C1-inh compositions and methods for the prevention and treatment of disorders associated with c1 esterase inhibitor deficency
AU2017210042B2 (en) 2016-01-20 2021-01-21 396419 B.C. Ltd. Compositions and methods for inhibiting Factor D
WO2018136827A1 (en) 2017-01-20 2018-07-26 Vitrisa Therapeutics, Inc. Stem-loop compositions and methods for inhibiting factor d
JP7378046B2 (en) * 2018-07-17 2023-11-13 国立大学法人 熊本大学 Blood-brain barrier permeable peptide
JP2022500427A (en) * 2018-09-17 2022-01-04 国立大学法人京都大学 Administration of anti-C5 agents for the treatment of liver injury or liver failure
AU2020388572A1 (en) 2019-11-20 2022-05-26 Alkahest, Inc. Blood plasma fractions for use in liver regeneration
US11484551B2 (en) 2019-11-20 2022-11-01 Alkahest, Inc. Method of treating liver failure with plasma fraction IV-4
CA3218096A1 (en) * 2021-05-19 2022-11-24 Viktoria Kheifets Blood plasma fractions for use in liver regeneration
CN114209813A (en) * 2021-11-30 2022-03-22 广西医科大学第一附属医院 Application of targeted complement inhibitor in preparation of medicine for improving cholestatic liver injury
CN114588251A (en) * 2022-02-10 2022-06-07 广西医科大学第一附属医院 Application of targeted complement inhibitors in the preparation of drugs for improving liver aging
WO2025015317A2 (en) * 2023-07-13 2025-01-16 Kriya Therapeutics, Inc. Complement pathway inhibitor fusions and methods of using the same

Family Cites Families (132)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981481A (en) 1974-12-06 1999-11-09 The Johns Hopkins University Human C3b/C4b receptor (CR1)
US5212071A (en) 1988-04-01 1993-05-18 The Johns Hopkins University Nucleic acids encoding a human C3b/C4b receptor (CR1)
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4845083A (en) 1983-10-05 1989-07-04 Merck Frosst Canada, Inc. Method of inhibiting mammalian leukotriene biosynthesis
JPH0742235B2 (en) 1985-11-08 1995-05-10 三共株式会社 Prophylactic / therapeutic agent for autoimmune diseases
US5260203A (en) 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
US5256642A (en) 1988-04-01 1993-10-26 The Johns Hopkins University Compositions of soluble complement receptor 1 (CR1) and a thrombolytic agent, and the methods of use thereof
DE3830271A1 (en) 1988-09-06 1990-03-15 Goetze Otto MEDIUM WITH IMMUNE SUPPRESSIVE EFFECT
US5328470A (en) 1989-03-31 1994-07-12 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
EP0402226A1 (en) 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Transformation vectors for yeast yarrowia
FR2648133B1 (en) 1989-06-08 1992-02-21 Sanofi Sa N-SUBSTITUTED LAURAMIDES, THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM
US5331090A (en) 1989-09-08 1994-07-19 California Institute Of Biological Research CR2 ligand compositions and methods for modulating immune cell functions
US5310729A (en) 1990-04-20 1994-05-10 California Institute Of Biological Research Interferon-related polypeptides as CR2 ligands and their use for modulating immune cell functions
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
US6458360B1 (en) 1990-04-25 2002-10-01 The Johns Hopkins University Soluble complement regulatory molecules
GB9102635D0 (en) 1991-02-07 1991-03-27 British Bio Technology Compounds
EP1413587A2 (en) 1991-05-03 2004-04-28 Washington University Modified complement system regulator
DE4222534A1 (en) 1992-07-09 1994-01-13 Behringwerke Ag Use of complement inhibitors for the manufacture of a medicament for the prophylaxis and therapy of inflammatory bowel and skin diseases and purpura
US5976540A (en) 1993-05-17 1999-11-02 T Cell Sciences, Inc. Compositions comprising complement related proteins and carbohydrates, and methods for producing and using said compositions
US5679546A (en) 1993-09-24 1997-10-21 Cytomed, Inc. Chimeric proteins which block complement activation
US5869615A (en) 1994-01-03 1999-02-09 Washington University Modified complement proteases
US6074642A (en) 1994-05-02 2000-06-13 Alexion Pharmaceuticals, Inc. Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis
US5679345A (en) 1994-06-02 1997-10-21 The Johns Hopkins University Method for preventing complement-dependent rejection of organ or tissue transplants
US6309636B1 (en) 1995-09-14 2001-10-30 Cancer Research Institute Of Contra Costa Recombinant peptides derived from the Mc3 anti-BA46 antibody, methods of use thereof, and methods of humanizing antibody peptides
HU223006B1 (en) 1994-10-25 2004-03-01 Glaxo Group Ltd. Binding agents to cd23
US6165463A (en) 1997-10-16 2000-12-26 Inhale Therapeutic Systems, Inc. Dispersible antibody compositions and methods for their preparation and use
AU3487697A (en) 1996-06-14 1998-01-07 Johns Hopkins University School Of Medicine, The Use of chimeric vaccinia virus complement control proteins to inhibit complement
US5922320A (en) 1996-06-14 1999-07-13 Georgetown University Recombinant proCVF
WO1998007835A2 (en) 1996-08-21 1998-02-26 Sugen, Inc. Crystal structures of a protein tyrosine kinase
US6214966B1 (en) 1996-09-26 2001-04-10 Shearwater Corporation Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
GB9624731D0 (en) 1996-11-28 1997-01-15 Univ Leicester Complement inhibitor
US6368596B1 (en) 1997-07-08 2002-04-09 Board Of Regents, The University Of Texas System Compositions and methods for homoconjugates of antibodies which induce growth arrest or apoptosis of tumor cells
WO1999010009A1 (en) 1997-08-26 1999-03-04 Gliatech Inc. A process for inhibiting complement activation via the alternative pathway
US8088386B2 (en) 1998-03-20 2012-01-03 Genentech, Inc. Treatment of complement-associated disorders
WO1999037149A1 (en) 1998-01-27 1999-07-29 Brigham & Women's Hospital Methods of treating cytotoxic damage
US6956107B2 (en) 1998-02-20 2005-10-18 Tanox, Inc. Inhibitors of complement activation
US7112327B2 (en) 1998-02-20 2006-09-26 Tanox, Inc. Inhibition of complement activation
ES2488819T3 (en) 1998-02-20 2014-08-29 Genentech, Inc. Inhibitors of complement activation
AU3066699A (en) 1998-03-03 1999-09-20 Johns Hopkins University, The Smallpox inhibitor of complement enzymes (spice) protein and methods of inhibiting complement activation
AU762799B2 (en) 1998-06-12 2003-07-03 Henry M. Jackson Foundation For The Advancement Of Military Medicine Enhancement of B cell activation and immunoglobulin secretion by co-stimulation of receptors for antigen and EBV Gp350/220
US6572856B1 (en) 1998-09-10 2003-06-03 The University Of Virginia Patent Foundation Methods for the prevention and treatment of cancer using anti-C3b(i) antibodies
EP1001021B1 (en) 1998-09-25 2003-08-27 Wolfgang Prodinger Monoclonal antibody to human CD21, and its uses
US6224866B1 (en) 1998-10-07 2001-05-01 Biocrystal Ltd. Immunotherapy of B cell involvement in progression of solid, nonlymphoid tumors
WO2000021559A2 (en) 1998-10-09 2000-04-20 Musc Foundation For Research Development Blocking factor b to treat complement-mediated immune disease
EP1051432B1 (en) 1998-12-08 2007-01-24 Biovation Limited Method for reducing immunogenicity of proteins
CA2359816C (en) 1999-01-06 2010-08-03 Genenews Inc. Method for the detection of gene transcripts in blood and uses thereof
MXPA01011279A (en) 1999-05-07 2002-07-02 Genentech Inc Treatment of autoimmune diseases with antagonists which bind to b cell surface markers.
US7282562B2 (en) 1999-08-31 2007-10-16 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
GB9930659D0 (en) 1999-12-24 2000-02-16 Bio Discovery Ltd Inhibitors of complement activation
GB0008582D0 (en) 2000-04-08 2000-05-31 Adprotech Plc DNA immunization vectors
CA2407715C (en) 2000-04-29 2009-03-24 University Of Iowa Research Foundation Diagnostics and therapeutics for macular degeneration-related disorders
US7439330B2 (en) 2000-05-08 2008-10-21 President And Fellows Of Harvard College Anti-glycated CD59 antibodies and uses thereof
JP2004508420A (en) 2000-09-18 2004-03-18 アイデック　ファーマスーティカルズ　コーポレイション Combination therapy for treating autoimmune diseases using B cell depleting antibody / immunomodulatory antibody combination
WO2002068579A2 (en) 2001-01-10 2002-09-06 Pe Corporation (Ny) Kits, such as nucleic acid arrays, comprising a majority of human exons or transcripts, for detecting expression and other uses thereof
US7635676B2 (en) 2001-02-21 2009-12-22 Alavita Pharmaccuticals, Inc. Modified annexin proteins and methods for their use in organ transplantation
US7635680B2 (en) 2001-02-21 2009-12-22 Alavita Pharmaceuticals, Inc. Attenuation of reperfusion injury
US6962903B2 (en) 2001-02-21 2005-11-08 Alavita, Inc. Modified annexin proteins and methods for preventing thrombosis
US7645739B2 (en) 2001-02-21 2010-01-12 Alavita Pharmaceuticals, Inc. Modified annexin compositions and methods of using same
US6820011B2 (en) 2001-04-11 2004-11-16 The Regents Of The University Of Colorado Three-dimensional structure of complement receptor type 2 and uses thereof
JP2004529945A (en) 2001-05-17 2004-09-30 ラ ホヤ ファーマシューティカル カンパニー Method of treating antibody-mediated pathology using agents that inhibit CD21
US7378094B2 (en) 2001-08-29 2008-05-27 University Of Virginia Patent Foundation Therapeutic uses of complement receptor 2
EP1336618A1 (en) * 2002-02-15 2003-08-20 HANS-KNÖLL-INSTITUT FÜR NATURSTOFF-FORSCHUNG e.V. Porcine complement regulator factor H and its use
US20030180292A1 (en) 2002-03-14 2003-09-25 Idec Pharmaceuticals Treatment of B cell malignancies using anti-CD40L antibodies in combination with anti-CD20 antibodies and/or chemotherapeutics and radiotherapy
WO2003084524A1 (en) 2002-03-29 2003-10-16 Neurogen Corporation Combination therapy for the treatment of conditions with pathogenic inflammatory components
US7538195B2 (en) 2002-06-14 2009-05-26 Immunogen Inc. Anti-IGF-I receptor antibody
CA2496834C (en) 2002-09-06 2014-03-18 Alexion Pharmaceuticals, Inc. Method of treatment of asthma using antibodies to complement component c5
US20050271660A1 (en) 2002-09-06 2005-12-08 Alexion Pharmaceuticals, Inc. Nebulization of monoclonal antibodies for treating pulmonary diseases
US7541440B2 (en) 2002-09-30 2009-06-02 Immunomedics, Inc. Chimeric, human and humanized anti-granulocyte antibodies and methods of use
WO2004031240A1 (en) 2002-10-04 2004-04-15 Stichting Sanquin Bloedvoorziening Monoclonal antibody anti-c3-2 directed against the third component of complement (c3) and its use in methods to inhibit complement activation
PT1569685E (en) * 2002-11-15 2012-11-02 Univ Colorado Regents Complement receptor 2 targeted complement modulators
US7534427B2 (en) 2002-12-31 2009-05-19 Immunomedics, Inc. Immunotherapy of B cell malignancies and autoimmune diseases using unconjugated antibodies and conjugated antibodies and antibody combinations and fusion proteins
WO2004075838A2 (en) 2003-02-21 2004-09-10 Rikshospitalet-Radiumhospitalet Hf Method and compositions for the treatment of meconium aspiration syndrome
MXPA05010414A (en) * 2003-03-28 2005-12-14 Applied Research Systems Use of clusterin for the treatment and/or prevention of peripheral neurological diseases.
WO2004103288A2 (en) 2003-05-13 2004-12-02 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Method of preventing recurrent miscarriages
JP4029772B2 (en) 2003-05-16 2008-01-09 株式会社日立製作所 Magnetic head and magnetic recording / reproducing apparatus using the same
NZ544163A (en) 2003-06-02 2009-06-26 Evolutec Ltd Complement inhibitors
EP1488798A1 (en) * 2003-06-18 2004-12-22 Institut National De La Sante Et De La Recherche Medicale (Inserm) HIP/PAP polypeptide composition for use in liver regeneration and for the prevention of liver failure
EP1644409B1 (en) 2003-07-03 2016-12-21 PLS-Design GmbH Complement depletion using recombinant human c3-derivatives
AU2004263538B2 (en) 2003-08-08 2009-09-17 Immunomedics, Inc. Bispecific antibodies for inducing apoptosis of tumor and diseased cells
US7638481B2 (en) 2003-09-05 2009-12-29 University Of Louisville Research Foundation, Inc. Treatment of spinal cord injury
JP2007513072A (en) 2003-11-05 2007-05-24 パリンゲン インコーポレーテッド Enhanced B cell cytotoxicity in CDIM binding antibodies
US8454963B2 (en) 2003-11-13 2013-06-04 Musc Foundation For Research Development Tissue targeted complement modulators
US7959919B2 (en) 2003-11-19 2011-06-14 Novelmed Therapeutics, Inc. Method of inhibiting factor B-mediated complement activation
AU2005207003C1 (en) 2004-01-20 2013-06-13 Humanigen, Inc. Antibody specificity transfer using minimal essential binding determinants
WO2005072479A2 (en) 2004-01-27 2005-08-11 University Of Southern California Polymer-bound antibody concer therapeutic agent
PT1713503E (en) 2004-02-10 2013-11-14 Nat Jewish Health Inhibition of factor b, the alternative complement pathway and methods related thereto
PL1713503T3 (en) 2004-02-10 2014-02-28 Univ Colorado Regents Inhibition of factor b, the alternative complement pathway and methods related thereto
SI1755674T1 (en) * 2004-05-14 2015-04-30 Alexion Pharmaceuticals, Inc. Prolongation of survival of an allograft by inhibiting complement activity
US7919094B2 (en) 2004-06-10 2011-04-05 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
WO2006012621A2 (en) 2004-07-23 2006-02-02 University Of Virginia Patent Foundation Compositions and methods for regulating the alternative pathway of complement
MX2007001638A (en) 2004-08-11 2009-02-12 Trubion Pharmaceuticals Inc Binding domain fusion proteins.
WO2006024547A2 (en) 2004-09-03 2006-03-09 Creabilis Therapeutics S.P.A. Protease resistant human and non-human hmgb1 box-a mutants and their therapeutic/diagnostic use
US7563443B2 (en) 2004-09-17 2009-07-21 Domantis Limited Monovalent anti-CD40L antibody polypeptides and compositions thereof
EP1812062B1 (en) 2004-10-25 2022-03-09 Merck Sharp & Dohme Corp. Anti-addl antibodies and uses thereof
US7423128B2 (en) 2004-11-03 2008-09-09 Amgen Fremont Inc. Anti-properdin antibodies, and methods for making and using same
ES2429541T3 (en) 2004-11-16 2013-11-15 Kalobios Pharmaceuticals, Inc. Immunoglobulin variable region cassette exchange
BRPI0518289A2 (en) 2004-11-18 2008-11-11 Univ Yale Methods and compositions for the treatment of eye disorders
AU2006211625A1 (en) 2005-01-14 2006-08-10 The Regents Of The University Of California Compositions and methods for inhibiting drusen formation and for diagnosing or treating drusen-related disorders
NZ608860A (en) 2005-02-14 2014-10-31 Univ Iowa Res Found Methods and reagents for treatment and diagnosis of age-related macular degeneration
CA2610340C (en) 2005-05-26 2016-02-16 Vernon Michael Holers Inhibition of the alternative complement pathway for treatment of traumatic brain injury, spinal cord injury and related conditions
WO2007012144A1 (en) * 2005-07-29 2007-02-01 Australian Stem Cell Centre Limited Compositions and methods for growth of pluripotent cells
JP2009512626A (en) 2005-09-08 2009-03-26 ディーエスエム アイピー アセッツ ビー．ブイ． Method for treating or preventing age-related macular degeneration
CA2621953A1 (en) 2005-09-09 2007-03-22 University Of Iowa Research Foundation Biomarkers associated with age-related macular degeneration
CA2623016A1 (en) 2005-09-19 2007-03-29 Palingen, Inc. Treatment of b cell diseases using anti-germline antibody binding agents
KR20180002911A (en) 2005-11-04 2018-01-08 제넨테크, 인크. Use of complement pathway inhibitors to treat ocular diseases
NZ570802A (en) * 2006-03-02 2012-03-30 Alexion Pharma Inc Prolongation of survival of an allograft by inhibiting complement activity
WO2007112403A2 (en) 2006-03-27 2007-10-04 The Regents Of The University Of Colorado Prevention and treatment of ischemia-reperfusion injury
KR101317235B1 (en) 2006-04-21 2013-10-15 조마 테크놀로지 리미티드 Antagonist anti-cd40 antibody pharmaceutical compositions
EP1854810A1 (en) 2006-05-09 2007-11-14 PanGenetics B.V. Deimmunized antagonistic anti-human CD40 monoclonal antibody from the ch5D12 antibody
EP2044111B1 (en) 2006-06-21 2014-08-13 MUSC Foundation For Research Development Targeting complement factor h for treatment of diseases
US7705475B2 (en) 2006-08-03 2010-04-27 Stats Chippac Ltd. Integrated circuit package system
CL2007003161A1 (en) 2006-11-02 2008-05-30 Genentech Inc ANTI-FACTOR ANTIBODIES D; NUCLEIC ACIDS THAT CODE THEM; VECTOR AND CELL LINE THAT UNDERSTAND THEM; METHOD OF PRODUCTION; PHARMACEUTICAL COMPOSITION THAT INCLUDES ANTIBODIES; AND ITS USE TO TREAT DISORDERS MEDIATED BY THE COMPLEMENT AS
CA2680344A1 (en) 2007-03-14 2008-11-20 Woodruff Emlen Humaneered anti-factor b antibody
PE20090329A1 (en) 2007-05-30 2009-03-27 Abbott Lab HUMANIZED ANTIBODIES AGAINST GLOBULOMER AB (20-42) AND ITS USES
EP2162470A2 (en) 2007-06-07 2010-03-17 Genentech, Inc. C3b antibodies and methods for the prevention and treatment of complement- associated disorders
CN101970002B (en) 2007-08-27 2016-05-18 诺福麦德治疗学股份有限公司 By the method for inhibiting complement activation with factor bb specific antibodies
CL2008003241A1 (en) 2007-11-02 2009-07-31 Novartis Ag Binding molecule comprising an antigen-binding portion that binds to a c3b neoepitope; pharmaceutical composition comprising it; and its use to treat eye disorders
AU2008323939A1 (en) 2007-11-08 2009-05-14 Genentech, Inc. Anti-factor B antibodies and their uses
KR100951695B1 (en) 2007-12-24 2010-04-07 (주)페타리 Isolator and its manufacturing method
EP2262831B1 (en) 2008-03-03 2015-01-21 NovelMed Therapeutics, Inc. Anti-properdin antibodies
SG10201405377XA (en) 2008-08-05 2014-12-30 Novartis Ag Compositions and methods for antibodies targeting complement protein c5
US7964105B2 (en) 2008-08-07 2011-06-21 William Harris Moss Method for improving belt press dewatering
ES2719496T3 (en) 2008-11-12 2019-07-10 Medimmune Llc Antibody formulation
US8840868B2 (en) 2009-02-04 2014-09-23 The Regents Of The University Of Colorado, A Body Corporate Non-invasive detection of complement-mediated inflammation using CR2-targeted nanoparticles
US20100291106A1 (en) 2009-05-06 2010-11-18 Novartis Ag Compositions and methods for antibodies targeting complement protein c3b
US9291622B2 (en) 2009-05-21 2016-03-22 Apellis Pharmaceuticals, Inc. Complement assays and uses thereof
WO2011003098A1 (en) 2009-07-02 2011-01-06 Musc Foundation For Research Development Methods of stimulating liver regeneration
US10239937B2 (en) 2009-11-05 2019-03-26 Alexion Pharmaceuticals, Inc. Treatment of paroxysmal nocturnal hemoglobinuria, hemolytic anemias and disease states involving intravascular and extravascular hemolysis
CN103038252A (en) 2010-05-14 2013-04-10 科罗拉多大学董事会,法人团体 Modified Complement Receptor 2 (CR2) Targeting Group
WO2011163412A1 (en) 2010-06-22 2011-12-29 The Regents Of The University Of Colorado, A Body Corporate Antibodies to the c3d fragment of complement component 3
CN103248395A (en) 2012-02-09 2013-08-14 中兴通讯股份有限公司 Narrow-band interference suppression method and device
US9803005B2 (en) 2012-05-24 2017-10-31 Alexion Pharmaceuticals, Inc. Humaneered anti-factor B antibody

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WO2011003098A1 (en) 2011-01-06
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US20120171206A1 (en) 2012-07-05
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EP2453906A4 (en) 2014-01-15
US9066925B2 (en) 2015-06-30

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