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MD921G2 - Arylpropionic derivatives, process for preparation and the pharmaceutical composition on base thereof - Google Patents

Arylpropionic derivatives, process for preparation and the pharmaceutical composition on base thereof

Info

Publication number
MD921G2
MD921G2 MD96-0285A MD960285A MD921G2 MD 921 G2 MD921 G2 MD 921G2 MD 960285 A MD960285 A MD 960285A MD 921 G2 MD921 G2 MD 921G2
Authority
MD
Moldova
Prior art keywords
pharmaceutical composition
preparation
base
arylpropionic
relates
Prior art date
Application number
MD96-0285A
Other languages
Romanian (ro)
Russian (ru)
Inventor
Germano Carganico
Casellas David Mauleon
Perez M. Luisa Garcia
Original Assignee
Laboratorios Menarini S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8278730&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MD921(G2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Laboratorios Menarini S.A. filed Critical Laboratorios Menarini S.A.
Publication of MD921G2 publication Critical patent/MD921G2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/10—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with one amino group and at least two hydroxy groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Invenţia se referă la sărurile acidului arilpropionic, şi anume la sarea de trometamină a acidului (+)-(S)-2-(3-benzoilfenil) propionic cu formula (I):Invenţia se referă, de asemenea, la un procedeu de obţinere a lor şi la o compoziţie farmaceutică, care conţine o cantitate terapeutic eficientă a acestor compuşi şi un purtător netoxic farmaceutic acceptabil.Rezultatul tehnic constă în obţinerea compuşilor cu acţiune analgezică şi antiinflamatoare mai pronunţată.The invention relates to arylpropionic acid salts, namely to the trometamine salt of (+) - (S) -2- (3-benzoylphenyl) propionic acid of formula (I): The invention also relates to a process for obtaining and to a pharmaceutical composition, which contains a therapeutically effective amount of these compounds and a pharmaceutically acceptable non-toxic carrier. The technical result is to obtain compounds with more pronounced analgesic and anti-inflammatory action.

MD96-0285A 1992-11-10 1993-11-09 Arylpropionic derivatives, process for preparation and the pharmaceutical composition on base thereof MD921G2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES09202260A ES2058024B1 (en) 1992-11-10 1992-11-10 NEW ARILPROPIONIC DERIVATIVE, MANUFACTURING PROCEDURE OF THE SAME AND ITS USE AS AN ANALGESIC.
PCT/EP1993/003127 WO1994011332A1 (en) 1992-11-10 1993-11-09 A novel arylpropionic derivative, a process for the preparation and the use thereof as an analgesic agent

Publications (1)

Publication Number Publication Date
MD921G2 true MD921G2 (en) 1998-10-31

Family

ID=8278730

Family Applications (1)

Application Number Title Priority Date Filing Date
MD96-0285A MD921G2 (en) 1992-11-10 1993-11-09 Arylpropionic derivatives, process for preparation and the pharmaceutical composition on base thereof

Country Status (26)

Country Link
US (1) US5554789A (en)
EP (1) EP0668851B1 (en)
JP (1) JP3778516B2 (en)
KR (1) KR100284838B1 (en)
AT (1) ATE153649T1 (en)
AU (1) AU674040B2 (en)
BG (1) BG61723B1 (en)
BR (1) BR9307408A (en)
CA (1) CA2149013C (en)
CZ (1) CZ286621B6 (en)
DE (2) DE69311130T2 (en)
DK (1) DK0668851T3 (en)
ES (2) ES2058024B1 (en)
FI (1) FI108637B (en)
GR (2) GR960300012T1 (en)
HU (2) HU217973B (en)
MD (1) MD921G2 (en)
NO (2) NO304306B1 (en)
NZ (1) NZ257557A (en)
PL (1) PL175265B1 (en)
RO (1) RO118712B1 (en)
RU (1) RU2128160C1 (en)
SK (1) SK280550B6 (en)
UA (1) UA44233C2 (en)
UY (1) UY24179A1 (en)
WO (1) WO1994011332A1 (en)

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ES2124196B1 (en) * 1997-06-04 1999-12-01 Menarini Lab PROCEDURE FOR THE MANUFACTURE OF A SEMI-SOLID PHARMACEUTICAL FORM CONTAINING DEXKETOPROPHEN TROMETAMOL AND ITS USE IN THE TOPICAL TREATMENT OF INFLAMMATION.
ATE445838T1 (en) 2001-07-25 2009-10-15 Raptor Pharmaceutical Inc COMPOSITIONS AND METHODS FOR MODULATING TRANSPORT ACROSS THE BLOOD-BRAIN BARRIER
US20080051411A1 (en) * 2002-12-17 2008-02-28 Cink Russell D Salts of Fenofibric Acid and Pharmaceutical Formulations Thereof
WO2004054568A1 (en) * 2002-12-17 2004-07-01 Abbott Gmbh & Co. Kg Formulation comprising fenofibric acid, a physiologically acceptable salt or derivative thereof
CA2789097C (en) 2005-04-28 2017-02-21 Proteus Digital Health, Inc. Pharma-informatics system
EP1739072A1 (en) * 2005-06-15 2007-01-03 Laboratorios Menarini S.A. Polymorphic forms of dexketoprofen trometamol, preparation and pharmaceutical compositions thereof
JP2010503710A (en) 2006-09-18 2010-02-04 ラプトール ファーマシューティカル インコーポレイテッド Treatment of liver damage by administration of receptor-related protein (RAP) conjugates
TWI364413B (en) * 2008-07-25 2012-05-21 Univ Nat Central Racemic ibuprofen amine salt and synthesis method thereof
DK2350082T3 (en) 2008-10-31 2015-04-20 C A I R Biosciences Gmbh Choline and thromethamine salt of licofelone
NZ616673A (en) 2009-02-20 2014-08-29 To Bbb Holding B V Glutathione-based drug delivery system
ES2942923T3 (en) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Dermal delivery compositions comprising complexes of active agent-calcium phosphate particles and methods of use thereof
ES2350670B1 (en) * 2009-06-10 2011-12-07 Polichem, S.L. KETOPROPHENE VETERINARY COMPOSITION
CN101928214B (en) * 2009-06-19 2012-12-19 黄石世星药业有限责任公司 Method for synthesizing dexketoprofen trometamol
EP2475636A1 (en) * 2009-06-30 2012-07-18 Abdi Ibrahim Ilac Sanayi ve Ticaret Anonim Sirketi A process for preparing dexketoprofen trometamol form a and form b crystals
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN102557976B (en) * 2010-12-15 2015-06-10 辽宁盛京制药有限公司 Bromfenac organic salt, and preparation method thereof, composition thereof and application thereof
TR201205317A2 (en) 2011-05-18 2012-12-21 B�Lg�� Mahmut Effervescent formulations containing dexketoprofen.
TR201104864A2 (en) 2011-05-18 2012-12-21 B�Lg�� Mahmut Water-soluble formulations containing dexketoprofen.
CN102381986A (en) * 2011-07-25 2012-03-21 南京特丰药业股份有限公司 Preparation methods of S-(+)-ibuprofen tromethamine salt and oral solution thereof
WO2013022410A2 (en) 2011-08-08 2013-02-14 Mahmut Bilgic Production method for effervescent formulations comprising dexketoprofen
WO2013095315A1 (en) 2011-12-19 2013-06-27 Mahmut Bilgic Formulations comprising dexketoprofen (particle size 300-2500 micrometer)
WO2013100877A1 (en) 2011-12-27 2013-07-04 Mahmut Bilgic Dexketoprofen formulations
ES2501415T3 (en) 2012-06-06 2016-02-22 Galenicum Health S.L. Fast-acting stable pharmaceutical compositions
EP2759293A1 (en) 2013-01-25 2014-07-30 Laboratorios Lesvi, S.L. Pharmaceutical compositions of (+)-(s)-2-(3-benzoylphenyl)propionic acid tromethamine salt
ES2512497T1 (en) 2013-02-06 2014-10-24 Galenicum Health S.L. Process for preparing a stable pharmaceutical composition comprising dexketoprofen trometamol
ITMI20130210A1 (en) 2013-02-14 2014-08-15 Menarini Lab PHARMACEUTICAL COMPOSITIONS CONTAINING DEXKETOPROPHENES AND TRAMADOL
TR201616365A1 (en) 2016-11-14 2018-05-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Oral pharmaceutical compositions of dexketoprofen and eletriptan
AU2017364349A1 (en) 2016-11-28 2019-07-11 Sarin PARAYIL Novel organic crystalline salt of haloacetic acid
TR201618765A2 (en) 2016-12-16 2018-07-23 Imuneks Farma Ilac Sanayi Ve Ticaret Anonim Sirketi Combinations of non-steroidal anti-inflammatory drugs and H2 receptor antagonists for the treatment of pain and inflammation.
KR102552315B1 (en) * 2020-11-11 2023-07-06 대원제약주식회사 Pharmaceutical composition with reduced gastrointestinal disorder comprising novel salt of pelubiprofen as an active ingredient
KR102462607B1 (en) * 2020-11-11 2022-11-03 대원제약주식회사 Pharmaceutical composition with improved stability comprising novel salt of pelubiprofen as an active ingredient
TWI864650B (en) * 2022-03-25 2024-12-01 南韓商日東製藥股份有限公司 Novel salt of glp-1 receptor agonist compound, preparation method thereof and pharmaceutical composition comprising thereof

Citations (16)

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Publication number Priority date Publication date Assignee Title
US427996A (en) * 1890-05-13 houg-hton
US3641127A (en) * 1967-01-27 1972-02-08 Rhone Poulenc Sa (3-benzoylphenyl) alkanoic acids
GB1291386A (en) * 1969-03-24 1972-10-04 Syntex Corp Improvements in or relating to 2-(6'-substituted-2'-naphthyl) propionic acid derivatives and salts thereof
US3821289A (en) * 1972-07-03 1974-06-28 Rorer Inc William H Tetrahydronaphthylalkanoic acids and their derivatives
DE2508895A1 (en) * 1974-03-07 1975-09-18 Prodotti Antibiotici Spa SALT OF PHENYLALCANCARBONIC ACIDS WITH BASIC AMINO ACIDS
GB1408853A (en) * 1972-03-17 1975-10-08 Upjohn Co Medical process and treatment
GB1488778A (en) * 1975-07-28 1977-10-12 Roussel Uclaf Salt of alpha-methyl-(5-benzoyl-2-thiophene)-acetic acid processes for preparing it and compositions containing it
US4097674A (en) * 1975-03-17 1978-06-27 Syntex Corporation 2-Naphthylacetic acid derivatives
EP0008226A2 (en) * 1978-08-08 1980-02-20 Fujisawa Pharmaceutical Co., Ltd. Phenyl-alkanoic acid derivatives, the preparation thereof and pharmaceutical compositions containing them
GB2059768A (en) * 1979-09-27 1981-04-29 Ilona Kahan Water-soluble derivatives of non-steroidal anti-inflammatory agnets and a process for the production thereof
EP0136470A2 (en) * 1983-08-05 1985-04-10 Merckle GmbH Injectable solution for the treatment of inflammations
FR2580641A1 (en) * 1985-04-19 1986-10-24 Seuref Ag ARYLALCANOIC DERIVATIVES OF IMIDAZOLIUM, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
EP0227078A1 (en) * 1985-12-20 1987-07-01 Wisconsin Alumni Research Foundation Process for preparing (S)-alpha-methylarylacetic acids
US4748174A (en) * 1986-01-03 1988-05-31 Therapicon S.R.L. Water soluble salts of an NSAID with meglumine/glucamine
WO1989004658A1 (en) * 1987-11-17 1989-06-01 Abraham Sunshine Onset-hastened/enhanced analgesia using s(+) ketoprofen
EP0396839A2 (en) * 1989-05-12 1990-11-14 American Home Products Corporation Naphthalenepropionic acid salts

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FR1201726A (en) * 1959-06-20 1960-01-05 Process for obtaining flavonic derivatives from the leaves of certain plants
OA04219A (en) * 1971-12-03 1979-12-31 Rhone Poulenc Sa Novel process for the preparation of (3-benzol-phenyl) -2 propionic acid and the like.
FR2278331A1 (en) * 1974-01-24 1976-02-13 Roussel Uclaf NEW CARBOXYLIC ACIDS AND THEIR DERIVATIVES, THEIR APPLICATION AS MEDICINAL PRODUCTS AND THEIR PREPARATION PROCESS
ES455698A1 (en) * 1977-02-07 1978-01-01 Invest Tecnica Aplicada Procedure for the preparation of a new butanolaminic derivative. (Machine-translation by Google Translate, not legally binding)
IT1207420B (en) * 1984-08-06 1989-05-17 Zambon Spa CARBOXYLIC ACIDS. PROCEDURE FOR THE PREPARATION OF
JPH02502534A (en) * 1987-12-18 1990-08-16 チバ‐ガイギー　アクチェンゲゼルシャフト Tromethamine salt of 1-methyl-β-oxo-α-(phenylcarbamoyl)-2-pyrrolepropionitrile

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US427996A (en) * 1890-05-13 houg-hton
US3641127A (en) * 1967-01-27 1972-02-08 Rhone Poulenc Sa (3-benzoylphenyl) alkanoic acids
GB1291386A (en) * 1969-03-24 1972-10-04 Syntex Corp Improvements in or relating to 2-(6'-substituted-2'-naphthyl) propionic acid derivatives and salts thereof
GB1408853A (en) * 1972-03-17 1975-10-08 Upjohn Co Medical process and treatment
US3821289A (en) * 1972-07-03 1974-06-28 Rorer Inc William H Tetrahydronaphthylalkanoic acids and their derivatives
DE2508895A1 (en) * 1974-03-07 1975-09-18 Prodotti Antibiotici Spa SALT OF PHENYLALCANCARBONIC ACIDS WITH BASIC AMINO ACIDS
US4097674A (en) * 1975-03-17 1978-06-27 Syntex Corporation 2-Naphthylacetic acid derivatives
GB1488778A (en) * 1975-07-28 1977-10-12 Roussel Uclaf Salt of alpha-methyl-(5-benzoyl-2-thiophene)-acetic acid processes for preparing it and compositions containing it
EP0008226A2 (en) * 1978-08-08 1980-02-20 Fujisawa Pharmaceutical Co., Ltd. Phenyl-alkanoic acid derivatives, the preparation thereof and pharmaceutical compositions containing them
GB2059768A (en) * 1979-09-27 1981-04-29 Ilona Kahan Water-soluble derivatives of non-steroidal anti-inflammatory agnets and a process for the production thereof
EP0136470A2 (en) * 1983-08-05 1985-04-10 Merckle GmbH Injectable solution for the treatment of inflammations
FR2580641A1 (en) * 1985-04-19 1986-10-24 Seuref Ag ARYLALCANOIC DERIVATIVES OF IMIDAZOLIUM, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
EP0227078A1 (en) * 1985-12-20 1987-07-01 Wisconsin Alumni Research Foundation Process for preparing (S)-alpha-methylarylacetic acids
US4748174A (en) * 1986-01-03 1988-05-31 Therapicon S.R.L. Water soluble salts of an NSAID with meglumine/glucamine
WO1989004658A1 (en) * 1987-11-17 1989-06-01 Abraham Sunshine Onset-hastened/enhanced analgesia using s(+) ketoprofen
EP0396839A2 (en) * 1989-05-12 1990-11-14 American Home Products Corporation Naphthalenepropionic acid salts

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Yamagushi T. et al., Folia Pharmacol. Japon. 90, 2955, 1987. *

Also Published As

Publication number Publication date
EP0668851B1 (en) 1997-05-28
NO951790D0 (en) 1995-05-08
DE69311130D1 (en) 1997-07-03
HU217973B (en) 2000-05-28
HK1006306A1 (en) 1999-02-19
DK0668851T3 (en) 1997-12-22
FI952230A0 (en) 1995-05-09
HU9802850D0 (en) 1999-02-01
CA2149013A1 (en) 1994-05-26
NO951790L (en) 1995-07-06
SK60395A3 (en) 1995-09-13
ES2058024B1 (en) 1995-05-01
SK280550B6 (en) 2000-03-13
HU219975B (en) 2001-10-28
FI952230L (en) 1995-05-09
UY24179A1 (en) 1996-09-03
HU9501375D0 (en) 1995-06-28
RU95112575A (en) 1997-06-20
KR100284838B1 (en) 2001-04-02
JPH08503203A (en) 1996-04-09
CZ114995A3 (en) 1995-10-18
FI108637B (en) 2002-02-28
AU674040B2 (en) 1996-12-05
DE69311130T2 (en) 1997-09-18
WO1994011332A1 (en) 1994-05-26
US5554789A (en) 1996-09-10
CZ286621B6 (en) 2000-05-17
BR9307408A (en) 1999-08-24
BG61723B1 (en) 1998-04-30
UA44233C2 (en) 2002-02-15
JP3778516B2 (en) 2006-05-24
CA2149013C (en) 2004-08-10
NO2006007I1 (en) 2006-08-14
HUT71903A (en) 1996-02-28
EP0668851A1 (en) 1995-08-30
ES2081780T3 (en) 1997-07-01
ES2081780T1 (en) 1996-03-16
NZ257557A (en) 1996-01-26
BG99609A (en) 1996-01-31
DE668851T1 (en) 1996-10-10
GR3024344T3 (en) 1997-10-31
GR960300012T1 (en) 1996-03-31
PL175265B1 (en) 1998-12-31
ES2058024A1 (en) 1994-10-16
RO118712B1 (en) 2003-09-30
NO304306B1 (en) 1998-11-30
ATE153649T1 (en) 1997-06-15
RU2128160C1 (en) 1999-03-27
AU5421094A (en) 1994-06-08
PL308466A1 (en) 1995-07-24

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Legal Events

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MK4A Patent for invention expired