MD839G2 - Biologically active agent having immunomodulating properties, method for its obtaining, preparation based on it and method for normalization of human and animal organism physiological state - Google Patents
Biologically active agent having immunomodulating properties, method for its obtaining, preparation based on it and method for normalization of human and animal organism physiological stateInfo
- Publication number
- MD839G2 MD839G2 MD95-0377A MD950377A MD839G2 MD 839 G2 MD839 G2 MD 839G2 MD 950377 A MD950377 A MD 950377A MD 839 G2 MD839 G2 MD 839G2
- Authority
- MD
- Moldova
- Prior art keywords
- baa
- animal tissue
- obtaining
- biologically active
- base
- Prior art date
Links
- 241001465754 Metazoa Species 0.000 title abstract 10
- 241000282414 Homo sapiens Species 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 238000010606 normalization Methods 0.000 title abstract 4
- 230000035790 physiological processes and functions Effects 0.000 title abstract 4
- 238000002360 preparation method Methods 0.000 title abstract 4
- 239000013543 active substance Substances 0.000 title abstract 3
- 230000002519 immonomodulatory effect Effects 0.000 title abstract 2
- 230000007062 hydrolysis Effects 0.000 abstract 5
- 238000006460 hydrolysis reaction Methods 0.000 abstract 5
- 239000000126 substance Substances 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 2
- 239000000945 filler Substances 0.000 abstract 2
- 210000004517 glycocalyx Anatomy 0.000 abstract 2
- 239000004615 ingredient Substances 0.000 abstract 2
- 230000003248 secreting effect Effects 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000004140 cleaning Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 230000005714 functional activity Effects 0.000 abstract 1
- 238000000265 homogenisation Methods 0.000 abstract 1
- 230000036039 immunity Effects 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 230000000063 preceeding effect Effects 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 230000008929 regeneration Effects 0.000 abstract 1
- 238000011069 regeneration method Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/05—Immunological preparations stimulating the reticulo-endothelial system, e.g. against cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The group of inventions relates to the chemic-pharmaceutical industry, particularly, to the biologically active agents (BAA) obtaining having immunomodulating effect for using in medicine and veterinary science with the aim to normalisate the human and animals physiological body state, particularly, for restabilation of the functional activity of tissues and organs.The biologically active agent (BAA) in accordance with the present invention includes the organic substances on the base of hydrolysis products of the disintegrated animal tissue, particularly, thermostable low-molecular components of morphoplasm and glycocalix cells which are modificated at the embriogenesis, and/or proliferation, and/or cell differenciation, and/or pathology, preceeding, and/or accompanying the regeneration, and/or tissue reparation.Method for BAA obtaining includs disintegration of animal raw tissue, hydrolysis of the obtained ingredients with further hydrolysis products separation, filtration, and secreting the supernatante as the desired product, moreover, before animal tissue hydrolysis is carried out its homogenisation, and cleaning of supernatante from non-disintegrated animal tissue elements with supernatante secreting which contains the ingredients having morphoplasma, and glycocalix cells components.The preparation for normalisation of physiological state of human beings and animals comprises organic substances on the base of the disintegrated animal tissue hydrolysis products in the quantity of 0,001-85,0%, the rest is the filler.Method for normalisation of the physiological state of human beings and animals by injection in the body of the preparation including the organic substance on the base of disintegrated animal tissue hydrolisis products in quantity of 0,001-85,0% and 15,0-99,999% of filler.The technical result consists in the fact that the obtained BAA range and preparations on its base which have the wide application in veterinary science, and medicine may be used for normalisation of physiological states at the deseases treatment, the control of which is carried out by the organism immunity system.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU5063049 RU2041715C1 (en) | 1992-07-21 | 1992-07-21 | Biologically active remedy, method for its producing, preparation containing the mentioned remedy and method for applying the preparation |
| UA93030288A UA2164C2 (en) | 1992-07-21 | 1992-12-17 | Biologically tool that possesses immunomodulating properties, the method of its receipt, drugs based on it AND METHOD FOR NORMALIZATION physiological state of the human body and animals in diseases generated MAINLY pathological AND / OR foreign body cells, microorganisms and / or products of their life, from the use of such THE DRUG |
| PCT/UA1993/000003 WO1994002104A1 (en) | 1992-07-21 | 1993-07-20 | Biologically active agent having immunomodulating properties, method for its obtaining and pharmaceutical preparation based on it |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD839F1 MD839F1 (en) | 1997-09-30 |
| MD839G2 true MD839G2 (en) | 1998-05-31 |
Family
ID=26666279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD95-0377A MD839G2 (en) | 1992-07-21 | 1993-07-20 | Biologically active agent having immunomodulating properties, method for its obtaining, preparation based on it and method for normalization of human and animal organism physiological state |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0673652B1 (en) |
| AT (1) | ATE214283T1 (en) |
| AU (1) | AU4767693A (en) |
| BG (1) | BG61680B1 (en) |
| CA (1) | CA2149146A1 (en) |
| DE (1) | DE69331704T2 (en) |
| HU (1) | HUT73378A (en) |
| MD (1) | MD839G2 (en) |
| PL (1) | PL173321B1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116844160B (en) * | 2023-09-01 | 2023-11-28 | 武汉互创联合科技有限公司 | Embryo development quality assessment system based on main body identification |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU139404A1 (en) * | 1960-12-10 | 1961-11-30 | Н.Г. Беленький | Method for the production of tissue preparations |
| FR2413912A1 (en) * | 1978-01-10 | 1979-08-03 | Bontemps Raymond | Frozen biogenic foetal material in normal saline - for regeneration and re-organisation of cells |
| SU904707A1 (en) * | 1979-06-25 | 1982-02-15 | Ленинградский Ветеринарный Институт | Agent for increasing young stock organism resistancy and method of producing it |
| US4455302A (en) * | 1973-10-24 | 1984-06-19 | Robertson Harry J | Medical protein hydrolysate, process of making the same and processes of utilizing the protein hydrolysate to aid in healing traumatized areas |
| EP0249563A1 (en) * | 1986-06-12 | 1987-12-16 | Gérard Laumond | Embryonic animal organ tissue extracts useful as stimulating agents for human organic metabolic functions |
| SU1442064A3 (en) * | 1983-10-05 | 1988-11-30 | Золько Базель Аг, (Фирма) | Method of producing extract possessing immunomodulating action from animal raw material |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU544136B2 (en) * | 1979-11-22 | 1985-05-16 | Cellena (Cell Engineering) A.G. | A water soluble fraction capable of controlling the immune reactions of a host against allogenic cells or tissue, the pharmaceutical compositions containing said fraction |
| EP0083673B1 (en) * | 1982-01-11 | 1987-06-24 | Theurer, Karl Eugen, Prof.Dr.med. | Products for intravasal application of water-soluble or emulsifiable antigenic organ extracts |
| US4468379A (en) * | 1982-05-06 | 1984-08-28 | Endeavor Corp. | Leukocyte extracts for affecting the immune system |
-
1993
- 1993-07-20 CA CA002149146A patent/CA2149146A1/en not_active Abandoned
- 1993-07-20 AT AT94905611T patent/ATE214283T1/en active
- 1993-07-20 PL PL93308535A patent/PL173321B1/en not_active IP Right Cessation
- 1993-07-20 DE DE69331704T patent/DE69331704T2/en not_active Expired - Lifetime
- 1993-07-20 MD MD95-0377A patent/MD839G2/en not_active IP Right Cessation
- 1993-07-20 HU HU9500410A patent/HUT73378A/en unknown
- 1993-07-20 EP EP94905611A patent/EP0673652B1/en not_active Expired - Lifetime
- 1993-07-20 AU AU47676/93A patent/AU4767693A/en not_active Abandoned
-
1995
- 1995-02-20 BG BG99446A patent/BG61680B1/en unknown
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU139404A1 (en) * | 1960-12-10 | 1961-11-30 | Н.Г. Беленький | Method for the production of tissue preparations |
| US4455302A (en) * | 1973-10-24 | 1984-06-19 | Robertson Harry J | Medical protein hydrolysate, process of making the same and processes of utilizing the protein hydrolysate to aid in healing traumatized areas |
| FR2413912A1 (en) * | 1978-01-10 | 1979-08-03 | Bontemps Raymond | Frozen biogenic foetal material in normal saline - for regeneration and re-organisation of cells |
| SU904707A1 (en) * | 1979-06-25 | 1982-02-15 | Ленинградский Ветеринарный Институт | Agent for increasing young stock organism resistancy and method of producing it |
| SU1442064A3 (en) * | 1983-10-05 | 1988-11-30 | Золько Базель Аг, (Фирма) | Method of producing extract possessing immunomodulating action from animal raw material |
| EP0249563A1 (en) * | 1986-06-12 | 1987-12-16 | Gérard Laumond | Embryonic animal organ tissue extracts useful as stimulating agents for human organic metabolic functions |
Also Published As
| Publication number | Publication date |
|---|---|
| ATE214283T1 (en) | 2002-03-15 |
| DE69331704D1 (en) | 2002-04-18 |
| EP0673652A4 (en) | 1996-07-03 |
| BG61680B1 (en) | 1998-03-31 |
| EP0673652B1 (en) | 2002-03-13 |
| HUT73378A (en) | 1996-07-29 |
| EP0673652A1 (en) | 1995-09-27 |
| CA2149146A1 (en) | 1994-02-03 |
| PL308535A1 (en) | 1995-08-21 |
| AU4767693A (en) | 1994-02-14 |
| HU9500410D0 (en) | 1995-04-28 |
| BG99446A (en) | 1996-03-29 |
| DE69331704T2 (en) | 2002-10-31 |
| PL173321B1 (en) | 1998-02-27 |
| MD839F1 (en) | 1997-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Granted patent for invention | ||
| IF99 | Valid patent on 19990615 |
Free format text: EXPIRES: 20130720 |
|
| KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
| MM4A | Patent for invention definitely lapsed due to non-payment of fees |