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MD4300B1 - Inhibitor of HepG2 cell proliferation in liver cancer based on chloro-[2-phenyl(pyridine-2-yl)methanone-4-(3-methoxyphenyl)thiosemicarbazono]nickel - Google Patents

Inhibitor of HepG2 cell proliferation in liver cancer based on chloro-[2-phenyl(pyridine-2-yl)methanone-4-(3-methoxyphenyl)thiosemicarbazono]nickel Download PDF

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Publication number
MD4300B1
MD4300B1 MDA20120128A MD20120128A MD4300B1 MD 4300 B1 MD4300 B1 MD 4300B1 MD A20120128 A MDA20120128 A MD A20120128A MD 20120128 A MD20120128 A MD 20120128A MD 4300 B1 MD4300 B1 MD 4300B1
Authority
MD
Moldova
Prior art keywords
liver cancer
cell proliferation
inhibitor
hepg2 cell
thiosemicarbazono
Prior art date
Application number
MDA20120128A
Other languages
Romanian (ro)
Russian (ru)
Other versions
MD4300C1 (en
Inventor
Aurelian Gulea
Angela Jalbă
Victor Ţapcov
Sergiu Şova
Donald Poirier
Aliona Cotovaia
Original Assignee
Universitatea De Stat Din Moldova
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universitatea De Stat Din Moldova filed Critical Universitatea De Stat Din Moldova
Priority to MDA20120128A priority Critical patent/MD4300C1/en
Publication of MD4300B1 publication Critical patent/MD4300B1/en
Publication of MD4300C1 publication Critical patent/MD4300C1/en

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Abstract

The invention relates to chemistry, namely to the synthesis of coordinative compounds from the class of thiosemicarbazonates of transition metals and can be used in medicine as cytostatic agent in the prophylaxis and treatment of liver cancer.Summary of the invention consists in the fact that as inhibitor of HepG2 cell proliferation in liver cancer is proposed the use of a new compound, chloro-¢2-phenyl(pyridine-2-yl)methanone-4-(3-methoxyphenyl)thiosemicarbazono]nickel of formula:The claimed compound exhibits itself as an effective inhibitor of HepG2 cell proliferation in liver cancer at concentrations of 10-5 - 10-6 mol/L.
MDA20120128A 2012-12-28 2012-12-28 Inhibitor of HepG2 cell proliferation in liver cancer based on chloro-[2-phenyl(pyridine-2-yl)methanone-4-(3-methoxyphenyl)thiosemicarbazono]nickel MD4300C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MDA20120128A MD4300C1 (en) 2012-12-28 2012-12-28 Inhibitor of HepG2 cell proliferation in liver cancer based on chloro-[2-phenyl(pyridine-2-yl)methanone-4-(3-methoxyphenyl)thiosemicarbazono]nickel

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MDA20120128A MD4300C1 (en) 2012-12-28 2012-12-28 Inhibitor of HepG2 cell proliferation in liver cancer based on chloro-[2-phenyl(pyridine-2-yl)methanone-4-(3-methoxyphenyl)thiosemicarbazono]nickel

Publications (2)

Publication Number Publication Date
MD4300B1 true MD4300B1 (en) 2014-08-31
MD4300C1 MD4300C1 (en) 2015-03-31

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Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20120128A MD4300C1 (en) 2012-12-28 2012-12-28 Inhibitor of HepG2 cell proliferation in liver cancer based on chloro-[2-phenyl(pyridine-2-yl)methanone-4-(3-methoxyphenyl)thiosemicarbazono]nickel

Country Status (1)

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MD (1) MD4300C1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD4407C1 (en) * 2015-04-29 2016-10-31 Государственный Университет Молд0 Inhibitor of human myeloid leukemia HL-60 cells based on bis[N-(prop-2-en-1-yl)-2-(pyridine-2-ylmethylidene)hydrazinecarbothioamide]nickel(II) chloride hydrate

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD890G2 (en) * 1996-06-24 1998-07-31 Николае ЕРЕМИЯ Method for animals immunologic system potetiation
CN102038934B (en) * 2005-11-03 2012-08-29 福建医科大学 Application of cucurmosin in preparation of drug for treating breast cancer
ES2381212T3 (en) * 2006-04-12 2012-05-24 Vertex Pharmaceuticals Incorporated 4,5-Dihydro- [1,2,4] triazolo [4,3-F] pteridines as PLK1 protein kinase inhibitors for the treatment of proliferative disorders
CN100569781C (en) * 2007-12-14 2009-12-16 中国科学院南海海洋研究所 A dimeric flavonoid compound, its preparation method and its application in the preparation of anticancer drugs
CN101204401B (en) * 2007-12-14 2010-05-19 中国科学院南海海洋研究所 A kind of sea urchin extract and its preparation method and anticancer application
CN101333236A (en) * 2008-08-05 2008-12-31 浙江大学 Preparation method of critocin and application in antitumor drugs
CN102219822B (en) * 2011-03-24 2013-01-09 上海交通大学 Ganoderic acid T amide derivative TLTO-A and synthetic method and application thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD4407C1 (en) * 2015-04-29 2016-10-31 Государственный Университет Молд0 Inhibitor of human myeloid leukemia HL-60 cells based on bis[N-(prop-2-en-1-yl)-2-(pyridine-2-ylmethylidene)hydrazinecarbothioamide]nickel(II) chloride hydrate

Also Published As

Publication number Publication date
MD4300C1 (en) 2015-03-31

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FG4A Patent for invention issued
KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees