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MD4014C2 - Polyoxometalate complexes with antitumor activity - Google Patents

Polyoxometalate complexes with antitumor activity Download PDF

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Publication number
MD4014C2
MD4014C2 MDA20090046A MD20090046A MD4014C2 MD 4014 C2 MD4014 C2 MD 4014C2 MD A20090046 A MDA20090046 A MD A20090046A MD 20090046 A MD20090046 A MD 20090046A MD 4014 C2 MD4014 C2 MD 4014C2
Authority
MD
Moldova
Prior art keywords
antitumor activity
synthesis
complex compounds
polyoxometalate
polyoxometalate complex
Prior art date
Application number
MDA20090046A
Other languages
Romanian (ro)
Russian (ru)
Other versions
MD4014B1 (en
Inventor
Татьяна ГУЦУЛ
Анатол ДИМОГЛО
Максим СОКОЛОВ
Севал КОРКМАЗ
Original Assignee
Татьяна ГУЦУЛ
Димогло Анатолий
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Татьяна ГУЦУЛ, Димогло Анатолий filed Critical Татьяна ГУЦУЛ
Priority to MDA20090046A priority Critical patent/MD4014C2/en
Publication of MD4014B1 publication Critical patent/MD4014B1/en
Publication of MD4014C2 publication Critical patent/MD4014C2/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to the synthesis of polyoxometalate complex compounds possessing antitumor activity.Summary of the invention consists in the synthesis of polyoxometalate complex compounds of formula:[N(CH3)4]5+n[Se2W19-nV3+nO71]·mH2O, where n=0 or 2, m=12 or 17, where selenium atoms (IV) are central.The result of the invention consists in the synthesis of polyoxometalate complex compounds possesing 85…92% inhibiting effect of the tumor cells at a concentration of 10…100 µM.
MDA20090046A 2009-04-23 2009-04-23 Polyoxometalate complexes with antitumor activity MD4014C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MDA20090046A MD4014C2 (en) 2009-04-23 2009-04-23 Polyoxometalate complexes with antitumor activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MDA20090046A MD4014C2 (en) 2009-04-23 2009-04-23 Polyoxometalate complexes with antitumor activity

Publications (2)

Publication Number Publication Date
MD4014B1 MD4014B1 (en) 2010-02-26
MD4014C2 true MD4014C2 (en) 2010-09-30

Family

ID=43568899

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20090046A MD4014C2 (en) 2009-04-23 2009-04-23 Polyoxometalate complexes with antitumor activity

Country Status (1)

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MD (1) MD4014C2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD4282C1 (en) * 2012-12-11 2014-11-30 ИНСТИТУТ ЭЛЕКТРОННОЙ ИНЖЕНЕРИИ И НАНОТЕХНОЛОГИЙ "D. Ghitu" АНМ Use of polyoxometalate complexes with central selenium atoms as compounds possessing antitumor activity
DE102015000812A1 (en) 2015-01-21 2016-07-21 Smart Material Printing B.V. Hydrous cleaning and personal care products with biocidal activity
DE102015000813A1 (en) 2015-01-21 2016-07-21 Smart Material Printing B.V. Method of destroying drugs and toxins and their metabolites using polyoxometalate micro and / or nanoparticles
DE102015000814A1 (en) 2015-01-21 2016-07-21 Smart Material Printing B.V. Biocide equipment of articles with polyoxometalate micro and / or nanoparticles
EP3247210A1 (en) 2015-01-21 2017-11-29 Smartmaterialprinting B.V. Biocidal treatment of objects and water-containing cleaning and body-care products with polyoxometalate microparticles and/or nanoparticles
DE102018003906A1 (en) 2018-05-07 2019-11-07 Smart Material Printing Use of polyoxometalates against the infestation of eukaryotic cultures, viral cultures and microorganism populations by mollicutes and mollicutene-inhibiting and killing polyoxometalate-containing substances and processes

Citations (17)

* Cited by examiner, † Cited by third party
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JPS61267514A (en) * 1984-11-20 1986-11-27 Nippon Kayaku Co Ltd Antitumor agent
JPS63107959A (en) * 1985-11-15 1988-05-12 Nippon Kayaku Co Ltd Novel selenium compound
JPH01102023A (en) * 1987-10-16 1989-04-19 Nippon Kayaku Co Ltd Antitumor agent
JPH0228190A (en) * 1988-07-15 1990-01-30 Tsumura & Co Novel selenious acid platinum complex and antitumor agent containing the same complex as active ingredient
JPH02134362A (en) * 1988-11-16 1990-05-23 Nippon Kayaku Co Ltd Novel selenium compound
WO1994005849A1 (en) * 1992-08-28 1994-03-17 THE UNITED STATES OF AMERICA as represented by THE SECRETARY, U.S. DEPARTMENT OF AGRICULTURE Oxidative bleaching of wood pulp by vanadium-substituted polyoxometalates
DE19751637A1 (en) * 1997-10-30 1999-05-06 Alexander Dr Manhart Antitumor medicament containing interleukin II, N-acetyl-cysteine and selenium has T-lymphocyte cytotoxicity stimulating activity
JPH11140067A (en) * 1997-10-20 1999-05-25 Oxis Isle Of Man Ltd Use of new organic selenium compound as proxidant, and preparation thereof, pharmaceutical composition and its application
RU2185819C1 (en) * 2001-10-18 2002-07-27 Дорофеенко Алла Ивановна Agent showing antitumor effect
US6656509B1 (en) * 1998-06-09 2003-12-02 Biosyn Arzneimittel Gmbh Combination of selenium-containing compounds with cytostatics
WO2004014832A2 (en) * 2002-08-02 2004-02-19 Vanetta S.P.A. Redox process particularly for the production of menadione and use of polyoxometalates
US6911470B1 (en) * 1988-09-22 2005-06-28 Raymond F. Schinazi Polyoxometalate compounds as antiviral agents
US20050197399A1 (en) * 2003-05-13 2005-09-08 Marwan Fakih Method of augmenting the antitumor activity of anticancer agents
GB2417685A (en) * 2003-05-13 2006-03-08 Health Research Inc Method for augmenting the antitumor activity of anti-cancer agents
US20060258697A1 (en) * 2003-05-13 2006-11-16 Rustum Youcef M Method of augmenting the antitumor activity of anticancer agents
CN101148445A (en) * 2007-01-26 2008-03-26 温州医学院 Method for preparing o-dihydroxyflavone-selenium complexes and medical use
RU2324688C2 (en) * 2001-06-08 2008-05-20 Пекинь Юниверсити Bis-benzizo selenium zolonyl derivatives with antitumor, antiinflammatory and antithrombotic activity and their application

Patent Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61267514A (en) * 1984-11-20 1986-11-27 Nippon Kayaku Co Ltd Antitumor agent
JPS63107959A (en) * 1985-11-15 1988-05-12 Nippon Kayaku Co Ltd Novel selenium compound
JPH01102023A (en) * 1987-10-16 1989-04-19 Nippon Kayaku Co Ltd Antitumor agent
JPH0228190A (en) * 1988-07-15 1990-01-30 Tsumura & Co Novel selenious acid platinum complex and antitumor agent containing the same complex as active ingredient
US6911470B1 (en) * 1988-09-22 2005-06-28 Raymond F. Schinazi Polyoxometalate compounds as antiviral agents
JPH02134362A (en) * 1988-11-16 1990-05-23 Nippon Kayaku Co Ltd Novel selenium compound
WO1994005849A1 (en) * 1992-08-28 1994-03-17 THE UNITED STATES OF AMERICA as represented by THE SECRETARY, U.S. DEPARTMENT OF AGRICULTURE Oxidative bleaching of wood pulp by vanadium-substituted polyoxometalates
JPH11140067A (en) * 1997-10-20 1999-05-25 Oxis Isle Of Man Ltd Use of new organic selenium compound as proxidant, and preparation thereof, pharmaceutical composition and its application
DE19751637A1 (en) * 1997-10-30 1999-05-06 Alexander Dr Manhart Antitumor medicament containing interleukin II, N-acetyl-cysteine and selenium has T-lymphocyte cytotoxicity stimulating activity
US6656509B1 (en) * 1998-06-09 2003-12-02 Biosyn Arzneimittel Gmbh Combination of selenium-containing compounds with cytostatics
RU2324688C2 (en) * 2001-06-08 2008-05-20 Пекинь Юниверсити Bis-benzizo selenium zolonyl derivatives with antitumor, antiinflammatory and antithrombotic activity and their application
RU2185819C1 (en) * 2001-10-18 2002-07-27 Дорофеенко Алла Ивановна Agent showing antitumor effect
WO2004014832A2 (en) * 2002-08-02 2004-02-19 Vanetta S.P.A. Redox process particularly for the production of menadione and use of polyoxometalates
US20050197399A1 (en) * 2003-05-13 2005-09-08 Marwan Fakih Method of augmenting the antitumor activity of anticancer agents
GB2417685A (en) * 2003-05-13 2006-03-08 Health Research Inc Method for augmenting the antitumor activity of anti-cancer agents
US20060258697A1 (en) * 2003-05-13 2006-11-16 Rustum Youcef M Method of augmenting the antitumor activity of anticancer agents
CN101148445A (en) * 2007-01-26 2008-03-26 温州医学院 Method for preparing o-dihydroxyflavone-selenium complexes and medical use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Prudent R., Moucadel V., Laudet B., Barette C., Lafanechere L., Hasenknopf B., Li J., Bareyt S., Lacote E., Thorimbert S., Malacria M., Gouzerh P., Cochet C. Identification of polyoxometalates as nanomolar noncompetitive inhibitors of protein kinase CK2. Chemistry & Biology, 2008, vol. 15, p. 683…692. *

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Publication number Publication date
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FG4A Patent for invention issued
KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees