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MA60224B1 - Compositions, méthodes et systèmes pour l'administration d'un médicament en aérosol - Google Patents

Compositions, méthodes et systèmes pour l'administration d'un médicament en aérosol

Info

Publication number
MA60224B1
MA60224B1 MA60224A MA60224A MA60224B1 MA 60224 B1 MA60224 B1 MA 60224B1 MA 60224 A MA60224 A MA 60224A MA 60224 A MA60224 A MA 60224A MA 60224 B1 MA60224 B1 MA 60224B1
Authority
MA
Morocco
Prior art keywords
compositions
systems
methods
acting
drug delivery
Prior art date
Application number
MA60224A
Other languages
English (en)
Inventor
David Lechuga-Ballesteros
Vidya JOSHI
James ARCHBELL
Kellisa LACHACZ
Charina LAMPA
Lauren MELLO
Gertrude GUTIERREZ
Penny Tan
Michael Riebe
Original Assignee
Astrazeneca Pharmaceuticals Lp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=82748203&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA60224(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Pharmaceuticals Lp filed Critical Astrazeneca Pharmaceuticals Lp
Publication of MA60224B1 publication Critical patent/MA60224B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/16—Fluorine compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0013—Details of inhalators; Constructional features thereof with inhalation check valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des compositions, des méthodes et des systèmes pour l'administration par voie pulmonaire de principes actifs par l'intermédiaire d'un aérosol-doseur. Dans certains modes de réalisation, les compositions comprennent un milieu de suspension de HFO-1234ze(E), des particules de principe actif et des particules de suspension. Les particules de principe actif peuvent comprendre un, deux, trois ou quatre principes actifs choisis parmi un antagoniste muscarinique à longue durée d'action (AMLA), un β2-agoniste à longue durée d'action (LABA), un β-agoniste à courte durée d'action (SABA), un corticostéroïde inhalé (CSI) et un agent anti-inflammatoire non corticostéroïde.
MA60224A 2021-07-09 2022-07-08 Compositions, méthodes et systèmes pour l'administration d'un médicament en aérosol MA60224B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202163220362P 2021-07-09 2021-07-09
US202163282356P 2021-11-23 2021-11-23
PCT/US2022/036542 WO2023283438A1 (fr) 2021-07-09 2022-07-08 Compositions, méthodes et systèmes pour l'administration d'un médicament en aérosol
EP22751897.4A EP4175620B1 (fr) 2021-07-09 2022-07-08 Compositions, méthodes et systèmes pour l'administration d'un médicament en aérosol

Publications (1)

Publication Number Publication Date
MA60224B1 true MA60224B1 (fr) 2024-06-28

Family

ID=82748203

Family Applications (3)

Application Number Title Priority Date Filing Date
MA61888A MA61888B1 (fr) 2021-07-09 2022-07-08 Compositions, procédés et systèmes pour l'administration de médicament en aérosol
MA60223A MA60223B1 (fr) 2021-07-09 2022-07-08 Compositions, procédés et systèmes pour l'administration d'un médicament en aérosol
MA60224A MA60224B1 (fr) 2021-07-09 2022-07-08 Compositions, méthodes et systèmes pour l'administration d'un médicament en aérosol

Family Applications Before (2)

Application Number Title Priority Date Filing Date
MA61888A MA61888B1 (fr) 2021-07-09 2022-07-08 Compositions, procédés et systèmes pour l'administration de médicament en aérosol
MA60223A MA60223B1 (fr) 2021-07-09 2022-07-08 Compositions, procédés et systèmes pour l'administration d'un médicament en aérosol

Country Status (28)

Country Link
US (5) US20240358662A1 (fr)
EP (6) EP4393478A3 (fr)
JP (3) JP2024525567A (fr)
KR (3) KR20240042437A (fr)
AU (3) AU2022306682A1 (fr)
CA (3) CA3226153A1 (fr)
CL (3) CL2024000041A1 (fr)
CO (3) CO2024000631A2 (fr)
CR (3) CR20240063A (fr)
DK (3) DK4175620T3 (fr)
DO (3) DOP2024000004A (fr)
EC (1) ECSP24011022A (fr)
ES (3) ES2983201T3 (fr)
FI (3) FI4175619T3 (fr)
HR (3) HRP20240725T1 (fr)
HU (3) HUE067547T2 (fr)
IL (3) IL309908A (fr)
LT (3) LT4175620T (fr)
MA (3) MA61888B1 (fr)
MX (3) MX2024000468A (fr)
PE (3) PE20240807A1 (fr)
PL (3) PL4175620T3 (fr)
PT (3) PT4175619T (fr)
RS (3) RS65597B1 (fr)
SI (3) SI4197528T1 (fr)
SM (3) SMT202400368T1 (fr)
TW (3) TW202317079A (fr)
WO (3) WO2023283439A1 (fr)

Families Citing this family (9)

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CN119836292A (zh) * 2022-04-28 2025-04-15 阿斯利康(瑞典)有限公司 用于治疗哮喘的沙丁胺醇和布地奈德的组合物和方法
CN116270464B (zh) * 2023-03-01 2025-09-30 深圳市贝美药业有限公司 一种克立硼罗气雾剂及其制备方法
FR3150798B1 (fr) 2023-07-07 2025-11-21 Aptar France Sas Dispositif de distribution de produit fluide
WO2025179179A1 (fr) * 2024-02-23 2025-08-28 Astrazeneca Ab Polythérapie à triple combinaison pour bpco
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US12383516B1 (en) 2025-01-06 2025-08-12 Amphastar Pharmaceuticals, Inc. Albuterol aerosol suspension formulation for oral inhalation with high amount of green propellant hydrofluoroolefin (HFO) and free of co-solvent

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Also Published As

Publication number Publication date
US20240252432A1 (en) 2024-08-01
SI4175619T1 (sl) 2024-08-30
PT4197528T (pt) 2024-06-06
ES2981709T3 (es) 2024-10-10
EP4393478A3 (fr) 2024-09-11
PT4175620T (pt) 2024-06-21
EP4197528B1 (fr) 2024-04-03
RS65537B1 (sr) 2024-06-28
EP4175620B1 (fr) 2024-04-10
CA3226557A1 (fr) 2023-01-12
IL309908A (en) 2024-03-01
TW202317081A (zh) 2023-05-01
HUE067283T2 (hu) 2024-10-28
KR20240042436A (ko) 2024-04-02
IL309907A (en) 2024-03-01
HUE067547T2 (hu) 2024-10-28
WO2023283441A1 (fr) 2023-01-12
PL4175620T3 (pl) 2024-08-05
MX2024000468A (es) 2024-04-05
US20230026203A1 (en) 2023-01-26
RS65597B1 (sr) 2024-06-28
SI4175620T1 (sl) 2024-08-30
CA3226155A1 (fr) 2023-01-12
AU2022305962A1 (en) 2024-01-25
US20240325298A1 (en) 2024-10-03
JP2024527348A (ja) 2024-07-24
HRP20240753T1 (hr) 2024-09-13
WO2023283439A1 (fr) 2023-01-12
PE20240808A1 (es) 2024-04-18
PE20241067A1 (es) 2024-05-13
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