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MA47082B1 - Amides aromatiques d'acide carboxylique en tant qu'antagonistes des recepteurs bradykinin b1 - Google Patents

Amides aromatiques d'acide carboxylique en tant qu'antagonistes des recepteurs bradykinin b1

Info

Publication number
MA47082B1
MA47082B1 MA47082A MA47082A MA47082B1 MA 47082 B1 MA47082 B1 MA 47082B1 MA 47082 A MA47082 A MA 47082A MA 47082 A MA47082 A MA 47082A MA 47082 B1 MA47082 B1 MA 47082B1
Authority
MA
Morocco
Prior art keywords
carboxylic acid
aromatic carboxylic
bradykinin
acid amides
receptor antagonists
Prior art date
Application number
MA47082A
Other languages
English (en)
Other versions
MA47082A (fr
Inventor
Andrea Rotgeri
Stefan BÄURLE
Jens Nagel
Jürgen Klar
Alexandra Rausch
Nicole Schmidt
Adam Davenport
Christopher Stimson
Ina Gröticke
Thomas Dyrks
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of MA47082A publication Critical patent/MA47082A/fr
Publication of MA47082B1 publication Critical patent/MA47082B1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

La présente invention concerne des composés amides aromatique d'acide carboxylique représentés par la formule générale (i) tel que décrit et défini dans la description, des compositions pharmaceutiques et des associations comprenant lesdits composés et l'utilisation desdits composés pour la fabrication d'une composition pharmaceutique destinée au traitement ou à la prophylaxie d'une maladie, en tant qu'agent unique ou en association avec d'autres principes actifs.
MA47082A 2016-12-23 2017-12-18 Amides aromatiques d'acide carboxylique en tant qu'antagonistes des recepteurs bradykinin b1 MA47082B1 (fr)

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EP16206750 2016-12-23
PCT/EP2017/083290 WO2018114786A1 (fr) 2016-12-23 2017-12-18 Amides aromatiques d'acide carboxylique en tant qu'antagonistes du récepteur de la bradykinine b1

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MA47082A MA47082A (fr) 2019-10-30
MA47082B1 true MA47082B1 (fr) 2022-11-30

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US12023319B2 (en) * 2016-12-23 2024-07-02 Bayer Pharma Aktiengesellschaft Carboxylic acid aromatic amides
TW202317519A (zh) 2021-07-05 2023-05-01 德商拜耳廠股份有限公司 2-(1-環丁基-1h-吡唑-4-基)-5-[({1-[2-氟-4-(三氟甲基)-苯基]環丙基}羰基)胺基]苯甲酸之膽鹼鹽
TW202321219A (zh) 2021-08-11 2023-06-01 大陸商四川海思科製藥有限公司 雜環衍生物及其組合物和藥學上的應用
WO2023054626A1 (fr) * 2021-09-30 2023-04-06 住友ファーマ株式会社 Dérivé de cyclopropanamide
CN114591338B (zh) * 2022-03-31 2023-05-09 苏州欧康维视生物科技有限公司 一种Syk和VEGFR2双靶点抑制剂的制备方法及其用途

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GB0102687D0 (en) 2001-02-02 2001-03-21 Pharmacia & Upjohn Spa Oxazolyl-pyrazole derivatives active as kinase inhibitors,process for their preparation and pharmaceutical compositions comprising them
CA2473778A1 (fr) 2002-02-08 2003-08-14 Merck & Co., Inc. Derives de n-biphenylmethyl aminocycloalcanecarboxamide
US20070124389A1 (en) 2005-11-28 2007-05-31 Lucent Technologies Inc. Anti-spam application storage system
ES2398319T3 (es) 2005-12-28 2013-03-15 Vertex Pharmaceuticals Incorporated Derivados de 1-(benzo[D][1,3]dioxol-5-il)-N-(fenil)ciclopropano-carboxamida y compuestos relacionados como moduladores de transportadores de casetes de unión a ATP para el tratamiento de la fibrosis quística
AR068509A1 (es) 2007-09-19 2009-11-18 Jerini Ag Antagosnistas del receptor de bradiquinina b1
TW201217312A (en) * 2010-09-22 2012-05-01 Gruenenthal Gmbh Substituted benzamide compounds
HUP1000598A2 (en) * 2010-11-05 2012-09-28 Richter Gedeon Nyrt Indole derivatives
US9062013B2 (en) * 2011-02-02 2015-06-23 Bionomics Limited Positive allosteric modulators of the α7 nicotinic acetylcholine receptor and uses thereof
WO2012112363A1 (fr) 2011-02-14 2012-08-23 Merck Sharp & Dohme Corp. Inhibiteurs de cystéine protéases, les cathepsines
WO2012112567A1 (fr) 2011-02-15 2012-08-23 Georgetown University Inhibiteurs d'agbl2 à petite molécule
EP2862860B1 (fr) * 2012-06-15 2016-12-21 Taisho Pharmaceutical Co., Ltd. COMPOSés de 1,3-OXAZOLIDINE OU 1,3-OXAZINANE COMME ANTAGONISTES DU RéCEPTEUR DE L'ORéXINE
HUE064656T2 (hu) 2016-03-28 2024-04-28 Incyte Corp Pirrolotriazin vegyületek mint TAM inhibitorok
HRP20241686T1 (hr) 2016-12-23 2025-02-14 Heidelberg Pharma Research Gmbh Konjugati amanitina s protutijelom

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EA201991490A1 (ru) 2019-12-30
ECSP19044591A (es) 2019-06-30
MA47082A (fr) 2019-10-30
HRP20220132T1 (hr) 2022-04-15
CN115068468B (zh) 2025-02-25
WO2018114786A1 (fr) 2018-06-28
CN115137726B (zh) 2024-08-13
CN115073421B (zh) 2023-12-19
HUE057973T2 (hu) 2022-06-28
GEP20227378B (en) 2022-05-10
MX2019007647A (es) 2019-09-16
TWI762542B (zh) 2022-05-01
PL3558960T3 (pl) 2022-05-02
AR110432A1 (es) 2019-03-27
PE20191249A1 (es) 2019-09-18
DK3558960T3 (da) 2022-03-21
CU24528B1 (es) 2021-06-08
CR20190298A (es) 2019-08-21
NI201900063A (es) 2019-10-29
RS62999B1 (sr) 2022-03-31
EP3558960B1 (fr) 2022-01-05
IL267440A (en) 2019-08-29
PH12019501424B1 (en) 2023-08-04
BR112019012920A2 (pt) 2019-12-31
CA3047815A1 (fr) 2018-06-28
ES2908638T3 (es) 2022-05-03
CU20190062A7 (es) 2020-02-04
KR20190100944A (ko) 2019-08-29
NZ754079A (en) 2024-12-20
AU2017381629A1 (en) 2019-06-20
JP2020502213A (ja) 2020-01-23
PH12019501424A1 (en) 2020-02-10
US11905270B2 (en) 2024-02-20
KR102542790B1 (ko) 2023-06-15
CN110325523A (zh) 2019-10-11
AU2017381629B2 (en) 2022-01-20
CN115068468A (zh) 2022-09-20
JOP20190156B1 (ar) 2023-09-17
TW201831449A (zh) 2018-09-01
LT3558960T (lt) 2022-02-25
EP3558960A1 (fr) 2019-10-30
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UY37538A (es) 2018-07-31
EA039447B1 (ru) 2022-01-27
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