MA45639B1 - Combinaison d'antagonistes purs du récepteur 5-ht6 avec des inhibiteurs d'acétylcholinestérase - Google Patents
Combinaison d'antagonistes purs du récepteur 5-ht6 avec des inhibiteurs d'acétylcholinestéraseInfo
- Publication number
- MA45639B1 MA45639B1 MA45639A MA45639A MA45639B1 MA 45639 B1 MA45639 B1 MA 45639B1 MA 45639 A MA45639 A MA 45639A MA 45639 A MA45639 A MA 45639A MA 45639 B1 MA45639 B1 MA 45639B1
- Authority
- MA
- Morocco
- Prior art keywords
- combination
- pure
- receptor antagonists
- acetylcholinesterase inhibitors
- treatment
- Prior art date
Links
- 108091005435 5-HT6 receptors Proteins 0.000 title abstract 2
- 239000000544 cholinesterase inhibitor Substances 0.000 title abstract 2
- 239000002464 receptor antagonist Substances 0.000 title abstract 2
- 229940044551 receptor antagonist Drugs 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000002671 adjuvant Substances 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/305—Mercury compounds
- A61K31/31—Mercury compounds containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
Abstract
La présente invention concerne des antagonistes purs du récepteur 5-ht6, ou un/des sel(s) pharmaceutiquement acceptable(s) de ceux-ci en combinaison avec ou en tant qu'adjuvants d'inhibiteurs d'acétylcholinestérase et leur utilisation dans le traitement de troubles cognitifs. L'invention concerne en outre la composition pharmaceutique contenant ladite combinaison.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201641017205 | 2016-05-18 | ||
| PCT/IB2016/054673 WO2017199071A1 (fr) | 2016-05-18 | 2016-08-03 | Combinaison d'antagonistes purs du récepteur 5-ht6 avec des inhibiteurs d'acétylcholinestérase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA45639B1 true MA45639B1 (fr) | 2020-06-30 |
Family
ID=56940098
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA45639A MA45639B1 (fr) | 2016-05-18 | 2016-08-03 | Combinaison d'antagonistes purs du récepteur 5-ht6 avec des inhibiteurs d'acétylcholinestérase |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US11458135B2 (fr) |
| EP (1) | EP3484467B1 (fr) |
| JP (1) | JP6606299B2 (fr) |
| KR (1) | KR102015484B1 (fr) |
| CN (2) | CN114642667A (fr) |
| AU (1) | AU2016407427B2 (fr) |
| BR (1) | BR112018073419A2 (fr) |
| CA (1) | CA3023819C (fr) |
| CY (1) | CY1123013T1 (fr) |
| DK (1) | DK3484467T3 (fr) |
| EA (1) | EA036347B1 (fr) |
| ES (1) | ES2796181T3 (fr) |
| HR (1) | HRP20200872T1 (fr) |
| HU (1) | HUE050819T2 (fr) |
| IL (1) | IL262921B (fr) |
| LT (1) | LT3484467T (fr) |
| MA (1) | MA45639B1 (fr) |
| MD (1) | MD3484467T2 (fr) |
| ME (1) | ME03731B (fr) |
| MX (1) | MX381768B (fr) |
| NZ (1) | NZ748280A (fr) |
| PL (1) | PL3484467T3 (fr) |
| PT (1) | PT3484467T (fr) |
| RS (1) | RS60422B1 (fr) |
| SG (1) | SG11201809856SA (fr) |
| SI (1) | SI3484467T1 (fr) |
| SM (1) | SMT202000292T1 (fr) |
| WO (1) | WO2017199071A1 (fr) |
| ZA (1) | ZA201807468B (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111084776A (zh) * | 2018-10-24 | 2020-05-01 | 中国科学院昆明动物研究所 | 匹立尼酸及其衍生物用于治疗和/或预防神经退行性疾病的用途 |
| CN111084768A (zh) * | 2018-10-24 | 2020-05-01 | 中国科学院昆明动物研究所 | 吉非罗齐及其衍生物用于治疗和/或预防神经退行性疾病的用途 |
| HRP20250882T1 (hr) | 2019-12-02 | 2025-09-26 | Suven Life Sciences Limited | Kombinacije masupirdina sa donepezilom ili memantinom za liječenje bihevioralnih i psiholoških simptoma kod pacijenata sa demencijom |
| MX2022006535A (es) * | 2019-12-02 | 2022-09-09 | Suven Life Sciences Ltd | Métodos para tratar síntomas de comportamiento y psicológicos en pacientes con demencia. |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ540840A (en) * | 2002-11-28 | 2008-12-24 | Suven Life Sciences Ltd | N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them |
| SI1581538T1 (sl) * | 2002-12-18 | 2007-08-31 | Suven Life Sciences Ltd | Tetraciklični 3-substituirani indoli z afiniteto za receptor serotonina |
| PE20071143A1 (es) * | 2006-01-13 | 2008-01-20 | Wyeth Corp | Composicion farmaceutica que comprende un inhibidor de acetilcolinesterasa y un antagonista 5-hidroxitriptamina-6 |
| US20100120747A1 (en) * | 2006-06-23 | 2010-05-13 | Laboratorios Del Dr. Esteve, S.A. | Combination of a cholinesterase inhibitor and a compound with 5-ht6 receptor affinity |
| AR061637A1 (es) | 2006-06-26 | 2008-09-10 | Epix Delaware Inc | Composiciones y metodos de tratamiento de trastornos del snc |
| JO3459B1 (ar) | 2012-09-09 | 2020-07-05 | H Lundbeck As | تركيبات صيدلانية لعلاج مرض الزهايمر |
| DK3077375T3 (en) | 2013-12-02 | 2017-09-11 | Suven Life Sciences Ltd | PROCEDURE FOR LARGE SCALE PREPARATION OF 1 - [(2-BROMPHENYL) SULPHONYL] -5-METHOXY-3 - [(4-METHYL-1-PIPERAZINYL) METHYL] -1H-INDOL-DIMESYLATE-MONOHYDRATE |
| JP6629322B2 (ja) * | 2014-08-16 | 2020-01-15 | スヴェン・ライフ・サイエンシズ・リミテッド | １−［（２−ブロモフェニル）スルフォニル］−５−メトキシ−３−［（４−メチル−１−ピペラジニル）メチル］−１ｈ−インドールジメシレート一水和物の活性代謝産物及びその活性代謝産物のジメシレート二水和物の塩 |
-
2016
- 2016-08-03 SI SI201630791T patent/SI3484467T1/sl unknown
- 2016-08-03 MX MX2018014185A patent/MX381768B/es unknown
- 2016-08-03 ES ES16766622T patent/ES2796181T3/es active Active
- 2016-08-03 KR KR1020187035983A patent/KR102015484B1/ko active Active
- 2016-08-03 EA EA201892529A patent/EA036347B1/ru unknown
- 2016-08-03 CN CN202210321209.2A patent/CN114642667A/zh active Pending
- 2016-08-03 SG SG11201809856SA patent/SG11201809856SA/en unknown
- 2016-08-03 ME MEP-2020-109A patent/ME03731B/fr unknown
- 2016-08-03 JP JP2018559336A patent/JP6606299B2/ja active Active
- 2016-08-03 SM SM20200292T patent/SMT202000292T1/it unknown
- 2016-08-03 NZ NZ748280A patent/NZ748280A/en unknown
- 2016-08-03 PL PL16766622T patent/PL3484467T3/pl unknown
- 2016-08-03 HR HRP20200872TT patent/HRP20200872T1/hr unknown
- 2016-08-03 LT LTEP16766622.1T patent/LT3484467T/lt unknown
- 2016-08-03 CA CA3023819A patent/CA3023819C/fr active Active
- 2016-08-03 MA MA45639A patent/MA45639B1/fr unknown
- 2016-08-03 AU AU2016407427A patent/AU2016407427B2/en active Active
- 2016-08-03 CN CN201680085574.0A patent/CN109069468A/zh active Pending
- 2016-08-03 MD MDE20190594T patent/MD3484467T2/ro unknown
- 2016-08-03 WO PCT/IB2016/054673 patent/WO2017199071A1/fr not_active Ceased
- 2016-08-03 DK DK16766622.1T patent/DK3484467T3/da active
- 2016-08-03 RS RS20200635A patent/RS60422B1/sr unknown
- 2016-08-03 US US16/099,161 patent/US11458135B2/en active Active
- 2016-08-03 HU HUE16766622A patent/HUE050819T2/hu unknown
- 2016-08-03 BR BR112018073419-5A patent/BR112018073419A2/pt not_active Application Discontinuation
- 2016-08-03 PT PT167666221T patent/PT3484467T/pt unknown
- 2016-08-03 EP EP16766622.1A patent/EP3484467B1/fr active Active
-
2018
- 2018-11-07 ZA ZA2018/07468A patent/ZA201807468B/en unknown
- 2018-11-11 IL IL262921A patent/IL262921B/en active IP Right Grant
-
2020
- 2020-05-29 CY CY20201100489T patent/CY1123013T1/el unknown
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