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MA42301B1 - Sel cristallin de fumarate de (s)-[3,4-difluoro-2-(2-fluoro-4-iodophénylamino)phényl][3-hydroxy-3-(pipéridin-2-yl)azétidin-1-yl]-méthanone - Google Patents

Sel cristallin de fumarate de (s)-[3,4-difluoro-2-(2-fluoro-4-iodophénylamino)phényl][3-hydroxy-3-(pipéridin-2-yl)azétidin-1-yl]-méthanone

Info

Publication number
MA42301B1
MA42301B1 MA42301A MA42301A MA42301B1 MA 42301 B1 MA42301 B1 MA 42301B1 MA 42301 A MA42301 A MA 42301A MA 42301 A MA42301 A MA 42301A MA 42301 B1 MA42301 B1 MA 42301B1
Authority
MA
Morocco
Prior art keywords
iodophenylamino
azetidin
piperidin
fluoro
hydroxy
Prior art date
Application number
MA42301A
Other languages
English (en)
Other versions
MA42301A (fr
Inventor
Adrian St. Clair BROWN
Original Assignee
Exelixis, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=56411938&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA42301(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Exelixis, Inc. filed Critical Exelixis, Inc.
Publication of MA42301A publication Critical patent/MA42301A/fr
Publication of MA42301B1 publication Critical patent/MA42301B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne le sel cristallin de fumarate de (S)-[3,4-difluoro-2-(2-fluoro-4-iodophénylamino)phényl][3-hydroxy-3-(pipéridin-2-yl)azétidin-1-yl]-méthanone. L'invention concerne également des compositions pharmaceutiques comprenant le sel cristallin de fumarate de (S)-[3,4-difluoro-2-(2-fluoro-4-iodophénylamino)phényl][3-hydroxy-3-(pipéridin-2-yl)azétidin-1-yl]-méthanone. L'invention concerne également des procédés de traitement de cancers comprenant l'administration à un patient qui en a besoin du sel cristallin de fumarate de (S)-[3,4-difluoro-2-(2-fluoro-4-iodophénylamino)phényl][3-hydroxy-3-(pipéridin-2-yl)azétidin-1-yl]-méthanone.
MA42301A 2015-06-30 2016-06-30 Sel cristallin de fumarate de (s)-[3,4-difluoro-2-(2-fluoro-4-iodophénylamino)phényl][3-hydroxy-3-(pipéridin-2-yl)azétidin-1-yl]-méthanone MA42301B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562187009P 2015-06-30 2015-06-30
PCT/US2016/040444 WO2017004393A1 (fr) 2015-06-30 2016-06-30 Sel cristallin de fumarate de (s)-[3,4-difluoro-2-(2-fluoro-4-iodophénylamino)phényl][3-hydroxy-3-(pipéridin-2-yl)azétidin-1-yl]-méthanone
EP16738971.7A EP3317264B1 (fr) 2015-06-30 2016-06-30 Sel cristallin de fumarate de (s)-[3,4-difluoro-2-(2-fluoro-4-iodophénylamino)phényl][3-hydroxy-3-(pipéridin-2-yl)azétidin-1-yl]-méthanone

Publications (2)

Publication Number Publication Date
MA42301A MA42301A (fr) 2018-05-09
MA42301B1 true MA42301B1 (fr) 2025-12-31

Family

ID=56411938

Family Applications (1)

Application Number Title Priority Date Filing Date
MA42301A MA42301B1 (fr) 2015-06-30 2016-06-30 Sel cristallin de fumarate de (s)-[3,4-difluoro-2-(2-fluoro-4-iodophénylamino)phényl][3-hydroxy-3-(pipéridin-2-yl)azétidin-1-yl]-méthanone

Country Status (31)

Country Link
US (3) US10590102B2 (fr)
EP (1) EP3317264B1 (fr)
JP (3) JP7338950B2 (fr)
KR (1) KR102695324B1 (fr)
CN (2) CN118290395A (fr)
AR (1) AR105483A1 (fr)
AU (2) AU2016288209B2 (fr)
CA (1) CA2990222C (fr)
CL (1) CL2017003475A1 (fr)
CO (1) CO2018000086A2 (fr)
CR (1) CR20180056A (fr)
DK (1) DK3317264T3 (fr)
FI (1) FI3317264T3 (fr)
HK (1) HK1252433A1 (fr)
HR (1) HRP20251507T1 (fr)
IL (2) IL256423B (fr)
LT (1) LT3317264T (fr)
MA (1) MA42301B1 (fr)
MX (1) MX390250B (fr)
MY (1) MY192545A (fr)
PE (1) PE20180692A1 (fr)
PH (1) PH12017502414A1 (fr)
PT (1) PT3317264T (fr)
RS (1) RS67509B1 (fr)
RU (2) RU2021132394A (fr)
SG (1) SG10202105196YA (fr)
SM (1) SMT202500458T1 (fr)
TW (2) TWI710556B (fr)
UA (1) UA124728C2 (fr)
WO (1) WO2017004393A1 (fr)
ZA (1) ZA201708760B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ706723A (en) 2012-10-12 2018-07-27 Exelixis Inc Novel process for making compounds for use in the treatment of cancer
AR105483A1 (es) 2015-06-30 2017-10-11 Exelixis Inc Sal de fumarato cristalina de (s)-[3,4-difluoro-2-(2-fluoro-4-yodofenilamino)fenil][3-hidroxi-3-(piperidin-2-il)azetidin-1-il]-metanona
EP4272735B1 (fr) * 2015-06-30 2025-06-18 Genentech, Inc. Comprimés à libération immédiate contenant un médicament et procédés de formation des comprimés
ES2928773T3 (es) 2017-01-17 2022-11-22 Heparegenix Gmbh Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos
GB201717809D0 (en) * 2017-10-30 2017-12-13 Azad Pharmaceutical Ingredients Ag Process for the production of cobimetinib
WO2020187674A1 (fr) 2019-03-15 2020-09-24 Sandoz Ag Hémisuccinate de (s)-[3,4-difluoro-2-(2-fluoro-4-iodophénylamino)phényl][3-hydroxy-3-(pipéridin-2-yl) azétidin-1-yl]méthanone cristallin
WO2024111001A1 (fr) * 2022-11-25 2024-05-30 Msn Laboratories Private Limited, R&D Center Formes cristallines de fumarate de n-(4-(6,7-diméthoxyquinoléin-4-yloxy)phényl)-n'-(4-fluorophényl)cyclopropane-1,1-dicarboxamide et leur procédé de préparation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA94571C2 (en) 2004-10-20 2011-05-25 Мерк Сероно С.А. 3-arylamino pyridine derivatives
BRPI0611375A2 (pt) 2005-05-23 2010-08-31 Novartis Ag formas cristalinas e outras de sais de ácido láctico de 4-amino-5-flúor-3-[6-(4-metilpiperazin-1-il)-1h-benzimid azol-2-il]-1h-quinolin-2-ona
NZ567140A (en) 2005-10-07 2011-09-30 Exelixis Inc Azetidines as MEK inhibitors for the treatment of proliferative diseases
CA2658725A1 (fr) 2006-08-16 2008-02-21 Exelixis, Inc. Procedes d'utilisation de modulateurs pi3k etmek
CN105106199A (zh) 2006-12-14 2015-12-02 埃克塞利希斯股份有限公司 使用mek抑制剂的方法
WO2008124085A2 (fr) 2007-04-03 2008-10-16 Exelixis, Inc. Méthodes d'utilisation de combinaisons d'inhibiteurs de mek et de jak-2
NZ706723A (en) 2012-10-12 2018-07-27 Exelixis Inc Novel process for making compounds for use in the treatment of cancer
JP6835472B2 (ja) 2013-03-05 2021-02-24 ユニバーシティ オブ テネシー リサーチ ファウンデーション 癌の処置のための組成物
CN105246508A (zh) 2013-03-14 2016-01-13 基因泰克公司 Mek抑制剂化合物与her3/egfr抑制剂化合物的组合及使用方法
AR105483A1 (es) 2015-06-30 2017-10-11 Exelixis Inc Sal de fumarato cristalina de (s)-[3,4-difluoro-2-(2-fluoro-4-yodofenilamino)fenil][3-hidroxi-3-(piperidin-2-il)azetidin-1-il]-metanona

Also Published As

Publication number Publication date
ZA201708760B (en) 2022-06-29
AU2021200202B2 (en) 2022-09-08
BR112017028516A2 (pt) 2018-08-28
CN107810183A (zh) 2018-03-16
IL256423B (en) 2022-09-01
TW201718535A (zh) 2017-06-01
CO2018000086A2 (es) 2018-04-10
MX2017017037A (es) 2018-04-30
WO2017004393A1 (fr) 2017-01-05
JP2021035967A (ja) 2021-03-04
RU2018103172A (ru) 2019-07-31
JP2018519318A (ja) 2018-07-19
US20200255398A1 (en) 2020-08-13
RU2018103172A3 (fr) 2019-10-31
RS67509B1 (sr) 2025-12-31
EP3317264B1 (fr) 2025-09-10
PH12017502414A1 (en) 2018-06-25
RU2021132394A (ru) 2021-11-18
TWI710556B (zh) 2020-11-21
HK1252433A1 (zh) 2019-05-24
JP7338950B2 (ja) 2023-09-05
MY192545A (en) 2022-08-26
DK3317264T3 (da) 2025-12-01
AU2016288209B2 (en) 2020-10-22
TW202108568A (zh) 2021-03-01
NZ739160A (en) 2024-10-25
AU2021200202A1 (en) 2021-03-18
IL256423A (en) 2018-02-28
HRP20251507T1 (hr) 2026-01-02
CR20180056A (es) 2018-05-25
CN118290395A (zh) 2024-07-05
US10590102B2 (en) 2020-03-17
US11254649B2 (en) 2022-02-22
MX390250B (es) 2025-03-20
US20220056010A1 (en) 2022-02-24
AU2016288209A1 (en) 2018-02-08
KR102695324B1 (ko) 2024-08-13
MA42301A (fr) 2018-05-09
AR105483A1 (es) 2017-10-11
NZ777527A (en) 2024-10-25
UA124728C2 (uk) 2021-11-10
TWI775187B (zh) 2022-08-21
JP2023025000A (ja) 2023-02-21
CA2990222C (fr) 2023-09-26
PE20180692A1 (es) 2018-04-23
IL295052A (en) 2022-09-01
SG10202105196YA (en) 2021-06-29
CL2017003475A1 (es) 2018-07-13
LT3317264T (lt) 2025-12-29
US20180346442A1 (en) 2018-12-06
KR20180021775A (ko) 2018-03-05
RU2762181C2 (ru) 2021-12-16
SMT202500458T1 (it) 2026-01-12
FI3317264T3 (fi) 2025-12-05
CA2990222A1 (fr) 2017-01-05
PT3317264T (pt) 2025-12-12
EP3317264A1 (fr) 2018-05-09

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