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MA38625A1 - Process for the preparation of erythrocytes loaded with one or more substances of pharmaceutical interest, and erythrocytes thus obtained - Google Patents

Process for the preparation of erythrocytes loaded with one or more substances of pharmaceutical interest, and erythrocytes thus obtained

Info

Publication number
MA38625A1
MA38625A1 MA38625A MA38625A MA38625A1 MA 38625 A1 MA38625 A1 MA 38625A1 MA 38625 A MA38625 A MA 38625A MA 38625 A MA38625 A MA 38625A MA 38625 A1 MA38625 A1 MA 38625A1
Authority
MA
Morocco
Prior art keywords
erythrocytes
substances
loaded
preparation
pharmaceutical interest
Prior art date
Application number
MA38625A
Other languages
French (fr)
Other versions
MA38625B1 (en
Inventor
Giovanni Mambrini
Luca Benatti
Giovanni Capogrossi
Marco Mandolini
Original Assignee
Erydel Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erydel Spa filed Critical Erydel Spa
Priority claimed from PCT/IB2014/061338 external-priority patent/WO2014181309A1/en
Publication of MA38625A1 publication Critical patent/MA38625A1/en
Publication of MA38625B1 publication Critical patent/MA38625B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/18—Erythrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La présente invention concerne un procédé pour préparer des érythrocytes chargés d'une ou plusieurs substances d'intérêt pharmaceutique. La présente invention concerne également des érythrocytes chargés ainsi obtenus et des compositions pharmaceutiques comprenant ladite population d'érythrocytes chargés, ainsi que leur application thérapeutique, en particulier dans le traitement d'ataxie-télangiectasie.The present invention relates to a process for preparing erythrocytes loaded with one or more substances of pharmaceutical interest. The present invention also relates to charged red blood cells thus obtained and pharmaceutical compositions comprising said population of packed erythrocytes, as well as their therapeutic application, in particular in the treatment of ataxia-telangiectasia.

MA38625A 2013-05-10 2014-05-09 Process for the preparation of erythrocytes loaded with one or more substances of pharmaceutical interest, and erythrocytes thus obtained MA38625B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000280A ITRM20130280A1 (en) 2013-05-10 2013-05-10 PROCEDURE FOR THE PREPARATION OF ERYTHROCYTES LOADED WITH ONE OR MORE SUBSTANCES OF PHARMACEUTICAL INTEREST.
PCT/IB2014/061338 WO2014181309A1 (en) 2013-05-10 2014-05-09 Process for the preparation of erythrocytes loaded with one or more substances of pharmaceutical interest and so obtained erythrocytes

Publications (2)

Publication Number Publication Date
MA38625A1 true MA38625A1 (en) 2017-09-29
MA38625B1 MA38625B1 (en) 2018-04-30

Family

ID=48672714

Family Applications (1)

Application Number Title Priority Date Filing Date
MA38625A MA38625B1 (en) 2013-05-10 2014-05-09 Process for the preparation of erythrocytes loaded with one or more substances of pharmaceutical interest, and erythrocytes thus obtained

Country Status (2)

Country Link
IT (1) ITRM20130280A1 (en)
MA (1) MA38625B1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4327710A (en) * 1980-06-18 1982-05-04 The United States Of America As Represented By The Secretary Of Agriculture Process for encapsulating additives in resealed erythrocytes for disseminating chemicals via the circulatory system
EP0882448B1 (en) * 1997-05-05 2005-01-12 DIDECO S.r.l. Method of encapsulating biologically active agents within erythrocytes and apparatus therefor
IT1399590B1 (en) * 2010-04-26 2013-04-26 Erydel Spa APPARATUS AND KIT FOR ENCAPSING AT LEAST A COMPOUND FOR THERAPEUTIC AND / OR DIAGNOSTIC USE WITHIN ERYTHROCYTES

Also Published As

Publication number Publication date
MA38625B1 (en) 2018-04-30
ITRM20130280A1 (en) 2014-11-11

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