MA38502A1 - Isolated human monoclonal antibody or antigen-binding fragment thereof that specifically binds to human gremlin-1 useful for the treatment of fibrosis, cancers and inhibition of angiogenesis - Google Patents
Isolated human monoclonal antibody or antigen-binding fragment thereof that specifically binds to human gremlin-1 useful for the treatment of fibrosis, cancers and inhibition of angiogenesisInfo
- Publication number
- MA38502A1 MA38502A1 MA38502A MA38502A MA38502A1 MA 38502 A1 MA38502 A1 MA 38502A1 MA 38502 A MA38502 A MA 38502A MA 38502 A MA38502 A MA 38502A MA 38502 A1 MA38502 A1 MA 38502A1
- Authority
- MA
- Morocco
- Prior art keywords
- fibrosis
- useful
- treatment
- angiogenesis
- cancers
- Prior art date
Links
- 206010016654 Fibrosis Diseases 0.000 title abstract 3
- 230000004761 fibrosis Effects 0.000 title abstract 3
- 101001032872 Homo sapiens Gremlin-1 Proteins 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 102000046318 human GREM1 Human genes 0.000 title abstract 2
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 239000012634 fragment Substances 0.000 title 1
- 230000014399 negative regulation of angiogenesis Effects 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 210000003734 kidney Anatomy 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
La présente invention concerne des anticorps se liant au gremlin-1 humain (grem1), et des méthodes d'utilisation. Selon certains modes de réalisation de l'invention, les anticorps sont des anticorps complètement humains qui se lient à grem1. Les anticorps selon l'invention sont utiles pour inhiber ou neutraliser l'activité de grem1, fournissant ainsi un moyen de traitement d'une maladie ou d'un trouble associé à grem1, tels qu'une fibrose ou un cancer. Selon certains modes de réalisation, les anticorps selon la présente invention sont utilisés dans le traitement d'au moins un symptôme ou complication d'une fibrose du foie, des poumons ou du rein.The present invention relates to human gremlin-1 binding antibodies (grem1), and methods of use. In some embodiments of the invention, the antibodies are fully human antibodies that bind to gram1. The antibodies of the invention are useful for inhibiting or neutralizing gram1 activity, thereby providing a means of treating a gram-related disease or disorder, such as fibrosis or cancer. According to some embodiments, the antibodies of the present invention are used in the treatment of at least one symptom or complication of fibrosis of the liver, lungs or kidney.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361782874P | 2013-03-14 | 2013-03-14 | |
| PCT/US2014/021471 WO2014159010A1 (en) | 2013-03-14 | 2014-03-07 | Human antibodies to grem 1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA38502A1 true MA38502A1 (en) | 2017-10-31 |
Family
ID=60765504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA38502A MA38502A1 (en) | 2013-03-14 | 2014-03-07 | Isolated human monoclonal antibody or antigen-binding fragment thereof that specifically binds to human gremlin-1 useful for the treatment of fibrosis, cancers and inhibition of angiogenesis |
Country Status (1)
| Country | Link |
|---|---|
| MA (1) | MA38502A1 (en) |
-
2014
- 2014-03-07 MA MA38502A patent/MA38502A1/en unknown
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