MA37445B1 - Lyophilisation d'agent tensioactif pulmonaire liposomal synthétique - Google Patents
Lyophilisation d'agent tensioactif pulmonaire liposomal synthétiqueInfo
- Publication number
- MA37445B1 MA37445B1 MA37445A MA37445A MA37445B1 MA 37445 B1 MA37445 B1 MA 37445B1 MA 37445 A MA37445 A MA 37445A MA 37445 A MA37445 A MA 37445A MA 37445 B1 MA37445 B1 MA 37445B1
- Authority
- MA
- Morocco
- Prior art keywords
- lyophilization
- pulmonary surfactant
- synthetic
- synthetic liposomal
- liposomal pulmonary
- Prior art date
Links
- 239000003580 lung surfactant Substances 0.000 title abstract 3
- 238000004108 freeze drying Methods 0.000 title 1
- 229940066294 lung surfactant Drugs 0.000 abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/395—Alveolar surfactant peptides; Pulmonary surfactant peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0082—Lung surfactant, artificial mucus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
- F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Abstract
L'invention concerne des agents tensioactifs pulmonaires lyophilisés présentant une surface spécifique et une porosité augmentées. Des procédés de préparation des agents tensioactifs pulmonaires lyophilisés sont également décrits.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261616827P | 2012-03-28 | 2012-03-28 | |
| PCT/US2013/034464 WO2013149074A1 (fr) | 2012-03-28 | 2013-03-28 | Lyophilisation d'agent tensioactif pulmonaire liposomal synthétique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA37445A1 MA37445A1 (fr) | 2016-04-29 |
| MA37445B1 true MA37445B1 (fr) | 2017-01-31 |
Family
ID=48096305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA37445A MA37445B1 (fr) | 2012-03-28 | 2014-10-22 | Lyophilisation d'agent tensioactif pulmonaire liposomal synthétique |
Country Status (35)
| Country | Link |
|---|---|
| US (3) | US9554999B2 (fr) |
| EP (2) | EP2723323B1 (fr) |
| JP (1) | JP6178402B2 (fr) |
| KR (1) | KR102123129B1 (fr) |
| CN (1) | CN104271118B (fr) |
| AU (2) | AU2013237985B2 (fr) |
| BR (1) | BR112014024057A8 (fr) |
| CA (1) | CA2867649C (fr) |
| CL (1) | CL2014002553A1 (fr) |
| CO (1) | CO7081146A2 (fr) |
| CR (1) | CR20140449A (fr) |
| CU (1) | CU20140116A7 (fr) |
| CY (1) | CY1117380T1 (fr) |
| DK (1) | DK2723323T3 (fr) |
| EC (1) | ECSP14024363A (fr) |
| ES (1) | ES2557805T3 (fr) |
| HK (1) | HK1206979A1 (fr) |
| HR (1) | HRP20151392T1 (fr) |
| HU (1) | HUE026363T2 (fr) |
| IL (1) | IL234688B (fr) |
| IN (1) | IN2014DN08538A (fr) |
| MA (1) | MA37445B1 (fr) |
| MX (1) | MX359654B (fr) |
| MY (1) | MY164868A (fr) |
| NZ (1) | NZ630219A (fr) |
| PE (1) | PE20142302A1 (fr) |
| PL (1) | PL2723323T3 (fr) |
| PT (1) | PT2723323E (fr) |
| RS (1) | RS54513B1 (fr) |
| RU (1) | RU2671500C2 (fr) |
| SG (1) | SG11201405944PA (fr) |
| SI (1) | SI2723323T1 (fr) |
| SM (1) | SMT201500320B (fr) |
| WO (2) | WO2013149013A1 (fr) |
| ZA (1) | ZA201406982B (fr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201405944PA (en) * | 2012-03-28 | 2014-10-30 | Discovery Lab Inc | Lyophilization of synthetic liposomal pulmonary surfactant |
| EP3222273B1 (fr) * | 2014-11-18 | 2019-09-25 | National Institute for Materials Science | Procédé de fabrication de particule poreuse |
| WO2016108534A1 (fr) * | 2014-12-30 | 2016-07-07 | 주식회사 삼양바이오팜 | Produit lyophilisé de nanoparticules de polymère, et son procédé de préparation |
| HUE053799T2 (hu) * | 2015-07-10 | 2021-07-28 | Byondis Bv | Antitest-duokarmicin gyógyszer-konjugátumokat tartalmazó készítmények |
| KR102716928B1 (ko) | 2015-07-22 | 2024-10-11 | 닛토덴코 가부시키가이샤 | 나노 입자 동결건조물 형태를 위한 조성물 및 방법 |
| JP7012512B2 (ja) * | 2017-11-13 | 2022-01-28 | 清水建設株式会社 | 管理装置、製造システムおよび管理方法 |
| CA3085944A1 (fr) * | 2017-12-21 | 2019-06-27 | Civitas Therapeutics, Inc. | Formulations de tensioactifs pour l'inhalation |
| CN108853061A (zh) * | 2018-10-09 | 2018-11-23 | 兆科药业（合肥）有限公司 | 一种人工合成肺表面活性剂药物组合物及与之的肠溶胶囊和其制备方法及用途 |
| WO2020142420A1 (fr) * | 2018-12-31 | 2020-07-09 | Novus Therapeutics, Inc. | Nouvelle substance médicamenteuse à base d'alliage de tensioactif-lipide, ses procédés de production et compositions pharmaceutiques la comprenant |
| US11287185B1 (en) | 2020-09-09 | 2022-03-29 | Stay Fresh Technology, LLC | Freeze drying with constant-pressure and constant-temperature phases |
| KR102545292B1 (ko) * | 2021-01-28 | 2023-06-16 | 인천대학교 산학협력단 | 마이크로캡슐 형성용 생체 적합 계면활성제 합성방법 |
| EP4366691A1 (fr) * | 2021-07-05 | 2024-05-15 | Chiesi Farmaceutici S.p.A. | Procédé de préparation d'un tensioactif pulmonaire |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE751108R (fr) | 1969-06-06 | 1970-11-03 | Berliet Automobiles | Dispositif pour la mesure precise de la consommation specifiquedes moteurs a combustion |
| JPS59164724A (ja) * | 1983-03-10 | 1984-09-17 | Tokyo Tanabe Co Ltd | サ−フアクタント及びそれを含有する呼吸窮迫症候群治療剤 |
| US5260273A (en) | 1988-01-06 | 1993-11-09 | The Scripps Research Institute | Pulmonary surfactant protein and related polypeptide |
| PT877602E (pt) | 1996-01-24 | 2002-07-31 | Byk Gulden Lomberg Chem Fab | Processo para o fabrico de composicoes de surfactantes pulmonares em po |
| WO1997035882A1 (fr) * | 1996-03-27 | 1997-10-02 | Ortho Pharmaceutical Corporation | Compositions lyophilisees de peptides tensioactifs pulmonaires |
| US6652837B1 (en) | 1996-05-24 | 2003-11-25 | Massachusetts Institute Of Technology | Preparation of novel particles for inhalation |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US5855913A (en) | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US7638493B2 (en) | 2004-04-29 | 2009-12-29 | Sannamu Lee | Artificial pulmonary surfactant compositions and use of the same |
| US7582312B2 (en) * | 2004-11-15 | 2009-09-01 | Discovery Laboratories, Inc. | Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof |
| CA2612937C (fr) * | 2005-07-22 | 2014-05-06 | Amgen Inc. | Lyophilisats proteiques concentres, procedes associes et leurs utilisations |
| EP1997502A1 (fr) | 2007-06-01 | 2008-12-03 | CHIESI FARMACEUTICI S.p.A. | Agents tensioactifs reconstitués dotés de propriétés améliorées |
| SG11201405944PA (en) * | 2012-03-28 | 2014-10-30 | Discovery Lab Inc | Lyophilization of synthetic liposomal pulmonary surfactant |
-
2013
- 2013-03-28 SG SG11201405944PA patent/SG11201405944PA/en unknown
- 2013-03-28 BR BR112014024057A patent/BR112014024057A8/pt not_active Application Discontinuation
- 2013-03-28 US US14/387,707 patent/US9554999B2/en active Active
- 2013-03-28 MX MX2014011483A patent/MX359654B/es active IP Right Grant
- 2013-03-28 DK DK13716655.9T patent/DK2723323T3/en active
- 2013-03-28 HR HRP20151392T patent/HRP20151392T1/hr unknown
- 2013-03-28 MY MYPI2014002699A patent/MY164868A/en unknown
- 2013-03-28 ES ES13716655.9T patent/ES2557805T3/es active Active
- 2013-03-28 IN IN8538DEN2014 patent/IN2014DN08538A/en unknown
- 2013-03-28 NZ NZ630219A patent/NZ630219A/en not_active IP Right Cessation
- 2013-03-28 RU RU2014143247A patent/RU2671500C2/ru active
- 2013-03-28 WO PCT/US2013/034364 patent/WO2013149013A1/fr not_active Ceased
- 2013-03-28 PT PT137166559T patent/PT2723323E/pt unknown
- 2013-03-28 CA CA2867649A patent/CA2867649C/fr active Active
- 2013-03-28 RS RS20150867A patent/RS54513B1/sr unknown
- 2013-03-28 SI SI201330112T patent/SI2723323T1/sl unknown
- 2013-03-28 PL PL13716655T patent/PL2723323T3/pl unknown
- 2013-03-28 PE PE2014001494A patent/PE20142302A1/es not_active Application Discontinuation
- 2013-03-28 WO PCT/US2013/034464 patent/WO2013149074A1/fr not_active Ceased
- 2013-03-28 CN CN201380022948.0A patent/CN104271118B/zh active Active
- 2013-03-28 JP JP2015503612A patent/JP6178402B2/ja active Active
- 2013-03-28 HU HUE13716655A patent/HUE026363T2/en unknown
- 2013-03-28 EP EP13716655.9A patent/EP2723323B1/fr active Active
- 2013-03-28 AU AU2013237985A patent/AU2013237985B2/en not_active Ceased
- 2013-03-28 KR KR1020147029784A patent/KR102123129B1/ko active Active
- 2013-03-28 EP EP14188473.4A patent/EP2837377A1/fr not_active Withdrawn
- 2013-11-27 US US14/091,712 patent/US8748397B2/en active Active
- 2013-11-27 US US14/091,608 patent/US8748396B2/en active Active
-
2014
- 2014-09-16 IL IL234688A patent/IL234688B/en active IP Right Grant
- 2014-09-25 ZA ZA2014/06982A patent/ZA201406982B/en unknown
- 2014-09-25 CL CL2014002553A patent/CL2014002553A1/es unknown
- 2014-09-25 CR CR20140449A patent/CR20140449A/es unknown
- 2014-09-29 CU CUP2014000116A patent/CU20140116A7/es unknown
- 2014-09-30 CO CO14216241A patent/CO7081146A2/es unknown
- 2014-10-22 MA MA37445A patent/MA37445B1/fr unknown
- 2014-10-24 EC ECIEPI201424363A patent/ECSP14024363A/es unknown
-
2015
- 2015-08-06 HK HK15107596.6A patent/HK1206979A1/en unknown
- 2015-12-21 SM SM201500320T patent/SMT201500320B/it unknown
- 2015-12-22 CY CY20151101180T patent/CY1117380T1/el unknown
-
2017
- 2017-10-06 AU AU2017239624A patent/AU2017239624B2/en active Active
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