MA35305B1 - Nouveaux acides pipéridinylmonocarboxyliques à titre d'agonistes des récepteurs de s1p1 - Google Patents
Nouveaux acides pipéridinylmonocarboxyliques à titre d'agonistes des récepteurs de s1p1Info
- Publication number
- MA35305B1 MA35305B1 MA36356A MA36356A MA35305B1 MA 35305 B1 MA35305 B1 MA 35305B1 MA 36356 A MA36356 A MA 36356A MA 36356 A MA36356 A MA 36356A MA 35305 B1 MA35305 B1 MA 35305B1
- Authority
- MA
- Morocco
- Prior art keywords
- receptor agonists
- piperidinylmonocarboxylic
- acids
- new
- compounds
- Prior art date
Links
- 239000000018 receptor agonist Substances 0.000 title abstract 2
- 229940044601 receptor agonist Drugs 0.000 title abstract 2
- DNUTZBZXLPWRJG-UHFFFAOYSA-N 1-Piperidine carboxylic acid Chemical class OC(=O)N1CCCCC1 DNUTZBZXLPWRJG-UHFFFAOYSA-N 0.000 title 1
- 102000011011 Sphingosine 1-phosphate receptors Human genes 0.000 title 1
- 108050001083 Sphingosine 1-phosphate receptors Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- DUYSYHSSBDVJSM-KRWOKUGFSA-N sphingosine 1-phosphate Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)COP(O)(O)=O DUYSYHSSBDVJSM-KRWOKUGFSA-N 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Virology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
Abstract
Cette invention concerne de nouveaux composés agissant comme des agonistes des récepteurs s1 p (sphingosine-1-phosphate), des compositions les contenant, l'utilisation de ces composés en médecine et leur procédé de préparation.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11305433A EP2511275A1 (fr) | 2011-04-12 | 2011-04-12 | Nouveaux acides pipéridiniles monocarboxyliques comme agonistes du récepteur S1P1 |
| PCT/EP2012/056470 WO2012140020A1 (fr) | 2011-04-12 | 2012-04-10 | Nouveaux acides pipéridinylmonocarboxyliques à titre d'agonistes des récepteurs de s1p1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA35305B1 true MA35305B1 (fr) | 2014-08-01 |
Family
ID=43984071
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA36356A MA35305B1 (fr) | 2011-04-12 | 2013-10-22 | Nouveaux acides pipéridinylmonocarboxyliques à titre d'agonistes des récepteurs de s1p1 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US9266867B2 (fr) |
| EP (2) | EP2511275A1 (fr) |
| JP (1) | JP6050315B2 (fr) |
| KR (1) | KR101854152B1 (fr) |
| CN (1) | CN103619838B (fr) |
| AU (1) | AU2012241981B2 (fr) |
| BR (1) | BR112013026434B1 (fr) |
| CA (1) | CA2833180C (fr) |
| CO (1) | CO6801772A2 (fr) |
| DK (1) | DK2697219T3 (fr) |
| EA (1) | EA023638B1 (fr) |
| EC (1) | ECSP13012983A (fr) |
| ES (1) | ES2544616T3 (fr) |
| HU (1) | HUE025443T2 (fr) |
| IL (1) | IL228844A (fr) |
| MA (1) | MA35305B1 (fr) |
| MX (1) | MX342926B (fr) |
| PH (1) | PH12013502142A1 (fr) |
| PL (1) | PL2697219T3 (fr) |
| PT (1) | PT2697219E (fr) |
| SG (1) | SG194183A1 (fr) |
| TN (1) | TN2013000425A1 (fr) |
| UA (1) | UA110822C2 (fr) |
| WO (1) | WO2012140020A1 (fr) |
| ZA (1) | ZA201307820B (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3484880T3 (pl) | 2016-07-13 | 2021-04-06 | Leo Pharma A/S | Heteroaromatyczne modulatory receptora sierocego gamma spokrewnionego z receptorem retinoidowym |
| CN111807954B (zh) * | 2019-04-10 | 2024-04-05 | 广东东阳光药业股份有限公司 | 一种辛波莫德中间体的制备方法 |
| WO2022220612A1 (fr) * | 2021-04-14 | 2022-10-20 | 주식회사 엘지화학 | Procédé de préparation d'intermédiaire pour la synthèse d'un agoniste du récepteur de la sphingosine-1-phosphate |
| CN113332435B (zh) * | 2021-06-18 | 2022-10-18 | 广州中医药大学(广州中医药研究院) | 鞘氨醇-1-磷酸4受体激动剂及其与真武汤联合在制备治疗慢性肾小球肾炎药物中的应用 |
| WO2024029638A1 (fr) * | 2022-08-01 | 2024-02-08 | 한국과학기술연구원 | Nouveau dérivé d'hétérocyclyl-phényl-méthylamine, son procédé de préparation et son utilisation pour la prévention, le soulagement ou le traitement de la sclérose en plaques |
| WO2025083549A1 (fr) | 2023-10-16 | 2025-04-24 | Sun Pharma Advanced Research Company Limited | Méthodes et combinaisons d'inhibiteurs de la voie il-23 et de modulateurs de la voie de signalisation s1p pour le traitement de maladies auto-immunes |
| CN117623967A (zh) * | 2023-11-16 | 2024-03-01 | 迪嘉药业集团股份有限公司 | 一种替米沙坦中间体3-甲基-4-氨基苯甲酸的制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE441654T1 (de) * | 2002-01-18 | 2009-09-15 | Merck & Co Inc | Edg-rezeptoragonisten |
| AU2003276043A1 (en) | 2002-06-17 | 2003-12-31 | Merck & Co., Inc. | 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)pyrrolidine-3-carboxylates as edg receptor agonists |
| BRPI0711358A2 (pt) | 2006-05-09 | 2011-09-27 | Pfizer Prod Inc | derivados do ácido cicloalquilamino e suas composições farmacêuticas |
| AU2007334436A1 (en) * | 2006-12-15 | 2008-06-26 | Abbott Laboratories | Novel oxadiazole compounds |
| EP2014653A1 (fr) | 2007-06-15 | 2009-01-14 | Bioprojet | Nouveaux dérivés d'acide dicarboxylique comme agonistes du recepteur S1P1 |
| WO2009043889A2 (fr) * | 2007-10-04 | 2009-04-09 | Merck Serono S.A. | Dérivés d'oxadiazole |
| GB0725102D0 (en) * | 2007-12-21 | 2008-01-30 | Glaxo Group Ltd | Compounds |
| KR101589332B1 (ko) * | 2008-12-05 | 2016-01-27 | 아스텔라스세이야쿠 가부시키가이샤 | ２ｈ-크로멘 화합물 및 그의 유도체 |
| EP2305660A1 (fr) * | 2009-09-25 | 2011-04-06 | Almirall, S.A. | Nouveaux dérivés de thiadiazole |
| EP2366702A1 (fr) * | 2010-03-18 | 2011-09-21 | Almirall, S.A. | Nouveaux dérivés d'oxadiazole |
| BR112013019683B1 (pt) * | 2011-02-07 | 2022-04-19 | Biogen Inc | Compostos que modulam s1p, composição farmacêutica, e uso dos mesmos |
-
2011
- 2011-04-12 EP EP11305433A patent/EP2511275A1/fr not_active Withdrawn
-
2012
- 2012-04-10 KR KR1020137030008A patent/KR101854152B1/ko active Active
- 2012-04-10 US US14/111,438 patent/US9266867B2/en active Active
- 2012-04-10 SG SG2013076591A patent/SG194183A1/en unknown
- 2012-04-10 BR BR112013026434-9A patent/BR112013026434B1/pt active IP Right Grant
- 2012-04-10 WO PCT/EP2012/056470 patent/WO2012140020A1/fr not_active Ceased
- 2012-04-10 PT PT127146744T patent/PT2697219E/pt unknown
- 2012-04-10 ES ES12714674.4T patent/ES2544616T3/es active Active
- 2012-04-10 PH PH1/2013/502142A patent/PH12013502142A1/en unknown
- 2012-04-10 JP JP2014504282A patent/JP6050315B2/ja active Active
- 2012-04-10 HU HUE12714674A patent/HUE025443T2/en unknown
- 2012-04-10 PL PL12714674T patent/PL2697219T3/pl unknown
- 2012-04-10 CA CA2833180A patent/CA2833180C/fr active Active
- 2012-04-10 DK DK12714674.4T patent/DK2697219T3/en active
- 2012-04-10 AU AU2012241981A patent/AU2012241981B2/en active Active
- 2012-04-10 EA EA201301150A patent/EA023638B1/ru not_active IP Right Cessation
- 2012-04-10 MX MX2013011984A patent/MX342926B/es active IP Right Grant
- 2012-04-10 EP EP12714674.4A patent/EP2697219B1/fr active Active
- 2012-04-10 CN CN201280022925.5A patent/CN103619838B/zh active Active
- 2012-10-04 UA UAA201313012A patent/UA110822C2/uk unknown
-
2013
- 2013-10-13 IL IL228844A patent/IL228844A/en active IP Right Grant
- 2013-10-14 TN TNP2013000425A patent/TN2013000425A1/fr unknown
- 2013-10-21 EC ECSP13012983 patent/ECSP13012983A/es unknown
- 2013-10-21 ZA ZA2013/07820A patent/ZA201307820B/en unknown
- 2013-10-22 MA MA36356A patent/MA35305B1/fr unknown
- 2013-11-12 CO CO13265458A patent/CO6801772A2/es not_active Application Discontinuation
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