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MA33070B1 - Pyrrolopyrimidinedione dimere et son utilisation dans le traitement de maladies respiratoires - Google Patents

Pyrrolopyrimidinedione dimere et son utilisation dans le traitement de maladies respiratoires

Info

Publication number
MA33070B1
MA33070B1 MA34129A MA34129A MA33070B1 MA 33070 B1 MA33070 B1 MA 33070B1 MA 34129 A MA34129 A MA 34129A MA 34129 A MA34129 A MA 34129A MA 33070 B1 MA33070 B1 MA 33070B1
Authority
MA
Morocco
Prior art keywords
treatment
pyroloprimendione
dimol
respiratory diseases
pneumonia
Prior art date
Application number
MA34129A
Other languages
Arabic (ar)
English (en)
Inventor
Harry Finch
Christine Edwards
Janus Kulagowski
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42026259&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA33070(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0901616A external-priority patent/GB0901616D0/en
Priority claimed from GB0908068A external-priority patent/GB0908068D0/en
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of MA33070B1 publication Critical patent/MA33070B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L'invention porte sur le composé de formule (I) en tant qu'inhibiteur de l'élastase des neutrophiles humains, utile pour le traitement par inhalation d'une inflammation pulmonaire.
MA34129A 2009-01-30 2010-01-22 Pyrrolopyrimidinedione dimere et son utilisation dans le traitement de maladies respiratoires MA33070B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0901616A GB0901616D0 (en) 2009-01-30 2009-01-30 Enzyme inhibitors
GB0908068A GB0908068D0 (en) 2009-05-11 2009-05-11 Enzyme inhibitors
PCT/GB2010/050092 WO2010086638A1 (fr) 2009-01-30 2010-01-22 Pyrrolopyrimidinedione dimère et son utilisation dans le traitement de maladies respiratoires

Publications (1)

Publication Number Publication Date
MA33070B1 true MA33070B1 (fr) 2012-02-01

Family

ID=42026259

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34129A MA33070B1 (fr) 2009-01-30 2010-01-22 Pyrrolopyrimidinedione dimere et son utilisation dans le traitement de maladies respiratoires

Country Status (19)

Country Link
US (1) US8455505B2 (fr)
EP (1) EP2391629B1 (fr)
JP (1) JP2012516316A (fr)
KR (1) KR20110124217A (fr)
CN (1) CN102300865B (fr)
AU (1) AU2010209456A1 (fr)
BR (1) BRPI1005684A2 (fr)
CA (1) CA2751054A1 (fr)
CL (1) CL2011001838A1 (fr)
CO (1) CO6420348A2 (fr)
EA (1) EA201190087A1 (fr)
ES (1) ES2399908T3 (fr)
IL (1) IL214353A0 (fr)
MA (1) MA33070B1 (fr)
MX (1) MX2011007697A (fr)
PE (1) PE20120368A1 (fr)
SG (1) SG173463A1 (fr)
TN (1) TN2011000356A1 (fr)
WO (1) WO2010086638A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9657015B2 (en) * 2014-07-31 2017-05-23 Boehringer Ingelheim International Gmbh Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
CN120383525A (zh) * 2025-06-30 2025-07-29 潍坊市海欣药业有限公司 一种2-甲基-4-乙酰基苯甲酸的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
GB0502258D0 (en) * 2005-02-03 2005-03-09 Argenta Discovery Ltd Compounds and their use
WO2009013444A1 (fr) * 2007-07-25 2009-01-29 Argenta Discovery Limited Tétrahydropyrrolopyrimidinediones et leur utilisation comme inhibiteurs de l'élastase des neutrophiles humains
PL2024367T3 (pl) 2006-05-04 2011-05-31 Chiesi Farm Spa Tetrahydropirolopirymidynodiony i ich zastosowanie jako inhibitory ludzkiej elastazy neutrofilowej

Also Published As

Publication number Publication date
CL2011001838A1 (es) 2012-01-06
ES2399908T3 (es) 2013-04-04
BRPI1005684A2 (pt) 2018-06-12
MX2011007697A (es) 2011-10-12
JP2012516316A (ja) 2012-07-19
WO2010086638A1 (fr) 2010-08-05
SG173463A1 (en) 2011-09-29
KR20110124217A (ko) 2011-11-16
US8455505B2 (en) 2013-06-04
TN2011000356A1 (en) 2013-03-27
CN102300865B (zh) 2013-12-04
CA2751054A1 (fr) 2010-08-05
PE20120368A1 (es) 2012-05-04
EA201190087A1 (ru) 2012-05-30
IL214353A0 (en) 2011-09-27
CO6420348A2 (es) 2012-04-16
US20120027692A1 (en) 2012-02-02
EP2391629B1 (fr) 2012-10-31
CN102300865A (zh) 2011-12-28
EP2391629A1 (fr) 2011-12-07
AU2010209456A1 (en) 2011-08-18

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