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MA29781B1 - Procede regioselectif de preparation de benzimidazole thiophenes - Google Patents

Procede regioselectif de preparation de benzimidazole thiophenes

Info

Publication number
MA29781B1
MA29781B1 MA30750A MA30750A MA29781B1 MA 29781 B1 MA29781 B1 MA 29781B1 MA 30750 A MA30750 A MA 30750A MA 30750 A MA30750 A MA 30750A MA 29781 B1 MA29781 B1 MA 29781B1
Authority
MA
Morocco
Prior art keywords
thiophenes
preparing benzimidazole
regioselective process
preparing
benzimidazole
Prior art date
Application number
MA30750A
Other languages
English (en)
Inventor
Keith Hornberger
Mui Cheung
Mark Andrew Pobanz
Kyle Allen Emmitte
Kevin Wayne Kuntz
Jennifer Gabriel Badiang
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of MA29781B1 publication Critical patent/MA29781B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D333/40—Thiophene-2-carboxylic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

L'INVENTION CONCERNE UN PROCÉDÉ DE PRÉPARATION DE COMPOSÉS DE BENZIMIDAZOLE THIOPHÈNE DE FORMULE I. L'INVENTION CONCERNE EN OUTRE DES PRODUITS INTERMÉDIAIRES UTILISÉS DANS CE PROCÉDÉ.
MA30750A 2005-09-06 2008-03-17 Procede regioselectif de preparation de benzimidazole thiophenes MA29781B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71430105P 2005-09-06 2005-09-06

Publications (1)

Publication Number Publication Date
MA29781B1 true MA29781B1 (fr) 2008-09-01

Family

ID=37605702

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30750A MA29781B1 (fr) 2005-09-06 2008-03-17 Procede regioselectif de preparation de benzimidazole thiophenes

Country Status (18)

Country Link
US (1) US20080249301A1 (fr)
EP (1) EP1924572B1 (fr)
JP (1) JP2009507022A (fr)
KR (1) KR20080045266A (fr)
CN (1) CN101304986A (fr)
AT (1) ATE453634T1 (fr)
AU (1) AU2006287771A1 (fr)
BR (1) BRPI0615705A2 (fr)
CA (1) CA2621073A1 (fr)
DE (1) DE602006011482D1 (fr)
EA (1) EA200800549A1 (fr)
ES (1) ES2338590T3 (fr)
IL (1) IL189769A0 (fr)
MA (1) MA29781B1 (fr)
MX (1) MX2008003172A (fr)
NO (1) NO20081101L (fr)
WO (1) WO2007030366A1 (fr)
ZA (1) ZA200801950B (fr)

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CA2621879A1 (fr) * 2005-09-06 2007-03-15 Smithkline Beecham Corporation Composes de benzimidazole thiophene
JP2009507020A (ja) * 2005-09-06 2009-02-19 スミスクライン ビーチャム コーポレーション Ｐｌｋ調節物質としてのルベンゾイミダゾールチオフェン化合物
JP5498703B2 (ja) 2006-01-23 2014-05-21 バーテックス ファーマシューティカルズ インコーポレイテッド プロテインキナーゼのインヒビターとして有用なチオフェン−カルボキサミド
WO2007120760A2 (fr) 2006-04-13 2007-10-25 Vertex Pharmaceuticals Incorporated Thiophène-carboxamides servant d'inhibiteurs de protéines kinases
WO2007139795A1 (fr) 2006-05-23 2007-12-06 Vertex Pharmaceuticals Incorporated Thiophène-carboxamides inhibiteurs des protéines kinases
EP2027116A2 (fr) 2006-05-23 2009-02-25 Vertex Pharmaceuticals Incorporated Thiophène-carboxamides pouvant être employés en tant qu'inhibiteurs de protéine kinase
US7615643B2 (en) 2006-06-02 2009-11-10 Smithkline Beecham Corporation Benzimidazole thiophene compounds
JP2010531887A (ja) * 2007-06-26 2010-09-30 グラクソスミスクライン エルエルシー ベンズイミダゾールチオフェンの調製方法
EP2100894A1 (fr) 2008-03-12 2009-09-16 4Sc Ag Pyridopyrimidinones utilisés comme inhibiteurs de la kinase de type Plk1 (polo-like kinase)
CA3215310A1 (fr) 2010-04-12 2011-10-20 Supernus Pharmaceuticals Inc. Procedes de fabrication de sels de viloxazine et leurs nouveaux polymorphes
US20130315895A1 (en) 2010-07-01 2013-11-28 Takeda Pharmaceutical Company Limited COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET
US8754114B2 (en) 2010-12-22 2014-06-17 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
EP2565186A1 (fr) 2011-09-02 2013-03-06 Hybrigenics S.A. Inhibiteurs sélectifs et réversibles de la protéase 7 spécifique de l'ubiquitine
US9309221B2 (en) 2012-04-10 2016-04-12 Sumitomo Dainippon Pharma Co., Ltd. 1-substituted indazole derivative
CN107652289B (zh) 2012-06-13 2020-07-21 因塞特控股公司 作为fgfr抑制剂的取代的三环化合物
US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
JP6449244B2 (ja) 2013-04-19 2019-01-09 インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ Ｆｇｆｒ抑制剤としての二環式複素環
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
WO2016134294A1 (fr) 2015-02-20 2016-08-25 Incyte Corporation Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
ES2751669T3 (es) 2015-02-20 2020-04-01 Incyte Corp Heterociclos bicíclicos como inhibidores FGFR
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
AU2018388404B2 (en) 2017-12-22 2023-11-02 HiberCell Inc. Aminopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors
CN119241541A (zh) 2018-05-04 2025-01-03 因赛特公司 Fgfr抑制剂的固体形式和其制备方法
PE20210919A1 (es) 2018-05-04 2021-05-19 Incyte Corp Sales de un inhibidor de fgfr
WO2020185532A1 (fr) 2019-03-08 2020-09-17 Incyte Corporation Méthodes de traitement du cancer au moyen d'un inhibiteur de fgfr
CN109988098A (zh) * 2019-05-23 2019-07-09 常州工程职业技术学院 一种(r)-n-叔丁氧羰基-3-羟甲基哌啶的合成方法
TW202112767A (zh) 2019-06-17 2021-04-01 美商佩特拉製藥公司 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
WO2021067374A1 (fr) 2019-10-01 2021-04-08 Incyte Corporation Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr
GEP20247679B (en) 2019-10-14 2024-10-10 Incyte Corp Bicyclic heterocycles as fgfr inhibitors
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
CA3163875A1 (fr) 2019-12-04 2021-06-10 Incyte Corporation Heterocycles tricycliques en tant qu'inhibiteurs de fgfr
IL293001A (en) 2019-12-04 2022-07-01 Incyte Corp Derivatives of fgfr repressors
US12012409B2 (en) 2020-01-15 2024-06-18 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
JP2024513575A (ja) 2021-04-12 2024-03-26 インサイト・コーポレイション Ｆｇｆｒ阻害剤及びネクチン－４標的化剤を含む併用療法
AR126101A1 (es) 2021-06-09 2023-09-13 Incyte Corp Heterociclos tricíclicos como inhibidores de fgfr
WO2022261160A1 (fr) 2021-06-09 2022-12-15 Incyte Corporation Hétérocycles tricycliques en tant qu'inhibiteurs de fgfr

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5990146A (en) * 1997-08-20 1999-11-23 Warner-Lambert Company Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation
US6162804A (en) * 1997-09-26 2000-12-19 Merck & Co., Inc. Tyrosine kinase inhibitors
GB0005642D0 (en) * 2000-03-10 2000-05-03 Astrazeneca Uk Ltd Chemical compounds
US7244744B2 (en) * 2001-11-01 2007-07-17 Icagen, Inc. Piperidines
NZ538134A (en) * 2002-08-08 2006-03-31 Smithkline Beecham Corp Thiophene compounds
WO2004041777A2 (fr) * 2002-10-30 2004-05-21 Merck & Co., Inc. Modulateurs d'heteroarylpiperidine de l'activite des recepteurs de la chimiokine
EP1685128A1 (fr) * 2003-10-16 2006-08-02 Smithkline Beecham Corporation Procede de preparation de thiophenes de benzimidazole

Also Published As

Publication number Publication date
BRPI0615705A2 (pt) 2016-08-23
ZA200801950B (en) 2009-09-30
WO2007030366A1 (fr) 2007-03-15
DE602006011482D1 (de) 2010-02-11
CN101304986A (zh) 2008-11-12
NO20081101L (no) 2008-04-04
IL189769A0 (en) 2008-08-07
ES2338590T3 (es) 2010-05-10
EP1924572B1 (fr) 2009-12-30
EP1924572A1 (fr) 2008-05-28
AU2006287771A1 (en) 2007-03-15
US20080249301A1 (en) 2008-10-09
EA200800549A1 (ru) 2008-08-29
JP2009507022A (ja) 2009-02-19
MX2008003172A (es) 2008-03-18
KR20080045266A (ko) 2008-05-22
CA2621073A1 (fr) 2007-03-15
ATE453634T1 (de) 2010-01-15

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